sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 1.000 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.499 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.494 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.493 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.490 | |
| 2jam | J60 | Calcium/calmodulin-dependent protein kinase type 1G | 2.7.11.17 | 0.489 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.484 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.484 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.482 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.482 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.481 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.477 | |
| 4l4x | NDP | AmphI | / | 0.477 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.475 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.471 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.471 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.471 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.469 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.469 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.469 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.468 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.468 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.468 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.467 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.467 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.467 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.466 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.466 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.466 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.464 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.464 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.464 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.463 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.463 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.462 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.462 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.461 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.461 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.461 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.461 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.461 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.460 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.460 | |
| 3pft | FMN | Flavin reductase | / | 0.460 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.460 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.460 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.459 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.459 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.459 | |
| 4i0b | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.459 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.458 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.458 | |
| 5fl3 | ADP | Pili retraction protein PilT | / | 0.458 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.457 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.457 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.457 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.456 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.455 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.454 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.454 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.454 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.454 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.454 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.454 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.454 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.454 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 2gcq | DOI | Adenylosuccinate synthetase | / | 0.453 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3ieu | GDP | GTPase Era | / | 0.453 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.453 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1gqt | ACP | Ribokinase | / | 0.452 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.452 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.452 | |
| 4fd2 | ADP | Chaperone protein ClpB | / | 0.452 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.452 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.451 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.451 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.451 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.451 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.451 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.451 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.451 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.451 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.451 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.451 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.450 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.450 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.450 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4hxy | NDP | Plm1 | / | 0.450 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.450 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.449 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.449 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.449 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.449 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.449 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.449 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.448 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.448 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.448 | |
| 3qfb | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.448 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.448 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.447 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.447 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.447 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.447 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.447 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.447 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.447 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.447 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.446 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.446 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.446 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4dpl | NAP | Malonyl-CoA reductase | 1.2.1.75 | 0.446 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.446 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.445 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.445 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.445 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.445 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.444 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.444 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.444 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.444 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.444 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.444 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.444 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 5cyo | GDP | Septin-9 | / | 0.444 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.443 | |
| 1h6v | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.443 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.443 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.443 | |
| 3nf4 | FAD | Acyl-CoA dehydrogenase domain-containing protein | / | 0.443 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.443 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.443 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.443 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.443 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.443 | |
| 4nvk | 2NY | Peroxidase | / | 0.443 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.443 | |
| 4z54 | GDP | Neuronal-specific septin-3 | / | 0.443 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.443 | |
| 5jjs | SAH | Genome polyprotein | / | 0.443 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.442 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.442 | |
| 2y3s | TIR | TamL | / | 0.442 | |
| 3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.442 | |
| 3iaa | TYD | CalG2 | / | 0.442 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.442 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.442 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.441 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.441 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.441 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.441 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.441 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.441 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.440 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.440 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.440 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.440 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.440 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.440 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 |