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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3int FDA UDP-galactopyranose mutase 5.4.99.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3int FDAUDP-galactopyranose mutase 5.4.99.9 1.405
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 1.218
1wam FADUDP-galactopyranose mutase 5.4.99.9 1.171
3kyb FADUDP-galactopyranose mutase 5.4.99.9 1.148
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 1.064
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.966
4mo2 FDAUDP-galactopyranose mutase / 0.921
4dsg FADUncharacterized protein / 0.900
4mo2 FADUDP-galactopyranose mutase / 0.893
3cnt FADPolyamine oxidase FMS1 / 0.838
3utg FDAUDP-galactopyranose mutase / 0.837
2iid FADL-amino-acid oxidase 1.4.3.2 0.827
4u8p FDAUDP-galactopyranose mutase / 0.824
2yg3 FADPutrescine oxidase / 0.823
2yg6 FADPutrescine oxidase / 0.822
4wx1 FDAUDP-galactopyranose mutase / 0.818
3uth FDAUDP-galactopyranose mutase / 0.816
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.815
3he3 FADUDP-galactopyranose mutase / 0.814
3mj4 FADUDP-galactopyranose mutase / 0.813
4u8k FDAUDP-galactopyranose mutase / 0.812
2e1m FADL-glutamate oxidase / 0.806
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.805
3zdn FADMonoamine oxidase N 1.4.3.4 0.805
3utf FDAUDP-galactopyranose mutase / 0.804
4u8l FDAUDP-galactopyranose mutase / 0.800
4gde FDAUDP-galactopyranose mutase / 0.797
4u8j FDAUDP-galactopyranose mutase / 0.797
2yg7 FADPutrescine oxidase / 0.790
4u8i FDAUDP-galactopyranose mutase / 0.790
1tdk FADL-amino-acid oxidase 1.4.3.2 0.789
3hdy FADUDP-galactopyranose mutase / 0.789
1tdn FADL-amino-acid oxidase 1.4.3.2 0.788
2yg4 FADPutrescine oxidase / 0.784
4u8o FDAUDP-galactopyranose mutase / 0.784
4gdp FADPolyamine oxidase FMS1 / 0.783
1reo FADL-amino-acid oxidase 1.4.3.2 0.782
3ukf FDAUDP-galactopyranose mutase / 0.780
2jae FADL-amino acid oxidase / 0.779
3ukk FADUDP-galactopyranose mutase / 0.779
1f8r FADL-amino-acid oxidase 1.4.3.2 0.777
4i58 FADCyclohexylamine Oxidase / 0.775
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.773
5br7 FADUDP-galactopyranose mutase / 0.772
2gv8 FADThiol-specific monooxygenase 1.14.13 0.771
3qj4 FADRenalase / 0.771
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.770
4gus FADLysine-specific histone demethylase 1B 1 0.770
1f8s FADL-amino-acid oxidase 1.4.3.2 0.769
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.769
2jb1 FADL-amino acid oxidase / 0.768
4u8m FDAUDP-galactopyranose mutase / 0.767
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.765
4u8n FDAUDP-galactopyranose mutase / 0.765
2b9x FADPutative aminooxidase / 0.764
2b9y FADPutative aminooxidase / 0.764
3bi2 FADPolyamine oxidase FMS1 / 0.764
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.764
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.763
2q0l FADThioredoxin reductase 1.8.1.9 0.760
1tdo FADL-amino-acid oxidase 1.4.3.2 0.758
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.756
2q7v FADThioredoxin reductase / 0.756
4dsh FDAUncharacterized protein / 0.756
1z6l FADPolyamine oxidase FMS1 / 0.755
2gvc FADThiol-specific monooxygenase 1.14.13 0.755
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.752
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.750
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.750
4cnk FADL-amino acid oxidase / 0.749
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.748
2xlr FADPutative flavin-containing monooxygenase / 0.745
4fwe FADLysine-specific histone demethylase 1B 1 0.745
1f8w FADNADH peroxidase 1.11.1.1 0.744
2xvf FADPutative flavin-containing monooxygenase / 0.744
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.744
1nhs FADNADH peroxidase 1.11.1.1 0.743
4guu FA9Lysine-specific histone demethylase 1B 1 0.738
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.737
3lov FADProtoporphyrinogen oxidase / 0.737
3cty FADProbable thioredoxin reductase / 0.736
1h81 FADPolyamine oxidase 1.5.3.14 0.735
2qa1 FADPgaE / 0.735
2bac FADPutative aminooxidase / 0.734
3cge FADCoenzyme A disulfide reductase / 0.734
2gew FADCholesterol oxidase 1.1.3.6 0.733
2ba9 FADPutative aminooxidase / 0.732
3uka FADUDP-galactopyranose mutase / 0.732
2xvi FADPutative flavin-containing monooxygenase / 0.731
2jb2 FADL-amino acid oxidase / 0.730
2npx FADNADH peroxidase 1.11.1.1 0.730
1nhq FADNADH peroxidase 1.11.1.1 0.729
1h83 FADPolyamine oxidase 1.5.3.14 0.728
3gwf FADCyclohexanone monooxygenase / 0.727
3hdy FDAUDP-galactopyranose mutase / 0.727
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.726
3cnj FADCholesterol oxidase 1.1.3.6 0.726
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.726
4u2l SFDCholesterol oxidase 1.1.3.6 0.725
