Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g6h FAD Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 1.244
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 1.112
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 1.108
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 1.097
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 1.070
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 1.065
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.927
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.857
3icr FADCoenzyme A disulfide reductase / 0.833
4hb9 FADUncharacterized protein / 0.822
2r9z FADGlutathione amide reductase / 0.815
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.811
1f8w FADNADH peroxidase 1.11.1.1 0.808
1trb FADThioredoxin reductase 1.8.1.9 0.808
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.807
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.800
2q7v FADThioredoxin reductase / 0.799
1tdf FADThioredoxin reductase 1.8.1.9 0.796
1tde FADThioredoxin reductase 1.8.1.9 0.795
1ges FADGlutathione reductase 1.8.1.7 0.792
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.791
3ict FADCoenzyme A disulfide reductase / 0.790
4em3 FADCoenzyme A disulfide reductase / 0.785
1nhr FADNADH peroxidase 1.11.1.1 0.782
2x8h FADThioredoxin glutathione reductase / 0.782
3ics FADCoenzyme A disulfide reductase / 0.781
2x8g FADThioredoxin glutathione reductase / 0.778
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.777
4gcm FADThioredoxin reductase 1.8.1.9 0.777
2wow FADTrypanothione reductase / 0.775
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.775
1ger FADGlutathione reductase 1.8.1.7 0.772
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.772
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.767
2eq6 FADDihydrolipoyl dehydrogenase / 0.765
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.759
3fbs FADOxidoreductase / 0.759
4opi FDAConserved Archaeal protein / 0.759
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.758
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.758
4opt FDAConserved Archaeal protein / 0.757
2gr0 FADFerredoxin reductase / 0.756
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.755
1nhp FADNADH peroxidase 1.11.1.1 0.754
3cge FADCoenzyme A disulfide reductase / 0.752
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.752
2zbw FADFerredoxin--NADP reductase / 0.751
4emw FADCoenzyme A disulfide reductase / 0.751
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.751
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.750
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.750
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.746
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.745
2gqw FADFerredoxin reductase / 0.743
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.743
2rab FADGlutathione amide reductase / 0.742
3f8d FADNADH oxidase/thioredoxin reductase / 0.742
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.742
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.741
4nte FADDepH / 0.741
3rp8 FADFAD-dependent urate hydroxylase / 0.740
1k0j FADp-hydroxybenzoate hydroxylase / 0.739
1zk7 FADMercuric reductase 1.16.1.1 0.739
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.739
3cgd FADCoenzyme A disulfide reductase / 0.737
3urh FADDihydrolipoyl dehydrogenase / 0.737
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.736
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.736
2hqm FADGlutathione reductase 1.8.1.7 0.736
4em4 FADCoenzyme A disulfide reductase / 0.736
4opg FDAConserved Archaeal protein / 0.736
3cgc FADCoenzyme A disulfide reductase / 0.733
2b9x FADPutative aminooxidase / 0.732
2bab FADPutative aminooxidase / 0.732
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.731
2whd FADThioredoxin reductase / 0.731
1npx FADNADH peroxidase 1.11.1.1 0.730
4eqw FADCoenzyme A disulfide reductase / 0.730
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.729
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.729
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.728
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.728
1cl0 FADThioredoxin reductase 1.8.1.9 0.727
3atr FDAConserved Archaeal protein / 0.727
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.727
4opl FDAConserved Archaeal protein / 0.727
1nhq FADNADH peroxidase 1.11.1.1 0.726
2gr3 FADFerredoxin reductase / 0.726
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.726
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.726
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.725
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.725
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.724
4bjz FADProbable salicylate monooxygenase / 0.723
4opc FDAConserved Archaeal protein / 0.723
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.723
2jb2 FADL-amino acid oxidase / 0.722
4j2w FADKynurenine 3-monooxygenase / 0.722
1q1r FADPutidaredoxin reductase 1.18.1.5 0.721
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.721
4ccq FADThioredoxin reductase / 0.721
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.721
3cgb FADCoenzyme A disulfide reductase / 0.720
2eq7 FADDihydrolipoyl dehydrogenase / 0.719
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.719
4fwf FADLysine-specific histone demethylase 1B 1 0.718
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.717
4opd FDAConserved Archaeal protein / 0.716
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.715
2cdu FADNADH oxidase / 0.714
4j31 FADKynurenine 3-monooxygenase / 0.714
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.713
4qi7 FADCellobiose dehydrogenase / 0.713
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.712
1bzl FADTrypanothione reductase 1.8.1.12 0.711
2b9w FADPutative aminooxidase / 0.711
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.711
2npx FADNADH peroxidase 1.11.1.1 0.711
4a5l FADThioredoxin reductase / 0.711
4eqx FADCoenzyme A disulfide reductase / 0.711
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.711
