sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1av5 | AP2 | Histidine triad nucleotide-binding protein 1 | 3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1av5 | AP2 | Histidine triad nucleotide-binding protein 1 | 3 | 1.000 | |
| 1rzy | 5AS | Histidine triad nucleotide-binding protein 1 | 3 | 0.614 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.568 | |
| 5i2f | BS5 | Histidine triad nucleotide-binding protein 1 | 3 | 0.567 | |
| 3oxk | 5GP | Histidine triad nucleotide-binding protein | 3 | 0.557 | |
| 3qgz | ADN | Histidine triad nucleotide-binding protein 1 | 3 | 0.552 | |
| 4eqe | KAA | Histidine triad nucleotide-binding protein 1 | 3 | 0.538 | |
| 5fit | AP2 | Bis(5'-adenosyl)-triphosphatase | 3.6.1.29 | 0.516 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.505 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.496 | |
| 3n1s | 5GP | Purine nucleoside phosphoramidase | / | 0.496 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.494 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.494 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.492 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.489 | |
| 3n1t | 5GP | Purine nucleoside phosphoramidase | / | 0.489 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.488 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.486 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.485 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.484 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.483 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.483 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.482 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.481 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.479 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.478 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 4egu | 5GP | Putative histidine triad (HIT) protein | / | 0.477 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.477 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.476 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.475 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.473 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.473 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.472 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.472 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.472 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.471 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.470 | |
| 2gd0 | MRS | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.469 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.469 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.468 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4h5c | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.468 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.467 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.467 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.467 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.466 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.466 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.466 | |
| 1fml | RTL | Retinol dehydratase | / | 0.465 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.465 | |
| 3vf2 | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.465 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.465 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.465 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.464 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.464 | |
| 3ou7 | SAM | SAM-dependent methyltransferase | / | 0.464 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.463 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.463 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.462 | |
| 4phl | PIL | Phosphodiesterase | / | 0.462 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.461 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3gki | CLR | Niemann-Pick C1 protein | / | 0.461 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.461 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.461 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.461 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4h5e | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.461 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1khr | COA | Streptogramin A acetyltransferase | 2.3.1 | 0.460 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.460 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.460 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.460 | |
| 2ycy | P32 | Beta-1 adrenergic receptor | / | 0.460 | |
| 1nbh | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.459 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.459 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.458 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.458 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.458 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.457 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.457 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.457 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1ppj | ANY | Cytochrome b | / | 0.456 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.456 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3zm5 | IGM | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.456 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.455 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.455 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.455 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.455 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.455 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.454 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.454 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.453 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.453 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.453 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.453 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.452 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.452 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.452 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.452 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.452 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.451 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 4ydq | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.451 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.450 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.450 | |
| 3vew | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.450 | |
| 4dem | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.450 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.449 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.449 | |
| 2yim | MC4 | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.449 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.449 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.449 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.449 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.449 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 2gci | MRR | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.448 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.448 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
| 3upy | FOM | Oxidoreductase, putative | / | 0.448 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.448 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 1i9c | 5AD | Glutamate mutase epsilon subunit | / | 0.447 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.447 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.447 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.447 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3tgy | ASC | Lactoperoxidase | 1.11.1.7 | 0.447 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.447 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 5c41 | ACP | Ribokinase | / | 0.447 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.446 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.446 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.446 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.446 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.446 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 4lb2 | DM5 | Serum albumin | / | 0.446 | |
| 4onq | SFG | DNA methyltransferase | / | 0.446 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.445 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.445 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.445 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.445 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.445 | |
| 3up0 | D7S | aceDAF-12 | / | 0.445 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.445 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.445 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.445 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4ekl | 0RF | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.445 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.445 | |
| 5a2y | UTP | Mitochondrial poly(A) polymerase | / | 0.445 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.445 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.445 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.445 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.444 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.444 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.444 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.444 | |
| 3up3 | XCA | aceDAF-12 | / | 0.444 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.444 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.444 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.444 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.444 | |
| 1kf6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.443 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.443 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.443 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.443 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.443 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.443 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.443 | |
| 4f6x | ZYL | Dehydrosqualene synthase | / | 0.443 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.443 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.443 | |
| 4ys0 | ADP | Protein translocase subunit SecA | / | 0.443 | |
| 5cvf | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.442 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.442 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2oa1 | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.442 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.442 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.442 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.442 | |
| 4id5 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.442 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.441 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.441 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.441 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.441 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.441 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.441 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.441 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1an5 | CB3 | Thymidylate synthase | / | 0.440 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1g6o | ADP | Cag alpha | / | 0.440 | |
| 1kqg | HQO | Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit | / | 0.440 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.440 | |
| 2wvm | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.440 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.440 | |
| 4jvj | 1MV | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.440 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.440 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.440 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.440 |