sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 1.000 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.598 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.581 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.578 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.577 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.574 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.564 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.560 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.555 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.552 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.550 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.542 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.539 | |
| 3eem | 53V | Uncharacterized protein | / | 0.538 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.531 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.531 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.530 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.530 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.528 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.527 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.525 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.523 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.522 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.521 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.520 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.517 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.513 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.513 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.513 | |
| 3qly | 55V | Uncharacterized protein | / | 0.511 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.511 | |
| 3cse | N22 | Uncharacterized protein | / | 0.510 | |
| 3eel | 53T | Uncharacterized protein | / | 0.510 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.506 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.500 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.500 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.500 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.499 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.495 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.495 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.494 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.493 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.489 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.488 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.487 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.487 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.486 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.485 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.484 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.484 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.482 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.479 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.478 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.478 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.477 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.474 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.474 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.473 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.471 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.471 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.471 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.471 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.469 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.469 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.469 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.468 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.468 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.467 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.467 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.467 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.466 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.466 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.465 | |
| 1fml | RTL | Retinol dehydratase | / | 0.465 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.465 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.465 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.465 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.465 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.465 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.464 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.464 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.463 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.463 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.463 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.462 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.462 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.462 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.461 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.461 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.461 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.461 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.461 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.460 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.460 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.460 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.460 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.460 | |
| 4y7c | NAP | NADPH--cytochrome P450 reductase | / | 0.460 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.459 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.459 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3lu8 | IQX | Serum albumin | / | 0.458 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.458 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.458 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.458 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.457 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.457 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.457 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.457 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.456 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.456 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 1zky | 689 | Estrogen receptor | / | 0.455 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.455 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.455 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.455 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.454 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.454 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.454 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.454 | |
| 3tdl | 11D | Serum albumin | / | 0.454 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.453 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.453 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.453 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.453 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.453 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.453 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.453 | |
| 4pd6 | URI | Nucleoside permease | / | 0.453 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.453 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.452 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.452 | |
| 1xpc | AIT | Estrogen receptor | / | 0.452 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.452 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.452 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.452 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4l9k | EHF | Serum albumin | / | 0.452 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.452 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.451 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.451 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.451 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 2fai | 459 | Estrogen receptor | / | 0.450 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.450 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.450 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.450 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.450 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.449 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.449 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 2k62 | ITL | Fatty acid-binding protein, liver | / | 0.449 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.449 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.449 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.449 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.449 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.448 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2vwp | NDP | Glucose 1-dehydrogenase | / | 0.448 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.448 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.448 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.448 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.447 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1qip | GNB | Lactoylglutathione lyase | 4.4.1.5 | 0.447 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.447 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.447 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.447 | |
| 4l8u | 9AZ | Serum albumin | / | 0.447 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.446 | |
| 1qin | GIP | Lactoylglutathione lyase | 4.4.1.5 | 0.446 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.446 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.446 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.446 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.446 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.446 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.446 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.445 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.445 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.445 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 4au7 | SAH | Histone-lysine N-methyltransferase KMT5C | 2.1.1.43 | 0.445 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.445 | |
| 4ug7 | 1EV | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1oky | STU | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.444 | |
| 2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.444 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.444 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.444 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4iah | 1DX | Alr2278 protein | / | 0.444 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.444 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.443 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.443 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.443 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.443 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3eek | 53S | Uncharacterized protein | / | 0.443 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.443 | |
| 3n5x | XFK | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.443 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.443 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.442 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.442 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.442 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.442 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2pog | WST | Estrogen receptor | / | 0.442 | |
| 2y3r | TRK | TamL | / | 0.442 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.442 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4jsf | QJ4 | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.442 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4xwt | U5P | Ribonuclease J | / | 0.442 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.441 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.441 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.441 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.441 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.440 | |
| 1l2i | ETC | Estrogen receptor | / | 0.440 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.440 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2g5o | DRQ | Estrogen receptor | / | 0.440 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.440 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.440 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.440 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.440 | |
| 3ufw | HW0 | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4yal | 2AM | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.440 |