Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1unlRRCCyclin-dependent-like kinase 52.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1unlRRCCyclin-dependent-like kinase 52.7.11.11.000
4eor4SPCyclin-dependent kinase 22.7.11.220.566
2r64740Cyclin-dependent kinase 22.7.11.220.560
1ke6LS2Cyclin-dependent kinase 22.7.11.220.550
1vyw292Cyclin-dependent kinase 22.7.11.220.550
1h1s4SPCyclin-dependent kinase 22.7.11.220.549
2wxvWXVCyclin-dependent kinase 22.7.11.220.547
3ddpRC8Cyclin-dependent kinase 22.7.11.220.543
1oguST8Cyclin-dependent kinase 22.7.11.220.542
3s2pPMUCyclin-dependent kinase 22.7.11.220.538
3qu0X40Cyclin-dependent kinase 22.7.11.220.536
1h1r6CPCyclin-dependent kinase 22.7.11.220.530
2iw84SPCyclin-dependent kinase 22.7.11.220.530
3r83Z14Cyclin-dependent kinase 22.7.11.220.530
1ckpPVBCyclin-dependent kinase 22.7.11.220.528
3bhtMFRCyclin-dependent kinase 22.7.11.220.528
3pj8404Cyclin-dependent kinase 22.7.11.220.528
3sqq99ZCyclin-dependent kinase 22.7.11.220.528
4bcoT6QCyclin-dependent kinase 22.7.11.220.528
2btrU73Cyclin-dependent kinase 22.7.11.220.527
2w06FRVCyclin-dependent kinase 22.7.11.220.527
2btsU32Cyclin-dependent kinase 22.7.11.220.524
3ddqRRCCyclin-dependent kinase 22.7.11.220.522
1h0w207Cyclin-dependent kinase 22.7.11.220.519
3r73X87Cyclin-dependent kinase 22.7.11.220.518
1ke9LS5Cyclin-dependent kinase 22.7.11.220.517
2a4lRRCCyclin-dependent kinase 22.7.11.220.515
1ke7LS3Cyclin-dependent kinase 22.7.11.220.513
1oi9N20Cyclin-dependent kinase 22.7.11.220.513
1oiyN41Cyclin-dependent kinase 22.7.11.220.513
3rjc06ZCyclin-dependent kinase 22.7.11.220.513
1unhIXMCyclin-dependent-like kinase 52.7.11.10.511
3r1yX76Cyclin-dependent kinase 22.7.11.220.511
4bcpT3CCyclin-dependent kinase 22.7.11.220.511
4ek816KCyclin-dependent kinase 22.7.11.220.511
3qxoX65Cyclin-dependent kinase 22.7.11.220.510
4bgh3I6Cyclin-dependent kinase 22.7.11.220.510
3raiX85Cyclin-dependent kinase 22.7.11.220.508
4fki09KCyclin-dependent kinase 22.7.11.220.506
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.505
3qtzX42Cyclin-dependent kinase 22.7.11.220.504
3rni21ZCyclin-dependent kinase 22.7.11.220.504
3rpv26ZCyclin-dependent kinase 22.7.11.220.504
1gih1PUCyclin-dependent kinase 22.7.11.220.503
3s0o50ZCyclin-dependent kinase 22.7.11.220.503
1w0xOLOCyclin-dependent kinase 22.7.11.220.502
2wihP48Cyclin-dependent kinase 22.7.11.220.502
3iggEFQCyclin-dependent kinase 22.7.11.220.502
3qwkX62Cyclin-dependent kinase 22.7.11.220.502
3qzgX67Cyclin-dependent kinase 22.7.11.220.502
3r7vZ02Cyclin-dependent kinase 22.7.11.220.502
3r7yZ04Cyclin-dependent kinase 22.7.11.220.502
4ek610KCyclin-dependent kinase 22.7.11.220.502
2x1nX1NCyclin-dependent kinase 22.7.11.220.501
3my5RFZCyclin-dependent kinase 22.7.11.220.500
3qtuX44Cyclin-dependent kinase 22.7.11.220.500
2b52D42Cyclin-dependent kinase 22.7.11.220.498
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.498
4fkj11KCyclin-dependent kinase 22.7.11.220.498
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.496
1oitHDTCyclin-dependent kinase 22.7.11.220.495
3ezrEZRCyclin-dependent kinase 22.7.11.220.495
1ke5LS1Cyclin-dependent kinase 22.7.11.220.494
2duv371Cyclin-dependent kinase 22.7.11.220.494
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.494
2a0cCK9Cyclin-dependent kinase 22.7.11.220.493
2uznC96Cyclin-dependent kinase 22.7.11.220.493
2wotZZGTGF-beta receptor type-12.7.11.300.493
3rk507ZCyclin-dependent kinase 22.7.11.220.493
3rm719ZCyclin-dependent kinase 22.7.11.220.493
4fkpLS5Cyclin-dependent kinase 22.7.11.220.493
2bkzSBCCyclin-dependent kinase 22.7.11.220.492
2iw94SPCyclin-dependent kinase 22.7.11.220.491
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.491
3lfnA27Cyclin-dependent kinase 22.7.11.220.491
2wpa889Cyclin-dependent kinase 22.7.11.220.490
3qqfX07Cyclin-dependent kinase 22.7.11.220.490
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.490
4fkg4CKCyclin-dependent kinase 22.7.11.220.490
