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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5eypLOCTubulin beta chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5eypLOCTubulin beta chain/1.000
5itzLOCTubulin beta-2B chain/0.651
4o2bLOCTubulin beta-2B chain/0.648
3ut5LOCTubulin beta chain/0.579
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.508
1jipKTN6-deoxyerythronolide B hydroxylase/0.498
1jioDEB6-deoxyerythronolide B hydroxylase/0.496
3bheBZNGag-Pol polyprotein3.4.23.160.491
4nh82LCHeat shock protein HSP 90-alpha/0.485
3inxJZCHeat shock protein HSP 90-alpha/0.483
3bc3OPTCathepsin L13.4.22.150.482
4nb6444Nuclear receptor ROR-gamma/0.482
2nnhREACytochrome P450 2C8/0.480
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.480
3a1nNADNDP-sugar epimerase/0.478
3vt8YI3Vitamin D3 receptor/0.478
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.477
3tqhNDPQuinone oxidoreductase/0.477
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.476
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.476
5hs1VORLanosterol 14-alpha demethylase/0.476
3mnrSD1Heat shock protein HSP 90-alpha/0.475
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.474
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.474
4g7gVFVLanosterol 14-alpha-demethylase/0.474
1yw2PGJMitogen-activated protein kinase 14/0.473
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.473
3lu8IQXSerum albumin/0.473
1pmn984Mitogen-activated protein kinase 102.7.11.240.472
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.472
1dhjMTXDihydrofolate reductase1.5.1.30.470
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.470
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
3gw9VNILanosterol 14-alpha-demethylase/0.470
3zk5Z18Cytochrome P450 monooxygenase PikC/0.470
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.469
4ia2BIVVitamin D3 receptor A/0.469
1ie4T44Transthyretin/0.468
1nq7ARLNuclear receptor ROR-beta/0.468
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.468
2q4wFADCytokinin dehydrogenase 71.5.99.120.468
2vf0F89Thymidylate synthase/0.468
4uymVOR14-alpha sterol demethylase Cyp51B/0.468
1uykPUXHeat shock protein HSP 90-alpha/0.467
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.467
4ambDUDPutative glycosyl transferase/0.467
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.466
3begANPSRSF protein kinase 12.7.11.10.466
4r20AERCytochrome P450 family 17 polypeptide 2/0.466
1xl2189Gag-Pol polyprotein3.4.23.160.465
3o0iP54Heat shock protein HSP 90-alpha/0.465
4ia7BIVVitamin D3 receptor A/0.465
4tuvCPZCytochrome P450 1191.140.465
1uy7PU4Heat shock protein HSP 90-alpha/0.464
1v9aSAHUncharacterized protein/0.464
3p3zP3ZPutative cytochrome P450/0.464
3p99LNPLanosterol 14-alpha-demethylase/0.464
3tk3CPZCytochrome P450 2B41.14.14.10.464
4ia1BIVVitamin D3 receptor A/0.464
4jx1CAMCamphor 5-monooxygenase1.14.15.10.464
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.464
1m13HYFNuclear receptor subfamily 1 group I member 2/0.463
2h55DZ8Heat shock protein HSP 90-alpha/0.463
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.463
1sn5T3Transthyretin/0.462
2c7xNRBCytochrome P450 monooxygenase PikC/0.462
4elb34RDihydrofolate reductase/0.462
1rdt570Peroxisome proliferator-activated receptor gamma/0.461
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.461
1s19MC9Vitamin D3 receptor/0.460
3dxjNE6DNA-directed RNA polymerase subunit beta/0.460
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.460
3mg3ECHOrange carotenoid-binding protein/0.460
3vt5YI2Vitamin D3 receptor/0.460
5ifiPRXAcetyl-coenzyme A synthetase/0.460
2ykjYKJHeat shock protein HSP 90-alpha/0.459
4b7sQLECytochrome P450 monooxygenase PikC/0.459
4cd2FOLDihydrofolate reductase1.5.1.30.459
4ia3BIVVitamin D3 receptor A/0.459
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1sn0T44Transthyretin/0.458
2f1kNAPPrephenate dehydrogenase/0.458
3t2kFADSulfide-quinone reductase/0.458
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.458
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.458
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.457
3t2yFADSulfide-quinone reductase/0.457
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
4a99FADTetX family tetracycline inactivation enzyme/0.457
1nzdUPGDNA beta-glucosyltransferase/0.456
1uy8PU5Heat shock protein HSP 90-alpha/0.456
1uyfPU1Heat shock protein HSP 90-alpha/0.456
3adaNADSubunit alpha of sarocosine oxidase/0.456
3vt9YI4Vitamin D3 receptor/0.456
2fwzH71Heat shock protein HSP 90-alpha/0.455
