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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gqf FAD Uncharacterized protein HI_0933

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gqf FADUncharacterized protein HI_0933 / 1.223
4cnj FADL-amino acid oxidase / 0.815
3nlc FADUncharacterized protein / 0.805
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.802
4gcm FADThioredoxin reductase 1.8.1.9 0.797
1b8s FADCholesterol oxidase 1.1.3.6 0.796
3v76 FDAUncharacterized protein / 0.793
2q7v FADThioredoxin reductase / 0.787
4rek FADCholesterol oxidase 1.1.3.6 0.787
3icr FADCoenzyme A disulfide reductase / 0.786
1ijh FADCholesterol oxidase 1.1.3.6 0.785
3gyj FADCholesterol oxidase 1.1.3.6 0.785
4u2t FADCholesterol oxidase 1.1.3.6 0.784
1n4u FAECholesterol oxidase 1.1.3.6 0.781
2gew FADCholesterol oxidase 1.1.3.6 0.781
3cnj FADCholesterol oxidase 1.1.3.6 0.781
3gyi FADCholesterol oxidase 1.1.3.6 0.781
4xwr FADCholesterol oxidase 1.1.3.6 0.781
4u2s FDACholesterol oxidase 1.1.3.6 0.780
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.774
1mxt FAECholesterol oxidase 1.1.3.6 0.771
1n4v FADCholesterol oxidase 1.1.3.6 0.771
3ish FADThioredoxin reductase 1.8.1.9 0.768
1b4v FADCholesterol oxidase 1.1.3.6 0.766
1n1p FADCholesterol oxidase 1.1.3.6 0.766
1n4w FADCholesterol oxidase 1.1.3.6 0.766
4xxg FADCholesterol oxidase 1.1.3.6 0.766
1cc2 FADCholesterol oxidase 1.1.3.6 0.765
3b6d FAECholesterol oxidase 1.1.3.6 0.765
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.765
1cbo FADCholesterol oxidase 1.1.3.6 0.762
4jn9 FADDepH / 0.761
4u2l SFDCholesterol oxidase 1.1.3.6 0.760
1yqz FADCoenzyme A disulfide reductase / 0.759
4cnk FADL-amino acid oxidase / 0.759
3ics FADCoenzyme A disulfide reductase / 0.758
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.757
4qi4 FADCellobiose dehydrogenase / 0.757
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.755
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.751
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.750
3lsh FADPyranose 2-oxidase / 0.748
2igo FADPyranose 2-oxidase / 0.747
3pl8 FADPyranose 2-oxidase / 0.747
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.747
4j57 FADThioredoxin reductase 2 1.8.1.9 0.746
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.746
2x8h FADThioredoxin glutathione reductase / 0.745
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.744
4eqs FADCoenzyme A disulfide reductase / 0.744
4qi5 FADCellobiose dehydrogenase / 0.744
2x8g FADThioredoxin glutathione reductase / 0.742
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.737
4fwe FADLysine-specific histone demethylase 1B 1 0.736
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.735
2b9w FADPutative aminooxidase / 0.735
4ntd FADThioredoxin reductase / 0.735
4em4 FADCoenzyme A disulfide reductase / 0.733
4z24 FADPutative GMC-type oxidoreductase R135 1 0.730
4opc FDAConserved Archaeal protein / 0.727
4qi7 FADCellobiose dehydrogenase / 0.727
2ign FADPyranose 2-oxidase / 0.726
3fbs FADOxidoreductase / 0.725
3ict FADCoenzyme A disulfide reductase / 0.725
3t37 FADPyridoxine 4-oxidase / 0.725
4emw FADCoenzyme A disulfide reductase / 0.725
1cf3 FADGlucose oxidase 1.1.3.4 0.723
3qj4 FADRenalase / 0.720
3r9u FADThioredoxin reductase / 0.720
2jk6 FADTrypanothione reductase / 0.719
2zbw FADFerredoxin--NADP reductase / 0.718
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.718
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.717
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.717
3vqr FADPutative oxidoreductase / 0.716
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.715
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.714
3cgb FADCoenzyme A disulfide reductase / 0.714
1get FADGlutathione reductase 1.8.1.7 0.713
1z6l FADPolyamine oxidase FMS1 / 0.713
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.713
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.713
2npx FADNADH peroxidase 1.11.1.1 0.712
3axb FADPutative oxidoreductase / 0.712
3k4c FADPyranose 2-oxidase / 0.712
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.712
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.711
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.711
2eq8 FADDihydrolipoyl dehydrogenase / 0.710
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.710
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.710
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.708
3lsi FADPyranose 2-oxidase / 0.708
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.706
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.706
1tdf FADThioredoxin reductase 1.8.1.9 0.704
1typ FADTrypanothione reductase 1.8.1.12 0.704
3hdy FDAUDP-galactopyranose mutase / 0.704
4gus FADLysine-specific histone demethylase 1B 1 0.704
4nte FADDepH / 0.703
1cl0 FADThioredoxin reductase 1.8.1.9 0.702
1tde FADThioredoxin reductase 1.8.1.9 0.702
1trb FADThioredoxin reductase 1.8.1.9 0.702
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.701
2eq6 FADDihydrolipoyl dehydrogenase / 0.700
2wba FADTrypanothione reductase 1.8.1.12 0.700
4nev FADTrypanothione reductase / 0.700
1bzl FADTrypanothione reductase 1.8.1.12 0.699
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.699
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.699
1npx FADNADH peroxidase 1.11.1.1 0.698
1ryi FADGlycine oxidase 1.4.3.19 0.698
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.698
2y48 FADLysine-specific histone demethylase 1A 1 0.697
4bjz FADProbable salicylate monooxygenase / 0.697
4j33 FADKynurenine 3-monooxygenase / 0.696
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.696
