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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdwFIDAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdwFIDAldose reductase1.1.1.211.000
1pwmFIDAldose reductase1.1.1.210.780
2pdyFIDAldose reductase1.1.1.210.740
2fz8ZSTAldose reductase1.1.1.210.695
2pd9FIDAldose reductase1.1.1.210.682
3s3gTLTAldose reductase1.1.1.210.663
2agtFIDAldose reductase1.1.1.210.659
2f2kTGGAldose reductase1.1.1.210.658
2is72CLAldose reductase1.1.1.210.654
2inzOHPAldose reductase1.1.1.210.643
3v35NTIAldose reductase1.1.1.210.632
1ef3FIDAldose reductase1.1.1.210.628
2iki388Aldose reductase1.1.1.210.623
3p2vDOYAldose reductase1.1.1.210.623
3u2cSUZAldose reductase1.1.1.210.620
2nvcITAAldose reductase1.1.1.210.616
4gabFIDAldo-keto reductase family 1 member B101.1.10.593
1z8962PAldose reductase1.1.1.210.586
2iqdLPAAldose reductase1.1.1.210.584
2ikj393Aldose reductase1.1.1.210.580
2pdj393Aldose reductase1.1.1.210.574
1ekoI84Aldose reductase1.1.1.210.571
3ghrLDTAldose reductase1.1.1.210.569
1ah0SBIAldose reductase1.1.1.210.568
3ghsLDTAldose reductase1.1.1.210.568
2hv5ZSTAldose reductase1.1.1.210.567
1t40ID5Aldose reductase1.1.1.210.564
1zuaTOLAldo-keto reductase family 1 member B101.1.10.562
3m64393Aldose reductase1.1.1.210.562
1el3I84Aldose reductase1.1.1.210.561
5liu388Aldo-keto reductase family 1 member B101.1.10.559
2pdh47DAldose reductase1.1.1.210.557
2dv0ZSTAldose reductase1.1.1.210.556
2i16LDTAldose reductase1.1.1.210.554
2pdfZSTAldose reductase1.1.1.210.553
2fzdTOLAldose reductase1.1.1.210.548
3lqlLDTAldose reductase1.1.1.210.542
4ga8SBIAldo-keto reductase family 1 member B101.1.10.542
3ghtLDTAldose reductase1.1.1.210.541
2pdkSBIAldose reductase1.1.1.210.538
3g5eQ74Aldose reductase1.1.1.210.537
2hvoZSTAldose reductase1.1.1.210.533
3ghuLDTAldose reductase1.1.1.210.528
2pdu393Aldose reductase1.1.1.210.524
1t41ID5Aldose reductase1.1.1.210.519
2pdp393Aldose reductase1.1.1.210.518
4wevSUZAldo-keto reductase family 1 member B101.1.10.517
2duzZSTAldose reductase1.1.1.210.514
3mb9ZSTAldose reductase1.1.1.210.513
1z3n3NAAldose reductase1.1.1.210.512
1us0LDTAldose reductase1.1.1.210.511
2fz9ZSTAldose reductase1.1.1.210.511
2fzbTOLAldose reductase1.1.1.210.511
3m4h388Aldose reductase1.1.1.210.511
2pdxZSTAldose reductase1.1.1.210.509
4gca2X9Aldose reductase1.1.1.210.508
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.505
3lboLDTAldose reductase1.1.1.210.505
1pwlBFIAldose reductase1.1.1.210.499
3lenZSTAldose reductase1.1.1.210.498
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.498
4dbw511Aldo-keto reductase family 1 member C3/0.497
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.20.495
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.495
2pdn47DAldose reductase1.1.1.210.493
1ieiZESAldose reductase1.1.1.210.492
2pzn393Aldose reductase1.1.1.210.492
4fam0SZAldo-keto reductase family 1 member C3/0.492
2pdc393Aldose reductase1.1.1.210.490
2ikhLITAldose reductase1.1.1.210.489
2vrjNCWBeta-glucosidase A3.2.1.210.489
4bfwZVWPantothenate kinase2.7.1.330.489
1ah3TOLAldose reductase1.1.1.210.488
1rxjBNIStreptavidin/0.488
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.486
2duxZSTAldose reductase1.1.1.210.484
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.483
2xlpNAPPutative flavin-containing monooxygenase/0.482
3ld5LDTAldose reductase1.1.1.210.482
2pdlTOLAldose reductase1.1.1.210.481
2hzqSTRApolipoprotein D/0.480
2pdq47DAldose reductase1.1.1.210.480
1ry0PG2Aldo-keto reductase family 1 member C3/0.479
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.479
2f3815MAldo-keto reductase family 1 member C3/0.478
3dr7GPDGDP-perosamine synthase/0.478
3r8hZOMAldo-keto reductase family 1 member C3/0.477
1p0pBCHCholinesterase3.1.1.80.476
2qxwLDTAldose reductase1.1.1.210.476
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.475
4dyp0MSNucleoprotein/0.474
3af1GDPPantothenate kinase2.7.1.330.473
3nn6HNK6-hydroxy-L-nicotine oxidase/0.473
1xidASCXylose isomerase5.3.1.50.472
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.472
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.472
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.471
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.471
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.470
2ipw2CLAldose reductase1.1.1.210.469
3t423T4Aldose reductase1.1.1.210.469
2bjsACVIsopenicillin N synthase1.21.3.10.468
3lz5LDTAldose reductase1.1.1.210.468
3gyf51PDihydrofolate reductase1.5.1.30.467
3n0hTOPDihydrofolate reductase1.5.1.30.467
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.467
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.467
4kn104JFolate receptor beta/0.467
