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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gy3ATPCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gy3ATPCyclin-dependent kinase 22.7.11.221.000
4eomATPCyclin-dependent kinase 22.7.11.220.557
1qmzATPCyclin-dependent kinase 22.7.11.220.543
2i40BLZCyclin-dependent kinase 22.7.11.220.543
2b55D31Cyclin-dependent kinase 22.7.11.220.539
2cchATPCyclin-dependent kinase 22.7.11.220.532
4bcqTJFCyclin-dependent kinase 22.7.11.220.531
1pkdUCNCyclin-dependent kinase 22.7.11.220.530
3r7iX9ICyclin-dependent kinase 22.7.11.220.530
1h1r6CPCyclin-dependent kinase 22.7.11.220.521
1jstATPCyclin-dependent kinase 22.7.11.220.516
4bcpT3CCyclin-dependent kinase 22.7.11.220.512
1h1q2A6Cyclin-dependent kinase 22.7.11.220.509
3qwkX62Cyclin-dependent kinase 22.7.11.220.508
2wpa889Cyclin-dependent kinase 22.7.11.220.507
3rm719ZCyclin-dependent kinase 22.7.11.220.506
4fkg4CKCyclin-dependent kinase 22.7.11.220.506
3qwjX6ACyclin-dependent kinase 22.7.11.220.504
3bhtMFRCyclin-dependent kinase 22.7.11.220.503
1h1s4SPCyclin-dependent kinase 22.7.11.220.502
1oiuN76Cyclin-dependent kinase 22.7.11.220.502
4erwSTUCyclin-dependent kinase 22.7.11.220.500
1b39ATPCyclin-dependent kinase 22.7.11.220.498
4eor4SPCyclin-dependent kinase 22.7.11.220.498
1oguST8Cyclin-dependent kinase 22.7.11.220.495
2x1nX1NCyclin-dependent kinase 22.7.11.220.495
3ddpRC8Cyclin-dependent kinase 22.7.11.220.495
1vyw292Cyclin-dependent kinase 22.7.11.220.494
2c5nCK8Cyclin-dependent kinase 22.7.11.220.494
3a7hATPSerine/threonine-protein kinase 242.7.11.10.494
3qtwX3ACyclin-dependent kinase 22.7.11.220.494
1g5sI17Cyclin-dependent kinase 22.7.11.220.493
1gih1PUCyclin-dependent kinase 22.7.11.220.492
3ddqRRCCyclin-dependent kinase 22.7.11.220.492
4fx360KCyclin-dependent kinase 22.7.11.220.492
4gmy0X5Tyrosine-protein kinase JAK2/0.492
1h0vUN4Cyclin-dependent kinase 22.7.11.220.491
2qo9ANPEphrin type-A receptor 32.7.10.10.491
3my5RFZCyclin-dependent kinase 22.7.11.220.491
3ral04ZCyclin-dependent kinase 22.7.11.220.490
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.488
3r73X87Cyclin-dependent kinase 22.7.11.220.488
4qmlANPSerine/threonine-protein kinase 242.7.11.10.488
2pz5ACPFibroblast growth factor receptor 2/0.487
4bcnT9NCyclin-dependent kinase 22.7.11.220.487
4nj32KDCyclin-dependent kinase 22.7.11.220.487
1ke8LS4Cyclin-dependent kinase 22.7.11.220.486
1oitHDTCyclin-dependent kinase 22.7.11.220.485
2c6o4SPCyclin-dependent kinase 22.7.11.220.485
2r64740Cyclin-dependent kinase 22.7.11.220.485
2uzlC94Cyclin-dependent kinase 22.7.11.220.485
3rm618ZCyclin-dependent kinase 22.7.11.220.485
2pzpACPFibroblast growth factor receptor 2/0.484
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.484
1v1k3FPCyclin-dependent kinase 22.7.11.220.483
1di8DTQCyclin-dependent kinase 22.7.11.220.482
3qtqX35Cyclin-dependent kinase 22.7.11.220.482
3uli1N3Cyclin-dependent kinase 22.7.11.220.482
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.482
1oi9N20Cyclin-dependent kinase 22.7.11.220.481
2r3r6SCCyclin-dependent kinase 22.7.11.220.481
3r9dX6BCyclin-dependent kinase 22.7.11.220.481
4bcoT6QCyclin-dependent kinase 22.7.11.220.481
4eon1ROCyclin-dependent kinase 22.7.11.220.481
4fkj11KCyclin-dependent kinase 22.7.11.220.481
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.481
