sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ytz | URC | Xanthine dehydrogenase/oxidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ytz | URC | Xanthine dehydrogenase/oxidase | / | 1.000 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.531 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.508 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.499 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.498 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.494 | |
| 3hqd | ANP | Kinesin-like protein KIF11 | / | 0.494 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.494 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.486 | |
| 1avd | BTN | Avidin | / | 0.484 | |
| 3s6a | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.483 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.483 | |
| 2rs1 | W84 | Genome polyprotein | / | 0.482 | |
| 1zdw | FLV | Prenyltransferase | / | 0.480 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.480 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 2c4c | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.477 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 2r2g | EMF | Eugenol synthase 1 | 1.1.1.318 | 0.476 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.475 | |
| 5fkm | TDC | Tetracycline repressor protein class D | / | 0.475 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.474 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.474 | |
| 3qvw | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.474 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.473 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.473 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.473 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.473 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.472 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.472 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.472 | |
| 4y9x | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.472 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.471 | |
| 2y03 | 5FW | Beta-1 adrenergic receptor | / | 0.471 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.471 | |
| 4hl5 | 15W | Tankyrase-2 | 2.4.2.30 | 0.471 | |
| 4mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.471 | |
| 5fit | AP2 | Bis(5'-adenosyl)-triphosphatase | 3.6.1.29 | 0.470 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.469 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.469 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.468 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.468 | |
| 4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.468 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.468 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.468 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.466 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.466 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.466 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.466 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.465 | |
| 4l9q | 9TP | Serum albumin | / | 0.465 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.465 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.465 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.465 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.464 | |
| 1pf7 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.464 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.464 | |
| 4qof | FMN | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.464 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.464 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.464 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.463 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.463 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.463 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.463 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 5doz | NDP | JamJ | / | 0.463 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.462 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.462 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.462 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.462 | |
| 3o8h | O8H | HTH-type transcriptional regulator EthR | / | 0.462 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.462 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.462 | |
| 1a8t | 061 | Metallo-beta-lactamase type 2 | / | 0.461 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.461 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.461 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.461 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.461 | |
| 4e2y | JHZ | Methyltransferase | / | 0.461 | |
| 1pt8 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.460 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3nix | FAD | Flavoprotein/dehydrogenase | / | 0.460 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.460 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.460 | |
| 4bui | W2E | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 4buu | F38 | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.460 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.459 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.459 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4abz | T1C | Tetracycline repressor protein class D | / | 0.459 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.459 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.458 | |
| 3anp | DCC | Transcriptional repressor, TetR family | / | 0.458 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.458 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.458 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.458 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.457 | |
| 2jdc | CAO | Probable acetyltransferase | / | 0.457 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.457 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.457 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2pch | SAH | Diphthine synthase | / | 0.456 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.456 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.456 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.456 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4hkk | AGI | Tankyrase-2 | 2.4.2.30 | 0.456 | |
| 4pu2 | PLU | Aminopeptidase N | / | 0.456 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.456 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.455 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.455 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.455 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.455 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.455 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.455 | |
| 4phl | PIL | Phosphodiesterase | / | 0.455 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.454 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4f1o | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.454 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.454 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.453 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.453 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.453 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.453 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.453 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2c4i | BTN | Avidin | / | 0.452 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.452 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.452 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.452 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.452 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4iah | 1DX | Alr2278 protein | / | 0.452 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 2eer | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.451 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.451 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.451 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.451 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.451 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.451 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.451 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 4iue | AJ4 | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
| 1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.450 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.450 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.450 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.450 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.450 | |
| 3fne | 8PC | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 3n62 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.450 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 4hlk | 431 | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.450 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.450 | |
| 5ej4 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.450 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.449 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.449 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.449 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 2uyw | BTN | Avd protein | / | 0.449 | |
| 2xvm | SAH | Tellurite methyltransferase | 2.1.1.265 | 0.449 | |
| 3e78 | TPP | High affinity transport system protein p37 | / | 0.449 | |
| 3n1t | 5GP | Purine nucleoside phosphoramidase | / | 0.449 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.449 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.449 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.449 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.449 | |
| 4hlf | 15Z | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.448 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1p4m | ADP | Riboflavin kinase | 2.7.1.26 | 0.448 | |
| 1suw | NAP | NAD kinase | / | 0.448 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.448 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.448 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.448 | |
| 3mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.448 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.448 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.448 | |
| 4z9r | NAD | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.448 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.447 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2igy | A2T | Plasmepsin 2 | / | 0.447 | |
| 2iut | AGS | DNA translocase FtsK | / | 0.447 | |
| 2rhq | GAX | Phenylalanine--tRNA ligase alpha subunit | / | 0.447 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.447 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.447 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.447 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.446 | |
| 2bry | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.446 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3ndv | AIC | Beta-peptidyl aminopeptidase BapA | / | 0.446 | |
| 4a2b | AGS | Cell division protein FtsA | / | 0.446 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.446 | |
| 4f0f | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.446 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4ntc | FAD | Thioredoxin reductase gliT | / | 0.446 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.446 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.446 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.446 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.445 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.445 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.445 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.445 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.445 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.445 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.445 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4buf | F36 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.445 | |
| 4fps | 0UX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 4l0s | 1UZ | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4y6n | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.445 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.445 | |
| 1c7o | PPG | Hemolysin | / | 0.444 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.444 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.444 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.444 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3upr | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.444 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.444 | |
| 4cym | GCP | Ras-related protein Rab-32 | / | 0.444 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.444 | |
| 4gut | FAD | Lysine-specific histone demethylase 1B | 1 | 0.444 | |
| 4l31 | F08 | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4s26 | SAH | Phosphomethylpyrimidine synthase, chloroplastic | 4.1.99.17 | 0.444 | |
| 4zvn | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.444 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1e94 | ANP | ATP-dependent protease ATPase subunit HslU | / | 0.443 | |
| 1i7l | ATP | Synapsin-2 | / | 0.443 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.443 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.443 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.443 | |
| 2jdd | ACO | Probable acetyltransferase | / | 0.443 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.443 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.443 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.443 | |
| 3ang | DCC | Transcriptional repressor, TetR family | / | 0.443 | |
| 3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.443 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.443 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.443 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.443 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.443 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3p0g | P0G | Beta-2 adrenergic receptor | / | 0.443 | |
| 1n1e | NDE | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.442 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.442 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.442 | |
| 1zm4 | TAD | Exotoxin A | 2.4.2.36 | 0.442 | |
| 2zw5 | COA | Bleomycin acetyltransferase | / | 0.442 | |
| 3eey | SAM | rRNA methylase | / | 0.442 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.442 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.442 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.442 | |
| 4e32 | DWN | Methyltransferase | / | 0.442 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.442 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4lmn | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.442 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.441 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.441 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.441 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.441 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 2bra | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.441 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3br9 | DEY | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3g1m | RF3 | HTH-type transcriptional regulator EthR | / | 0.441 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.441 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.441 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.441 | |
| 4bls | APC | NTPase P4 | / | 0.441 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.441 | |
| 4l0i | 1UW | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.441 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.441 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.440 | |
| 2xb5 | I7T | Tetracycline repressor protein class D | / | 0.440 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.440 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 3qfr | FAD | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.440 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.440 | |
| 4ju9 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.440 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.440 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.440 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.440 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.440 |