sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1kt7 | RTL | Retinol-binding protein 4 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1kt7 | RTL | Retinol-binding protein 4 | / | 1.000 | |
| 1kt4 | RTL | Retinol-binding protein 4 | / | 0.759 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.671 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.668 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.657 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.636 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.623 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.600 | |
| 1kt5 | RTL | Retinol-binding protein 4 | / | 0.540 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.535 | |
| 4pd6 | URI | Nucleoside permease | / | 0.504 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.497 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.494 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.491 | |
| 1osv | CHC | Bile acid receptor | / | 0.488 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.486 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.486 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.483 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.483 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.480 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.478 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.478 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.478 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.477 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.477 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.476 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.476 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.476 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.474 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.474 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.474 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.473 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.472 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.472 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.472 | |
| 3eq6 | BCO | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.472 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.470 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.470 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.469 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.469 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.469 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.469 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.469 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.468 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.467 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.466 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.466 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.466 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.466 | |
| 5a3b | APR | SIR2 family protein | / | 0.466 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.465 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.465 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.465 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.465 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.464 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.464 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.464 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.464 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.464 | |
| 4lb2 | DM5 | Serum albumin | / | 0.464 | |
| 4o7u | THF | Thymidylate synthase | / | 0.464 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.463 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3h1j | SMA | Cytochrome b | / | 0.462 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.462 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.462 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.461 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.461 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.461 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.460 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4i42 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.460 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.459 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.459 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.459 | |
| 5ag5 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.458 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.457 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.457 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.457 | |
| 3two | NDP | Mannitol dehydrogenase | / | 0.457 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.457 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.457 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.457 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.457 | |
| 4hxy | NDP | Plm1 | / | 0.457 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 5l3d | FAD | Lysine-specific histone demethylase 1A | 1 | 0.457 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.456 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.456 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.456 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.456 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3di6 | PDZ | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.456 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 5av3 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.456 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.455 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.455 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.455 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.455 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.455 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.454 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.454 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.454 | |
| 4uya | AGS | Mitogen-activated protein kinase kinase kinase 21 | 2.7.11.25 | 0.454 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.454 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1r2j | FAD | FkbI | / | 0.453 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.453 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2q5q | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.453 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4b1f | KRH | Glutamate racemase | / | 0.453 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.453 | |
| 2dji | FAD | Pyruvate oxidase | / | 0.452 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.452 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.452 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.452 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.452 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 4a32 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 4l8u | 9AZ | Serum albumin | / | 0.452 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.451 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.451 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3v2u | ATP | Protein GAL3 | / | 0.451 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.451 | |
| 5a27 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 5ag7 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.450 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.450 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.450 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.450 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.450 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.450 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.450 | |
| 3zln | H0Y | Bcl-2-like protein 1 | / | 0.450 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4iaw | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.450 | |
| 4rrx | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.450 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.449 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.449 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.449 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.448 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.448 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 3bhr | THG | Thymidylate synthase | / | 0.448 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.448 | |
| 3bzu | A21 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.448 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3sa0 | NRA | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.448 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.448 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.448 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.448 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.447 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.447 | |
| 2f2u | M77 | Rho-associated protein kinase 2 | 2.7.11.1 | 0.447 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.447 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.447 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.447 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.447 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.447 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.447 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.447 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.447 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.447 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.446 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.446 | |
| 1sus | SAH | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.446 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 2bx8 | AZQ | Serum albumin | / | 0.446 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.446 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.446 | |
| 3up0 | D7S | aceDAF-12 | / | 0.446 | |
| 4a30 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.446 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.446 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.446 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.445 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.445 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.445 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.445 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.445 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.445 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1err | RAL | Estrogen receptor | / | 0.444 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.444 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.444 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 3ang | DCC | Transcriptional repressor, TetR family | / | 0.444 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.444 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.444 | |
| 1dtp | APU | Diphtheria toxin | / | 0.443 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.443 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.443 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.443 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.443 | |
| 2yg6 | FAD | Putrescine oxidase | / | 0.443 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.443 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.443 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3reo | SAH | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.443 | |
| 3rha | FDA | Putrescine oxidase | / | 0.443 | |
| 3saz | 043 | Malate synthase G | / | 0.443 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.443 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4msg | 2C6 | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.443 | |
| 4zvl | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.442 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rx0 | 2MC | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.442 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.442 | |
| 2acw | UPG | Glycosyltransferase | / | 0.442 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3o7l | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.442 | |
| 4b12 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.442 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.442 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.442 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1geu | NAD | Glutathione reductase | 1.8.1.7 | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1q0q | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.441 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.441 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.441 | |
| 2d4e | NAD | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] | / | 0.441 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.441 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.441 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.441 | |
| 2xvw | 9NR | Serum albumin | / | 0.441 | |
| 3cnt | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.441 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.441 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.441 | |
| 4eop | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.441 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 4qij | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.441 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.440 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.440 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1v5e | FAD | Pyruvate oxidase | / | 0.440 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.440 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.440 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.440 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.440 | |
| 2k5t | COA | PanD regulatory factor | / | 0.440 | |
| 2pa3 | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.440 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2wpx | ACO | Orf14 | / | 0.440 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.440 | |
| 4f9b | 0SY | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.440 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.440 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4nu6 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.440 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.440 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.440 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.440 |