2c69CT8Cyclin-dependent kinase 22.7.11.220.480
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.480
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.479
3qx2X63Cyclin-dependent kinase 22.7.11.220.479
3qzhX69Cyclin-dependent kinase 22.7.11.220.479
1b38ATPCyclin-dependent kinase 22.7.11.220.478
2r3gSC9Cyclin-dependent kinase 22.7.11.220.478
3fz1B98Cyclin-dependent kinase 22.7.11.220.478
3wblPDYCyclin-dependent kinase 22.7.11.220.478
4eol1ROCyclin-dependent kinase 22.7.11.220.478
1aq1STUCyclin-dependent kinase 22.7.11.220.477
3qxoX65Cyclin-dependent kinase 22.7.11.220.477
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.477
2iw84SPCyclin-dependent kinase 22.7.11.220.476
3dogNNNCyclin-dependent kinase 22.7.11.220.476
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.475
2r3fSC8Cyclin-dependent kinase 22.7.11.220.475
3iggEFQCyclin-dependent kinase 22.7.11.220.475
3r1yX76Cyclin-dependent kinase 22.7.11.220.475
3rkb12ZCyclin-dependent kinase 22.7.11.220.475
3s2pPMUCyclin-dependent kinase 22.7.11.220.474
4fkr45KCyclin-dependent kinase 22.7.11.220.474
1ckpPVBCyclin-dependent kinase 22.7.11.220.473
2pmlANPUncharacterized protein/0.473
3r7uX96Cyclin-dependent kinase 22.7.11.220.473
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.473
4cfnJYMCyclin-dependent kinase 22.7.11.220.473
4fki09KCyclin-dependent kinase 22.7.11.220.473
2uzdC85Cyclin-dependent kinase 22.7.11.220.472
3ig7EFPCyclin-dependent kinase 22.7.11.220.472
3r6xX84Cyclin-dependent kinase 22.7.11.220.472
3rmf20ZCyclin-dependent kinase 22.7.11.220.472
3tnwF18Cyclin-dependent kinase 22.7.11.220.472
2a0cCK9Cyclin-dependent kinase 22.7.11.220.471
1cm8ANPMitogen-activated protein kinase 12/0.470
2c6eHPMAurora kinase A2.7.11.10.470
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.470
2wxvWXVCyclin-dependent kinase 22.7.11.220.470
3roy22ZCyclin-dependent kinase 22.7.11.220.470
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.469
3rk507ZCyclin-dependent kinase 22.7.11.220.469
4eoi1ROCyclin-dependent kinase 22.7.11.220.469
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.468
2fvdLIACyclin-dependent kinase 22.7.11.220.468
2np8CC3Aurora kinase A2.7.11.10.468
3lfnA27Cyclin-dependent kinase 22.7.11.220.468
3qqfX07Cyclin-dependent kinase 22.7.11.220.468
1e9hINRCyclin-dependent kinase 22.7.11.220.467
1h1pCMGCyclin-dependent kinase 22.7.11.220.467
1p2a5BNCyclin-dependent kinase 22.7.11.220.467
3a7jADPSerine/threonine-protein kinase 242.7.11.10.467
3r7vZ02Cyclin-dependent kinase 22.7.11.220.467
3rpr25ZCyclin-dependent kinase 22.7.11.220.467
4acm7YGCyclin-dependent kinase 22.7.11.220.467
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.467
2c6tDT5Cyclin-dependent kinase 22.7.11.220.466
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.466
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.466
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.465
2qo7ANPEphrin type-A receptor 32.7.10.10.465
2w17I19Cyclin-dependent kinase 22.7.11.220.465
3lfsA07Cyclin-dependent kinase 22.7.11.220.465
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.465
3rk909ZCyclin-dependent kinase 22.7.11.220.465
4eop1ROCyclin-dependent kinase 22.7.11.220.465
1fvt106Cyclin-dependent kinase 22.7.11.220.464
1pxoCK7Cyclin-dependent kinase 22.7.11.220.464
2c4g514Cyclin-dependent kinase 22.7.11.220.464
3qqlX03Cyclin-dependent kinase 22.7.11.220.464
