sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 1.000 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.678 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.640 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.624 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.618 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.606 | |
| 1u0z | RDC | Endoplasmin | / | 0.596 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.595 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.590 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.588 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.582 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.575 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.573 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.570 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 1u0y | PA7 | Endoplasmin | / | 0.568 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.565 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.561 | |
| 1qy5 | NEC | Endoplasmin | / | 0.560 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.559 | |
| 3ied | AN2 | HSP90 | / | 0.556 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 2fyp | RDE | Endoplasmin | / | 0.552 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.548 | |
| 2gfd | RDA | Endoplasmin | / | 0.547 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.547 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.545 | |
| 2hg1 | N5O | Endoplasmin | / | 0.545 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.542 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.541 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 1qy8 | RDI | Endoplasmin | / | 0.535 | |
| 1ysz | NEC | Endoplasmin | / | 0.535 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.535 | |
| 1u2o | NEC | Endoplasmin | / | 0.534 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.533 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.533 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 2gqp | PA7 | Endoplasmin | / | 0.528 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.524 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.521 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.521 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.519 | |
| 2hch | N5A | Endoplasmin | / | 0.518 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.512 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.508 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.503 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.498 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.491 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.490 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.488 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.487 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.487 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.481 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.479 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.477 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.477 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.474 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.474 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.474 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.472 | |
| 2xx5 | 13N | ATP-dependent molecular chaperone HSP82 | / | 0.471 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.471 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.471 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.471 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.470 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.470 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.469 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.468 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.467 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.465 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.464 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.464 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.464 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.463 | |
| 2q8i | RDC | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | 2.7.11.2 | 0.461 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.461 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1yt0 | ADP | Endoplasmin | / | 0.460 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.460 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.460 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.459 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.458 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.458 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.458 | |
| 3s2u | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.458 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.458 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.458 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.457 | |
| 2o1u | ANP | Endoplasmin | / | 0.457 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.457 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.456 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.456 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.456 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.455 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.455 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 4er7 | AW3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.455 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.454 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.454 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.454 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.454 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.453 | |
| 2ccu | 2D9 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1r2j | FAD | FkbI | / | 0.452 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.452 | |
| 2esa | GDM | Endoplasmin | / | 0.452 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.452 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.452 | |
| 4e93 | GUI | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.452 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.451 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.451 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.450 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.449 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.449 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.449 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.449 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.449 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.448 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.446 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.446 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3a3b | RBF | Lumazine protein | / | 0.446 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4ebf | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.446 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.446 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.446 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.445 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2x9f | X9F | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.444 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4e2d | FMN | Dehydrogenase | / | 0.444 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.444 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1ajx | AH1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2cjp | VPR | Epoxide hydrolase | / | 0.443 | |
| 3b2e | ADP | ATPase GET3 | / | 0.443 | |
| 3ggx | GGX | Gag-Pol polyprotein | / | 0.443 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3u9e | COA | Lmo1369 protein | / | 0.443 | |
| 4eop | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.442 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.442 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.442 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.442 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.442 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.442 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.442 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.442 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.442 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1efa | NPF | Lactose operon repressor | / | 0.441 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.441 | |
| 2z6i | FMN | 2-nitropropane dioxygenase | / | 0.441 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.441 | |
| 3gga | GGW | Gag-Pol polyprotein | / | 0.441 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3qaa | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 4g2r | H1L | Probable propionyl-CoA carboxylase beta chain 6 | 6.4.1.3 | 0.441 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.441 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.441 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 1vij | BAY | Gag-Pol polyprotein | / | 0.440 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.440 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 |