sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 1.000 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.505 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.502 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.502 | |
| 3ld6 | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.501 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.497 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.493 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.490 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.490 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.489 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.488 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.488 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.488 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.484 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.484 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.482 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.481 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.480 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.480 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.480 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.479 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.479 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.478 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.478 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.477 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.477 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 3v2u | ATP | Protein GAL3 | / | 0.476 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.475 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.475 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.475 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.474 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.474 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.474 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.474 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.474 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.474 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.473 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.473 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.473 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.472 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.471 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.471 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.471 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.470 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.470 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.470 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.470 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.470 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.469 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.468 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.467 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.467 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.466 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.466 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.466 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.466 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.466 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 3eks | CY9 | Actin-5C | / | 0.465 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.465 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.465 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.464 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.464 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.464 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.464 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.463 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.463 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.463 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.463 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.462 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.462 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.462 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.462 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.462 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.461 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.461 | |
| 3pft | FMN | Flavin reductase | / | 0.461 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.461 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.460 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.460 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.460 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.459 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.458 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2po3 | T4K | 4-dehydrase | / | 0.458 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.458 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.458 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.457 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2dsg | SAH | Diphthine synthase | / | 0.457 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.457 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.457 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.456 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.456 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.456 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.456 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.456 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.456 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.456 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.455 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.455 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.455 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.455 | |
| 4j7h | TRH | PCZA361.3 | / | 0.455 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.455 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.454 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.454 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.454 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 2glr | GTX | Glutathione S-transferase P 1 | 2.5.1.18 | 0.453 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.453 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.453 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.453 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.453 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.453 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.453 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.453 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.453 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.452 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.452 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.452 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.452 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 2nr4 | FMN | Conserved protein | / | 0.452 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.452 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.452 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.452 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.452 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.451 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.451 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.451 | |
| 2ejz | SAH | Diphthine synthase | / | 0.451 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.451 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.451 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.451 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.451 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.450 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.450 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4p53 | NAI | 2-epi-5-epi-valiolone synthase | / | 0.450 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.450 | |
| 5bv3 | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.450 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.449 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1ppj | ANY | Cytochrome b | / | 0.449 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.449 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.449 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.449 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.448 | |
| 2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.448 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.448 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4bxk | 1IU | Angiotensin-converting enzyme | 3.2.1 | 0.448 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.448 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.448 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.448 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.447 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.447 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.447 | |
| 1eio | GCH | Gastrotropin | / | 0.446 | |
| 1lke | DOG | Bilin-binding protein | / | 0.446 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.446 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.446 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.446 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.446 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.446 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.446 | |
| 2x3j | ATP | AcsD | / | 0.446 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.446 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.446 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.446 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.446 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.445 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.445 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.445 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.445 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.445 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.444 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.444 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2owg | SAH | Diphthine synthase | / | 0.444 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.444 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.444 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.444 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.444 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.444 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.444 | |
| 4dh0 | MR8 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.444 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.443 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.443 | |
| 1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.443 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.443 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.443 | |
| 1c7o | PPG | Hemolysin | / | 0.442 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.442 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.442 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.442 | |
| 4h0v | NAD | Iota toxin component Ia | / | 0.442 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.442 | |
| 4kl1 | PCG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.442 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.442 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.442 | |
| 1aqv | 0HG | Glutathione S-transferase P | 2.5.1.18 | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1xh5 | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2e07 | SAH | Diphthine synthase | / | 0.441 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.441 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.441 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.441 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.441 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.441 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.441 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.441 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.441 | |
| 4lut | DCS | Alanine racemase | / | 0.441 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.441 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.440 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.440 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2x95 | X95 | Angiotensin-converting enzyme | 3.4.15.1 | 0.440 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.440 | |
| 3eah | 327 | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.440 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 |