sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1il0 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1il0 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 1.000 | |
| 1soz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.516 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.501 | |
| 2r3y | VAL_TYR_TRP_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.497 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.489 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.488 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.487 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.487 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.485 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.481 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.481 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.481 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.479 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.479 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.479 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.478 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.477 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.476 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.476 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.476 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.476 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.475 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.474 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.474 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.473 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.473 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.473 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.472 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.472 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.472 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.471 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.470 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.469 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.469 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.469 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.469 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.469 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.469 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.469 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.468 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.468 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.468 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.467 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.466 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.466 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.466 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.466 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.466 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.466 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.465 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.465 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.465 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.465 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.465 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.465 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.464 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.464 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 3stx | BKA | Methylketone synthase I | / | 0.464 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.463 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.463 | |
| 1qvn | FRI | Interleukin-2 | / | 0.463 | |
| 1tys | DHF | Thymidylate synthase | / | 0.463 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.463 | |
| 2k5t | COA | PanD regulatory factor | / | 0.463 | |
| 2o3z | AI7 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.463 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.463 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.463 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.463 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.463 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.463 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.463 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.462 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.462 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.462 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.462 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.461 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.461 | |
| 3wd7 | COA | Acridone synthase | / | 0.461 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.461 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.461 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.460 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.460 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.459 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.459 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.459 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.459 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.458 | |
| 1s1p | NAP | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.458 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.458 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.458 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.458 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4btj | ATP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.458 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1 | / | 0.458 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1-binding protein 1 | / | 0.458 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.458 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.457 | |
| 1q4u | 4CA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.457 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.457 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.457 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.457 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 3zuy | TCH | Transporter | / | 0.457 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.457 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.457 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.456 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.456 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.456 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.456 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.456 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.455 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.455 | |
| 3cp9 | C19 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.455 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.455 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.455 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.455 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.454 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.454 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.454 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.454 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.454 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.454 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.454 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.453 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.453 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.453 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.453 | |
| 4b1f | KRH | Glutamate racemase | / | 0.453 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.452 | |
| 1zdw | FLV | Prenyltransferase | / | 0.452 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.452 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4irn | FAD | AnaB | / | 0.452 | |
| 4okx | 198 | Androgen receptor | / | 0.452 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.451 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.451 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.451 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.451 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.451 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.451 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.450 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.450 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2xgo | ZKD | Uncharacterized protein | / | 0.450 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.450 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 3iw6 | PP0 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.450 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.449 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.449 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.449 | |
| 3ntd | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.449 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.449 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4e0i | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.449 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.449 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.449 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.449 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4pl4 | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.449 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.449 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.449 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 1osv | CHC | Bile acid receptor | / | 0.448 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.448 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.448 | |
| 2p15 | EZT | Estrogen receptor | / | 0.448 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.448 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.448 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.448 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.448 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.448 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.448 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4jd3 | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.448 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.448 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.448 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.448 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.448 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.448 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.447 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.447 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.447 | |
| 2fy5 | SOP | Choline O-acetyltransferase | 2.3.1.6 | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.447 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.447 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.447 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.447 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.447 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.446 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.446 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 3bhr | THG | Thymidylate synthase | / | 0.446 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.446 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3stw | 2TD | Methylketone synthase I | / | 0.446 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.446 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.445 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.445 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.445 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.445 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.445 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.445 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.445 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.445 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.445 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.445 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.445 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.445 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.445 | |
| 1ci7 | CB3 | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.444 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2izu | P01 | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.444 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.444 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.444 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.444 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.444 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.444 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.444 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.444 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.443 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.443 | |
| 1ppj | ANY | Cytochrome b | / | 0.443 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 2v5x | V5X | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 2zgz | GNP | Plasmid segregation protein ParM | / | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.443 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.443 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.443 | |
| 3oht | 1N1 | Mitogen-activated protein kinase | / | 0.443 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.443 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 4wlo | NAI | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.443 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1iqr | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.442 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.442 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.442 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.442 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1ryi | FAD | Glycine oxidase | 1.4.3.19 | 0.442 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.442 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.442 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3i6r | J5Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.442 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.442 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.442 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.442 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.442 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.442 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.442 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.442 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.441 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.441 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.441 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.441 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.441 | |
| 3vhk | BPK | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3wy0 | COA | Uncharacterized protein | / | 0.441 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.441 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.441 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.441 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.440 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2go4 | TUX | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.440 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.440 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.440 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.440 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.440 | |
| 3dr8 | ACO | L-methionine sulfoximine/L-methionine sulfone acetyltransferase | / | 0.440 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.440 | |
| 4eh7 | 0OO | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.440 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.440 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.440 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.440 |