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.464
1finATPCyclin-dependent kinase 22.7.11.220.463
2qoqANPEphrin type-A receptor 32.7.10.10.463
2vgpAD6Aurora kinase B-A2.7.11.10.463
3c50ADPRhodopsin kinase/0.463
3ezrEZRCyclin-dependent kinase 22.7.11.220.463
3ql8X01Cyclin-dependent kinase 22.7.11.220.463
3rpv26ZCyclin-dependent kinase 22.7.11.220.463
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
1ke9LS5Cyclin-dependent kinase 22.7.11.220.462
2btrU73Cyclin-dependent kinase 22.7.11.220.462
2uzbC75Cyclin-dependent kinase 22.7.11.220.462
3miaANPCyclin-dependent kinase 92.7.11.220.462
1unlRRCCyclin-dependent-like kinase 52.7.11.10.461
2py3ACPFibroblast growth factor receptor 2/0.461
2w05FRTCyclin-dependent kinase 22.7.11.220.461
2wihP48Cyclin-dependent kinase 22.7.11.220.461
3qqkX02Cyclin-dependent kinase 22.7.11.220.461
4jrnANPRhoptry kinase family protein/0.461
4oavACP2-5A-dependent ribonuclease3.1.260.461
2uzeC95Cyclin-dependent kinase 22.7.11.220.460
3nup3NUCyclin-dependent kinase 62.7.11.220.460
3qx4X4BCyclin-dependent kinase 22.7.11.220.460
3sqq99ZCyclin-dependent kinase 22.7.11.220.460
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.460
2f2cAP9Cyclin-dependent kinase 62.7.11.220.459
4fklCK2Cyclin-dependent kinase 22.7.11.220.459
1vyzN5BCyclin-dependent kinase 22.7.11.220.458
1w8cN69Cyclin-dependent kinase 22.7.11.220.458
3qqhX0ACyclin-dependent kinase 22.7.11.220.458
3qtrX36Cyclin-dependent kinase 22.7.11.220.458
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.458
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.458
1jpaANPEphrin type-B receptor 22.7.10.10.457
2acxANPG protein-coupled receptor kinase 62.7.11.160.457
2b52D42Cyclin-dependent kinase 22.7.11.220.457
2bheBRYCyclin-dependent kinase 22.7.11.220.457
4ek610KCyclin-dependent kinase 22.7.11.220.457
4eok4SPCyclin-dependent kinase 22.7.11.220.457
5aaaVGHALK tyrosine kinase receptor2.7.10.10.457
1ke7LS3Cyclin-dependent kinase 22.7.11.220.456
2c5yMTWCyclin-dependent kinase 22.7.11.220.456
2xmyCDKCyclin-dependent kinase 22.7.11.220.456
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.456
3q5iANPProtein kinase, putative/0.456
4eos1ROCyclin-dependent kinase 22.7.11.220.456
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.455
3r1sX73Cyclin-dependent kinase 22.7.11.220.455
2qocANPEphrin type-A receptor 32.7.10.10.454
3lfqA28Cyclin-dependent kinase 22.7.11.220.454
3s00Z60Cyclin-dependent kinase 22.7.11.220.454
4bgh3I6Cyclin-dependent kinase 22.7.11.220.454
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1ke6LS2Cyclin-dependent kinase 22.7.11.220.453
1urwI1PCyclin-dependent kinase 22.7.11.220.453
2bkzSBCCyclin-dependent kinase 22.7.11.220.453
3qziX72Cyclin-dependent kinase 22.7.11.220.453
3r8zZ63Cyclin-dependent kinase 22.7.11.220.453
4qmpDKISerine/threonine-protein kinase 242.7.11.10.453
5aniES4Cyclin-dependent kinase 22.7.11.220.453
2etm7PYFocal adhesion kinase 12.7.10.20.452
2henADPEphrin type-B receptor 22.7.10.10.452
2of4979Tyrosine-protein kinase Lck2.7.10.20.452
3r8vZ62Cyclin-dependent kinase 22.7.11.220.452
3r9nZ68Cyclin-dependent kinase 22.7.11.220.452
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.452
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.451
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.451
4k33ACPFibroblast growth factor receptor 32.7.10.10.451
