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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1qx4FADNADH-cytochrome b5 reductase 31.6.2.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1qx4FADNADH-cytochrome b5 reductase 31.6.2.21.000
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.576
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.559
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.557
2cndFADNitrate reductase [NADH]1.7.1.10.534
1cnfFADNitrate reductase [NADH]1.7.1.10.501
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.492
2hizLIJBeta-secretase 13.4.23.460.489
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.487
4q71FADBifunctional protein PutA/0.486
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.482
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.480
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.480
1icpFMN12-oxophytodienoate reductase 11.3.1.420.479
2c20NADUDP-glucose 4-epimerase/0.478
4xguADPPutative pachytene checkpoint protein 2/0.477
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.476
1mj9COAHistone acetyltransferase ESA1/0.475
1xe55FEPlasmepsin-23.4.23.390.473
2iyfERYOleandomycin glycosyltransferase2.4.10.473
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.473
4ambDUDPutative glycosyl transferase/0.472
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.471
1mjaCOAHistone acetyltransferase ESA1/0.470
2b3dFADModulator of drug activity B/0.470
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.470
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
4g3jVNTLanosterol 14-alpha-demethylase/0.469
2g1n1IGRenin3.4.23.150.467
3lqfNADGalactitol dehydrogenase/0.467
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.467
4mo2FADUDP-galactopyranose mutase/0.467
1cf3FADGlucose oxidase1.1.3.40.466
2vkeTACTetracycline repressor protein class D/0.466
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
2g247IGRenin3.4.23.150.465
1cneFADNitrate reductase [NADH]1.7.1.10.464
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.464
2gesCOKPantothenate kinase2.7.1.330.464
3h2sNDPPutative NADH-flavin reductase/0.464
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
4dbzNDPPutative ketoacyl reductase1.3.10.463
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
2bf4FADNADPH--cytochrome P450 reductase/0.462
2il2LIXRenin3.4.23.150.462
1g6kNADGlucose 1-dehydrogenase1.1.1.470.461
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.461
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.461
3nsh957Beta-secretase 13.4.23.460.460
4dc0NDPPutative ketoacyl reductase1.3.10.460
4gl4NAIAlcohol dehydrogenase class-3/0.460
4i0i957Beta-secretase 13.4.23.460.460
4yaiNAIC alpha-dehydrogenase/0.460
1icsFMN12-oxophytodienoate reductase 11.3.1.420.459
1x1aSAMC-20 methyltransferase/0.459
1yqdNAPSinapyl alcohol dehydrogenase/0.459
2f3fAXFBeta-secretase 13.4.23.460.459
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.459
3ai3NDPNADPH-sorbose reductase/0.459
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.459
3p62FMNPentaerythritol tetranitrate reductase/0.459
3w8eNAD3-hydroxybutyrate dehydrogenase/0.459
2ikuLIYRenin3.4.23.150.458
3vf30GSBeta-secretase 13.4.23.460.458
4a83DXCMajor pollen allergen Bet v 1-A/0.458
4g7gVFVLanosterol 14-alpha-demethylase/0.458
4lxk1YTBeta-secretase 13.4.23.460.458
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1rwbNADGlucose 1-dehydrogenase1.1.1.470.457
2abbFMNPentaerythritol tetranitrate reductase/0.457
2wf4ZY4Beta-secretase 13.4.23.460.457
3djjFADGlutathione reductase, mitochondrial1.8.1.70.457
4egbNADdTDP-glucose 4,6-dehydratase/0.457
4yagNAIC alpha-dehydrogenase/0.457
1s20NAD2,3-diketo-L-gulonate reductase1.1.1.1300.456
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.456
2g1y5IGRenin3.4.23.150.456
2wf1ZY1Beta-secretase 13.4.23.460.456
3tr05GPGuanylate kinase/0.456
4blrUTPNTPase P4/0.456
4eb7PLPCysteine desulfurase IscS 2/0.456
4jicFMNGTN Reductase/0.456
5czySAMEukaryotic huntingtin interacting protein B/0.456
