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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s3wTQTDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s3wTQTDihydrofolate reductase1.5.1.31.000
4ddrMMVDihydrofolate reductase1.5.1.30.728
1bozPRDDihydrofolate reductase1.5.1.30.703
4g95OAGDihydrofolate reductase1.5.1.30.666
4kak06UDihydrofolate reductase1.5.1.30.659
3nxrD2DDihydrofolate reductase1.5.1.30.645
3nxoD2BDihydrofolate reductase1.5.1.30.642
3nxtD2EDihydrofolate reductase1.5.1.30.636
4kd79DRDihydrofolate reductase1.5.1.30.635
2w3aTOPDihydrofolate reductase1.5.1.30.633
3k47D09Dihydrofolate reductase1.5.1.30.633
3oafOAGDihydrofolate reductase1.5.1.30.625
3nxyD2HDihydrofolate reductase1.5.1.30.618
4qjcIXEDihydrofolate reductase1.5.1.30.613
4kfj1R0Dihydrofolate reductase1.5.1.30.609
3nxvD2FDihydrofolate reductase1.5.1.30.607
4kbn25UDihydrofolate reductase1.5.1.30.607
1dlrMXADihydrofolate reductase1.5.1.30.588
1u72MTXDihydrofolate reductase1.5.1.30.587
1pd8CO4Dihydrofolate reductase1.5.1.30.586
1hfpMOTDihydrofolate reductase1.5.1.30.583
1dr4HBIDihydrofolate reductase1.5.1.30.567
3cseN22Uncharacterized protein/0.563
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.551
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.550
1cd2FOLDihydrofolate reductase1.5.1.30.546
4h9814QUncharacterized protein/0.542
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.537
1hfqMOTDihydrofolate reductase1.5.1.30.532
3eigMTXDihydrofolate reductase1.5.1.30.527
3eek53SUncharacterized protein/0.526
1mvsDTMDihydrofolate reductase1.5.1.30.525
1vj3TABDihydrofolate reductase1.5.1.30.522
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.521
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.514
1hfrMOTDihydrofolate reductase1.5.1.30.513
1klkPMDDihydrofolate reductase1.5.1.30.513
1pd9CO4Dihydrofolate reductase1.5.1.30.513
1ohjCOPDihydrofolate reductase1.5.1.30.512
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.511
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.510
3qlxQLRUncharacterized protein/0.508
3l3rOAGDihydrofolate reductase1.5.1.30.507
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.507
3ntz3TZDihydrofolate reductase1.5.1.30.506
3qly55VUncharacterized protein/0.505
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.505
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.503
3eel53TUncharacterized protein/0.502
4m6l21VDihydrofolate reductase1.5.1.30.502
4h9753SDihydrofolate reductase1.5.1.30.500
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.498
1s3vTQDDihydrofolate reductase1.5.1.30.496
4h9506UDihydrofolate reductase1.5.1.30.495
1u71MXADihydrofolate reductase1.5.1.30.494
3eej53RUncharacterized protein/0.492
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.492
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.492
1yc2NADNAD-dependent protein deacylase 2/0.491
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.490
2cd2FOLDihydrofolate reductase1.5.1.30.490
4qa2SHHHistone deacetylase 83.5.1.980.490
1dr3HBIDihydrofolate reductase1.5.1.30.489
4ixeIXEDihydrofolate reductase1.5.1.30.489
3eem53VUncharacterized protein/0.488
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.488
1dg7WRBDihydrofolate reductase1.5.1.30.487
1kmsLIHDihydrofolate reductase1.5.1.30.485
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.484
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.481
4h9614QDihydrofolate reductase1.5.1.30.481
3q2mCKISpectinomycin phosphotransferase/0.480
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.479
1s3yTQTDihydrofolate reductase1.5.1.30.479
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.479
1s3uTQDDihydrofolate reductase1.5.1.30.478
2fzjDH3Dihydrofolate reductase1.5.1.30.478
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.478
2in6839Wee1-like protein kinase2.7.10.20.477
4g8zTOPDihydrofolate reductase1.5.1.30.477
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.476
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.476
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.475
4ej1FOLDihydrofolate reductase1.5.1.30.475
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.475
4kebFOLDihydrofolate reductase1.5.1.30.475
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.474
1m78CLZDihydrofolate reductase1.5.1.30.473
1synF89Thymidylate synthase/0.473
2jn3JN3Fatty acid-binding protein, liver/0.473
3up3XCAaceDAF-12/0.473
4iarERM5-hydroxytryptamine receptor 1B/0.473
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.473
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.472
4qa0SHHHistone deacetylase 83.5.1.980.472
3d80Q22Dihydrofolate reductase1.5.1.30.471
3ghwGHWDihydrofolate reductase1.5.1.30.471
4bwaN0BPyrrolysine--tRNA ligase/0.471
4e0u0MVCyclic dipeptide N-prenyltransferase/0.471
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.471
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.470
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
2z2w770Wee1-like protein kinase2.7.10.20.470
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
3tqbFOLDihydrofolate reductase/0.470
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.470
3njoPYVAbscisic acid receptor PYR1/0.469
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4qa1B3NHistone deacetylase 83.5.1.980.469
