sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1c4v | IH2 | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 1.000 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.688 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.667 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.667 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.662 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.658 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.657 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.657 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.656 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.654 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.652 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.651 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.646 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.645 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.638 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.638 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.637 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.636 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.634 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.634 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.633 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.632 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.631 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.631 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.629 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.629 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.627 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.624 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.623 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.623 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.621 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.619 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.618 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.618 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.617 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.613 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.612 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.611 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.609 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.608 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.606 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.606 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.606 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.604 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.603 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.603 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.601 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.600 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.600 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.599 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.599 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.599 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.598 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.598 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.597 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.594 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.593 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.593 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.592 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.592 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.591 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.587 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.587 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.585 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.585 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.585 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.580 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.577 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.577 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.574 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.571 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.570 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.568 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.564 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.562 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.562 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.560 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.560 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.558 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.557 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.555 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.555 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.555 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.553 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.551 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.551 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.549 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.548 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.548 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.548 | |
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 0.545 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.543 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.543 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.541 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.541 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.539 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.536 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.534 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.532 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.530 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.528 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.527 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.526 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.518 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.516 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.513 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.508 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.508 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.502 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.502 | |
| 1zsk | 421 | Coagulation factor XI | 3.4.21.27 | 0.501 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.500 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.500 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.498 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.497 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.496 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.496 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.495 | |
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 | 0.489 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.486 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3v2u | ATP | Protein GAL3 | / | 0.485 | |
| 1sqt | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.482 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.482 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.481 | |
| 2viv | VG2 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.480 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.480 | |
| 2g00 | 4QC | Coagulation factor X | 3.4.21.6 | 0.479 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.479 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.478 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.478 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.478 | |
| 2nr4 | FMN | Conserved protein | / | 0.477 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.475 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.473 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.471 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.471 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.471 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1wqv | PSM | Coagulation factor VII | 3.4.21.21 | 0.469 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.469 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.468 | |
| 1iqe | XMB | Coagulation factor X | 3.4.21.6 | 0.467 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.467 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.467 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 4fui | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.467 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.466 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.465 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.465 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.465 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.465 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.465 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.463 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.463 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.463 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1f92 | UKP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.460 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.460 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.460 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.460 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.460 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.459 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1lce | TMF | Thymidylate synthase | / | 0.459 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.459 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.459 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.458 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4btt | VYR | Coagulation factor X | 3.4.21.6 | 0.458 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.457 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.457 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4bup | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.457 | |
| 4fuf | 8UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.457 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.456 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.456 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.456 | |
| 3wie | DN4 | Glucose 1-dehydrogenase | / | 0.456 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.455 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.455 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.454 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.454 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.454 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.454 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.454 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.454 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.454 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.453 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.453 | |
| 2fah | GDP | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | 4.1.1.32 | 0.453 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.453 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.453 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.453 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.453 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.452 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.452 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.452 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
| 4btu | 6XS | Coagulation factor X | 3.4.21.6 | 0.452 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.452 | |
| 4y0k | NAP | AntE | / | 0.452 | |
| 5dp2 | NAP | CurF | / | 0.452 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.452 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.451 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.450 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.450 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.450 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.450 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.450 | |
| 1fml | RTL | Retinol dehydratase | / | 0.449 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2zp0 | PI0 | Coagulation factor VII | 3.4.21.21 | 0.449 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.449 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.449 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.449 | |
| 4e2y | JHZ | Methyltransferase | / | 0.449 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.448 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.448 | |
| 1sl3 | 170 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2y5g | FJD | Coagulation factor X | 3.4.21.6 | 0.448 | |
| 2z78 | H86 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.448 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.447 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.447 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.447 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.446 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.446 | |
| 2p2j | PRX | Acetyl-coenzyme A synthetase | / | 0.446 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.446 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.446 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.445 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.445 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.445 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.445 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.444 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.444 | |
| 3mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.444 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.444 | |
| 4fud | 6UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
| 1c1w | BAH | Prothrombin | 3.4.21.5 | 0.443 | |
| 1cne | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.443 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.443 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.443 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.443 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.443 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.443 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.442 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.442 | |
| 1owk | 303 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.442 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.442 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.442 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.442 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.442 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4l7h | 1W1 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.442 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 1gss | LEE | Glutathione S-transferase P | 2.5.1.18 | 0.441 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2c4f | GIL | Coagulation factor VII | 3.4.21.21 | 0.441 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.441 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.441 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.441 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.441 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.441 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.441 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.441 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4d8n | 0HM | Kallikrein-6 | 3.4.21 | 0.441 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.441 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.440 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.440 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.440 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.440 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.440 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.440 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.440 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.440 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.440 |