sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1skg | VAL_ALA_PHE_ARG_SER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1skg | VAL_ALA_PHE_ARG_SER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 1.000 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.579 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.548 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.539 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.522 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.510 | |
| 4hmb | PZZ | Phospholipase A2 VRV-PL-VIIIa | / | 0.508 | |
| 4eix | NIM | Phospholipase A2 VRV-PL-VIIIa | / | 0.507 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.490 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.489 | |
| 2oth | NIM | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.483 | |
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.480 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.476 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.475 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.472 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.471 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.471 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.470 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.469 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 2qvd | BER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.469 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.469 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.469 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.469 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.468 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.467 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.467 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.467 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.467 | |
| 4qf7 | C0R | Phospholipase A2 VRV-PL-VIIIa | / | 0.467 | |
| 4qgd | PZZ | Phospholipase A2 VRV-PL-VIIIa | / | 0.467 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.466 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.466 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.465 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.465 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.464 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.463 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.462 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.462 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.462 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.461 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.461 | |
| 3zs5 | SB2 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.461 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.461 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.461 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.460 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.460 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.460 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.460 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.460 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.459 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.458 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.458 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 2qhw | PZZ | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.457 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.457 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.457 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.456 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.456 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.456 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.455 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.455 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.455 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.455 | |
| 4dfl | 0K0 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.455 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.455 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.454 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.454 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.453 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.453 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.453 | |
| 4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.453 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.453 | |
| 1osv | CHC | Bile acid receptor | / | 0.452 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.452 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.452 | |
| 4l8u | 9AZ | Serum albumin | / | 0.452 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.452 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.451 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.451 | |
| 3p9t | TCL | Repressor | / | 0.451 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.450 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.450 | |
| 4ac0 | MIY | Tetracycline repressor protein class B from transposon Tn10 | / | 0.450 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.450 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.450 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.450 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.449 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.449 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.449 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.449 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.449 | |
| 1err | RAL | Estrogen receptor | / | 0.448 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.448 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.448 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.448 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.448 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.448 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.448 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.448 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.448 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.448 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.448 | |
| 5bn3 | ADP | NEQ263 | / | 0.448 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.447 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.447 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 2xy9 | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.447 | |
| 3jsk | AHZ | Thiamine thiazole synthase | / | 0.447 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.447 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.446 | |
| 1qvn | FRI | Interleukin-2 | / | 0.446 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.446 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.446 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.446 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.446 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.445 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 2rkf | AB1 | Pol protein | / | 0.445 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.445 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.445 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.445 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.445 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.444 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 2v19 | FMN | Dodecin | / | 0.444 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3bkb | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.444 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.444 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.444 | |
| 3okx | SAM | S-adenosyl-L-methionine-binding protein RPA0152 | / | 0.444 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 3unk | 0BY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4fst | HK4 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.444 | |
| 4phl | PIL | Phosphodiesterase | / | 0.444 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.444 | |
| 4xvr | GNP | GTPase HRas | / | 0.444 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.444 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.443 | |
| 1l0l | FMX | Cytochrome b | / | 0.443 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.443 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.443 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.443 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.443 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.443 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.443 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.443 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.443 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.443 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.443 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.443 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.443 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.442 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.442 | |
| 2d4e | NAD | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] | / | 0.442 | |
| 2qdx | FAD | Ferredoxin--NADP+ reductase | / | 0.442 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.442 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.442 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.442 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.442 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.442 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.442 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.441 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.441 | |
| 1q4u | 4CA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.441 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.441 | |
| 3lv1 | NAP | NAD(P)-dependent benzaldehyde dehydrogenase | 1.2.1.28 | 0.441 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.441 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.441 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.441 | |
| 4e4n | 0NL | Tyrosine-protein kinase JAK1 | / | 0.441 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.441 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 2pz5 | ACP | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 2qhy | MZ1 | Gag-Pol polyprotein | / | 0.440 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.440 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 4b6l | 9ZP | Serine/threonine-protein kinase PLK3 | 2.7.11.21 | 0.440 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4guu | FA9 | Lysine-specific histone demethylase 1B | 1 | 0.440 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.440 | |
| 4lts | LTS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 |