sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.822 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.788 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.786 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.782 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.764 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.761 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.759 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.759 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.756 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.755 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.749 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.748 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.743 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.742 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.742 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.741 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.737 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.736 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.735 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.734 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.734 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.733 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.722 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.720 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.718 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.713 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.712 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.711 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.708 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.707 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.704 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.696 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.687 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.687 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.677 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.674 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.672 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.666 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.666 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.665 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.650 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.594 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.584 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.582 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.574 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.569 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.568 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.566 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.564 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.564 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.559 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.557 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.548 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.547 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.544 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.542 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.539 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.537 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.532 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.522 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.513 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.513 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.511 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.511 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.504 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.490 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.488 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.485 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.482 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.481 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.480 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.479 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.477 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.476 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.476 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.474 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.473 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.471 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.471 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.471 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.470 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.470 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.467 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.467 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.466 | |
| 4iae | 1DX | Alr2278 protein | / | 0.466 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 3e6e | DCS | Alanine racemase | / | 0.465 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.464 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.464 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.464 | |
| 4iah | 1DX | Alr2278 protein | / | 0.464 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.464 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.463 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.463 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.463 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.463 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.463 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.463 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.462 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.462 | |
| 1c7o | PPG | Hemolysin | / | 0.461 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.461 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.461 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.461 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.460 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.460 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.459 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.459 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.459 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.459 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.459 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.459 | |
| 4jic | FMN | GTN Reductase | / | 0.459 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.458 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.458 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.458 | |
| 4n1g | CEI | Obelin | / | 0.457 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.456 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.456 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.456 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.456 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.456 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.455 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.455 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.455 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.455 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.454 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.454 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.454 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.454 | |
| 4rel | KMP | Glycosyltransferase | / | 0.454 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.454 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.453 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.453 | |
| 4nvk | 2NY | Peroxidase | / | 0.453 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2bxq | IMN | Serum albumin | / | 0.452 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.452 | |
| 2iml | FMN | Uncharacterized protein | / | 0.452 | |
| 2wow | NDP | Trypanothione reductase | / | 0.452 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.452 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.452 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.451 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.451 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.451 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.451 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.451 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.450 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.450 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.450 | |
| 4boe | CLR | Japanin | / | 0.450 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.450 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.449 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.449 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.449 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.449 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.449 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.449 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.449 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.449 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.449 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.448 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.448 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.448 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.447 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.447 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.447 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.447 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.447 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.447 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.447 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.447 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.447 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.446 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.446 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.446 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.446 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.446 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.446 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.446 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.446 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.446 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.445 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.445 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.445 | |
| 1ylu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.445 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 3eku | CY9 | Actin-5C | / | 0.445 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.445 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.445 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.445 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.444 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.444 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.444 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.444 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.444 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.444 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.444 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.444 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.444 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.444 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.444 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.444 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.444 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.443 | |
| 1dtp | APU | Diphtheria toxin | / | 0.443 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.443 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.443 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.443 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.443 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.443 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.443 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.443 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.443 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.443 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.443 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2dg4 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.442 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.442 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3b9l | AZZ | Serum albumin | / | 0.442 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.441 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.441 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.441 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.441 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.441 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.441 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4rnw | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.441 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.440 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.440 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3nbr | ASD | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.440 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 |