2fj1CTCTetracycline repressor protein class D/0.455
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.455
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.455
3cic316Beta-secretase 13.4.23.460.455
3k5c0BIBeta-secretase 13.4.23.460.455
3k5dXLIBeta-secretase 13.4.23.460.455
4e2dFMNDehydrogenase/0.455
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.455
4rvfTYDD-mycarose 3-C-methyltransferase/0.455
1mjbACOHistone acetyltransferase ESA1/0.454
1xddAAYIntegrin alpha-L/0.454
2c0cNAPProstaglandin reductase 310.454
2i7pACOPantothenate kinase 32.7.1.330.454
2rcyNAPPyrroline-5-carboxylate reductase/0.454
3k5fAYHBeta-secretase 13.4.23.460.454
3lpjZ75Beta-secretase 13.4.23.460.454
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
4d89BXDBeta-secretase 13.4.23.460.454
1f8fNADBenzyl alcohol dehydrogenase/0.453
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.453
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.453
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.453
2iko7IGRenin3.4.23.150.453
2rlcCHDCholoylglycine hydrolase3.5.1.240.453
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.453
1ae1NAPTropinone reductase 1/0.452
1bil0IURenin3.4.23.150.452
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.452
1gcoNADGlucose 1-dehydrogenase1.1.1.470.452
2fznFADBifunctional protein PutA1.5.5.20.452
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.452
4uugPXGBranched-chain amino acid aminotransferase, putative/0.452
2gv8NDPThiol-specific monooxygenase1.14.130.451
2wf3ZY3Beta-secretase 13.4.23.460.451
3lpiZ74Beta-secretase 13.4.23.460.451
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.451
3toxNAPPutative oxidoreductase/0.451
3vg10GTBeta-secretase 13.4.23.460.451
4gid0GHBeta-secretase 13.4.23.460.451
4j4nD44Peptidylprolyl isomerase/0.451
4rvgTYDD-mycarose 3-C-methyltransferase/0.451
4v2gITCTetracycline repressor protein class D/0.451
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1fy7COAHistone acetyltransferase ESA1/0.450
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.450
2a92NAIL-lactate dehydrogenase/0.450
2qzlIXSBeta-secretase 13.4.23.460.450
2vprTDCTetracycline repressor protein class H/0.450
3oetNADErythronate-4-phosphate dehydrogenase/0.450
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.450
4jayNAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.450
1geeNADGlucose 1-dehydrogenase1.1.1.470.449
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.449
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.449
4b79NADProbable short-chain dehydrogenase/0.449
4eb5PLPCysteine desulfurase IscS 2/0.449
4q4kFMNUncharacterized protein/0.449
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.448
2g226IGRenin3.4.23.150.448
2xx91NFGlutamate receptor 2/0.448
3b70NAPEnoyl reductase LovC10.448
3ig6438Urokinase-type plasminogen activator3.4.21.730.448
3qwbNDPProbable quinone oxidoreductase1.6.5.50.448
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.448
4e2bFMNDehydrogenase/0.448
1bwsNDPGDP-L-fucose synthase/0.447
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.447
1rneC60Renin3.4.23.150.447
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.447
2p83MR0Beta-secretase 13.4.23.460.447
2xveFADPutative flavin-containing monooxygenase/0.447
3lpkZ76Beta-secretase 13.4.23.460.447
3uylTYDProbable NDP-rhamnosyltransferase/0.447
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.447
2g1o2IGRenin3.4.23.150.446
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.446
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.446
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3bbrBHYGlutamate receptor 2/0.446
3bw4FMNPutative 2-nitropropane dioxygenase/0.446
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.446
3o0qADNVitamin B12-dependent ribonucleotide reductase/0.446
4esoNAPPutative oxidoreductase/0.446
4exg916Beta-secretase 13.4.23.460.446
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.446
5hs1VORLanosterol 14-alpha demethylase/0.446
1f8wFADNADH peroxidase1.11.1.10.445