1vyzN5BCyclin-dependent kinase 22.7.11.220.489
2j9mPY8Cyclin-dependent kinase 22.7.11.220.489
2r3p3SCCyclin-dependent kinase 22.7.11.220.489
4fkr45KCyclin-dependent kinase 22.7.11.220.489
1pxmCK5Cyclin-dependent kinase 22.7.11.220.488
3qqkX02Cyclin-dependent kinase 22.7.11.220.488
3rk909ZCyclin-dependent kinase 22.7.11.220.488
4ez30S0Cyclin-dependent kinase 22.7.11.220.488
4fkq42KCyclin-dependent kinase 22.7.11.220.488
4fx360KCyclin-dependent kinase 22.7.11.220.488
1g5sI17Cyclin-dependent kinase 22.7.11.220.487
2c4g514Cyclin-dependent kinase 22.7.11.220.487
3dogNNNCyclin-dependent kinase 22.7.11.220.487
3qzhX69Cyclin-dependent kinase 22.7.11.220.487
4lyn1YGCyclin-dependent kinase 22.7.11.220.487
1e1xNW1Cyclin-dependent kinase 22.7.11.220.486
2r3lSCWCyclin-dependent kinase 22.7.11.220.486
3ig7EFPCyclin-dependent kinase 22.7.11.220.486
3r8lZ30Cyclin-dependent kinase 22.7.11.220.486
4fkt48KCyclin-dependent kinase 22.7.11.220.486
1aq1STUCyclin-dependent kinase 22.7.11.220.485
1oirHDYCyclin-dependent kinase 22.7.11.220.485
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.485
3rpo24ZCyclin-dependent kinase 22.7.11.220.485
2c5nCK8Cyclin-dependent kinase 22.7.11.220.484
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.484
3r1qX75Cyclin-dependent kinase 22.7.11.220.484
3r1sX73Cyclin-dependent kinase 22.7.11.220.484
1e9hINRCyclin-dependent kinase 22.7.11.220.483
1oiuN76Cyclin-dependent kinase 22.7.11.220.482
1b38ATPCyclin-dependent kinase 22.7.11.220.481
3rk708ZCyclin-dependent kinase 22.7.11.220.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.480
3roy22ZCyclin-dependent kinase 22.7.11.220.480
3unk0BYCyclin-dependent kinase 22.7.11.220.480
4eos1ROCyclin-dependent kinase 22.7.11.220.480
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.480
1urwI1PCyclin-dependent kinase 22.7.11.220.479
3qwjX6ACyclin-dependent kinase 22.7.11.220.479
3unj0BXCyclin-dependent kinase 22.7.11.220.479
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.478
3r6xX84Cyclin-dependent kinase 22.7.11.220.478
3ral04ZCyclin-dependent kinase 22.7.11.220.478
1h1q2A6Cyclin-dependent kinase 22.7.11.220.477
2r3iSCFCyclin-dependent kinase 22.7.11.220.477
4acm7YGCyclin-dependent kinase 22.7.11.220.477
1di8DTQCyclin-dependent kinase 22.7.11.220.476
1pxkCK3Cyclin-dependent kinase 22.7.11.220.476
1y91CT9Cyclin-dependent kinase 22.7.11.220.476
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.476
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.476
1eh4IC1Casein kinase I homolog 12.7.11.10.475
3qtxX43Cyclin-dependent kinase 22.7.11.220.475
3r71X86Cyclin-dependent kinase 22.7.11.220.474
3r9hZ67Cyclin-dependent kinase 22.7.11.220.474
3rm618ZCyclin-dependent kinase 22.7.11.220.474
1v0pPVBCell division control protein 2 homolog2.7.11.220.473
2c6o4SPCyclin-dependent kinase 22.7.11.220.473
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3qqlX03Cyclin-dependent kinase 22.7.11.220.473
3qruX19Cyclin-dependent kinase 22.7.11.220.473
4eon1ROCyclin-dependent kinase 22.7.11.220.473
3r7eX88Cyclin-dependent kinase 22.7.11.220.472
3sw418KCyclin-dependent kinase 22.7.11.220.472
4cfnJYMCyclin-dependent kinase 22.7.11.220.472
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.471
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.471
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.471
2uzbC75Cyclin-dependent kinase 22.7.11.220.471
4b99R4LMitogen-activated protein kinase 72.7.11.240.471
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.470
3fz1B98Cyclin-dependent kinase 22.7.11.220.470
3uyt0CKCasein kinase I isoform delta2.7.11.10.470
4kd11QKCyclin-dependent kinase 22.7.11.220.470
1b39ATPCyclin-dependent kinase 22.7.11.220.469
2c6iDT1Cyclin-dependent kinase 22.7.11.220.469
3r7iX9ICyclin-dependent kinase 22.7.11.220.469
3r8pZ46Cyclin-dependent kinase 22.7.11.220.469
2uzeC95Cyclin-dependent kinase 22.7.11.220.468
2xmyCDKCyclin-dependent kinase 22.7.11.220.468