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.466
2w3mFOLDihydrofolate reductase1.5.1.30.466
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.466
1hfrMOTDihydrofolate reductase1.5.1.30.465
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1zq5E04Aldo-keto reductase family 1 member C3/0.465
2i17LDTAldose reductase1.1.1.210.465
2j3qTFLAcetylcholinesterase3.1.1.70.465
3m0iZSTAldose reductase1.1.1.210.465
3ugrIMNAldo-keto reductase family 1 member C3/0.465
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.465
1kmsLIHDihydrofolate reductase1.5.1.30.464
1mvtDTMDihydrofolate reductase1.5.1.30.464
1ry8RUTAldo-keto reductase family 1 member C3/0.464
2po3T4K4-dehydrase/0.464
3ai0PNWBeta-glucosidase/0.464
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
4kebFOLDihydrofolate reductase1.5.1.30.463
1ihiIU5Aldo-keto reductase family 1 member C2/0.462
2d06ESTSulfotransferase 1A12.8.2.10.462
2xupTZ5Acetylcholinesterase3.1.1.70.462
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.462
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.462
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.462
4fal0T0Aldo-keto reductase family 1 member C3/0.462
2zevIPEGeranylgeranyl pyrophosphate synthase/0.461
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.461
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.461
4m6kFOLDihydrofolate reductase1.5.1.30.461
2dhfDZFDihydrofolate reductase1.5.1.30.460
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.460
4j7gTRHPCZA361.3/0.460
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.459
4j7hTRHPCZA361.3/0.459
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.458
1ut6A8NAcetylcholinesterase3.1.1.70.458
1zgcA2EAcetylcholinesterase3.1.1.70.458
2vq7NAPPutative flavin-containing monooxygenase/0.458
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.458
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.458
4jtrIZPAldo-keto reductase family 1 member C2/0.458
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.458
2jgsBTNAvidin/0.457
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.457
1u70MTXDihydrofolate reductase1.5.1.30.456
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
4b7zQ4QAcetylcholinesterase3.1.1.70.456
4lcw1VYMajor histocompatibility complex class I-related gene protein/0.456
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4n3l2FNProthrombin3.4.21.50.456
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.456
4phlPILPhosphodiesterase/0.456
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.456
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.455
2vqqTFGHistone deacetylase 43.5.1.980.455
2xltNA0Putative flavin-containing monooxygenase/0.455
4b65NDPL-ornithine N(5)-monooxygenase/0.455
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.455
2pd5ZSTAldose reductase1.1.1.210.454
3f3y4OABile salt sulfotransferase2.8.2.140.454
3gwfFADCyclohexanone monooxygenase/0.454
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.454
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.454
4jq3ZOMAldo-keto reductase family 1 member C2/0.454
4yfy0FXVioF/0.454
1drfFOLDihydrofolate reductase1.5.1.30.453
1u65CP0Acetylcholinesterase3.1.1.70.453
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
1dpmEBPParathion hydrolase3.1.8.10.452
1rpwDIDHTH-type transcriptional regulator QacR/0.452
1xf0ASDAldo-keto reductase family 1 member C3/0.452
2xvhNAPPutative flavin-containing monooxygenase/0.452
3hdyGDUUDP-galactopyranose mutase/0.452
3ug8IMNAldo-keto reductase family 1 member C3/0.452
3v94WYQPhosphodiesterase/0.452
4dyb0MHNucleoprotein/0.452
5dsg0HKMuscarinic acetylcholine receptor M4/0.452
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.451
1pj6FOLDimethylglycine oxidase1.5.3.100.451
2fzjDH3Dihydrofolate reductase1.5.1.30.451
2vt4P32Beta-1 adrenergic receptor/0.451
3nu03TUDihydrofolate reductase1.5.1.30.451
4dbs0HVAldo-keto reductase family 1 member C3/0.451
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
1gpnHUBAcetylcholinesterase3.1.1.70.450
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.450
2ha6SCKAcetylcholinesterase3.1.1.70.450
2qw8NAPEugenol synthase 11.1.1.3180.450
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.450
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3l3rOAGDihydrofolate reductase1.5.1.30.450
4ey7E20Acetylcholinesterase3.1.1.70.450
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.450
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.450
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.450
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.449
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2xejOKDGlutamate carboxypeptidase 23.4.17.210.449
