Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3l04SN0N-acetylornithine carbamoyltransferase2.1.3.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3l04SN0N-acetylornithine carbamoyltransferase2.1.3.91.000
3kzoAN0N-acetylornithine carbamoyltransferase2.1.3.90.788
3l06SN0N-acetylornithine carbamoyltransferase2.1.3.90.742
3l05SN0N-acetylornithine carbamoyltransferase2.1.3.90.643
3m4nPA9N-acetylornithine carbamoyltransferase2.1.3.90.579
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.504
2bf7HBIPteridine reductase 11.5.1.330.495
1vbiNADMalate/L-lactate dehydrogenase family protein/0.494
1x8b824Wee1-like protein kinase2.7.10.20.486
3sl2ATPSensor histidine kinase WalK/0.484
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.481
1h60STRPentaerythritol tetranitrate reductase/0.478
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.477
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.476
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.474
2z4sADPChromosomal replication initiator protein DnaA/0.473
3vf60H6Glucokinase2.7.1.20.473
4ddrMMVDihydrofolate reductase1.5.1.30.473
1jcm137Tryptophan biosynthesis protein TrpCF4.1.1.480.472
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.472
2a9z26AAdenosine kinase2.7.1.200.471
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1w1wAGSStructural maintenance of chromosomes protein 1/0.470
3mjrAC2Deoxycytidine kinase2.7.1.740.469
4ai8DZAHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.469
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.468
3dntATPSerine/threonine-protein kinase toxin HipA/0.468
4bewACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.468
1lkeDOGBilin-binding protein/0.467
4lb2DM5Serum albumin/0.467
1b2lNDCAlcohol dehydrogenase1.1.1.10.466
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.466
3fhxPLPPyridoxal kinase2.7.1.350.465
4tx9AMZPhosphoribosyl isomerase A/0.465
4ea2RWZDehydrosqualene synthase/0.464
4pzsACOHistone acetyltransferase p300/0.464
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.463
2in6839Wee1-like protein kinase2.7.10.20.463
3eigMTXDihydrofolate reductase1.5.1.30.463
3lfzADPUncharacterized protein MJ1225/0.463
4b4w9L9Bifunctional protein FolD/0.463
4m11MXMProstaglandin G/H synthase 21.14.99.10.463
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.463
2a9y26AAdenosine kinase2.7.1.200.462
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
2wd8VGFPteridine reductase/0.461
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.461
2zuiCAMCamphor 5-monooxygenase1.14.15.10.461
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.461
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4f6vZYMDehydrosqualene synthase/0.461
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.460
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.460
1cq7PY5Aspartate aminotransferase2.6.1.10.459
2bfmTOPPteridine reductase 11.5.1.330.459
2cftPLPPyridoxal phosphate phosphatase/0.459
3epsATPIsocitrate dehydrogenase kinase/phosphatase/0.459
3l63CAMCamphor 5-monooxygenase1.14.15.10.459
1culFOKAdenylate cyclase type 2/0.458
1culFOKAdenylate cyclase type 5/0.458
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
3h4vDVPPteridine reductase 11.5.1.330.458
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.458
4cthRDFNeprilysin/0.458
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.458
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.457
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.457
3w4k3LDD-amino-acid oxidase1.4.3.30.457
4boeCLRJapanin/0.457
1bzfTMQDihydrofolate reductase1.5.1.30.456
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
3a0iAJIGlucokinase2.7.1.20.456
3c35KAIGlutamate receptor ionotropic, kainate 1/0.456
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.456
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.455
1bcpATPPertussis toxin subunit 4/0.455
1bcpATPPertussis toxin subunit 5/0.455
1h61PDNPentaerythritol tetranitrate reductase/0.455
4a2aATPCell division protein FtsA/0.455
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.455
2rd2QSIGlutamine--tRNA ligase6.1.1.180.454
2v59LZKBiotin carboxylase6.3.4.140.454
2xtnGTPGTPase IMAP family member 2/0.454
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.454
4jxxATPGlutamine--tRNA ligase6.1.1.180.454
4jyzATPGlutamine--tRNA ligase6.1.1.180.454
1hfqMOTDihydrofolate reductase1.5.1.30.453
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.453
2abaSTRPentaerythritol tetranitrate reductase/0.453
2bfaCB3Pteridine reductase 11.5.1.330.453
3b9lAZZSerum albumin/0.453
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.453
3zeiAWHO-acetylserine sulfhydrylase/0.453
4bfzZVZPantothenate kinase2.7.1.330.453
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.453
4i1nFOLDihydrofolate reductase1.5.1.30.453
4iarERM5-hydroxytryptamine receptor 1B/0.453
1sqkLARActin, alpha skeletal muscle/0.452
3keqNADRedox-sensing transcriptional repressor Rex/0.452
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.452
3s41S41Glucokinase2.7.1.20.452
3v0p4GWHisto-blood group ABO system transferase/0.452
4fhd0TTSpore photoproduct lyase/0.452
1ftlDNQGlutamate receptor 2/0.451
1gesFADGlutathione reductase1.8.1.70.451
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.451
2c29NAPDihydroflavonol 4-reductase/0.451
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3fgoACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
3hziATPSerine/threonine-protein kinase toxin HipA/0.451
3ivcFG4Pantothenate synthetase6.3.2.10.451
4r1lADPPhenylacetate-coenzyme A ligase/0.451
1hdrNADDihydropteridine reductase1.5.1.340.450
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.450
1kh3ANPArgininosuccinate synthase/0.450
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.450