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.724
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.724
2yg5 FADPutrescine oxidase / 0.723
4xbf FADLysine-specific histone demethylase 1A 1 0.723
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.722
4opc FDAConserved Archaeal protein / 0.722
2bab FADPutative aminooxidase / 0.721
2vq7 FADPutative flavin-containing monooxygenase / 0.721
3kve FADL-amino-acid oxidase / 0.720
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.719
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.719
1y56 ATPUncharacterized protein / 0.718
4ap3 FADSteroid monooxygenase / 0.718
1b4v FADCholesterol oxidase 1.1.3.6 0.715
1mxt FAECholesterol oxidase 1.1.3.6 0.714
1n1p FADCholesterol oxidase 1.1.3.6 0.714
1n4w FADCholesterol oxidase 1.1.3.6 0.714
3cgc FADCoenzyme A disulfide reductase / 0.714
3gyj FADCholesterol oxidase 1.1.3.6 0.714
4u2t FADCholesterol oxidase 1.1.3.6 0.714
4xxg FADCholesterol oxidase 1.1.3.6 0.714
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.713
1n4v FADCholesterol oxidase 1.1.3.6 0.713
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.713
3kkj FADRenalase / 0.713
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.712
2y48 FADLysine-specific histone demethylase 1A 1 0.712
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.712
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.711
4hsu FADLysine-specific histone demethylase 1B 1 0.710
1get FADGlutathione reductase 1.8.1.7 0.709
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.709
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.707
5l3d FADLysine-specific histone demethylase 1A 1 0.707
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.706
1cbo FADCholesterol oxidase 1.1.3.6 0.705
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.705
4j34 FADKynurenine 3-monooxygenase / 0.705
4jnq FDAThioredoxin reductase / 0.705
3cn8 FADPolyamine oxidase FMS1 / 0.704
3ka7 FADPutative oxidoreductase / 0.704
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.704
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.703
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.701
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
1qo8 FADFumarate reductase flavoprotein subunit / 0.699
4u2s FDACholesterol oxidase 1.1.3.6 0.699
2iw5 FADLysine-specific histone demethylase 1A 1 0.698
2xve FADPutative flavin-containing monooxygenase / 0.698
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.698
4yry FADGlutamate synthase, beta subunit / 0.698
2b9w FADPutative aminooxidase / 0.695
4b1b FADThioredoxin reductase 1.8.1.9 0.694
4cnj FADL-amino acid oxidase / 0.693
3bi5 FADPolyamine oxidase FMS1 / 0.692
3r9u FADThioredoxin reductase / 0.692
4fwj FADLysine-specific histone demethylase 1B 1 0.692
2dw4 FADLysine-specific histone demethylase 1A 1 0.691
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.691
1k0j FADp-hydroxybenzoate hydroxylase / 0.690
1yqz FADCoenzyme A disulfide reductase / 0.690
3nlc FADUncharacterized protein / 0.689
1cc2 FADCholesterol oxidase 1.1.3.6 0.688
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.688
1npx FADNADH peroxidase 1.11.1.1 0.687
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.687
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.686
4rsl FADFructosyl peptide oxidase / 0.686
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.685
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.685
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.684
2gqw FADFerredoxin reductase / 0.684
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.684
4rph FADUDP-galactopyranose mutase 5.4.99.9 0.684
3b6d FAECholesterol oxidase 1.1.3.6 0.683
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.683
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.683
1nhr FADNADH peroxidase 1.11.1.1 0.682
3ukk FDAUDP-galactopyranose mutase / 0.682
3ute FADUDP-galactopyranose mutase / 0.682
4c3x FAD3-ketosteroid dehydrogenase / 0.682
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.682
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.682
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.681
3rha FDAPutrescine oxidase / 0.681
3vqr FADPutative oxidoreductase / 0.681
4b68 FADL-ornithine N(5)-monooxygenase / 0.681
4opi FDAConserved Archaeal protein / 0.681
1d7l RFLp-hydroxybenzoate hydroxylase / 0.680
2xdo FADTetX family tetracycline inactivation enzyme / 0.680
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.680
3ukl FADUDP-galactopyranose mutase / 0.679
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.678
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.678
4nte FADDepH / 0.678
1d7y FADFerredoxin reductase / 0.677
1kif FADD-amino-acid oxidase 1.4.3.3 0.677