1d7y FADFerredoxin reductase / 0.710
1joa FADNADH peroxidase 1.11.1.1 0.710
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.709
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.708
2jb1 FADL-amino acid oxidase / 0.708
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.708
2q0k FADThioredoxin reductase 1.8.1.9 0.707
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.707
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.706
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.705
1q1w FADPutidaredoxin reductase 1.18.1.5 0.705
3ish FADThioredoxin reductase 1.8.1.9 0.705
4jn9 FADDepH / 0.705
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.705
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.703
2jae FADL-amino acid oxidase / 0.703
4bk2 FADProbable salicylate monooxygenase / 0.703
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
4yry FADGlutamate synthase, beta subunit / 0.702
2w0h FADTrypanothione reductase / 0.701
2eq9 FADDihydrolipoyl dehydrogenase / 0.700
2x3n FADProbable FAD-dependent monooxygenase / 0.699
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.699
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.699
2bac FADPutative aminooxidase / 0.698
3atq FDAConserved Archaeal protein / 0.698
4up3 FADThioredoxin reductase / 0.698
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.697
2yg5 FADPutrescine oxidase / 0.697
4j34 FADKynurenine 3-monooxygenase / 0.697
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.696
1yqz FADCoenzyme A disulfide reductase / 0.695
2b9y FADPutative aminooxidase / 0.695
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.694
1zx9 FADMercuric reductase 1.16.1.1 0.693
4la1 FADThioredoxin glutathione reductase / 0.693
1geu FADGlutathione reductase 1.8.1.7 0.692
4qi4 FADCellobiose dehydrogenase / 0.692
4bk3 FADProbable salicylate monooxygenase / 0.691
4j33 FADKynurenine 3-monooxygenase / 0.690
4opu FDAConserved Archaeal protein / 0.690
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.689
2ba9 FADPutative aminooxidase / 0.689
3ukf FDAUDP-galactopyranose mutase / 0.688
5buk FADFADH2-dependent halogenase / 0.687
2yg3 FADPutrescine oxidase / 0.685
4ntc FADThioredoxin reductase gliT / 0.685
2eq8 FADDihydrolipoyl dehydrogenase / 0.684
4i58 FADCyclohexylamine Oxidase / 0.684
4u8k FDAUDP-galactopyranose mutase / 0.684
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.683
3rha FDAPutrescine oxidase / 0.683
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.681
4ccr FADThioredoxin reductase / 0.680
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.679
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.679
1k0l FADp-hydroxybenzoate hydroxylase / 0.678
2qa2 FADPolyketide oxygenase CabE / 0.678
2h94 FADLysine-specific histone demethylase 1A 1 0.677
4u8n FDAUDP-galactopyranose mutase / 0.677
4z26 FADPutative GMC-type oxidoreductase R135 1 0.677
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.676
3t14 FADSulfide-quinone reductase / 0.676
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.675
4j36 FADKynurenine 3-monooxygenase / 0.675
4u8i FDAUDP-galactopyranose mutase / 0.675
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.674
3hdy FADUDP-galactopyranose mutase / 0.674
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.674
4u8p FDAUDP-galactopyranose mutase / 0.674
2vvl FADMonoamine oxidase N 1.4.3.4 0.673
3uth FDAUDP-galactopyranose mutase / 0.673
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.673
4u8m FDAUDP-galactopyranose mutase / 0.673
1f3p FADFerredoxin reductase / 0.671
4x4j FADPutative oxygenase / 0.671
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
1fec FADTrypanothione reductase 1.8.1.12 0.669
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.669
4ntd FADThioredoxin reductase / 0.669
3p9u FADTetX family tetracycline inactivation enzyme / 0.668
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.667
4gde FDAUDP-galactopyranose mutase / 0.666
4k2x FADPolyketide oxygenase/hydroxylase / 0.666
4fk1 FADPutative thioredoxin reductase / 0.665
4u8j FDAUDP-galactopyranose mutase / 0.665
1xpq FADPolyamine oxidase FMS1 / 0.664
3t2z FADSulfide-quinone reductase / 0.664
2yvf FADFerredoxin reductase / 0.663
4gus FADLysine-specific histone demethylase 1B 1 0.663
4gut FADLysine-specific histone demethylase 1B 1 0.663
1kif FADD-amino-acid oxidase 1.4.3.3 0.662
3bg7 FADPyranose 2-oxidase / 0.662
4eqr FADCoenzyme A disulfide reductase / 0.662
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.661
3lsh FADPyranose 2-oxidase / 0.661
4u8o FDAUDP-galactopyranose mutase / 0.661
4wx1 FDAUDP-galactopyranose mutase / 0.661
4jnq FDAThioredoxin reductase / 0.660
2q0l FADThioredoxin reductase 1.8.1.9 0.659
3fmw FADOxygenase / 0.659
3syi FADSulfide-quinone reductase / 0.659
3utg FDAUDP-galactopyranose mutase / 0.659
4dsh FDAUncharacterized protein / 0.659
4eqs FADCoenzyme A disulfide reductase / 0.659
2ign FADPyranose 2-oxidase / 0.658
4dsg FADUncharacterized protein / 0.658
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.657
2rgj FADFlavin-containing monooxygenase / 0.657
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.657
3d8x FADThioredoxin reductase 1 1.8.1.9 0.657
4mo2 FADUDP-galactopyranose mutase / 0.657
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.656
1ojt FADDihydrolipoyl dehydrogenase / 0.655
4cnk FADL-amino acid oxidase / 0.655
3bi2 FADPolyamine oxidase FMS1 / 0.654
3gyi FADCholesterol oxidase 1.1.3.6 0.654
3ept FDAPutative FAD-monooxygenase / 0.653
4j56 FADThioredoxin reductase 2 1.8.1.9 0.653
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.652
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.652
3cnd FADPolyamine oxidase FMS1 / 0.652
3zdn FADMonoamine oxidase N 1.4.3.4 0.652
2gr1 FADFerredoxin reductase / 0.651
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.650
1n4u FAECholesterol oxidase 1.1.3.6 0.650
1ng4 FADGlycine oxidase 1.4.3.19 0.650
2r0c FADPutative FAD-monooxygenase / 0.650
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.650
4rsl FADFructosyl peptide oxidase / 0.650
4xwr FADCholesterol oxidase 1.1.3.6 0.650