sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2yg6 | FAD | Putrescine oxidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2yg6 | FAD | Putrescine oxidase | / | 1.000 | |
| 3rha | FDA | Putrescine oxidase | / | 0.612 | |
| 2jb2 | FAD | L-amino acid oxidase | / | 0.565 | |
| 2jb1 | FAD | L-amino acid oxidase | / | 0.555 | |
| 1reo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.552 | |
| 2yg7 | FAD | Putrescine oxidase | / | 0.548 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.547 | |
| 2y48 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.542 | |
| 3zdn | FAD | Monoamine oxidase N | 1.4.3.4 | 0.542 | |
| 3cnt | FAD | Polyamine oxidase FMS1 | / | 0.538 | |
| 2iw5 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.534 | |
| 5l3d | FAD | Lysine-specific histone demethylase 1A | 1 | 0.534 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.533 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.532 | |
| 2uxx | FAJ | Lysine-specific histone demethylase 1A | 1 | 0.531 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.526 | |
| 3nn6 | FB0 | 6-hydroxy-L-nicotine oxidase | / | 0.523 | |
| 1yy5 | FAD | Polyamine oxidase FMS1 | / | 0.512 | |
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.512 | |
| 1tdk | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.508 | |
| 4i58 | FAD | Cyclohexylamine Oxidase | / | 0.508 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.507 | |
| 3kpf | FAD | Polyamine oxidase | 1.5.3.14 | 0.505 | |
| 1f8r | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.501 | |
| 1xpq | FAD | Polyamine oxidase FMS1 | / | 0.501 | |
| 1tdo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.499 | |
| 3kkj | FAD | Renalase | / | 0.498 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.497 | |
| 1f3p | FAD | Ferredoxin reductase | / | 0.496 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.495 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.494 | |
| 1tdn | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.493 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.492 | |
| 5g3s | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.491 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.490 | |
| 3k7t | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.490 | |
| 4ysh | FAD | Glycine oxidase | / | 0.489 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.488 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.487 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.485 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.485 | |
| 3if9 | FAD | Glycine oxidase | 1.4.3.19 | 0.483 | |
| 3vqr | FAD | Putative oxidoreductase | / | 0.483 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.483 | |
| 1h81 | FAD | Polyamine oxidase | 1.5.3.14 | 0.482 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.482 | |
| 2bab | FAD | Putative aminooxidase | / | 0.482 | |
| 4h4y | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.482 | |
| 2yr4 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.481 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.481 | |
| 2c3c | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.480 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.480 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.476 | |
| 3q9t | FAY | Uncharacterized protein | / | 0.476 | |
| 1lpf | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.475 | |
| 3l8k | ADP | Dihydrolipoamide dehydrogenase (PdhD-3) | / | 0.475 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.475 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.474 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.474 | |
| 3ad9 | FAD | Subunit beta of sarcosine oxidase | / | 0.474 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.474 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.473 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.473 | |
| 1jeh | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.473 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.472 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.472 | |
| 3kve | FAD | L-amino-acid oxidase | / | 0.472 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.472 | |
| 5fs6 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.472 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.471 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.471 | |
| 1get | FAD | Glutathione reductase | 1.8.1.7 | 0.470 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.470 | |
| 4ykg | NAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.470 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.469 | |
| 2bi7 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.469 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.469 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.469 | |
| 4h4s | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.469 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.469 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.468 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.468 | |
| 3axb | FAD | Putative oxidoreductase | / | 0.468 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.468 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.468 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.467 | |
| 2yqu | FAD | Dihydrolipoyl dehydrogenase | / | 0.466 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.466 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.466 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.465 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.465 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.465 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.464 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 4h4v | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.464 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.464 | |
| 5doz | NDP | JamJ | / | 0.464 | |
| 1geu | FAD | Glutathione reductase | 1.8.1.7 | 0.463 | |
| 1sny | NAP | LD36273p | / | 0.463 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.463 | |
| 1zmc | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.463 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.463 | |
| 2bac | FAD | Putative aminooxidase | / | 0.463 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.463 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.463 | |
| 5hxw | FAD | L-amino acid deaminase | / | 0.463 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.462 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.462 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1ng3 | FAD | Glycine oxidase | 1.4.3.19 | 0.461 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.461 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.460 | |
| 1fea | FAD | Trypanothione reductase | 1.8.1.12 | 0.460 | |
| 1nqo | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.460 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.460 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.460 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.459 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.459 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.459 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.459 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 4lii | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.459 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.459 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.458 | |
| 1lqu | FAD | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.458 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.458 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.458 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.458 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.458 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.458 | |
| 1osv | CHC | Bile acid receptor | / | 0.457 | |
| 1trb | FAD | Thioredoxin reductase | 1.8.1.9 | 0.457 | |
| 1ve9 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.457 | |
| 2ba9 | FAD | Putative aminooxidase | / | 0.457 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.457 | |
| 2eq7 | FAD | Dihydrolipoyl dehydrogenase | / | 0.457 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.457 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.457 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.457 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.457 | |
| 1d4c | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.456 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.456 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.456 | |