4lyn1YGCyclin-dependent kinase 22.7.11.220.451
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.451
1oirHDYCyclin-dependent kinase 22.7.11.220.450
1oiyN41Cyclin-dependent kinase 22.7.11.220.450
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.450
3c4wATPRhodopsin kinase/0.450
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.450
4fkpLS5Cyclin-dependent kinase 22.7.11.220.450
1h0w207Cyclin-dependent kinase 22.7.11.220.449
2a4lRRCCyclin-dependent kinase 22.7.11.220.449
2bhhRYUCyclin-dependent kinase 22.7.11.220.449
2btsU32Cyclin-dependent kinase 22.7.11.220.449
2j9mPY8Cyclin-dependent kinase 22.7.11.220.449
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.449
3r1qX75Cyclin-dependent kinase 22.7.11.220.449
3t8oATPRhodopsin kinase/0.449
4ix4ADPUncharacterized protein/0.449
2j0lANPFocal adhesion kinase 12.7.10.20.448
2r3o2SCCyclin-dependent kinase 22.7.11.220.448
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.448
4riyADPEpidermal growth factor receptor2.7.10.10.448
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.447
1e1vCMGCyclin-dependent kinase 22.7.11.220.446
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.446
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.446
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.446
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
4zseANPEpidermal growth factor receptor2.7.10.10.446
5auwQUEDeath-associated protein kinase 12.7.11.10.446
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.445
2w1hL0FCyclin-dependent kinase 22.7.11.220.445
2wotZZGTGF-beta receptor type-12.7.11.300.445
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3qrtX14Cyclin-dependent kinase 22.7.11.220.445
3r8lZ30Cyclin-dependent kinase 22.7.11.220.445
1w0xOLOCyclin-dependent kinase 22.7.11.220.444
2j0j4STFocal adhesion kinase 12.7.10.20.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
2r3kSCQCyclin-dependent kinase 22.7.11.220.444
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.444
3ti1B49Cyclin-dependent kinase 22.7.11.220.444
5drdATPAurora kinase A2.7.11.10.444
2duv371Cyclin-dependent kinase 22.7.11.220.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.443
2hog710Serine/threonine-protein kinase Chk12.7.11.10.442
2pwlACPFibroblast growth factor receptor 2/0.442
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.442
3rni21ZCyclin-dependent kinase 22.7.11.220.442
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.442
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.442
3vjoANPEpidermal growth factor receptor2.7.10.10.442
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.442
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
2xikJ60Serine/threonine-protein kinase 252.7.11.10.441
4fkw62KCyclin-dependent kinase 22.7.11.220.441
4fv8E63Mitogen-activated protein kinase 12.7.11.240.441
4jia1K3Tyrosine-protein kinase JAK2/0.441
5cvhADPCasein kinase II subunit alpha2.7.11.10.441
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.440
2j7t274Serine/threonine-protein kinase 102.7.11.10.440
2w1eL0EAurora kinase A2.7.11.10.440
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
4bgg844Activin receptor type-12.7.11.300.440
4ez30S0Cyclin-dependent kinase 22.7.11.220.440
4ez50RSCyclin-dependent kinase 62.7.11.220.440
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.440
4utdACPAurora kinase A2.7.11.10.440