sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4e9a | QAP | Peptide deformylase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4e9a | QAP | Peptide deformylase | / | 1.000 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.635 | |
| 2ew6 | Y13 | Peptide deformylase | / | 0.614 | |
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.608 | |
| 3pn4 | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.580 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.556 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.555 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.549 | |
| 1g2a | BB2 | Peptide deformylase | 3.5.1.88 | 0.542 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.496 | |
| 1lru | BB2 | Peptide deformylase | 3.5.1.88 | 0.492 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.491 | |
| 1g27 | BB1 | Peptide deformylase | 3.5.1.88 | 0.489 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.488 | |
| 1s17 | GNR | Peptide deformylase | / | 0.486 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.484 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1ws1 | BB2 | Peptide deformylase 1 | / | 0.480 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.480 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.480 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.480 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 4e9b | BB2 | Peptide deformylase | / | 0.479 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.477 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.474 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.473 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.473 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.473 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.472 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.472 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.472 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.472 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.471 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.471 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.471 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.470 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.469 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.469 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.468 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.467 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.467 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.467 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.466 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 3e8x | NAP | BH1520 protein | / | 0.466 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3uwb | BB2 | RIIA-RIIB membrane-associated protein | / | 0.466 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.466 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.465 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.465 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.465 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.465 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.464 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.464 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 2ejz | SAH | Diphthine synthase | / | 0.463 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.463 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.463 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.463 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 4cfa | WOP | Integrase | / | 0.463 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.462 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.462 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.461 | |
| 2y3r | TRK | TamL | / | 0.461 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.461 | |
| 4asj | N6A | Glucose-1-phosphate thymidylyltransferase | / | 0.461 | |
| 4bqr | IBH | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.461 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.460 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.460 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.459 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.459 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.458 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 3a3b | RBF | Lumazine protein | / | 0.458 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.458 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.457 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1mjh | ATP | Universal stress protein MJ0577 | / | 0.456 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.456 | |
| 4odo | FK5 | Peptidyl-prolyl cis-trans isomerase | / | 0.456 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.456 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.455 | |
| 4b4g | KKT | Glucose-1-phosphate thymidylyltransferase | / | 0.455 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.455 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3e3u | NVC | Peptide deformylase | 3.5.1.88 | 0.454 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.454 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.454 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.454 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.454 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.454 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.453 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.453 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4pd6 | URI | Nucleoside permease | / | 0.453 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.452 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.452 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 2hg1 | N5O | Endoplasmin | / | 0.451 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.451 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.451 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.450 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.450 | |
| 3eks | CY9 | Actin-5C | / | 0.450 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.450 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.450 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.450 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.450 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.449 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.449 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.449 | |
| 2uyw | BTN | Avd protein | / | 0.449 | |
| 4b2w | BZ0 | Glucose-1-phosphate thymidylyltransferase | / | 0.449 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.449 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.449 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.448 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.448 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.448 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.448 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.448 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.448 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.448 | |
| 1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.447 | |
| 2jam | J60 | Calcium/calmodulin-dependent protein kinase type 1G | 2.7.11.17 | 0.447 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.447 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.447 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.447 | |
| 3dol | GWI | Pol protein | / | 0.447 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.447 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.447 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.446 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2o12 | FMN | Chorismate synthase | / | 0.446 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.446 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.446 | |
| 4b5b | BBE | Glucose-1-phosphate thymidylyltransferase | / | 0.446 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.446 | |
| 4l8u | 9AZ | Serum albumin | / | 0.446 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4qec | NAP | ElxO | / | 0.446 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.445 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.445 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.445 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.445 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.445 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.445 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.444 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.444 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2gcq | DOI | Adenylosuccinate synthetase | / | 0.444 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.444 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.444 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.444 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.443 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.443 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.443 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2o2u | 738 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.443 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.443 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.443 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.443 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.443 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.442 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.442 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2y3r | TIR | TamL | / | 0.442 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.442 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.442 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.442 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.442 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.442 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.442 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.442 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.442 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.441 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 1k0l | FAD | p-hydroxybenzoate hydroxylase | / | 0.441 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.441 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1w4a | APC | NTPase P4 | / | 0.441 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.441 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.441 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.441 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.441 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.441 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.441 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.441 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.440 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.440 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2hut | SAH | Diphthine synthase | / | 0.440 | |
| 2nli | FMN | Lactate oxidase | / | 0.440 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.440 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.440 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.440 | |
| 4ftq | 4HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.440 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 |