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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1vdc FAD Thioredoxin reductase 1, mitochondrial 1.8.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 1.293
4ccr FADThioredoxin reductase / 0.962
4cbq FADThioredoxin reductase / 0.947
4up3 FADThioredoxin reductase / 0.941
4a65 FADThioredoxin reductase / 0.936
4a5l FADThioredoxin reductase / 0.923
4ccq FADThioredoxin reductase / 0.901
3d8x FADThioredoxin reductase 1 1.8.1.9 0.892
2whd FADThioredoxin reductase / 0.873
3itj FADThioredoxin reductase 1 1.8.1.9 0.859
1trb FADThioredoxin reductase 1.8.1.9 0.843
1tdf FADThioredoxin reductase 1.8.1.9 0.838
4jnq FDAThioredoxin reductase / 0.831
1cl0 FADThioredoxin reductase 1.8.1.9 0.825
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.820
2q0k FADThioredoxin reductase 1.8.1.9 0.801
4nev FADTrypanothione reductase / 0.797
4ntd FADThioredoxin reductase / 0.791
1tyt FADTrypanothione reductase 1.8.1.12 0.782
4gcm FADThioredoxin reductase 1.8.1.9 0.773
4jn9 FADDepH / 0.771
1tde FADThioredoxin reductase 1.8.1.9 0.769
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.765
1ger FADGlutathione reductase 1.8.1.7 0.761
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.759
2ywl FADThioredoxin reductase related protein / 0.752
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.750
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.750
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.745
2cvj FADThioredoxin reductase related protein / 0.745
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.744
2eq7 FADDihydrolipoyl dehydrogenase / 0.740
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.738
3urh FADDihydrolipoyl dehydrogenase / 0.738
3ish FADThioredoxin reductase 1.8.1.9 0.737
1get FADGlutathione reductase 1.8.1.7 0.735
4nte FADDepH / 0.734
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.733
3pl8 FADPyranose 2-oxidase / 0.731
2zbw FADFerredoxin--NADP reductase / 0.729
5buk FADFADH2-dependent halogenase / 0.728
2q7v FADThioredoxin reductase / 0.725
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.725
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.724
2wow FADTrypanothione reductase / 0.722
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.718
1npx FADNADH peroxidase 1.11.1.1 0.717
1ojt FADDihydrolipoyl dehydrogenase / 0.717
1feb FADTrypanothione reductase 1.8.1.12 0.716
3lad FADDihydrolipoyl dehydrogenase / 0.716
4k5r FADOxygenase / 0.716
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.715
1geu FADGlutathione reductase 1.8.1.7 0.715
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.715
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.715
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.713
3nlc FADUncharacterized protein / 0.713
4fk1 FADPutative thioredoxin reductase / 0.709
4fwf FADLysine-specific histone demethylase 1B 1 0.709
2igo FADPyranose 2-oxidase / 0.708
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.708
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.708
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.707
2a87 FADThioredoxin reductase 1.8.1.9 0.706
2r9z FADGlutathione amide reductase / 0.706
3b6d FAECholesterol oxidase 1.1.3.6 0.705
2jk6 FADTrypanothione reductase / 0.704
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.704
1ijh FADCholesterol oxidase 1.1.3.6 0.703
1zx9 FADMercuric reductase 1.16.1.1 0.703
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.703
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.702
2wba FADTrypanothione reductase 1.8.1.12 0.702
3atr FDAConserved Archaeal protein / 0.702
3k4c FADPyranose 2-oxidase / 0.701
4j57 FADThioredoxin reductase 2 1.8.1.9 0.700
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.699
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.699
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.699
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.698
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.697
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.697
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.697
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.695
5j60 FADThioredoxin reductase / 0.695
4mok FADPyranose 2-oxidase / 0.694
1qo8 FADFumarate reductase flavoprotein subunit / 0.693
2npx FADNADH peroxidase 1.11.1.1 0.693
