sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 1.000 | |
| 3qpv | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.638 | |
| 1k6m | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | 2.7.1.105 | 0.630 | |
| 2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.630 | |
| 4ma4 | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.588 | |
| 2i1v | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.582 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.565 | |
| 2axn | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | / | 0.558 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.508 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.498 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.495 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.494 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.491 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.487 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.485 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.484 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.483 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.482 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.481 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.479 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.478 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.477 | |
| 4egn | TWO | Cytochrome P450 | / | 0.477 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.477 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.474 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.474 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.473 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.472 | |
| 3ndv | AIC | Beta-peptidyl aminopeptidase BapA | / | 0.472 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.472 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.472 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.472 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.471 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.471 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.470 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.470 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 4okx | 198 | Androgen receptor | / | 0.470 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.468 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.468 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.468 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.468 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.467 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.467 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.467 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.466 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.465 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.465 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.465 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.465 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.465 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.465 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.464 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.464 | |
| 2a5y | ATP | Cell death protein 4 | / | 0.463 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.463 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.463 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.462 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.462 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.462 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2r9k | SGI | Beta-galactoside-specific lectin 1 | / | 0.461 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.461 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.461 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.461 | |
| 4im0 | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.461 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.461 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.460 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.460 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.460 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.460 | |
| 3zuy | TCH | Transporter | / | 0.460 | |
| 4kgm | ATP | Uncharacterized protein | / | 0.460 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.459 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 3id8 | MRK | Glucokinase | 2.7.1.2 | 0.458 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.458 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.458 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.458 | |
| 5ahs | COA | Acyl-CoA dehydrogenase | / | 0.458 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.457 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.457 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.457 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.457 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.457 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.456 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.456 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.456 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.456 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 4g3e | 0WC | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.456 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.456 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.455 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.455 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.455 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.455 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.455 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.455 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.454 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.454 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.454 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.454 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.454 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.454 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.454 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.453 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.453 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.453 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.453 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.453 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.453 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.453 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.453 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.453 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3zux | TCH | Transporter | / | 0.453 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.453 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.453 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.453 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.452 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2pnu | ENM | Androgen receptor | / | 0.452 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.452 | |
| 3gb4 | D3M | DdmC | / | 0.452 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.452 | |
| 4ie5 | MD6 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.452 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.452 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.451 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.451 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.451 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.451 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.451 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3rnn | RNN | Glutamate receptor 2 | / | 0.451 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.451 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.451 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.451 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.451 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.450 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3nxe | 2NC | Protease | / | 0.450 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.450 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.450 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.450 | |
| 4okt | 198 | Androgen receptor | / | 0.450 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.449 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.449 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.449 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.449 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.449 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.449 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.449 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.449 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.449 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.449 | |
| 5cdg | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.448 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.448 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.448 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.448 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.448 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.448 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.448 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.448 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.448 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.447 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.447 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.447 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.447 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.447 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.447 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.447 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.447 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.447 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.447 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.447 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.446 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 1rby | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.446 | |
| 1rc1 | KT3 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.446 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2bxm | IMN | Serum albumin | / | 0.446 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.446 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2kce | D16 | Thymidylate synthase | / | 0.446 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.446 | |
| 3fmw | FAD | Oxygenase | / | 0.446 | |
| 3gob | HXX | DdmC | / | 0.446 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.446 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.446 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.446 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.445 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.445 | |
| 1u0h | ONM | Adenylate cyclase type 2 | / | 0.445 | |
| 1u0h | ONM | Adenylate cyclase type 5 | / | 0.445 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.445 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.445 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3ept | FDA | Putative FAD-monooxygenase | / | 0.445 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.445 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.445 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.444 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1pt9 | TAP | NAD(P) transhydrogenase, mitochondrial | 1.6.1.2 | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.444 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.444 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 4alx | IZN | Acetylcholine-binding protein | / | 0.444 | |
| 4aql | TXC | Guanine deaminase | 3.5.4.3 | 0.444 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.444 | |
| 4irn | FAD | AnaB | / | 0.444 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4l8u | 9AZ | Serum albumin | / | 0.444 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1fg6 | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.443 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.443 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.443 | |
| 3wd7 | COA | Acridone synthase | / | 0.443 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.443 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.443 | |
| 4nfh | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 1qbu | 846 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.442 | |
| 2y4g | TIR | TamL | / | 0.442 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3b2e | ADP | ATPase GET3 | / | 0.442 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.441 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1v59 | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.441 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.441 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.441 | |
| 4kqw | NAP | Ketol-acid reductoisomerase (NADP(+)) | / | 0.441 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.441 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.440 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.440 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1pp9 | SMA | Cytochrome b | / | 0.440 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.440 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.440 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
| 3cgd | NAD | Coenzyme A disulfide reductase | / | 0.440 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3dag | FEG | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.440 | |
| 3dcr | KVS | Protease | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.440 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.440 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.440 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3qai | XNN | Ketohexokinase | / | 0.440 | |
| 3t2v | KKJ | Peptidoglycan recognition protein 1 | / | 0.440 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.440 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.440 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.440 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.440 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.440 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.440 |