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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.19

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.191.000
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.535
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.533
1aq1STUCyclin-dependent kinase 22.7.11.220.532
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.529
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.516
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.514
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.514
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.513
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.512
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.512
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.511
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.511
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.508
1u54ACPActivated CDC42 kinase 1/0.507
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.504
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.503
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.502
4eooATPCyclin-dependent kinase 22.7.11.220.501
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.501
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.500
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.500
2x1nX1NCyclin-dependent kinase 22.7.11.220.499
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.499
3zh8C58Protein kinase C iota type2.7.11.130.499
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.498
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.497
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.497
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.497
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.494
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.494
3gubGUBDeath-associated protein kinase 12.7.11.10.494
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.494
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.494
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.494
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.493
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
1g5sI17Cyclin-dependent kinase 22.7.11.220.491
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.491
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.491
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.490
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.490
2hog710Serine/threonine-protein kinase Chk12.7.11.10.489
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.488
5auwQUEDeath-associated protein kinase 12.7.11.10.488
2uzbC75Cyclin-dependent kinase 22.7.11.220.487
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.487
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.486
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.485
4ysjADPCalmodulin-like domain protein kinase/0.485
3rni21ZCyclin-dependent kinase 22.7.11.220.483
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.482
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.482
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.481
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.481
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.481
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.481
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.481
1fvv107Cyclin-dependent kinase 22.7.11.220.480
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.479
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.478
3sheI85MAP kinase-activated protein kinase 32.7.11.10.478
3tnwF18Cyclin-dependent kinase 22.7.11.220.478
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.477
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.477
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.477
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
5e92ANPTGF-beta receptor type-22.7.11.300.477
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
3bqr4RBDeath-associated protein kinase 3/0.476
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.476
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.475
2w17I19Cyclin-dependent kinase 22.7.11.220.475
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4bcmT7ZCyclin-dependent kinase 22.7.11.220.474
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.474
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.472
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.472
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.472
1h1s4SPCyclin-dependent kinase 22.7.11.220.471
4riyADPEpidermal growth factor receptor2.7.10.10.471
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.470
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.470
3gu6ADPDeath-associated protein kinase 12.7.11.10.470
3i60E86Mitogen-activated protein kinase 12.7.11.240.470
4k33ACPFibroblast growth factor receptor 32.7.10.10.470
5av4GENDeath-associated protein kinase 12.7.11.10.470
5dt3ATPAurora kinase A2.7.11.10.470
1oitHDTCyclin-dependent kinase 22.7.11.220.469
1pyePM1Cyclin-dependent kinase 22.7.11.220.469
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.469
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.468
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.468
