Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4cfd | S8Y | Integrase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4cfd | S8Y | Integrase | / | 1.000 | |
| 4cf1 | IY7 | Integrase | / | 0.679 | |
| 4chq | CWU | Integrase | / | 0.631 | |
| 4cfb | OM3 | Integrase | / | 0.607 | |
| 3zt3 | ZT4 | Integrase | / | 0.604 | |
| 4cgi | NZL | Integrase | / | 0.598 | |
| 4cju | JNS | Integrase | / | 0.595 | |
| 4ceo | G0T | Integrase | / | 0.592 | |
| 4cfa | WOP | Integrase | / | 0.589 | |
| 4ces | NFW | Integrase | / | 0.586 | |
| 4ced | 9NS | Integrase | / | 0.582 | |
| 4cgd | 8P3 | Integrase | / | 0.578 | |
| 4cef | D0T | Integrase | / | 0.575 | |
| 4cea | ZSW | Integrase | / | 0.573 | |
| 4ck2 | NVU | Integrase | / | 0.573 | |
| 4ceq | QCH | Integrase | / | 0.569 | |
| 4cjf | RVN | Integrase | / | 0.569 | |
| 4cgj | NZL | Integrase | / | 0.568 | |
| 3zsw | ZSW | Integrase | / | 0.567 | |
| 4cgg | K5Q | Integrase | / | 0.564 | |
| 3zsr | O3N | Integrase | / | 0.563 | |
| 4cez | O3N | Integrase | / | 0.563 | |
| 4cf0 | O5U | Integrase | / | 0.561 | |
| 4cje | Q31 | Integrase | / | 0.561 | |
| 4cec | 2SS | Integrase | / | 0.555 | |
| 4cer | VL4 | Integrase | / | 0.555 | |
| 4cf2 | 3GM | Integrase | / | 0.554 | |
| 4cf8 | V7H | Integrase | / | 0.554 | |
| 4cjk | H39 | Integrase | / | 0.552 | |
| 4cj3 | E4F | Integrase | / | 0.550 | |
| 4cj5 | 4VW | Integrase | / | 0.547 | |
| 4cif | JDX | Integrase | / | 0.540 | |
| 3zsq | O4N | Integrase | / | 0.538 | |
| 4cfc | 7NV | Integrase | / | 0.538 | |
| 4ck3 | K1T | Integrase | / | 0.538 | |
| 4cie | Y7N | Integrase | / | 0.536 | |
| 4ce9 | O3N | Integrase | / | 0.533 | |
| 3zsx | N44 | Integrase | / | 0.532 | |
| 4cj4 | S3G | Integrase | / | 0.531 | |
| 3zt0 | ZT0 | Integrase | / | 0.525 | |
| 4cee | B0T | Integrase | / | 0.524 | |
| 4cig | X0P | Integrase | / | 0.524 | |
| 4cjp | 4D2 | Integrase | / | 0.524 | |
| 4ck1 | OM1 | Integrase | / | 0.522 | |
| 4cgh | LOZ | Integrase | / | 0.520 | |
| 4cjq | VXO | Integrase | / | 0.519 | |
| 3zsv | ZSV | Integrase | / | 0.517 | |
| 4ceb | ZSV | Integrase | / | 0.517 | |
| 3zsz | OM2 | Integrase | / | 0.513 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.511 | |
| 4cjr | FYM | Integrase | / | 0.511 | |
| 3zt2 | ZT2 | Integrase | / | 0.507 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.506 | |
| 3zt1 | OM1 | Integrase | / | 0.504 | |
| 3zsy | OM3 | Integrase | / | 0.501 | |
| 4chy | C5Q | Integrase | / | 0.501 | |
| 3zcm | PX3 | Integrase | / | 0.495 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.493 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.490 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.489 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.487 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.487 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.483 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.482 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.482 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.481 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.478 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.478 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.477 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.474 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.474 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.473 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.472 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.472 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.471 | |
| 1b8u | NAD | Malate dehydrogenase | / | 0.470 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.470 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.470 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 5a3b | APR | SIR2 family protein | / | 0.470 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.469 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.469 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.469 | |
| 4cjs | L0Y | Integrase | / | 0.469 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.468 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.468 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.468 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.467 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.467 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.466 | |
| 2ohv | NHL | Glutamate racemase | / | 0.466 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.466 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.465 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.465 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.463 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.463 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.463 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.463 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.463 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.463 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.463 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.463 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.462 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.462 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.461 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.461 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.461 | |
| 4ros | APR | Malate dehydrogenase | / | 0.461 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.460 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.460 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.460 | |
| 3v2u | ATP | Protein GAL3 | / | 0.460 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.460 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.459 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.459 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.459 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.458 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.458 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.458 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 4ajn | 88V | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.457 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.457 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.457 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.456 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.456 | |
| 2i5b | ADP | Pyridoxine kinase | / | 0.456 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.456 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.456 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.455 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.455 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.455 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.455 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.455 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.455 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.454 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.454 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.454 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.454 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.454 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.453 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 2xs0 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.453 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.453 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.453 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.452 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.452 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.452 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.452 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.452 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.452 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.452 | |
| 4e2b | FMN | Dehydrogenase | / | 0.452 | |
| 4kh0 | ATP | Aspartate carbamoyltransferase regulatory chain {ECO:0000256|HAMAP-Rule:MF_00002} | / | 0.452 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.452 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.451 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.451 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.451 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.451 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.451 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.451 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.451 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.451 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.451 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.451 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.451 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.450 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 2xrw | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.450 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.450 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.450 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.450 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.450 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 4xj3 | GTP | Cyclic GMP-AMP synthase | / | 0.450 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.450 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.450 | |
| 1gqt | ACP | Ribokinase | / | 0.449 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.449 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.449 | |
| 4nif | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 5dp2 | NAP | CurF | / | 0.449 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.448 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.448 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.448 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.448 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.448 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.448 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.447 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.447 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.447 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.447 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.447 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 4u7w | NDP | MxaA | / | 0.447 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.447 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.447 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.446 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.446 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.446 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.446 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.446 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.446 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.446 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.446 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.446 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.446 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.446 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.446 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.446 | |
| 5a3c | NAD | SIR2 family protein | / | 0.446 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 1lev | CLI | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.445 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.445 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.445 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.445 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.445 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.445 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.445 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.444 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.444 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.444 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.444 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.444 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.444 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.444 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.444 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.444 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.444 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.443 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.443 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.443 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.443 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.443 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.443 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.443 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3cf0 | ADP | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.443 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.443 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.443 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.443 | |
| 4e8w | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.443 | |
| 4pd6 | URI | Nucleoside permease | / | 0.443 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.443 | |
| 1ea0 | FMN | Glutamate synthase [NADPH] large chain | 1.4.1.13 | 0.442 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1llz | FMN | Ferredoxin-dependent glutamate synthase 2 | 1.4.7.1 | 0.442 | |
| 1u1i | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.442 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.442 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.442 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.442 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.442 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.442 | |
| 3eej | 53R | Uncharacterized protein | / | 0.442 | |
| 3so9 | 017 | Pol protein | / | 0.442 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.442 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 4e8y | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.442 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.442 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4i9h | 1E4 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.442 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.442 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.441 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.441 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.441 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.441 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.441 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.441 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.441 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.441 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.441 | |
| 1fml | RTL | Retinol dehydratase | / | 0.440 | |
| 1kzi | THG | Thymidylate synthase | / | 0.440 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.440 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.440 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.440 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.440 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.440 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 |