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.449
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.449
3ocw3AMLipoprotein E/0.449
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4dya0MFNucleoprotein/0.449
4gd9BTNStreptavidin/0.449
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4kfjFOLDihydrofolate reductase1.5.1.30.449
5cxv0HKMuscarinic acetylcholine receptor M1/0.449
1blzACVIsopenicillin N synthase1.21.3.10.448
1obnASVIsopenicillin N synthase1.21.3.10.448
1ohjCOPDihydrofolate reductase1.5.1.30.448
2aj4ANPGalactokinase2.7.1.60.448
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.448
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
4a16H34Acetylcholinesterase3.1.1.70.448
5epvACPBlue-light-activated histidine kinase2.7.13.30.448
4mqt2CUMuscarinic acetylcholine receptor M2/0.448
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.447
1sreHABStreptavidin/0.447
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
2ipjFFAAldo-keto reductase family 1 member C2/0.447
2xufTZ4Acetylcholinesterase3.1.1.70.447
3af0GDPPantothenate kinase2.7.1.330.447
4e2yJHZMethyltransferase/0.447
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
4yu153NAldose reductase1.1.1.210.447
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.447
1dx6GNTAcetylcholinesterase3.1.1.70.446
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3aosJH2Hemolymph juvenile hormone binding protein/0.446
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.446
3htjETEbrA repressor/0.446
3rmeRMEAcidic mammalian chitinase3.2.1.140.446
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4jpg1OXPyruvate kinase PKM2.7.1.400.446
4jqaID8Aldo-keto reductase family 1 member C2/0.446
1hb1OCVIsopenicillin N synthase1.21.3.10.445
1oytFSNProthrombin3.4.21.50.445
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.445
2gl0ADNUncharacterized protein/0.445
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3sfy3FYUncharacterized protein/0.445
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.445
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.445
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.445
1d3dBZTProthrombin3.4.21.50.444
1pqc444Oxysterols receptor LXR-beta/0.444
1q84TZ4Acetylcholinesterase3.1.1.70.444
1ygjRMCPyridoxal kinase2.7.1.350.444
2jl1NAPTriphenylmethane reductase/0.444
2pdmZSTAldose reductase1.1.1.210.444
2xuhTZ4Acetylcholinesterase3.1.1.70.444
2xuiTZ5Acetylcholinesterase3.1.1.70.444
3qeoLLTDeoxycytidine kinase2.7.1.740.444
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4bfuZVUPantothenate kinase2.7.1.330.444
4da50H7Choline kinase alpha2.7.1.320.444
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.444
1lkeDOGBilin-binding protein/0.443
1lnmDTXBilin-binding protein/0.443
1pq944BOxysterols receptor LXR-beta/0.443
1s3uTQDDihydrofolate reductase1.5.1.30.443
3q9bB3NAcetylpolyamine amidohydrolase/0.443
4a33PS8Glycylpeptide N-tetradecanoyltransferase/0.443
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.443
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1dghNDPCatalase1.11.1.60.442
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.442
1ohkCOPDihydrofolate reductase1.5.1.30.442
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.442
2v7tSAH5'-fluoro-5'-deoxy-adenosine synthase/0.442
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
1d3pBT3Prothrombin3.4.21.50.441
1qvtPRLHTH-type transcriptional regulator QacR/0.441
1uhjCZBAequorin-2/0.441
2a5c8DAAvidin/0.441
2aot2PMHistamine N-methyltransferase2.1.1.80.441
2cbqTH2Neocarzinostatin/0.441
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.441
2iuzD1HEndochitinase B13.2.1.140.441
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.441
2yyeAPCSelenide, water dikinase2.7.9.30.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.441
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.441
3q7fED2Uncharacterized protein/0.441
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.441
4dbuBT9Aldo-keto reductase family 1 member C3/0.441
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.441
4jtqFLPAldo-keto reductase family 1 member C2/0.441
4usrFADMonooxygenase/0.441
1s1rNAPAldo-keto reductase family 1 member C3/0.440
2aovC2MHistamine N-methyltransferase2.1.1.80.440
2pdiZSTAldose reductase1.1.1.210.440
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.440
2xi4AFTAcetylcholinesterase3.1.1.70.440
2xuqTZ4Acetylcholinesterase3.1.1.70.440
3c1oNAPEugenol synthase/0.440
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.440
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3qwhKMP17beta-hydroxysteroid dehydrogenase/0.440
5a4vQUEGlutathione S-transferase F22.5.1.180.440