2w3vTOPDihydrofolate reductase/0.468
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.468
3tdaPN0Cytochrome P450 2D6/0.468
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.468
3emlZMAAdenosine receptor A2a/0.468
3uzaT4GAdenosine receptor A2a/0.468
3gieACPSensor histidine kinase DesK2.7.13.30.467
3lfcZ86Mitogen-activated protein kinase 14/0.467
5cc9DDFDihydrofolate reductase1.5.1.30.467
5cccDDFDihydrofolate reductase1.5.1.30.467
1aoeGW3Dihydrofolate reductase1.5.1.30.466
1ly3COGDihydrofolate reductase1.5.1.30.466
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.466
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.466
2zb8IMNProstaglandin reductase 21.3.1.480.466
3qls55VDihydrofolate reductase1.5.1.30.466
4j6cSTRCytochrome P450 monooxygenase/0.466
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
1e26GPBDihydrofolate reductase1.5.1.30.464
1pkfEPDEpothilone C/D epoxidase1.140.464
1yhoTRRDihydrofolate reductase1.5.1.30.464
3td8D2RDihydrofolate reductase1.5.1.30.464
1ia1TQ3Dihydrofolate reductase1.5.1.30.462
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
2w3mFOLDihydrofolate reductase1.5.1.30.462
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.462
4ixfIXFDihydrofolate reductase1.5.1.30.462
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.462
4m4821BSodium-dependent dopamine transporter/0.462
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.462
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.461
3qlzQLZUncharacterized protein/0.461
3vg9ZMAAdenosine receptor A2a/0.461
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4kfjFOLDihydrofolate reductase1.5.1.30.461
5d1bTSNHistone deacetylase 83.5.1.980.461
1dg5TOPDihydrofolate reductase1.5.1.30.460
1diuBDMDihydrofolate reductase1.5.1.30.460
1q5dEPBEpothilone C/D epoxidase1.140.460
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.460
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.460
3p9tTCLRepressor/0.460
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.460
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
1ej3CZHAequorin-2/0.459
1ly4COQDihydrofolate reductase1.5.1.30.459
1qxlFR8Adenosine deaminase3.5.4.40.459
2w3wVG9Dihydrofolate reductase/0.459
3c3dFO12-phospho-L-lactate transferase/0.459
2cleF6FTryptophan synthase alpha chain/0.458
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.458
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.458
3sa27DRDihydrofolate reductase/0.458
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.458
4cd2FOLDihydrofolate reductase1.5.1.30.458
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.458
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
2z7gEH9Adenosine deaminase3.5.4.40.457
3i8aN22Dihydrofolate reductase1.5.1.30.457
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3u8hBHPPhospholipase A2, membrane associated/0.457
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2x9vTMQPteridine reductase/0.456
3ezpB3NHistone deacetylase 83.5.1.980.456
3gyf51PDihydrofolate reductase1.5.1.30.456
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.456
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.456
4g1nNZTPyruvate kinase PKM2.7.1.400.456
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
1dyrTOPDihydrofolate reductase1.5.1.30.455
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.455
2d06ESTSulfotransferase 1A12.8.2.10.455
2io6330Wee1-like protein kinase2.7.10.20.455
3a1l2CCCytochrome P450/0.455
3c1xCKKHepatocyte growth factor receptor2.7.10.10.455
3k4551PDihydrofolate reductase1.5.1.30.455
3ns2PYVAbscisic acid receptor PYL2/0.455
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3v94WYQPhosphodiesterase/0.455
4equG6ISerine/threonine-protein kinase 102.7.11.10.455
1umlFR4Adenosine deaminase3.5.4.40.454
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.454
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3hv3R49Mitogen-activated protein kinase 14/0.454
3l8sBFFMitogen-activated protein kinase 14/0.454
4at0FADPossible succinate dehydrogenase/0.454
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4x5fFOLDihydrofolate reductase1.5.1.30.454
1iyzNDPProbable quinone oxidoreductase/0.453
1zg32HIIsoflavone 4'-O-methyltransferase/0.453
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.453
3vtcTK3Vitamin D3 receptor/0.453
4i1nFOLDihydrofolate reductase1.5.1.30.453
4ixgIXGDihydrofolate reductase1.5.1.30.453
1jomFFODihydrofolate reductase1.5.1.30.452
1kmvLIIDihydrofolate reductase1.5.1.30.452
3d4bDZDNAD-dependent protein deacetylase/0.452
3gcq1BUMitogen-activated protein kinase 14/0.452
3p3zP3ZPutative cytochrome P450/0.452
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.10.451
1lhuESTSex hormone-binding globulin/0.451
1w22NHBHistone deacetylase 83.5.1.980.451
2fziDH3Dihydrofolate reductase1.5.1.30.451
2lbdREARetinoic acid receptor gamma/0.451
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
4dm6TTBRetinoic acid receptor beta/0.451
4i8vBHFCytochrome P450 1A11.14.14.10.451
4iaq2GM5-hydroxytryptamine receptor 1B/0.451
4j6bPLOCytochrome P450 monooxygenase/0.451
1rx3MTXDihydrofolate reductase1.5.1.30.450
1z6tADPApoptotic protease-activating factor 1/0.450
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2bakAQZMitogen-activated protein kinase 14/0.450