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.468
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.468
4hge15VTyrosine-protein kinase JAK2/0.468
4i22IREEpidermal growth factor receptor2.7.10.10.468
2btrU73Cyclin-dependent kinase 22.7.11.220.467
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.467
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.467
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.467
4fkv61KCyclin-dependent kinase 22.7.11.220.467
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.467
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.467
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.466
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.465
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.465
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.465
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.465
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.464
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.464
1w0xOLOCyclin-dependent kinase 22.7.11.220.464
1xjdSTUProtein kinase C theta type2.7.11.130.464
3bu5ATPInsulin receptor2.7.10.10.464
3r9dX6BCyclin-dependent kinase 22.7.11.220.464
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.464
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.463
3rmf20ZCyclin-dependent kinase 22.7.11.220.463
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.463
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
4k8aK8AFocal adhesion kinase 12.7.10.20.463
1gih1PUCyclin-dependent kinase 22.7.11.220.462
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.462
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.462
2qo9ANPEphrin type-A receptor 32.7.10.10.462
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.462
2vv9IM9Cyclin-dependent kinase 22.7.11.220.462
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.461
1p2a5BNCyclin-dependent kinase 22.7.11.220.461
1pxoCK7Cyclin-dependent kinase 22.7.11.220.461
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.461
2pmlANPUncharacterized protein/0.461
2uzdC85Cyclin-dependent kinase 22.7.11.220.461
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.461
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.461
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.461
5auvAGIDeath-associated protein kinase 12.7.11.10.461
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.460
1x8b824Wee1-like protein kinase2.7.10.20.460
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.460
3rk708ZCyclin-dependent kinase 22.7.11.220.460
4dgo0JWCasein kinase II subunit alpha2.7.11.10.460
4eomATPCyclin-dependent kinase 22.7.11.220.460
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.460
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.459
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.459
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.459
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.459
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.459
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.459
4qmlANPSerine/threonine-protein kinase 242.7.11.10.459
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.458
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.458
3at4CCKCasein kinase II subunit alpha2.7.11.10.458
3dfcANPDeath-associated protein kinase 12.7.11.10.458
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.458
4d58BI9Focal adhesion kinase 12.7.10.20.458
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.458
4fv9E71Mitogen-activated protein kinase 12.7.11.240.458
2iw84SPCyclin-dependent kinase 22.7.11.220.457
2w4jADPDeath-associated protein kinase 12.7.11.10.457
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3gu5ANPDeath-associated protein kinase 12.7.11.10.457
3nynSGVG protein-coupled receptor kinase 62.7.11.160.457
4fks46KCyclin-dependent kinase 22.7.11.220.457
1e9hINRCyclin-dependent kinase 22.7.11.220.456
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
2qoqANPEphrin type-A receptor 32.7.10.10.456
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.456
3iok1P6Tyrosine-protein kinase JAK2/0.456
4ek816KCyclin-dependent kinase 22.7.11.220.456
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.456
4fv6E57Mitogen-activated protein kinase 12.7.11.240.456
1oguST8Cyclin-dependent kinase 22.7.11.220.455
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.455
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.455
4dgmAGICasein kinase II subunit alpha2.7.11.10.455
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.455
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.455
4jqeANPCasein kinase II subunit alpha2.7.11.10.455
4nj32KDCyclin-dependent kinase 22.7.11.220.455
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.454
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3qu0X40Cyclin-dependent kinase 22.7.11.220.454
4anmWULCasein kinase II subunit alpha2.7.11.10.454
4ii5ADPCyclin-dependent kinase 22.7.11.220.454
4xlvACPInsulin receptor2.7.10.10.454
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
2c5nCK8Cyclin-dependent kinase 22.7.11.220.453
3q5iANPProtein kinase, putative/0.453
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
1lp4ANPCasein kinase II subunit alpha2.7.11.10.452
