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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cct2E1Heat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cct2E1Heat shock protein HSP 90-alpha/1.000
2vcj2EQHeat shock protein HSP 90-alpha/0.765
2yecXQ0Heat shock protein HSP 90-alpha/0.753
2vci2GJHeat shock protein HSP 90-alpha/0.734
2yi7BZ8Heat shock protein HSP 90-alpha/0.732
2ye92D4Heat shock protein HSP 90-alpha/0.722
2wi5ZZ5Heat shock protein HSP 90-alpha/0.720
2bsmBSMHeat shock protein HSP 90-alpha/0.719
2wi1ZZ2Heat shock protein HSP 90-alpha/0.694
2uwd2GGHeat shock protein HSP 90-alpha/0.685
3ft5MO8Heat shock protein HSP 90-alpha/0.639
4egh0OYHeat shock protein HSP 90-alpha/0.638
2yjwYJWHeat shock protein HSP 90-alpha/0.627
2ye42FYHeat shock protein HSP 90-alpha/0.597
2wi2ZZ3Heat shock protein HSP 90-alpha/0.583
3hyz42CHeat shock protein HSP 90-alpha/0.574
4xcjADPHeat shock cognate 90 kDa protein/0.570
4xclAGSHeat shock cognate 90 kDa protein/0.570
3ekrPY9Heat shock protein HSP 90-alpha/0.562
1yc443PHeat shock protein HSP 90-alpha/0.560
4awq592Heat shock protein HSP 90-alpha/0.560
4egkRDCHeat shock protein HSP 90-alpha/0.552
2qg0A94Heat shock protein HSP 90-alpha/0.551
4fcq2N6Heat shock protein HSP 90-alpha/0.551
4eftEFTHeat shock protein HSP 90-alpha/0.545
2wi6ZZ6Heat shock protein HSP 90-alpha/0.542
4ipeANPTNF receptor-associated protein 1/0.538
3d0bSNXHeat shock protein HSP 90-alpha/0.534
1osfKOSHeat shock protein HSP 90-alpha/0.532
4hy6FJ1Heat shock protein HSP 90-alpha/0.532
1yetGDMHeat shock protein HSP 90-alpha/0.531
3opdHIEHeat shock protein 83/0.531
2xhtC0YHeat shock protein HSP 90-alpha/0.528
4awp99AHeat shock protein HSP 90-alpha/0.527
2bt0CT5Heat shock protein HSP 90-alpha/0.526
2iorADPChaperone protein HtpG/0.526
3t10ACPHeat shock protein HSP 90-alpha/0.525
4jqlVJ6Heat shock protein HSP 90-alpha/0.525
2bz5AB4Heat shock protein HSP 90-alpha/0.522
4xc0ACPHeat shock cognate 90 kDa protein/0.522
2yefANPHeat shock protein HSP 90-alpha/0.518
3vhaVHAHeat shock protein HSP 90-alpha/0.518
1yc14BCHeat shock protein HSP 90-alpha/0.517
3rlr3RRHeat shock protein HSP 90-alpha/0.517
2byh2D7Heat shock protein HSP 90-alpha/0.516
2wi72KLHeat shock protein HSP 90-alpha/0.516
3hhu819Heat shock protein HSP 90-alpha/0.516
4xdmGDMHeat shock cognate 90 kDa protein/0.515
2xd6XD6ATP-dependent molecular chaperone HSP82/0.514
4bqjXKLHeat shock protein HSP 90-alpha/0.512
2fypRDEEndoplasmin/0.511
1byqADPHeat shock protein HSP 90-alpha/0.509
4asg814ATP-dependent molecular chaperone HSP82/0.509
2gqpPA7Endoplasmin/0.508
2iwuNP5ATP-dependent molecular chaperone HSP82/0.507
2werRDCATP-dependent molecular chaperone HSP82/0.507
3hekBD0Heat shock protein HSP 90-alpha/0.507
2ykbYKBHeat shock protein HSP 90-alpha/0.506
1uyiPUZHeat shock protein HSP 90-alpha/0.505
2breKJ2ATP-dependent molecular chaperone HSP82/0.503
4fcr0TMHeat shock protein HSP 90-alpha/0.503
2yejZZ3Heat shock protein HSP 90-alpha/0.502
3hz142CHeat shock protein HSP 90-alpha/0.502
2yejXQKHeat shock protein HSP 90-alpha/0.500
2xjjL81Heat shock protein HSP 90-alpha/0.498
3inxJZCHeat shock protein HSP 90-alpha/0.497
2fwyH64Heat shock protein HSP 90-alpha/0.496
3whaWHAHeat shock protein HSP 90-alpha/0.496
3ezrEZRCyclin-dependent kinase 22.7.11.220.491
2xjxXJXHeat shock protein HSP 90-alpha/0.490
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.489
1u0zRDCEndoplasmin/0.488
3t1kANPHeat shock protein HSP 90-alpha/0.487
1gy3ATPCyclin-dependent kinase 22.7.11.220.486
2o1vADPEndoplasmin/0.486
2gfdRDAEndoplasmin/0.485
4ivgANPTNF receptor-associated protein 1/0.485
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.484
3rlp3RPHeat shock protein HSP 90-alpha/0.484
2o1uANPEndoplasmin/0.483
2uzlC94Cyclin-dependent kinase 22.7.11.220.483
2xx213CATP-dependent molecular chaperone HSP82/0.483