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.450
2dhfDZFDihydrofolate reductase1.5.1.30.450
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.450
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.450
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.450
3is9AC7Gag-Pol polyprotein2.7.7.490.450
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.450
3t8xT8XT-cell surface glycoprotein CD1b/0.450
4a9yAQZMitogen-activated protein kinase 14/0.450
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.450
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.450
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.449
1ndzFR5Adenosine deaminase3.5.4.40.449
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.449
4gr9372Ribosyldihydronicotinamide dehydrogenase [quinone]/0.449
4v12POGMaoC like domain protein/0.449
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.448
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.448
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.448
3cqeP91Wee1-like protein kinase2.7.10.20.448
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3srrQ20Dihydrofolate reductase1.5.1.30.448
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.448
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1x8b824Wee1-like protein kinase2.7.10.20.447
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.447
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.447
3n0hTOPDihydrofolate reductase1.5.1.30.447
3nj0PYVAbscisic acid receptor PYL2/0.447
3sgy06WDihydrofolate reductase1.5.1.30.447
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.447
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4j6dTESCytochrome P450 monooxygenase/0.447
3rfmCFFAdenosine receptor A2a/0.447
1o5rFR9Adenosine deaminase3.5.4.40.446
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.446
3c16FOKAdenylate cyclase type 2/0.446
3c16FOKAdenylate cyclase type 5/0.446
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3h3t16HCollagen type IV alpha-3-binding protein/0.446
3nu03TUDihydrofolate reductase1.5.1.30.446
3qm4PN0Cytochrome P450 2D6/0.446
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4ea2RWZDehydrosqualene synthase/0.446
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
5dc5B3NHistone deacetylase 83.5.1.980.446
3uzcT4EAdenosine receptor A2a/0.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1vruAAPGag-Pol polyprotein2.7.7.490.445
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.445
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.445
3arpDEQChitinase A/0.445
3biz61EWee1-like protein kinase2.7.10.20.445
3h3r14HCollagen type IV alpha-3-binding protein/0.445
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
3ix9MTXDihydrofolate reductase1.5.1.30.445
3r336MEDihydrofolate reductase1.5.1.30.445
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.445
4jlj1NMDeoxycytidine kinase2.7.1.740.445
5iubCLRAdenosine receptor A2a/0.445
1rkhVD2Vitamin D3 receptor/0.444
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.444
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.444
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3qlrQLRDihydrofolate reductase1.5.1.30.444
3tq9MTXDihydrofolate reductase/0.444
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
5dozNDPJamJ/0.444
7dfrFOLDihydrofolate reductase1.5.1.30.444
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.443
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.443
3vt7VDXVitamin D3 receptor/0.443
4jbtASDCytochrome P450 monooxygenase/0.443
1fd0254Retinoic acid receptor gamma/0.442
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
3sruQ26Dihydrofolate reductase1.5.1.30.442
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4rbs0RVMetallo-beta-lactamase type 2/0.442
1df7MTXDihydrofolate reductase1.5.1.30.441
1y6oMJIPhospholipase A2, major isoenzyme3.1.1.40.441
3akn11DFatty acid-binding protein, intestinal/0.441
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3hx3RETRetinaldehyde-binding protein 1/0.441
3iw8HIZMitogen-activated protein kinase 14/0.441
3pe2E1BCasein kinase II subunit alpha2.7.11.10.441
3s41S41Glucokinase2.7.1.20.441
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.441
4xe606UDihydrofolate reductase1.5.1.30.441
5iu4ZMAAdenosine receptor A2a/0.441
5uviZMAAdenosine receptor A2a/0.441
1ao8MTXDihydrofolate reductase1.5.1.30.440
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1ia2TQ4Dihydrofolate reductase1.5.1.30.440
1ohkCOPDihydrofolate reductase1.5.1.30.440
1rt5UC2Gag-Pol polyprotein2.7.7.490.440
1tl1H18Gag-Pol polyprotein2.7.7.490.440
1wxyFRKAdenosine deaminase3.5.4.40.440
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2fs4PZ1Renin3.4.23.150.440
2xtbKRMAdenosine kinase, putative/0.440
3c3eFO12-phospho-L-lactate transferase/0.440
3hziATPSerine/threonine-protein kinase toxin HipA/0.440
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3nfrEWQRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.440
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.440
4bftZVTPantothenate kinase2.7.1.330.440
4eiyZMAAdenosine receptor A2a/0.440
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4m2xTMQDihydrofolate reductase1.5.1.30.440
4p68MTXDihydrofolate reductase/0.440
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.440