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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b64 FAD L-ornithine N(5)-monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4b64 FADL-ornithine N(5)-monooxygenase / 1.274
4b63 FADL-ornithine N(5)-monooxygenase / 1.189
5cku FADL-ornithine N(5)-monooxygenase / 1.127
4nzh FADL-ornithine N(5)-monooxygenase / 1.087
4b65 FADL-ornithine N(5)-monooxygenase / 1.078
4b68 FADL-ornithine N(5)-monooxygenase / 1.054
4b69 FADL-ornithine N(5)-monooxygenase / 1.038
4b66 FADL-ornithine N(5)-monooxygenase / 0.961
4b67 FADL-ornithine N(5)-monooxygenase / 0.932
4tlx FDAKtzI / 0.873
3s5w FADL-ornithine N(5)-monooxygenase / 0.831
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.821
2vq7 FADPutative flavin-containing monooxygenase / 0.817
4tm4 FDAKtzI / 0.812
4tm1 FDAKtzI / 0.811
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.801
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.793
2gvc FADThiol-specific monooxygenase 1.14.13 0.789
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.788
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.786
4tlz FADKtzI / 0.781
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.775
4tm3 FADKtzI / 0.775
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.774
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.774
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.774
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.773
4cnk FADL-amino acid oxidase / 0.772
2xvi FADPutative flavin-containing monooxygenase / 0.769
4eqr FADCoenzyme A disulfide reductase / 0.763
3icr FADCoenzyme A disulfide reductase / 0.762
2q7v FADThioredoxin reductase / 0.755
3cty FADProbable thioredoxin reductase / 0.755
2yg3 FADPutrescine oxidase / 0.751
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.747
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.745
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.743
2xvf FADPutative flavin-containing monooxygenase / 0.741
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.741
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.734
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.734
3sz0 FADSulfide-quinone reductase / 0.734
4k5r FADOxygenase / 0.733
5hhf FDAUDP-galactopyranose mutase / 0.733
2vqb FADPutative flavin-containing monooxygenase / 0.729
2xvh FADPutative flavin-containing monooxygenase / 0.728
3syi FADSulfide-quinone reductase / 0.728
3cox FADCholesterol oxidase 1.1.3.6 0.725
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.724
2dw4 FADLysine-specific histone demethylase 1A 1 0.724
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.724
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.723
2rab FADGlutathione amide reductase / 0.722
3fbs FADOxidoreductase / 0.722
4tm0 FADKtzI / 0.721
1nhs FADNADH peroxidase 1.11.1.1 0.719
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.719
3bg7 FADPyranose 2-oxidase / 0.719
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.719
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.718
2npx FADNADH peroxidase 1.11.1.1 0.715
2xve FADPutative flavin-containing monooxygenase / 0.714
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.714
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.713
4gcm FADThioredoxin reductase 1.8.1.9 0.713
4guv FADTetX family tetracycline inactivation enzyme / 0.713
1zx9 FADMercuric reductase 1.16.1.1 0.712
3ict FADCoenzyme A disulfide reductase / 0.712
2e1m FADL-glutamate oxidase / 0.711
2yg4 FADPutrescine oxidase / 0.711
4u2t FADCholesterol oxidase 1.1.3.6 0.711
4u8o FDAUDP-galactopyranose mutase / 0.710
1geu FADGlutathione reductase 1.8.1.7 0.709
4u8l FDAUDP-galactopyranose mutase / 0.708
4x4j FADPutative oxygenase / 0.708
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.707
3cgd FADCoenzyme A disulfide reductase / 0.707
3rha FDAPutrescine oxidase / 0.707
4fwe FADLysine-specific histone demethylase 1B 1 0.707
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.707
4u8n FDAUDP-galactopyranose mutase / 0.707
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.706
4aos FADSteroid monooxygenase / 0.706
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.706
2tpr FADTrypanothione reductase 1.8.1.12 0.704
3atq FDAConserved Archaeal protein / 0.704
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.704
3ukf FDAUDP-galactopyranose mutase / 0.704
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.703
4hb9 FADUncharacterized protein / 0.702
1f8s FADL-amino-acid oxidase 1.4.3.2 0.701
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.701
1h83 FADPolyamine oxidase 1.5.3.14 0.700
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.700
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.699
2jb1 FADL-amino acid oxidase / 0.699
4j57 FADThioredoxin reductase 2 1.8.1.9 0.698
5l3d FADLysine-specific histone demethylase 1A 1 0.698
1mxt FAECholesterol oxidase 1.1.3.6 0.697
2hko FADLysine-specific histone demethylase 1A 1 0.697
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.697
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.697
1n4w FADCholesterol oxidase 1.1.3.6 0.696
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
3kve FADL-amino-acid oxidase / 0.696
3urh FADDihydrolipoyl dehydrogenase / 0.696
4rek FADCholesterol oxidase 1.1.3.6 0.696
4xxg FADCholesterol oxidase 1.1.3.6 0.696
1n1p FADCholesterol oxidase 1.1.3.6 0.695
1n4v FADCholesterol oxidase 1.1.3.6 0.695
2yg7 FADPutrescine oxidase / 0.695
3kpk FADSulfide-quinone reductase / 0.695
4ntd FADThioredoxin reductase / 0.695
4xwr FADCholesterol oxidase 1.1.3.6 0.695
3gyi FADCholesterol oxidase 1.1.3.6 0.694
3nix FADFlavoprotein/dehydrogenase / 0.694
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.693
3t2k FADSulfide-quinone reductase / 0.693
4cnj FADL-amino acid oxidase / 0.693
4gdp FADPolyamine oxidase FMS1 / 0.693
4mo2 FDAUDP-galactopyranose mutase / 0.693
1b8s FADCholesterol oxidase 1.1.3.6 0.692
4k2x FADPolyketide oxygenase/hydroxylase / 0.692