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.693
4eqr FADCoenzyme A disulfide reductase / 0.693
4mok FADPyranose 2-oxidase / 0.692
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.691
3lsm SFDPyranose 2-oxidase / 0.691
2hko FADLysine-specific histone demethylase 1A 1 0.690
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.690
4dna FADProbable glutathione reductase / 0.690
4gut FADLysine-specific histone demethylase 1B 1 0.690
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.690
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.689
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.689
4opl FDAConserved Archaeal protein / 0.689
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.688
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.686
3bi5 FADPolyamine oxidase FMS1 / 0.685
3bm1 FMNPutative NAD(P)H nitroreductase YdjA / 0.685
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.684
1gpe FADGlucose oxidase 1.1.3.4 0.684
2hqm FADGlutathione reductase 1.8.1.7 0.684
3cn8 FADPolyamine oxidase FMS1 / 0.684
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.684
2v6o FADThioredoxin glutathione reductase / 0.683
2yg3 FADPutrescine oxidase / 0.683
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.683
2cvj FADThioredoxin reductase related protein / 0.681
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.681
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.681
2yg4 FADPutrescine oxidase / 0.680
4ynt FDAGlucose oxidase, putative / 0.680
2dw4 FADLysine-specific histone demethylase 1A 1 0.679
3itj FADThioredoxin reductase 1 1.8.1.9 0.679
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
2eq9 FADDihydrolipoyl dehydrogenase / 0.678
3cty FADProbable thioredoxin reductase / 0.678
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
4bk3 FADProbable salicylate monooxygenase / 0.677
2jkc FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.676
3ept FDAPutative FAD-monooxygenase / 0.676
4hj4 FMNLOV protein / 0.676
1feb FADTrypanothione reductase 1.8.1.12 0.675
3lad FADDihydrolipoyl dehydrogenase / 0.675
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.675
4opt FDAConserved Archaeal protein / 0.675
1knr FADL-aspartate oxidase 1.4.3.16 0.674
2pdt FADVivid PAS protein VVD / 0.674
4j56 FADThioredoxin reductase 2 1.8.1.9 0.674
3cgc FADCoenzyme A disulfide reductase / 0.673
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.673
4fk1 FADPutative thioredoxin reductase / 0.672
5j60 FADThioredoxin reductase / 0.672
1gal FADGlucose oxidase 1.1.3.4 0.671
2w0h FADTrypanothione reductase / 0.671
2yg5 FADPutrescine oxidase / 0.671
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.671
4mih FADPyranose 2-oxidase 1.1.3.10 0.671
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.671
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
1ges FADGlutathione reductase 1.8.1.7 0.670
5buk FADFADH2-dependent halogenase / 0.670
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.669
4hsu FADLysine-specific histone demethylase 1B 1 0.669
4k5r FADOxygenase / 0.669
5l3d FADLysine-specific histone demethylase 1A 1 0.669
2r9z FADGlutathione amide reductase / 0.668
3cge FADCoenzyme A disulfide reductase / 0.668
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.668
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.668
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.667
3mzi FMNActivator of photopigment and puc expression / 0.665
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.665
4j34 FADKynurenine 3-monooxygenase / 0.664
3atr FDAConserved Archaeal protein / 0.663
3t50 FMNBlue-light-activated histidine kinase 2.7.13.3 0.663
1geu FADGlutathione reductase 1.8.1.7 0.662
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.662
2b9y FADPutative aminooxidase / 0.662
3gsi FADDimethylglycine oxidase 1.5.3.10 0.662
1fec FADTrypanothione reductase 1.8.1.12 0.661
3kpf FADPolyamine oxidase 1.5.3.14 0.661
4b65 FADL-ornithine N(5)-monooxygenase / 0.661
1n9l FMNPutative blue light receptor / 0.660
3jsk AHZThiamine thiazole synthase / 0.660
3rp8 FADFAD-dependent urate hydroxylase / 0.660
4guu FA9Lysine-specific histone demethylase 1B 1 0.660
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.659
1x0p FADTll0078 protein / 0.658
2q0l FADThioredoxin reductase 1.8.1.9 0.658
3f8d FADNADH oxidase/thioredoxin reductase / 0.658
4ntc FADThioredoxin reductase gliT / 0.657
2pia FMNPhthalate dioxygenase reductase / 0.656
4ccr FADThioredoxin reductase / 0.656
2h94 FADLysine-specific histone demethylase 1A 1 0.655
2iw5 FADLysine-specific histone demethylase 1A 1 0.655
3ada NADSubunit alpha of sarocosine oxidase / 0.655
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.655
4b4d FADFerredoxin-NADP reductase / 0.655
4la1 FADThioredoxin glutathione reductase / 0.655
4mo2 FDAUDP-galactopyranose mutase / 0.655
1h83 FADPolyamine oxidase 1.5.3.14 0.654
1nhs FADNADH peroxidase 1.11.1.1 0.654
3cnd FADPolyamine oxidase FMS1 / 0.654
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.654
2wow FADTrypanothione reductase / 0.653
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.652
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.651
1tyt FADTrypanothione reductase 1.8.1.12 0.651
2tpr FADTrypanothione reductase 1.8.1.12 0.651
2xdo FADTetX family tetracycline inactivation enzyme / 0.651
3urh FADDihydrolipoyl dehydrogenase / 0.651
4opg FDAConserved Archaeal protein / 0.651
1nhr FADNADH peroxidase 1.11.1.1 0.650
1zx9 FADMercuric reductase 1.16.1.1 0.650
3lov FADProtoporphyrinogen oxidase / 0.650
4ech FADPolyamine oxidase FMS1 / 0.650
5hsa FASAlcohol oxidase 1 1.1.3.13 0.650