3d7kD7KBenzaldehyde lyase/0.455
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
4ki8ADP60 kDa chaperonin/0.455
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1kgjFL8Transthyretin/0.454
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
3cv9VDXVitamin D3 dihydroxylase/0.454
3ibdCPZCytochrome P450 2B61.14.130.454
3mdvCL6Cholesterol 24-hydroxylase/0.454
1fmlRTLRetinol dehydratase/0.453
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1rbyKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.453
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.453
1uymPU3Heat shock protein HSP 90-beta/0.453
1wbpADPSRSF protein kinase 12.7.11.10.453
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.453
3b6zCO7Enoyl reductase LovC10.453
3l0lHC3Nuclear receptor ROR-gamma/0.453
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.453
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.453
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1uyePU9Heat shock protein HSP 90-alpha/0.452
2izrBRKCasein kinase I isoform gamma-32.7.11.10.452
3p6nDSOCamphor 5-monooxygenase1.14.15.10.452
3sz0FADSulfide-quinone reductase/0.452
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.452
3uoyNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.452
3zuxTCHTransporter/0.452
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.452
4c4jX21Dual specificity protein kinase TTK2.7.12.10.452
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.452
4ez8DHFThymidylate synthase2.1.1.450.452
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1tz8DESTransthyretin/0.451
1xuoLA1Integrin alpha-L/0.451
2ykcYKCHeat shock protein HSP 90-alpha/0.451
3gggNADPrephenate dehydrogenase/0.451
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.451
3vtdTKDVitamin D3 receptor/0.451
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.451
4cnkFADL-amino acid oxidase/0.451
4e2bFMNDehydrogenase/0.451
4fhh0U3Vitamin D3 receptor A/0.451
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.451
1db1VDXVitamin D3 receptor/0.450
1uy9PU6Heat shock protein HSP 90-alpha/0.450
2hcdBIVVitamin D3 receptor A/0.450
2jn3JN3Fatty acid-binding protein, liver/0.450
2y4gTIRTamL/0.450
3kpkFADSulfide-quinone reductase/0.450
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.450
3sh0SAXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.450
4fhi0S4Vitamin D3 receptor A/0.450
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.450
1bwsNDPGDP-L-fucose synthase/0.449
1j39UPGDNA beta-glucosyltransferase/0.449
1pkfEPDEpothilone C/D epoxidase1.140.449
1uydPU8Heat shock protein HSP 90-alpha/0.449
2ca0PXICytochrome P450 monooxygenase PikC/0.449
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.449
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.449
3pyy3YYTyrosine-protein kinase ABL12.7.10.20.449
3t2zFADSulfide-quinone reductase/0.449
3zuyTCHTransporter/0.449
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
1diuBDMDihydrofolate reductase1.5.1.30.448
2qg2A91Heat shock protein HSP 90-alpha/0.448
3w2sW2REpidermal growth factor receptor2.7.10.10.448
4a9mP9MBromodomain-containing protein 2/0.448
4g1d0VKVitamin D3 receptor A/0.448
4g1z0VPVitamin D3 receptor A/0.448
4ku5DCC3-oxoacyl-[ACP] synthase III/0.448
1dz6CAMCamphor 5-monooxygenase1.14.15.10.447
1phgMYTCamphor 5-monooxygenase1.14.15.10.447
2k62ITLFatty acid-binding protein, liver/0.447
2vn0TDZCytochrome P450 2C8/0.447
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.447
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.447
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.447
3vrwYS5Vitamin D3 receptor/0.447
3w0c6DSVitamin D3 receptor/0.447
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4cdmFADDeoxyribodipyrimidine photolyase/0.447
4g95OAGDihydrofolate reductase1.5.1.30.447
4gyiADPUncharacterized protein/0.447
4uyf73BBromodomain-containing protein 2/0.447
2dfvNADL-threonine 3-dehydrogenase/0.446
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.446
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
3hz5Z64Heat shock protein HSP 90-alpha/0.446
3s4qNK0Mitogen-activated protein kinase 14/0.446
3t1tGDPProbable gliding protein mglA/0.446
3vtbTKAVitamin D3 receptor/0.446
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4enhFVXCholesterol 24-hydroxylase/0.446
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4ly91YYGlucokinase regulatory protein/0.446
4v2gITCTetracycline repressor protein class D/0.446
4y8wSTRSteroid 21-hydroxylase/0.446
1c70L75Protease/0.445
1eupASD6-deoxyerythronolide B hydroxylase/0.445