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.483
3fln3FNMitogen-activated protein kinase 14/0.483
2xabVHDHeat shock protein HSP 90-alpha/0.482
2xk2ADPHeat shock protein HSP 90-alpha/0.482
4riyADPEpidermal growth factor receptor2.7.10.10.480
4b7p9UNHeat shock protein HSP 90-alpha/0.479
4ce17FKATP-dependent molecular chaperone HSP82/0.479
2wpa889Cyclin-dependent kinase 22.7.11.220.478
4bcpT3CCyclin-dependent kinase 22.7.11.220.478
4ce3L4VATP-dependent molecular chaperone HSP82/0.477
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.477
1j39UPGDNA beta-glucosyltransferase/0.475
3tnwF18Cyclin-dependent kinase 22.7.11.220.475
3hvcGG5Mitogen-activated protein kinase 14/0.474
3q9zTXQCasein kinase II subunit alpha2.7.11.10.474
4egiB2JHeat shock protein HSP 90-alpha/0.473
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.473
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.472
2vhzNAIAlanine dehydrogenase1.4.1.10.471
4eomATPCyclin-dependent kinase 22.7.11.220.471
2xjgXJGHeat shock protein HSP 90-alpha/0.470
3q5kD1UHeat shock protein 83-1/0.470
4cf8V7HIntegrase/0.470
1h1s4SPCyclin-dependent kinase 22.7.11.220.469
3flyFLYMitogen-activated protein kinase 14/0.469
3wv9FEGHmd co-occurring protein HcgE/0.469
1oguST8Cyclin-dependent kinase 22.7.11.220.468
2wxvWXVCyclin-dependent kinase 22.7.11.220.468
3r7iX9ICyclin-dependent kinase 22.7.11.220.468
4gk3L87Ephrin type-A receptor 32.7.10.10.467
1xl5190Gag-Pol polyprotein3.4.23.160.466
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.466
2ghlLIBMitogen-activated protein kinase 14/0.466
2csnCKICasein kinase I homolog 12.7.11.10.465
2esaGDMEndoplasmin/0.465
2xhrC0PHeat shock protein HSP 90-alpha/0.465
2xnbY8LCyclin-dependent kinase 22.7.11.220.465
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.464
4fx360KCyclin-dependent kinase 22.7.11.220.464
4l9q9TPSerum albumin/0.464
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.463
4loqSB4Mitogen-activated protein kinase 14/0.462
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.461
2ek2SAHDiphthine synthase/0.461
2xcmADPCytosolic heat shock protein 90/0.461
2yy7NADL-threonine dehydrogenase/0.461
3oafOAGDihydrofolate reductase1.5.1.30.461
3qzfX66Cyclin-dependent kinase 22.7.11.220.461
4eh90OQMitogen-activated protein kinase 14/0.461
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.461
3qtqX35Cyclin-dependent kinase 22.7.11.220.460
4erwSTUCyclin-dependent kinase 22.7.11.220.460
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.460
3rvg17PTyrosine-protein kinase JAK2/0.459
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.459
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.459
5auuLU2Death-associated protein kinase 12.7.11.10.459
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.459
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.458
1drhNAPDihydrofolate reductase1.5.1.30.457
4asf62UATP-dependent molecular chaperone HSP82/0.457
4dgo0JWCasein kinase II subunit alpha2.7.11.10.457
4jr7GNPCasein kinase II subunit alpha2.7.11.10.457
1oi9N20Cyclin-dependent kinase 22.7.11.220.456
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.456
2iw84SPCyclin-dependent kinase 22.7.11.220.456
2y6o1N1Ephrin type-A receptor 42.7.10.10.456
3o6o94MHeat shock protein 83/0.456
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.456
3zh8C58Protein kinase C iota type2.7.11.130.456
4hz519YDNA topoisomerase 4 subunit B/0.456
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1u2oNECEndoplasmin/0.455
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.455
2r3o2SCCyclin-dependent kinase 22.7.11.220.455
3dt1P40Mitogen-activated protein kinase 14/0.455
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.455
3upjU03Gag-Pol polyprotein/0.455
4l8u9AZSerum albumin/0.455
