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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mb714ICasein kinase II subunit alpha2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mb714ICasein kinase II subunit alpha2.7.11.11.000
3pe2E1BCasein kinase II subunit alpha2.7.11.10.624
5cvfATPCasein kinase II subunit alpha2.7.11.10.574
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.548
3at4CCKCasein kinase II subunit alpha2.7.11.10.541
3q9xEMOCasein kinase II subunit alpha2.7.11.10.529
2zjwREFCasein kinase II subunit alpha2.7.11.10.514
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.506
4grb0XGCasein kinase II subunit alpha2.7.11.10.501
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.497
3u4uLNHCasein kinase II subunit alpha2.7.11.10.496
4ez50RSCyclin-dependent kinase 62.7.11.220.496
3r0tFU9Casein kinase II subunit alpha2.7.11.10.495
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.491
5av2KMPDeath-associated protein kinase 12.7.11.10.490
4jr7GNPCasein kinase II subunit alpha2.7.11.10.489
4dgnLU2Casein kinase II subunit alpha2.7.11.10.488
3pe13NGCasein kinase II subunit alpha2.7.11.10.487
1m2pHNACasein kinase II subunit alpha2.7.11.10.484
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.484
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
3axwTIDCasein kinase II subunit alpha2.7.11.10.482
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
2w17I19Cyclin-dependent kinase 22.7.11.220.481
1pxmCK5Cyclin-dependent kinase 22.7.11.220.480
3wowANPCasein kinase II subunit alpha2.7.11.10.480
2vu3LZECyclin-dependent kinase 22.7.11.220.479
3rak03ZCyclin-dependent kinase 22.7.11.220.478
3mb601ICasein kinase II subunit alpha2.7.11.10.476
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.476
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.475
3lltANPProtein serine/threonine kinase-1/0.473
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.472
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.472
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.471
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.470
4hgs15GCasein kinase I isoform gamma-32.7.11.10.470
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.469
4bcmT7ZCyclin-dependent kinase 22.7.11.220.469
4gub0Y4Casein kinase II subunit alpha2.7.11.10.469
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.468
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
2w05FRTCyclin-dependent kinase 22.7.11.220.468
2fvdLIACyclin-dependent kinase 22.7.11.220.467
2pvmP29Casein kinase II subunit alpha2.7.11.10.467
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.467
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.467
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.467
4aguD15Cyclin-dependent kinase-like 1/0.467
4dgo0JWCasein kinase II subunit alpha2.7.11.10.467
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
2pvlP55Casein kinase II subunit alpha2.7.11.10.466
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.466
3nga3NGCasein kinase II subunit alpha2.7.11.10.466
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.466
1rfvADPPyridoxal kinase2.7.1.350.464
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.464
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.463
5cshATPCasein kinase II subunit alpha2.7.11.10.463
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.462
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.461
3lqfNADGalactitol dehydrogenase/0.461
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4hvi19STyrosine-protein kinase JAK32.7.10.20.461
4ix6ADPUncharacterized protein/0.461
2xrwANPMitogen-activated protein kinase 82.7.11.240.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.460
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.459
2w06FRVCyclin-dependent kinase 22.7.11.220.459
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.459
3oqfS51Renin3.4.23.150.459
3q9wEMOCasein kinase II subunit alpha2.7.11.10.459
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.459
5av3KMPDeath-associated protein kinase 12.7.11.10.459
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.458
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.458
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
1jklANPDeath-associated protein kinase 12.7.11.10.457
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.457
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4ocvANPAminoglycoside phosphotransferase/0.457
2hog710Serine/threonine-protein kinase Chk12.7.11.10.456
2vv9IM9Cyclin-dependent kinase 22.7.11.220.456
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3kvxFMYMitogen-activated protein kinase 102.7.11.240.456
3oqkS52Renin3.4.23.150.456
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.456
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
3py0SU9Cyclin-dependent kinase 22.7.11.220.455
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.454
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.454
2pvhP19Casein kinase II subunit alpha2.7.11.10.454
4anmWULCasein kinase II subunit alpha2.7.11.10.454
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.454
4eol1ROCyclin-dependent kinase 22.7.11.220.454
