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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w4x FAD Phenylacetone monooxygenase 1.14.13.92

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1w4x FADPhenylacetone monooxygenase 1.14.13.92 1.303
2ylz FADPhenylacetone monooxygenase 1.14.13.92 1.191
3gwf FADCyclohexanone monooxygenase / 1.015
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.967
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.923
3gwd FADCyclohexanone monooxygenase / 0.887
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.878
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.874
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.864
4fwf FADLysine-specific histone demethylase 1B 1 0.845
2gv8 FADThiol-specific monooxygenase 1.14.13 0.829
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.816
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.810
4ap3 FADSteroid monooxygenase / 0.809
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.809
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.807
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.804
3qj4 FADRenalase / 0.799
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.797
4gcm FADThioredoxin reductase 1.8.1.9 0.789
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.777
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.773
4ap1 FADSteroid monooxygenase / 0.772
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.768
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.766
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.765
2yg3 FADPutrescine oxidase / 0.765
4gus FADLysine-specific histone demethylase 1B 1 0.765
2yg5 FADPutrescine oxidase / 0.760
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.759
2gvc FADThiol-specific monooxygenase 1.14.13 0.758
2yg7 FADPutrescine oxidase / 0.752
3lsm SFDPyranose 2-oxidase / 0.752
4aos FADSteroid monooxygenase / 0.752
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.748
2gr0 FADFerredoxin reductase / 0.744
4gur FADLysine-specific histone demethylase 1B 1 0.743
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.743
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.742
2q7v FADThioredoxin reductase / 0.740
2yg6 FADPutrescine oxidase / 0.740
4i58 FADCyclohexylamine Oxidase / 0.739
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.738
4gut FADLysine-specific histone demethylase 1B 1 0.737
2b9x FADPutative aminooxidase / 0.736
2bac FADPutative aminooxidase / 0.735
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.735
2eq6 FADDihydrolipoyl dehydrogenase / 0.734
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.734
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.734
2yg4 FADPutrescine oxidase / 0.733
1f3p FADFerredoxin reductase / 0.732
5buk FADFADH2-dependent halogenase / 0.732
2dw4 FADLysine-specific histone demethylase 1A 1 0.731
2b9y FADPutative aminooxidase / 0.730
3f8p NADNADH oxidase/thioredoxin reductase / 0.730
1y56 ATPUncharacterized protein / 0.729
2gqw FADFerredoxin reductase / 0.729
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.728
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.727
2jb1 FADL-amino acid oxidase / 0.725
4cnk FADL-amino acid oxidase / 0.725
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.724
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.724
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.724
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.723
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.723
4hsu FADLysine-specific histone demethylase 1B 1 0.723
3bi5 FADPolyamine oxidase FMS1 / 0.722
4rek FADCholesterol oxidase 1.1.3.6 0.722
3sz0 FADSulfide-quinone reductase / 0.721
2xve FADPutative flavin-containing monooxygenase / 0.720
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.719
4fwj FADLysine-specific histone demethylase 1B 1 0.718
1b8s FADCholesterol oxidase 1.1.3.6 0.717
2zbw FADFerredoxin--NADP reductase / 0.717
1tde FADThioredoxin reductase 1.8.1.9 0.716
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.716
4cnj FADL-amino acid oxidase / 0.716
3mj4 FADUDP-galactopyranose mutase / 0.715
4u2l SFDCholesterol oxidase 1.1.3.6 0.715
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.714
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.713
2xvi FADPutative flavin-containing monooxygenase / 0.712