4s32ANPMitogen-activated protein kinase 12.7.11.240.455
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
1h1r6CPCyclin-dependent kinase 22.7.11.220.454
2r3kSCQCyclin-dependent kinase 22.7.11.220.454
3a8wATPProtein kinase C iota type2.7.11.130.454
3ibqATPPyridoxal kinase/0.454
3uli1N3Cyclin-dependent kinase 22.7.11.220.454
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.454
1oiuN76Cyclin-dependent kinase 22.7.11.220.453
2bbqPFGThymidylate synthase/0.453
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.453
2qi1MZ4Gag-Pol polyprotein/0.453
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.453
3iok1P6Tyrosine-protein kinase JAK2/0.453
3o3pGDDGlycosyl transferase, family 2/0.453
4as94QSATP-dependent molecular chaperone HSP82/0.453
4kshHTTDNA gyrase subunit B/0.453
4xczFONQdtf/0.453
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.452
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3bv2P38Mitogen-activated protein kinase 14/0.452
3dogNNNCyclin-dependent kinase 22.7.11.220.452
3nu3478Gag-Pol polyprotein3.4.23.160.452
3ttjJBIMitogen-activated protein kinase 102.7.11.240.452
4burFADApoptosis-inducing factor 1, mitochondrial1.1.10.452
4ce2BO5ATP-dependent molecular chaperone HSP82/0.452
4fv9E71Mitogen-activated protein kinase 12.7.11.240.452
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.451
2xa4AZ5Tyrosine-protein kinase JAK2/0.451
2xx413IATP-dependent molecular chaperone HSP82/0.451
3em3478Gag-Pol polyprotein3.4.23.160.451
3pj8404Cyclin-dependent kinase 22.7.11.220.451
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.451
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.451
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.450
4aa5NQBMitogen-activated protein kinase 14/0.450
4ix4ADPUncharacterized protein/0.450
1p2a5BNCyclin-dependent kinase 22.7.11.220.449
2zdt46CMitogen-activated protein kinase 102.7.11.240.449
3cnjFADCholesterol oxidase1.1.3.60.449
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.449
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.449
4qmpDKISerine/threonine-protein kinase 242.7.11.10.449
1qf5RPLAdenylosuccinate synthetase/0.448
2qo9ANPEphrin type-A receptor 32.7.10.10.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
2xrwANPMitogen-activated protein kinase 82.7.11.240.448
3em6017Gag-Pol polyprotein3.4.23.160.448
3qtwX3ACyclin-dependent kinase 22.7.11.220.448
3rk507ZCyclin-dependent kinase 22.7.11.220.448
3tucFPWTyrosine-protein kinase SYK2.7.10.20.448
4a99FADTetX family tetracycline inactivation enzyme/0.448
4gg70J8Hepatocyte growth factor receptor2.7.10.10.448
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.448
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.448
2c5nCK8Cyclin-dependent kinase 22.7.11.220.447
2iwsNP4ATP-dependent molecular chaperone HSP82/0.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.447
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.447
3iphG11Mitogen-activated protein kinase 14/0.447
4ccbOFGALK tyrosine kinase receptor2.7.10.10.447
4cj3E4FIntegrase/0.447
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.447
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
3a1nNADNDP-sugar epimerase/0.446
3bhtMFRCyclin-dependent kinase 22.7.11.220.446
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.446
3o9aK14Pol polyprotein/0.446
3rni21ZCyclin-dependent kinase 22.7.11.220.446
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.446
4s34ANPMitogen-activated protein kinase 12.7.11.240.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.445
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.445
2ylxFADPhenylacetone monooxygenase1.14.13.920.445
3a8tATPAdenylate isopentenyltransferase/0.445
3d7tSTUTyrosine-protein kinase CSK/0.445
3ncz3NCRho-associated protein kinase 12.7.11.10.445
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.445