2b52D42Cyclin-dependent kinase 22.7.11.220.452
3ddqRRCCyclin-dependent kinase 22.7.11.220.452
3my5RFZCyclin-dependent kinase 22.7.11.220.452
3pj8404Cyclin-dependent kinase 22.7.11.220.452
4fkw62KCyclin-dependent kinase 22.7.11.220.452
4yuqKS1Calmodulin-like domain protein kinase/0.452
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.451
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.451
2eufLQQCyclin-dependent kinase 62.7.11.220.451
2vu3LZECyclin-dependent kinase 22.7.11.220.451
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.451
4nifANPMitogen-activated protein kinase 12.7.11.240.451
1di8DTQCyclin-dependent kinase 22.7.11.220.450
2c6tDT5Cyclin-dependent kinase 22.7.11.220.450
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.450
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.450
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.450
3orkAGSSerine/threonine protein kinase/0.450
4bdaVFBSerine/threonine-protein kinase Chk22.7.11.10.450
4dgnLU2Casein kinase II subunit alpha2.7.11.10.450
1ol5ADPAurora kinase A2.7.11.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.449
2iw94SPCyclin-dependent kinase 22.7.11.220.449
2j0m4STFocal adhesion kinase 12.7.10.20.449
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.449
3ggfGVDSerine/threonine-protein kinase 26/0.449
4eok4SPCyclin-dependent kinase 22.7.11.220.449
1eh4IC1Casein kinase I homolog 12.7.11.10.448
1y91CT9Cyclin-dependent kinase 22.7.11.220.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
2wpa889Cyclin-dependent kinase 22.7.11.220.448
2zjwREFCasein kinase II subunit alpha2.7.11.10.448
3q9xEMOCasein kinase II subunit alpha2.7.11.10.448
4fkg4CKCyclin-dependent kinase 22.7.11.220.448
5av2KMPDeath-associated protein kinase 12.7.11.10.448
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.447
2c5yMTWCyclin-dependent kinase 22.7.11.220.447
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3cgfJNFMitogen-activated protein kinase 102.7.11.240.447
3gxlQIGTGF-beta receptor type-12.7.11.300.447
3t8oATPRhodopsin kinase/0.447
3ztxZTXAurora kinase B-A2.7.11.10.447
4lfiGNPCasein kinase II subunit alpha2.7.11.10.447
4qnaX11Serine/threonine-protein kinase 242.7.11.10.447
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1vjy460TGF-beta receptor type-12.7.11.300.446
2yaaATPDeath-associated protein kinase 2/0.446
3rak03ZCyclin-dependent kinase 22.7.11.220.446
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.446
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.446
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.446
4qmzB49Serine/threonine-protein kinase 242.7.11.10.446
5cvhADPCasein kinase II subunit alpha2.7.11.10.446
1jkkANPDeath-associated protein kinase 12.7.11.10.445
1unlRRCCyclin-dependent-like kinase 52.7.11.10.445
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.445
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.445
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.445
3nux3NVCyclin-dependent kinase 62.7.11.220.445
3sqq99ZCyclin-dependent kinase 22.7.11.220.445
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.445
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.445
4eor4SPCyclin-dependent kinase 22.7.11.220.445
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.445
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
1dayGNPCasein kinase II subunit alpha2.7.11.10.444
1gii1PUCyclin-dependent kinase 22.7.11.220.444
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3qtrX36Cyclin-dependent kinase 22.7.11.220.444
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.444
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.444
4wboANWRhodopsin kinase/0.444
5auxKMPDeath-associated protein kinase 12.7.11.10.444
2c4g514Cyclin-dependent kinase 22.7.11.220.443
3c4wATPRhodopsin kinase/0.443
3ddpRC8Cyclin-dependent kinase 22.7.11.220.443
3ezvEZVCyclin-dependent kinase 22.7.11.220.443
3lfqA28Cyclin-dependent kinase 22.7.11.220.443
3rk507ZCyclin-dependent kinase 22.7.11.220.443
4ek610KCyclin-dependent kinase 22.7.11.220.443
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
4i3zADPCyclin-dependent kinase 22.7.11.220.443
5drdATPAurora kinase A2.7.11.10.443
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.442
4fx360KCyclin-dependent kinase 22.7.11.220.442
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.442
1h1r6CPCyclin-dependent kinase 22.7.11.220.441
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
2acxANPG protein-coupled receptor kinase 62.7.11.160.441
2cchATPCyclin-dependent kinase 22.7.11.220.441
2csnCKICasein kinase I homolog 12.7.11.10.441
2uzeC95Cyclin-dependent kinase 22.7.11.220.441
2vagV25Dual specificity protein kinase CLK12.7.12.10.441
3lu8IQXSerum albumin/0.441
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.441
4gmy0X5Tyrosine-protein kinase JAK2/0.441
4utdACPAurora kinase A2.7.11.10.441
4zseANPEpidermal growth factor receptor2.7.10.10.441
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.441
1ke6LS2Cyclin-dependent kinase 22.7.11.220.440
1ke9LS5Cyclin-dependent kinase 22.7.11.220.440
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.440
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.440
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.440
5aacVGHALK tyrosine kinase receptor2.7.10.10.440