| 1ger | FAD | Glutathione reductase | 1.8.1.7 | 0.456 | |
| 1tdf | FAD | Thioredoxin reductase | 1.8.1.9 | 0.456 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.456 | |
| 1wc3 | APC | Adenylate cyclase | / | 0.456 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.456 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.456 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.456 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.455 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 3hdy | FAD | UDP-galactopyranose mutase | / | 0.455 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.455 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.455 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.455 | |
| 4mo2 | FDA | UDP-galactopyranose mutase | / | 0.455 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.455 | |
| 1gal | FAD | Glucose oxidase | 1.1.3.4 | 0.454 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2q0l | FAD | Thioredoxin reductase | 1.8.1.9 | 0.454 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.454 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.454 | |
| 3lb8 | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.454 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.454 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.453 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.453 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.453 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.453 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.452 | |
| 1zmd | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.452 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.452 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.452 | |
| 4h4p | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.452 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.452 | |
| 4rpj | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.452 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.451 | |
| 1tde | FAD | Thioredoxin reductase | 1.8.1.9 | 0.451 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.451 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.451 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.451 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 5j60 | FAD | Thioredoxin reductase | / | 0.451 | |
| 1f20 | NAP | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.450 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.450 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.450 | |
| 1znq | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.450 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.450 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.450 | |
| 1ps9 | FAD | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.449 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.449 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.449 | |
| 3e5r | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.449 | |
| 3eks | CY9 | Actin-5C | / | 0.449 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.449 | |
| 3s5w | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4rdi | ATP | tRNA threonylcarbamoyladenosine dehydratase | 6.1 | 0.449 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.449 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.448 | |
| 1n4w | FAD | Cholesterol oxidase | 1.1.3.6 | 0.448 | |
| 1u28 | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.448 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.448 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.448 | |
| 3hdy | FDA | UDP-galactopyranose mutase | / | 0.448 | |
| 3m13 | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.448 | |
| 4k9d | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.448 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 1iy8 | NAD | Levodione reductase | / | 0.447 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.447 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.447 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.447 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 3m12 | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.447 | |
| 3v2b | AR6 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.447 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.447 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.447 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.447 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.446 | |
| 1ges | FAD | Glutathione reductase | 1.8.1.7 | 0.446 | |
| 1l7e | NAI | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.446 | |
| 1p7c | T5A | Thymidine kinase | / | 0.446 | |
| 1wam | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 1wc5 | APC | Adenylate cyclase | / | 0.446 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.446 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.446 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.446 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.446 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.445 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.445 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.445 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.445 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.444 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.444 | |
| 3qj4 | FAD | Renalase | / | 0.444 | |
| 3uka | FAD | UDP-galactopyranose mutase | / | 0.444 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.444 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.444 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.444 | |
| 1e1l | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.443 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.443 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.443 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.443 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 3ka7 | FAD | Putative oxidoreductase | / | 0.443 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.443 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 4b67 | FAD | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4h50 | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.443 | |
| 4u8n | FDA | UDP-galactopyranose mutase | / | 0.443 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.443 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.443 | |
| 1ja1 | NAP | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.442 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.442 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.442 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.442 | |
| 2gr3 | FAD | Ferredoxin reductase | / | 0.442 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.442 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3ef6 | FAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.442 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.442 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.442 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4j1t | NAD | NAD/NADP transhydrogenase alpha subunit 1 | / | 0.442 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.442 | |
| 4jq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.442 | |
| 1cl0 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.441 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.441 | |
| 1mo9 | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.441 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2ard | FDA | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.441 | |
| 2b9x | FAD | Putative aminooxidase | / | 0.441 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.441 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.441 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3sju | NDP | Keto reductase | / | 0.441 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 4emj | FAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.441 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.440 | |
| 1ptj | SND | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1yqz | FAD | Coenzyme A disulfide reductase | / | 0.440 | |
| 2bry | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.440 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 2rir | NAP | Dipicolinate synthase subunit A | / | 0.440 | |
| 2yls | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.440 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.440 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 |