2wpwACOOrf14/0.450
2x9vTMQPteridine reductase/0.450
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.450
3ctj320Hepatocyte growth factor receptor2.7.10.10.450
4ph9IBPProstaglandin G/H synthase 21.14.99.10.450
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.449
1ihiIU5Aldo-keto reductase family 1 member C2/0.449
1mvtDTMDihydrofolate reductase1.5.1.30.449
2g78REACellular retinoic acid-binding protein 2/0.449
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.449
2y60M8FIsopenicillin N synthase1.21.3.10.449
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.449
3bi6396Wee1-like protein kinase2.7.10.20.449
3dhk23UProthrombin3.4.21.50.449
3upyFOMOxidoreductase, putative/0.449
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.449
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.449
4l0oPLPCystathionine gamma-synthase2.5.1.480.449
1d3pBT3Prothrombin3.4.21.50.448
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.448
2z4y252Geranylgeranyl pyrophosphate synthase/0.448
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.448
4jlm1NNDeoxycytidine kinase2.7.1.740.448
4lngJANCaaX farnesyltransferase beta subunit Ram1/0.448
4lrrCF9Thymidylate synthase/0.448
1e92HBIPteridine reductase 11.5.1.330.447
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.447
1s3uTQDDihydrofolate reductase1.5.1.30.447
1uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
2zb8IMNProstaglandin reductase 21.3.1.480.447
3arvSAUChitinase A/0.447
4c3yANB3-ketosteroid dehydrogenase/0.447
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
5ckwANPUncharacterized protein/0.447
1qtqQSIGlutamine--tRNA ligase6.1.1.180.446
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1u1f183Uridine phosphorylase2.4.2.30.446
1ygjRMCPyridoxal kinase2.7.1.350.446
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.446
3ekuCY9Actin-5C/0.446
3q7dNPXProstaglandin G/H synthase 21.14.99.10.446
3tlc7MDMicrocin C7 self-immunity protein MccF/0.446
4l4cCAMCamphor 5-monooxygenase1.14.15.10.446
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.445
1puaCOAHAT A1/0.445
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.445
1stdBFSScytalone dehydratase4.2.1.940.445
1uyuCAMCamphor 5-monooxygenase1.14.15.10.445
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
2ij7TPFMycocyclosin synthase1.14.21.90.445
2w3aTOPDihydrofolate reductase1.5.1.30.445
3d5wADPSerine/threonine-protein kinase PLK/0.445
3s55NADPutative short-chain dehydrogenase/reductase/0.445
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.445
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.445
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.445
5stdUNNScytalone dehydratase4.2.1.940.445
8dfrNDPDihydrofolate reductase1.5.1.30.445
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.444
1ia4TQ6Dihydrofolate reductase1.5.1.30.444
1je1GMPPurine nucleoside phosphorylase/0.444
1mxfMTXPutative pteridine reductase 2/0.444
1yqj6NPMitogen-activated protein kinase 14/0.444
2hveADPNucleoside diphosphate kinase A2.7.4.60.444
3njoPYVAbscisic acid receptor PYR1/0.444
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
4kbn25UDihydrofolate reductase1.5.1.30.444
4mleVO1Glucokinase2.7.1.20.444
4tyqAP5Adenylate kinase/0.444
5d7oAR6NAD-dependent protein deacetylase sirtuin-23.5.10.444
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1gtrATPGlutamine--tRNA ligase6.1.1.180.443
1i2lDCSAminodeoxychorismate lyase4.1.3.380.443
1thnADPAnti-sigma F factor/0.443
1trkTPPTransketolase 12.2.1.10.443
2gjlFMNNitronate monooxygenase1.13.12.160.443
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.443
3p9tTCLRepressor/0.443
3vi7CBDHematopoietic prostaglandin D synthase/0.443
3zoiM2WIsopenicillin N synthase1.21.3.10.443
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.443
4lzwTHMUridine phosphorylase/0.443
1icvFMNOxygen-insensitive NAD(P)H nitroreductase/0.442
1ot3THMDeoxynucleoside kinase/0.442
1p4aPCPPur operon repressor/0.442
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
2z52H23Geranylgeranyl pyrophosphate synthase/0.442
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.442
3h2sNDPPutative NADH-flavin reductase/0.442
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3t37FADPyridoxine 4-oxidase/0.442
4a6rTA8Probable aminotransferase/0.442
4bhw01KHistone acetyltransferase p300/0.442
4d9fDCSD-cysteine desulfhydrase/0.442
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.442
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.442
4rh10TTSpore photoproduct lyase/0.442
5dp2NAPCurF/0.442
5dhgDGVNociceptin receptor/0.442
1ai9NDPDihydrofolate reductase1.5.1.30.441
1kquBR4Phospholipase A2, membrane associated/0.441
2othNIMBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.441
2puiADPMethylthioribose kinase2.7.1.1000.441
3fhxPXLPyridoxal kinase2.7.1.350.441
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.441
3zkyWT4Isopenicillin N synthase1.21.3.10.441
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.441
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
5dcyNAPIridoid synthase1.3.1.990.441
5jtbZMAAdenosine receptor A2a/0.441
3qakUKAAdenosine receptor A2a/0.441
3emlZMAAdenosine receptor A2a/0.441
1disBDMDihydrofolate reductase1.5.1.30.440
1gw2FERPeroxidase C1A1.11.1.70.440
1jdzFMBPurine nucleoside phosphorylase/0.440
2jh0701Prothrombin3.4.21.50.440
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.440
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.440
2zseACPPantothenate kinase2.7.1.330.440
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.440
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.440
3s79ASDAromatase1.14.14.140.440
4ffrATPUncharacterized protein/0.440
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440