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.445
1ma0NADAlcohol dehydrogenase class-31.1.1.10.445
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
2c12FADNitroalkane oxidase1.7.3.10.445
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.445
2ignFADPyranose 2-oxidase/0.445
2irzI02Beta-secretase 13.4.23.460.445
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.445
2viyVG3Beta-secretase 13.4.23.460.445
2ylzFADPhenylacetone monooxygenase1.14.13.920.445
3d91REMRenin3.4.23.150.445
3ohh3HHBeta-secretase 13.4.23.460.445
4b1rITCTetracycline repressor protein class D/0.445
4frkDWDBeta-secretase 13.4.23.460.445
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.445
5jscFADPutative acyl-CoA dehydrogenase/0.445
1tysTMPThymidylate synthase/0.444
2gevCOKPantothenate kinase2.7.1.330.444
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.444
2vj6VG5Beta-secretase 13.4.23.460.444
2xlpFADPutative flavin-containing monooxygenase/0.444
3atzFMNProstaglandin F2a synthase/0.444
3d64NADAdenosylhomocysteinase/0.444
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
3zuyTCHTransporter/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1d0lBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1icqFMN12-oxophytodienoate reductase 11.3.1.420.443
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.443
1w6hTITPlasmepsin-23.4.23.390.443
2fdpFRPBeta-secretase 13.4.23.460.443
2tctCTCTetracycline repressor protein class D/0.443
3d3wNAPL-xylulose reductase1.1.1.100.443
3ogwIMNLactoperoxidase1.11.1.70.443
3rpeFADPutative modulator of drug activity/0.443
3sufSUEPolyprotein/0.443
3tjzGNPADP-ribosylation factor 1/0.443
3veu0GOBeta-secretase 13.4.23.460.443
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.443
4k6fNAPPutative Acetoacetyl-CoA reductase/0.443
4lcjNADC-terminal-binding protein 2/0.443
4loi1YCStimulator of interferon genes protein/0.443
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.443
5kwvANPPantothenate synthetase/0.443
1d0mBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.442
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
1galFADGlucose oxidase1.1.3.40.442
1j9zFADNADPH--cytochrome P450 reductase/0.442
1ja0FMNNADPH--cytochrome P450 reductase/0.442
1xe65FPPlasmepsin-23.4.23.390.442
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
2g1s4IGRenin3.4.23.150.442
2xfsJ01Uncharacterized protein/0.442
2xuqTZ4Acetylcholinesterase3.1.1.70.442
3duyAFJBeta-secretase 13.4.23.460.442
3f63GTXGlutathione transferase GST1-4/0.442
3hl0NADMaleylacetate reductase/0.442
3ixj586Beta-secretase 13.4.23.460.442
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.442
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.442
4j7xNAPSepiapterin reductase1.1.1.1530.442
4lxa1YSBeta-secretase 13.4.23.460.442
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.442
1beuIPLTryptophan synthase alpha chain/0.441
2b8l5HABeta-secretase 13.4.23.460.441
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
3ai2NDPNADPH-sorbose reductase/0.441
3f03FMNPentaerythritol tetranitrate reductase/0.441
3h3jNADL-lactate dehydrogenase 11.1.1.270.441
3o0o5ADVitamin B12-dependent ribonucleotide reductase/0.441
3p84FMNPentaerythritol tetranitrate reductase/0.441
3qbhQBHBeta-secretase 13.4.23.460.441
4b1c1B1Beta-secretase 13.4.23.460.441
4hwkNAPSepiapterin reductase1.1.1.1530.441
4k9h1QUBeta-secretase 13.4.23.460.441
1b2lNDCAlcohol dehydrogenase1.1.1.10.440
2f3rG5PGuanylate kinase2.7.4.80.440
2g263LGRenin3.4.23.150.440
2g8yNADHydroxycarboxylate dehydrogenase B/0.440
2ilvC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.440
2vnaNAPProstaglandin reductase 21.3.1.480.440
3bk2U5PRibonuclease J/0.440
3djgFADGlutathione reductase, mitochondrial1.8.1.70.440
3dm6757Beta-secretase 13.4.23.460.440
3fr5I4AFatty acid-binding protein, adipocyte/0.440
3k5gBJCBeta-secretase 13.4.23.460.440
3skgPB8Beta-secretase 13.4.23.460.440
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.440
5b0oADPFlagellum-specific ATP synthase3.6.3.140.440