3ish FADThioredoxin reductase 1.8.1.9 0.712
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.711
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.711
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.710
3k4c FADPyranose 2-oxidase / 0.710
2bab FADPutative aminooxidase / 0.708
3ukl FADUDP-galactopyranose mutase / 0.708
1zk7 FADMercuric reductase 1.16.1.1 0.706
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.705
2b9w FADPutative aminooxidase / 0.705
3cge FADCoenzyme A disulfide reductase / 0.705
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.705
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.704
4dsg FADUncharacterized protein / 0.704
5br7 FADUDP-galactopyranose mutase / 0.704
3pl8 FADPyranose 2-oxidase / 0.703
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.703
3cnd FADPolyamine oxidase FMS1 / 0.702
3he3 FADUDP-galactopyranose mutase / 0.702
4a99 FADTetX family tetracycline inactivation enzyme / 0.702
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.702
1cc2 FADCholesterol oxidase 1.1.3.6 0.701
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.701
3hdy FADUDP-galactopyranose mutase / 0.701
2ba9 FADPutative aminooxidase / 0.700
2q0l FADThioredoxin reductase 1.8.1.9 0.700
2jae FADL-amino acid oxidase / 0.699
2igo FADPyranose 2-oxidase / 0.698
3rha FDAPutrescine oxidase / 0.698
4mok FADPyranose 2-oxidase / 0.698
4nzh FADL-ornithine N(5)-monooxygenase / 0.698
1rsg FADPolyamine oxidase FMS1 / 0.697
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.697
4opg FDAConserved Archaeal protein / 0.697
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
4aox FADSteroid monooxygenase / 0.696
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
2ign FADPyranose 2-oxidase / 0.694
1trb FADThioredoxin reductase 1.8.1.9 0.693
2e1m FADL-glutamate oxidase / 0.693
4em3 FADCoenzyme A disulfide reductase / 0.693
4guu FA9Lysine-specific histone demethylase 1B 1 0.693
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.692
1f8w FADNADH peroxidase 1.11.1.1 0.691
1tdf FADThioredoxin reductase 1.8.1.9 0.691
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.691
2vqb FADPutative flavin-containing monooxygenase / 0.691
3icr FADCoenzyme A disulfide reductase / 0.691
4xwr FADCholesterol oxidase 1.1.3.6 0.691
2gew FADCholesterol oxidase 1.1.3.6 0.690
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.690
4xbf FADLysine-specific histone demethylase 1A 1 0.689
1geu FADGlutathione reductase 1.8.1.7 0.688
1yy5 FADPolyamine oxidase FMS1 / 0.688
4mo2 FADUDP-galactopyranose mutase / 0.688
2whd FADThioredoxin reductase / 0.687
3cgd FADCoenzyme A disulfide reductase / 0.687
2hqm FADGlutathione reductase 1.8.1.7 0.686
3atq FDAConserved Archaeal protein / 0.686
4tlz FADKtzI / 0.686
5hhf FDAUDP-galactopyranose mutase / 0.685
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.684
3lsh FADPyranose 2-oxidase / 0.684
5l3d FADLysine-specific histone demethylase 1A 1 0.684
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.683
3cox FADCholesterol oxidase 1.1.3.6 0.683
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.683
1b4v FADCholesterol oxidase 1.1.3.6 0.682
1nhs FADNADH peroxidase 1.11.1.1 0.682
1z6l FADPolyamine oxidase FMS1 / 0.682
4opi FDAConserved Archaeal protein / 0.682
1get FADGlutathione reductase 1.8.1.7 0.681
3bi2 FADPolyamine oxidase FMS1 / 0.681
3r9u FADThioredoxin reductase / 0.681
3ict FADCoenzyme A disulfide reductase / 0.680
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.680
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.679
2xlp FADPutative flavin-containing monooxygenase / 0.679
2xvf FADPutative flavin-containing monooxygenase / 0.679
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.678
1f8s FADL-amino-acid oxidase 1.4.3.2 0.678
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.678
4x4j FADPutative oxygenase / 0.678
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.677
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.677
1gal FADGlucose oxidase 1.1.3.4 0.676
3sx2 NADUncharacterized protein / 0.676
1c0l FADD-amino-acid oxidase 1.4.3.3 0.675
2jb2 FADL-amino acid oxidase / 0.675
2npx FADNADH peroxidase 1.11.1.1 0.675
2x3n FADProbable FAD-dependent monooxygenase / 0.675
4j2w FADKynurenine 3-monooxygenase / 0.675
1f8r FADL-amino-acid oxidase 1.4.3.2 0.674
1ges FADGlutathione reductase 1.8.1.7 0.674