3lfqA28Cyclin-dependent kinase 22.7.11.220.468
4fkv61KCyclin-dependent kinase 22.7.11.220.468
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.467
1pxoCK7Cyclin-dependent kinase 22.7.11.220.467
1r78FMDCyclin-dependent kinase 22.7.11.220.467
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.467
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.467
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.467
1fvt106Cyclin-dependent kinase 22.7.11.220.466
1ykr628Cyclin-dependent kinase 22.7.11.220.466
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.466
2uzoC62Cyclin-dependent kinase 22.7.11.220.466
2vtsLZCCyclin-dependent kinase 22.7.11.220.466
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
3rmf20ZCyclin-dependent kinase 22.7.11.220.466
3s1h56ZCyclin-dependent kinase 22.7.11.220.466
1h0vUN4Cyclin-dependent kinase 22.7.11.220.465
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.465
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
2r3r6SCCyclin-dependent kinase 22.7.11.220.464
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.464
4bcqTJFCyclin-dependent kinase 22.7.11.220.464
4fko20KCyclin-dependent kinase 22.7.11.220.464
1hckATPCyclin-dependent kinase 22.7.11.220.463
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.463
2xneASHAurora kinase A2.7.11.10.463
4eok4SPCyclin-dependent kinase 22.7.11.220.463
2uzdC85Cyclin-dependent kinase 22.7.11.220.462
3sheI85MAP kinase-activated protein kinase 32.7.11.10.462
1qmzATPCyclin-dependent kinase 22.7.11.220.461
1v1k3FPCyclin-dependent kinase 22.7.11.220.461
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.461
4aacAAVMitogen-activated protein kinase 14/0.461
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.461
4fod0UVALK tyrosine kinase receptor2.7.10.10.461
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.461
1gz8MBPCyclin-dependent kinase 22.7.11.220.460
2c6tDT5Cyclin-dependent kinase 22.7.11.220.460
2fvdLIACyclin-dependent kinase 22.7.11.220.460
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.460
3qx2X63Cyclin-dependent kinase 22.7.11.220.460
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.460
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.460
2c6mDT5Cyclin-dependent kinase 22.7.11.220.459
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.459
3t8oATPRhodopsin kinase/0.459
4fks46KCyclin-dependent kinase 22.7.11.220.459
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.458
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
2cchATPCyclin-dependent kinase 22.7.11.220.458
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.458
1pyePM1Cyclin-dependent kinase 22.7.11.220.457
3ezvEZVCyclin-dependent kinase 22.7.11.220.457
3qrtX14Cyclin-dependent kinase 22.7.11.220.457
3tnwF18Cyclin-dependent kinase 22.7.11.220.457
1dm2HMDCyclin-dependent kinase 22.7.11.220.456
1w8cN69Cyclin-dependent kinase 22.7.11.220.456
3mdvCL6Cholesterol 24-hydroxylase/0.456
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.456
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.456
5dr6SKEAurora kinase A2.7.11.10.456
2bhhRYUCyclin-dependent kinase 22.7.11.220.455
2uzlC94Cyclin-dependent kinase 22.7.11.220.455
1pxlCK4Cyclin-dependent kinase 22.7.11.220.454
1pxpCK8Cyclin-dependent kinase 22.7.11.220.454
2i40BLZCyclin-dependent kinase 22.7.11.220.454
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.454
3wblPDYCyclin-dependent kinase 22.7.11.220.454
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.454
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.453
2b55D31Cyclin-dependent kinase 22.7.11.220.453
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.453
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.453
2r3kSCQCyclin-dependent kinase 22.7.11.220.453
3ql8X01Cyclin-dependent kinase 22.7.11.220.453
3qx4X4BCyclin-dependent kinase 22.7.11.220.453
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.453
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.453