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.445
1kkq471Peroxisome proliferator-activated receptor alpha/0.445
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2fwyH64Heat shock protein HSP 90-alpha/0.445
2vzmNRBCytochrome P450 monooxygenase PikC/0.445
2ykeYKEHeat shock protein HSP 90-alpha/0.445
3e5aVX6Aurora kinase A2.7.11.10.445
3iupNDPPossible NADH oxidoreductase/0.445
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.445
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3vt7VDXVitamin D3 receptor/0.445
4fgg0U5Dihydrofolate reductase1.5.1.30.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.445
4o701QKBromodomain-containing protein 4/0.445
4q72FADBifunctional protein PutA/0.445
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.444
1uy6PU3Heat shock protein HSP 90-alpha/0.444
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.444
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.444
2om9AJAPeroxisome proliferator-activated receptor gamma/0.444
2wepADPATP-dependent molecular chaperone HSP82/0.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3c1y2BADNA integrity scanning protein DisA/0.444
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3ic9FADPutative dihydrolipoamide dehydrogenase/0.444
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.444
3wmxNADNAD dependent epimerase/dehydratase/0.444
3zep1NXTyrosine-protein kinase JAK32.7.10.20.444
4as94QSATP-dependent molecular chaperone HSP82/0.444
4eevL1XHepatocyte growth factor receptor2.7.10.10.444
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.444
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.444
4l8u9AZSerum albumin/0.444
4xiwAZMCarbonic anhydrase, alpha type/0.444
1bygSTUTyrosine-protein kinase CSK/0.443
2d29FADAcyl-CoA dehydrogenase/0.443
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
2znnS44Peroxisome proliferator-activated receptor alpha/0.443
3inwJZBHeat shock protein HSP 90-alpha/0.443
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.443
3w5tLHPVitamin D3 receptor/0.443
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
4nxvGDPMitochondrial dynamics protein MID51/0.443
4q0a4OAVitamin D3 receptor A/0.443
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
1fm9570Peroxisome proliferator-activated receptor gamma/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1rkhVD2Vitamin D3 receptor/0.442
2j0dERYCytochrome P450 3A4/0.442
2rcyNAPPyrroline-5-carboxylate reductase/0.442
3a9wNADNDP-sugar epimerase/0.442
3ad9NADSubunit alpha of sarocosine oxidase/0.442
3d0bSNXHeat shock protein HSP 90-alpha/0.442
3gqvNAPEnoyl reductase LovC10.442
3mdmFJZCholesterol 24-hydroxylase/0.442
3p6oETGCamphor 5-monooxygenase1.14.15.10.442
4cnjFADL-amino acid oxidase/0.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
4nka2K7Fibroblast growth factor receptor 1/0.442
4rupH97Vitamin D3 receptor A/0.442
1h74ADPHomoserine kinase2.7.1.390.441
1nooCAHCamphor 5-monooxygenase1.14.15.10.441
1rf7DHFDihydrofolate reductase1.5.1.30.441
2d4vNADIsocitrate dehydrogenase [NADP]/0.441
2hasC3OVitamin D3 receptor/0.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2zlcVDXVitamin D3 receptor/0.441
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.441
3h3t16HCollagen type IV alpha-3-binding protein/0.441
3t14FADSulfide-quinone reductase/0.441
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.441
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4gu610NFocal adhesion kinase 12.7.10.20.441
4o1mNADEnoyl-acyl carrier reductase/0.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1ictT44Transthyretin/0.440
1ma0NADAlcohol dehydrogenase class-31.1.1.10.440
1yc34BCHeat shock protein HSP 90-alpha/0.440
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.440
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.440
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.440
3atzFMNProstaglandin F2a synthase/0.440
3eigMTXDihydrofolate reductase1.5.1.30.440
3h8bNSYCathepsin L13.4.22.150.440
3jw3TOPDihydrofolate reductase/0.440
3oafOAGDihydrofolate reductase1.5.1.30.440
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
3wd7COAAcridone synthase/0.440
4awq592Heat shock protein HSP 90-alpha/0.440
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.440
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.440
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.440
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.440
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.440
4xyeNADFormate dehydrogenase/0.440