4fvqATPTyrosine-protein kinase JAK2/0.445
4nt03DUOrotidine 5'-phosphate decarboxylase4.1.1.230.445
4yuqKS1Calmodulin-like domain protein kinase/0.445
1e9hINRCyclin-dependent kinase 22.7.11.220.444
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2qhyMZ1Gag-Pol polyprotein/0.444
2tscCB3Thymidylate synthase/0.444
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2zuiCAMCamphor 5-monooxygenase1.14.15.10.444
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.444
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
3b28B2XHeat shock protein HSP 90-alpha/0.444
3r83Z14Cyclin-dependent kinase 22.7.11.220.444
4cd0AWJALK tyrosine kinase receptor2.7.10.10.444
4e6d0NUTyrosine-protein kinase JAK2/0.444
4fklCK2Cyclin-dependent kinase 22.7.11.220.444
4ksg920DNA gyrase subunit B/0.444
1h51FMNPentaerythritol tetranitrate reductase/0.443
1n1pFADCholesterol oxidase1.1.3.60.443
1towCRZFatty acid-binding protein, adipocyte/0.443
1vyzN5BCyclin-dependent kinase 22.7.11.220.443
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.443
2cciATPCyclin-dependent kinase 22.7.11.220.443
3pxkPXKFocal adhesion kinase 12.7.10.20.443
3r4nFU5Heat shock protein HSP 90-alpha/0.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
3uhmRFNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.443
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4i231C9Epidermal growth factor receptor2.7.10.10.443
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.443
4qmzB49Serine/threonine-protein kinase 242.7.11.10.443
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1rw8580TGF-beta receptor type-12.7.11.300.442
1xjdSTUProtein kinase C theta type2.7.11.130.442
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.442
2qbmCAMCamphor 5-monooxygenase1.14.15.10.442
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.442
3b9lAZZSerum albumin/0.442
3flzFLZMitogen-activated protein kinase 14/0.442
3fmh533Mitogen-activated protein kinase 14/0.442
4c04SFGProtein arginine N-methyltransferase 6/0.442
4qnaX11Serine/threonine-protein kinase 242.7.11.10.442
1mesDMPGag-Pol polyprotein3.4.23.160.441
1zz2B11Mitogen-activated protein kinase 14/0.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
2pz8APCNH(3)-dependent NAD(+) synthetase/0.441
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.441
2x4zX4ZSerine/threonine-protein kinase PAK 42.7.11.10.441
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.441
3ec0GRLGag-Pol polyprotein3.4.23.470.441
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.441
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.441
3qruX19Cyclin-dependent kinase 22.7.11.220.441
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4ez30S0Cyclin-dependent kinase 22.7.11.220.441
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.441
4okx198Androgen receptor/0.441
1esvLARActin, alpha skeletal muscle/0.440
1i59ANPChemotaxis protein CheA2.7.13.30.440
1rx8NAPDihydrofolate reductase1.5.1.30.440
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.440
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.440
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.440
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
2j7pGNPSignal recognition particle protein/0.440
2j7pGNPSignal recognition particle receptor FtsY/0.440
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3a4vNADNDP-sugar epimerase/0.440
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3cukFADD-amino-acid oxidase1.4.3.30.440
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3ral04ZCyclin-dependent kinase 22.7.11.220.440
3tiz3TICyclin-dependent kinase 22.7.11.220.440
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.440
4mp2PV1[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.440
4z0g5GPInosine-5'-monophosphate dehydrogenase/0.440