sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 1.000 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.594 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.593 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.586 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.575 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.567 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.551 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.522 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.506 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.495 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.494 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.492 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.488 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.485 | |
| 1qy5 | NEC | Endoplasmin | / | 0.481 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.481 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.479 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.478 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.478 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.477 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.477 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 3eks | CY9 | Actin-5C | / | 0.473 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.472 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.471 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.471 | |
| 3eku | CY9 | Actin-5C | / | 0.470 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.470 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.469 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.469 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.469 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.468 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.468 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.467 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.467 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.467 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.466 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.466 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.465 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.465 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.465 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.464 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.464 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.464 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.463 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.463 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.463 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.463 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.462 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.462 | |
| 5c7h | NDP | Putative oxidoreductase | / | 0.462 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.461 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.460 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.460 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.460 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.460 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.459 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.459 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.458 | |
| 2ejz | SAH | Diphthine synthase | / | 0.458 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.458 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.458 | |
| 3wag | TYD | Glycosyltransferase | / | 0.458 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.458 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.457 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.457 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.457 | |
| 3up0 | D7S | aceDAF-12 | / | 0.457 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.457 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.456 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.456 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.455 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.455 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.455 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 5bu2 | ADP | Uncharacterized protein | / | 0.455 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.454 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.454 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.454 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.453 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.453 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.453 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.453 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.453 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.452 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.452 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.452 | |
| 1qy8 | RDI | Endoplasmin | / | 0.452 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.452 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.452 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.452 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.452 | |
| 4l4x | NDP | AmphI | / | 0.452 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.451 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.451 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.451 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.451 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.451 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.451 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.450 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.450 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.450 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.450 | |
| 4nv1 | TYD | Formyl transferase | / | 0.450 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.450 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.449 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.449 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.449 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.449 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.449 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.449 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.449 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.449 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.449 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 1qcw | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.448 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.448 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.448 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.448 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4blr | UTP | NTPase P4 | / | 0.448 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.448 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.448 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 1tys | TMP | Thymidylate synthase | / | 0.447 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2ad5 | ADP | CTP synthase | / | 0.447 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.447 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.447 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3sw7 | 19K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.447 | |
| 4b00 | I6X | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4phl | PIL | Phosphodiesterase | / | 0.447 | |
| 4rfl | NDP | Glycerol-1-phosphate dehydrogenase [NAD(P)+] | / | 0.447 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.446 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.446 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 1zdw | FLV | Prenyltransferase | / | 0.446 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.446 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.446 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.446 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.446 | |
| 3wcz | NAP | Aldo-keto reductase AKR2E4 | / | 0.446 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.446 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.445 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.445 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.445 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.445 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.445 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.445 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.445 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.445 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.445 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.445 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.445 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.444 | |
| 1r2j | FAD | FkbI | / | 0.444 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.444 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.444 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.444 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.444 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.444 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.444 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.444 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.444 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.444 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.444 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1osv | CHC | Bile acid receptor | / | 0.443 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.443 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.443 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4e2d | FMN | Dehydrogenase | / | 0.443 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.443 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.442 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.442 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.442 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.442 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.442 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.442 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.442 | |
| 3d2p | COA | Amino-acid acetyltransferase | / | 0.442 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.442 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.442 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.442 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4lj6 | ACP | Chaperone protein ClpB | / | 0.442 | |
| 4rsy | B3N | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.442 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.441 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.441 | |
| 2gf6 | COA | Uncharacterized protein | / | 0.441 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.441 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 4iax | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.441 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 1cg3 | IMO | Adenylosuccinate synthetase | / | 0.440 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.440 | |
| 1l2s | STC | Beta-lactamase | 3.5.2.6 | 0.440 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.440 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.440 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.440 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.440 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.440 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.440 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.440 |