4u8p FDAUDP-galactopyranose mutase / 0.692
1n4u FAECholesterol oxidase 1.1.3.6 0.691
3b6d FAECholesterol oxidase 1.1.3.6 0.691
3cnj FADCholesterol oxidase 1.1.3.6 0.691
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.691
3t2y FADSulfide-quinone reductase / 0.691
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.691
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.690
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.690
3ukk FADUDP-galactopyranose mutase / 0.690
2gew FADCholesterol oxidase 1.1.3.6 0.689
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.689
4z24 FADPutative GMC-type oxidoreductase R135 1 0.689
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.688
3ics FADCoenzyme A disulfide reductase / 0.688
3k30 ADPHistamine dehydrogenase / 0.688
4a99 FADTetX family tetracycline inactivation enzyme / 0.688
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
3f8d FADNADH oxidase/thioredoxin reductase / 0.687
1bzl FADTrypanothione reductase 1.8.1.12 0.686
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
2x8h FADThioredoxin glutathione reductase / 0.686
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.685
1ijh FADCholesterol oxidase 1.1.3.6 0.684
2jk6 FADTrypanothione reductase / 0.684
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.684
3k4c FADPyranose 2-oxidase / 0.684
4u8m FDAUDP-galactopyranose mutase / 0.684
5dbj FADFADH2-dependent halogenase PltA / 0.683
2iw5 FADLysine-specific histone demethylase 1A 1 0.682
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.682
4u8j FDAUDP-galactopyranose mutase / 0.682
4yac NAIC alpha-dehydrogenase / 0.682
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.681
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.681
3lad FADDihydrolipoyl dehydrogenase / 0.681
1cbo FADCholesterol oxidase 1.1.3.6 0.680
2gr3 FADFerredoxin reductase / 0.680
3cgc FADCoenzyme A disulfide reductase / 0.680
1fec FADTrypanothione reductase 1.8.1.12 0.679
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.678
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.678
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1tyt FADTrypanothione reductase 1.8.1.12 0.676
1cf3 FADGlucose oxidase 1.1.3.4 0.675
2gv8 FADThiol-specific monooxygenase 1.14.13 0.675
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.674
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.673
4gus FADLysine-specific histone demethylase 1B 1 0.673
1reo FADL-amino-acid oxidase 1.4.3.2 0.672
2xlr FADPutative flavin-containing monooxygenase / 0.672
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.672
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.672
4nte FADDepH / 0.672
4u2s FDACholesterol oxidase 1.1.3.6 0.672
1d7l RFLp-hydroxybenzoate hydroxylase / 0.671
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.671
1f8r FADL-amino-acid oxidase 1.4.3.2 0.671
3zdn FADMonoamine oxidase N 1.4.3.4 0.671
2igo FADPyranose 2-oxidase / 0.670
4d7e FADPutative lysine-N-oxygenase / 0.670
4icy FADPgaE / 0.669
3pl8 FADPyranose 2-oxidase / 0.668
4la1 FADThioredoxin glutathione reductase / 0.668
4oa5 SAHO-methyltransferase family protein / 0.668
4mih FADPyranose 2-oxidase 1.1.3.10 0.667
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.666
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.666
4aox FADSteroid monooxygenase / 0.665
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.665
1get FADGlutathione reductase 1.8.1.7 0.664
1gxf FADTrypanothione reductase 1.8.1.12 0.664
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.664
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
4i58 FADCyclohexylamine Oxidase / 0.664
4yry FADGlutamate synthase, beta subunit / 0.664
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.662
1nhr FADNADH peroxidase 1.11.1.1 0.661
4mok FADPyranose 2-oxidase / 0.660
2r0c FADPutative FAD-monooxygenase / 0.659
1gal FADGlucose oxidase 1.1.3.4 0.658
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.658
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.658
2w0h FADTrypanothione reductase / 0.658
3bi5 FADPolyamine oxidase FMS1 / 0.658
3ute FADUDP-galactopyranose mutase / 0.658
2eq6 FADDihydrolipoyl dehydrogenase / 0.657
2uxx FAJLysine-specific histone demethylase 1A 1 0.657
4em3 FADCoenzyme A disulfide reductase / 0.657
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.657
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.656
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.656
2xlp FADPutative flavin-containing monooxygenase / 0.656
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.656
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.656
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.656
4j33 FADKynurenine 3-monooxygenase / 0.656
4u2l SFDCholesterol oxidase 1.1.3.6 0.656
4usq FADPyridine nucleotide-disulfide oxidoreductase / 0.656
1b4v FADCholesterol oxidase 1.1.3.6 0.655
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.655
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
3nlc FADUncharacterized protein / 0.655
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.655
1cc2 FADCholesterol oxidase 1.1.3.6 0.654
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.654
1typ FADTrypanothione reductase 1.8.1.12 0.654
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.654
2ohi FMNType A flavoprotein FprA 1 0.654
3ish FADThioredoxin reductase 1.8.1.9 0.653
3lsh FADPyranose 2-oxidase / 0.653
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.653
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.653
4j2w FADKynurenine 3-monooxygenase / 0.653
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.653
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.652
3gyj FADCholesterol oxidase 1.1.3.6 0.652
3kpf FADPolyamine oxidase 1.5.3.14 0.652
4nev FADTrypanothione reductase / 0.651
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.650
3t2z FADSulfide-quinone reductase / 0.650
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.650