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2b53D23Cyclin-dependent kinase 22.7.11.220.452
2r3o2SCCyclin-dependent kinase 22.7.11.220.452
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.452
3gu83GUDeath-associated protein kinase 12.7.11.10.452
3r7uX96Cyclin-dependent kinase 22.7.11.220.452
3rahO1ZCyclin-dependent kinase 22.7.11.220.452
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.452
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.451
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.451
2c6kDT2Cyclin-dependent kinase 22.7.11.220.451
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.451
3r28XA0Cyclin-dependent kinase 22.7.11.220.451
3rak03ZCyclin-dependent kinase 22.7.11.220.451
4qmpDKISerine/threonine-protein kinase 242.7.11.10.451
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.450
2vttLZDCyclin-dependent kinase 22.7.11.220.450
2w17I19Cyclin-dependent kinase 22.7.11.220.450
3r8vZ62Cyclin-dependent kinase 22.7.11.220.450
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4fv8E63Mitogen-activated protein kinase 12.7.11.240.450
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
2oji33AMitogen-activated protein kinase 12.7.11.240.449
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3eyhIZATyrosine-protein kinase JAK1/0.449
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.449
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.449
3rpy27ZCyclin-dependent kinase 22.7.11.220.449
4bcnT9NCyclin-dependent kinase 22.7.11.220.449
4fob0USALK tyrosine kinase receptor2.7.10.10.449
4yuqKS1Calmodulin-like domain protein kinase/0.449
2b54D05Cyclin-dependent kinase 22.7.11.220.448
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.448
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.448
3a62STURibosomal protein S6 kinase beta-12.7.11.10.448
4bgg844Activin receptor type-12.7.11.300.448
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.448
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
1gii1PUCyclin-dependent kinase 22.7.11.220.447
1vjy460TGF-beta receptor type-12.7.11.300.447
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
3r9oZ71Cyclin-dependent kinase 22.7.11.220.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
3uli1N3Cyclin-dependent kinase 22.7.11.220.447
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jqeANPCasein kinase II subunit alpha2.7.11.10.447
4l9i8PRRhodopsin kinase/0.447
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.446
3h9f92MDual specificity protein kinase TTK2.7.12.10.446
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.446
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.445
2xnbY8LCyclin-dependent kinase 22.7.11.220.445
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
2acxANPG protein-coupled receptor kinase 62.7.11.160.444
2eufLQQCyclin-dependent kinase 62.7.11.220.444
2xikJ60Serine/threonine-protein kinase 252.7.11.10.444
4fklCK2Cyclin-dependent kinase 22.7.11.220.444
5aniES4Cyclin-dependent kinase 22.7.11.220.444
1gy3ATPCyclin-dependent kinase 22.7.11.220.443
1h1pCMGCyclin-dependent kinase 22.7.11.220.443
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.443
2r3fSC8Cyclin-dependent kinase 22.7.11.220.443
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.443
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.443
3s00Z60Cyclin-dependent kinase 22.7.11.220.443
4foc0UUALK tyrosine kinase receptor2.7.10.10.443
4qmzB49Serine/threonine-protein kinase 242.7.11.10.443
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.442
3qtrX36Cyclin-dependent kinase 22.7.11.220.442
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1lf3EH5Plasmepsin-23.4.23.390.441
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
1ke8LS4Cyclin-dependent kinase 22.7.11.220.440
1p2a5BNCyclin-dependent kinase 22.7.11.220.440
1u3dFADCryptochrome-1/0.440
2y9qANPMitogen-activated protein kinase 12.7.11.240.440
4eomATPCyclin-dependent kinase 22.7.11.220.440