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.677
2xvh FADPutative flavin-containing monooxygenase / 0.677
4tm1 FDAKtzI / 0.677
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
2v7g NADUrocanate hydratase 4.2.1.49 0.676
4bk3 FADProbable salicylate monooxygenase / 0.675
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.674
3cgd FADCoenzyme A disulfide reductase / 0.674
3f8p NADNADH oxidase/thioredoxin reductase / 0.674
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.674
4j33 FADKynurenine 3-monooxygenase / 0.674
1nhp FADNADH peroxidase 1.11.1.1 0.673
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.673
4b69 FADL-ornithine N(5)-monooxygenase / 0.673
5je4 SAHMethyl transferase / 0.673
4gut FADLysine-specific histone demethylase 1B 1 0.672
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
4j36 FADKynurenine 3-monooxygenase / 0.671
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.670
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.670
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.670
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.669
4j31 FADKynurenine 3-monooxygenase / 0.669
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.668
2r9z FADGlutathione amide reductase / 0.668
4bjz FADProbable salicylate monooxygenase / 0.667
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.667
4opt FDAConserved Archaeal protein / 0.667
5dju FMNNPH1-2 / 0.667
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.666
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.665
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.665
2q0k FADThioredoxin reductase 1.8.1.9 0.665
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.665
4j2w FADKynurenine 3-monooxygenase / 0.665
4k2x FADPolyketide oxygenase/hydroxylase / 0.665
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.664
1xpq FADPolyamine oxidase FMS1 / 0.664
3axb FADPutative oxidoreductase / 0.664
4gdc FADUDP-galactopyranose mutase / 0.664
4k5r FADOxygenase / 0.664
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.663
4yac NAIC alpha-dehydrogenase / 0.663
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.662
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.662
1gal FADGlucose oxidase 1.1.3.4 0.661
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.661
4rek FADCholesterol oxidase 1.1.3.6 0.661
3p9u FADTetX family tetracycline inactivation enzyme / 0.660
3qvp FADGlucose oxidase 1.1.3.4 0.660
4aox FADSteroid monooxygenase / 0.660
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.659
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.659
4j57 FADThioredoxin reductase 2 1.8.1.9 0.659
4mih FADPyranose 2-oxidase 1.1.3.10 0.659
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.658
2eq9 FADDihydrolipoyl dehydrogenase / 0.658
4kuk RBFPutative blue-light photoreceptor / 0.658
2tpr FADTrypanothione reductase 1.8.1.12 0.657
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.657
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.657
3we0 FADLysine 2-monooxygenase / 0.657
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.657
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
2x8h FADThioredoxin glutathione reductase / 0.656
2yvj FADFerredoxin reductase / 0.656
3gyi FADCholesterol oxidase 1.1.3.6 0.656
4aos FADSteroid monooxygenase / 0.656
1pdh FASp-hydroxybenzoate hydroxylase / 0.655
4gcm FADThioredoxin reductase 1.8.1.9 0.655
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.655
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
3f8r NAPNADH oxidase/thioredoxin reductase / 0.654
3fpz AHZThiamine thiazole synthase / 0.654
4icy FADPgaE / 0.654
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.653
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.653
3sz0 FADSulfide-quinone reductase / 0.653
4bk2 FADProbable salicylate monooxygenase / 0.653
4gur FADLysine-specific histone demethylase 1B 1 0.653
4ysh FADGlycine oxidase / 0.653
2vvl FADMonoamine oxidase N 1.4.3.4 0.652
3fbs FADOxidoreductase / 0.652
3pl8 FADPyranose 2-oxidase / 0.652
3s5w FADL-ornithine N(5)-monooxygenase / 0.652
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.652
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.651
3ish FADThioredoxin reductase 1.8.1.9 0.651
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.651
4opg FDAConserved Archaeal protein / 0.651
1b8s FADCholesterol oxidase 1.1.3.6 0.650
1feb FADTrypanothione reductase 1.8.1.12 0.650
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.650
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
2eq7 FADDihydrolipoyl dehydrogenase / 0.650
3k30 ADPHistamine dehydrogenase / 0.650
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.650