3cty FADProbable thioredoxin reductase / 0.674
4b66 FADL-ornithine N(5)-monooxygenase / 0.674
4u2s FDACholesterol oxidase 1.1.3.6 0.674
1n4u FAECholesterol oxidase 1.1.3.6 0.673
4j33 FADKynurenine 3-monooxygenase / 0.673
1nhr FADNADH peroxidase 1.11.1.1 0.672
2eq7 FADDihydrolipoyl dehydrogenase / 0.672
2gr3 FADFerredoxin reductase / 0.672
3kpf FADPolyamine oxidase 1.5.3.14 0.672
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.671
3kkj FADRenalase / 0.671
3p9u FADTetX family tetracycline inactivation enzyme / 0.671
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.671
3we0 FADLysine 2-monooxygenase / 0.671
3syi FADSulfide-quinone reductase / 0.670
3uka FADUDP-galactopyranose mutase / 0.670
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.669
1zx9 FADMercuric reductase 1.16.1.1 0.669
2vq7 FADPutative flavin-containing monooxygenase / 0.669
3bg7 FADPyranose 2-oxidase / 0.669
1ijh FADCholesterol oxidase 1.1.3.6 0.668
2y48 FADLysine-specific histone demethylase 1A 1 0.668
3lsi FADPyranose 2-oxidase / 0.668
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.667
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.667
1fec FADTrypanothione reductase 1.8.1.12 0.667
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.667
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.667
4mih FADPyranose 2-oxidase 1.1.3.10 0.667
4ntd FADThioredoxin reductase / 0.667
4qi7 FADCellobiose dehydrogenase / 0.667
1nhp FADNADH peroxidase 1.11.1.1 0.666
3f8r NAPNADH oxidase/thioredoxin reductase / 0.666
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.666
3zdn FADMonoamine oxidase N 1.4.3.4 0.666
2r9z FADGlutathione amide reductase / 0.665
3qvr FADGlucose oxidase 1.1.3.4 0.665
5hxw FADL-amino acid deaminase / 0.665
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.664
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.664
3utf FDAUDP-galactopyranose mutase / 0.664
4b1b FADThioredoxin reductase 1.8.1.9 0.664
4ech FADPolyamine oxidase FMS1 / 0.664
4j57 FADThioredoxin reductase 2 1.8.1.9 0.664
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.663
2yvf FADFerredoxin reductase / 0.663
3cgb FADCoenzyme A disulfide reductase / 0.663
3k30 ADPHistamine dehydrogenase / 0.663
3ukf FDAUDP-galactopyranose mutase / 0.663
4fwe FADLysine-specific histone demethylase 1B 1 0.663
3nlc FADUncharacterized protein / 0.662
3t2k FADSulfide-quinone reductase / 0.662
4u2t FADCholesterol oxidase 1.1.3.6 0.662
1cbo FADCholesterol oxidase 1.1.3.6 0.661
1h81 FADPolyamine oxidase 1.5.3.14 0.661
3gyi FADCholesterol oxidase 1.1.3.6 0.661
4b69 FADL-ornithine N(5)-monooxygenase / 0.661
4xxg FADCholesterol oxidase 1.1.3.6 0.661
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.660
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.660
2gr1 FADFerredoxin reductase / 0.660
3cnj FADCholesterol oxidase 1.1.3.6 0.660
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.660
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.660
5j60 FADThioredoxin reductase / 0.660
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.658
3t14 FADSulfide-quinone reductase / 0.658
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.658
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.658
4uir FADOleate hydratase 4.2.1.53 0.657
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.656
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.655
1joa FADNADH peroxidase 1.11.1.1 0.655
2iw5 FADLysine-specific histone demethylase 1A 1 0.655
3rfx NADUronate dehydrogenase / 0.655
1d7y FADFerredoxin reductase / 0.654
2rgo FADAlpha-Glycerophosphate Oxidase / 0.654
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.654
4gdp FADPolyamine oxidase FMS1 / 0.654
4yry FADGlutamate synthase, beta subunit / 0.654
4tvb NADHomospermidine synthase 2.5.1.44 0.653
4u8p FDAUDP-galactopyranose mutase / 0.653
1c0k FADD-amino-acid oxidase 1.4.3.3 0.652
2uxx FAJLysine-specific histone demethylase 1A 1 0.652
3cgc FADCoenzyme A disulfide reductase / 0.652
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.652
4mo2 FDAUDP-galactopyranose mutase / 0.652
1nhq FADNADH peroxidase 1.11.1.1 0.651
4jq9 FADDihydrolipoyl dehydrogenase / 0.651
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.650
2eq7 NADDihydrolipoyl dehydrogenase / 0.650
3f8d FADNADH oxidase/thioredoxin reductase / 0.650
4c5o FADPutative monooxygenase / 0.650