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2c3qGTXGlutathione S-transferase theta-12.5.1.180.453
2ckeIQUDeath-associated protein kinase 2/0.453
3ix8TX3Transcriptional activator protein LasR/0.453
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.453
1jwtBLIProthrombin3.4.21.50.452
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.452
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.452
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.452
2uxuNARHTH-type transcriptional regulator TtgR/0.451
2uzbC75Cyclin-dependent kinase 22.7.11.220.451
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.451
4btjATPTau-tubulin kinase 12.7.11.10.451
4hge15VTyrosine-protein kinase JAK2/0.451
1pjkANPCasein kinase II subunit alpha2.7.11.10.450
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.450
3at3ATKCasein kinase II subunit alpha2.7.11.10.450
3qtuX44Cyclin-dependent kinase 22.7.11.220.450
3r8lZ30Cyclin-dependent kinase 22.7.11.220.450
3r9dX6BCyclin-dependent kinase 22.7.11.220.450
3ral04ZCyclin-dependent kinase 22.7.11.220.450
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.450
4ivb1J5Tyrosine-protein kinase JAK1/0.450
5auvAGIDeath-associated protein kinase 12.7.11.10.450
1aq1STUCyclin-dependent kinase 22.7.11.220.449
1e9hINRCyclin-dependent kinase 22.7.11.220.449
2vtqLZACyclin-dependent kinase 22.7.11.220.449
3juhANPCasein kinase II subunit alpha2.7.11.10.449
3nbvANPKetohexokinase/0.449
3nux3NVCyclin-dependent kinase 62.7.11.220.449
3rkb12ZCyclin-dependent kinase 22.7.11.220.449
3unj0BXCyclin-dependent kinase 22.7.11.220.449
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.449
3zep1NXTyrosine-protein kinase JAK32.7.10.20.449
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4ic7ANPMitogen-activated protein kinase 72.7.11.240.449
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.449
1zdwFLVPrenyltransferase/0.448
2cdaNAPGlucose 1-dehydrogenase/0.448
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.448
2pmoHMDProtein kinase 7/0.448
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3sheI85MAP kinase-activated protein kinase 32.7.11.10.448
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4bfsZVSPantothenate kinase2.7.1.330.448
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.448
4fx360KCyclin-dependent kinase 22.7.11.220.448
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.448
5cu6ATPCasein kinase II subunit alpha2.7.11.10.448
2cchATPCyclin-dependent kinase 22.7.11.220.447
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.447
3gu7ADPDeath-associated protein kinase 12.7.11.10.447
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.447
4aqc88ATyrosine-protein kinase JAK2/0.447
4fkw62KCyclin-dependent kinase 22.7.11.220.447
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.447
4ii5ADPCyclin-dependent kinase 22.7.11.220.447
5e8ySTUTGF-beta receptor type-22.7.11.300.447
1gqtACPRibokinase/0.446
1zgaHMKIsoflavone 4'-O-methyltransferase/0.446
2g5cNADPrephenate dehydrogenase/0.446
2r3jSCJCyclin-dependent kinase 22.7.11.220.446
2z2w770Wee1-like protein kinase2.7.10.20.446
3ggpNADPrephenate dehydrogenase/0.446
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3rvhHQ2Lysine-specific demethylase 4A1.14.110.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.446
1rfuADPPyridoxal kinase2.7.1.350.445
2q7vFADThioredoxin reductase/0.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.445
4bgh3I6Cyclin-dependent kinase 22.7.11.220.445
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.445
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.445
4kwi1TJReductase homolog/0.445
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.444
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.443
2pauD5M5'-deoxynucleotidase YfbR/0.443
3bqr4RBDeath-associated protein kinase 3/0.443
3ohf3HFBeta-secretase 13.4.23.460.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.443
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.443
5av4GENDeath-associated protein kinase 12.7.11.10.443
2czfXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.442
2x9dITCTetracycline repressor protein class D/0.442
3cic316Beta-secretase 13.4.23.460.442
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.442
3pqbVGPPutative oxidoreductase/0.442
3vmmP0DAlanine--anticapsin ligase/0.442
3vt7VDXVitamin D3 receptor/0.442
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
5kbwRBFRiboflavin transporter RibU/0.442
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.441
1qo8FADFumarate reductase flavoprotein subunit/0.441
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.441
2q5g1FAPeroxisome proliferator-activated receptor delta/0.441
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
4hgt15GCasein kinase I isoform delta2.7.11.10.441
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
5uviZMAAdenosine receptor A2a/0.441
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.440
1gheACOAcetyltransferase2.3.10.440
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
2ojg19AMitogen-activated protein kinase 12.7.11.240.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.440
4yryFADGlutamate synthase, beta subunit/0.440
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
5cvhADPCasein kinase II subunit alpha2.7.11.10.440