4u2t FADCholesterol oxidase 1.1.3.6 0.693
1n1p FADCholesterol oxidase 1.1.3.6 0.692
1n4v FADCholesterol oxidase 1.1.3.6 0.692
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.692
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
2tpr FADTrypanothione reductase 1.8.1.12 0.691
5dbj FADFADH2-dependent halogenase PltA / 0.691
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.690
2gew FADCholesterol oxidase 1.1.3.6 0.690
3cox FADCholesterol oxidase 1.1.3.6 0.690
3f8d FADNADH oxidase/thioredoxin reductase / 0.690
3r9u FADThioredoxin reductase / 0.690
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.689
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.689
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.689
1mxt FAECholesterol oxidase 1.1.3.6 0.688
1nhp FADNADH peroxidase 1.11.1.1 0.688
4xxg FADCholesterol oxidase 1.1.3.6 0.688
1n4w FADCholesterol oxidase 1.1.3.6 0.687
4xwr FADCholesterol oxidase 1.1.3.6 0.687
1n4u FAECholesterol oxidase 1.1.3.6 0.686
2rab FADGlutathione amide reductase / 0.686
3cnj FADCholesterol oxidase 1.1.3.6 0.686
4rek FADCholesterol oxidase 1.1.3.6 0.686
3gyj FADCholesterol oxidase 1.1.3.6 0.685
2eq9 FADDihydrolipoyl dehydrogenase / 0.684
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
2gr3 FADFerredoxin reductase / 0.684
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.683
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.683
4jq9 FADDihydrolipoyl dehydrogenase / 0.683
1b8s FADCholesterol oxidase 1.1.3.6 0.682
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
4b1b FADThioredoxin reductase 1.8.1.9 0.682
4rje FNRLactate oxidase / 0.682
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.681
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.681
2yqu FADDihydrolipoyl dehydrogenase / 0.681
3rp8 FADFAD-dependent urate hydroxylase / 0.681
1fec FADTrypanothione reductase 1.8.1.12 0.680
1ges FADGlutathione reductase 1.8.1.7 0.680
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.680
3icr FADCoenzyme A disulfide reductase / 0.680
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.678
3qvp FADGlucose oxidase 1.1.3.4 0.678
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
2wp5 FADTrypanothione reductase / 0.677
4j56 FADThioredoxin reductase 2 1.8.1.9 0.677
2y48 FADLysine-specific histone demethylase 1A 1 0.676
3cgb FADCoenzyme A disulfide reductase / 0.676
4em4 FADCoenzyme A disulfide reductase / 0.676
4u2s FDACholesterol oxidase 1.1.3.6 0.676
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.675
2hko FADLysine-specific histone demethylase 1A 1 0.675
3ept FDAPutative FAD-monooxygenase / 0.674
3k4n FADPyranose 2-oxidase / 0.674
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.674
2ign FADPyranose 2-oxidase / 0.673
2eq6 FADDihydrolipoyl dehydrogenase / 0.672
2q0l FADThioredoxin reductase 1.8.1.9 0.672
3gyi FADCholesterol oxidase 1.1.3.6 0.672
4j33 FADKynurenine 3-monooxygenase / 0.672
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.672
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
2h94 FADLysine-specific histone demethylase 1A 1 0.671
2x8g FADThioredoxin glutathione reductase / 0.671
3kpk FADSulfide-quinone reductase / 0.671
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.670
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
1n9n FMNPutative blue light receptor / 0.670
2cdu FADNADH oxidase / 0.670
3cgc FADCoenzyme A disulfide reductase / 0.670
3cty FADProbable thioredoxin reductase / 0.670
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.670
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.670
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
1fea FADTrypanothione reductase 1.8.1.12 0.669
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.669
1zk7 FADMercuric reductase 1.16.1.1 0.669
4utm FNRXenobiotic reductase / 0.669
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.669
1d7y FADFerredoxin reductase / 0.668
2v0u FMNNPH1-1 / 0.668
2v1a FMNNPH1-1 / 0.668
2w0h FADTrypanothione reductase / 0.668
2yg4 FADPutrescine oxidase / 0.668
4mih FADPyranose 2-oxidase 1.1.3.10 0.668
1bzl FADTrypanothione reductase 1.8.1.12 0.667
1nhs FADNADH peroxidase 1.11.1.1 0.667
3ada NADSubunit alpha of sarocosine oxidase / 0.667
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.667
2bab FADPutative aminooxidase / 0.666
3ict FADCoenzyme A disulfide reductase / 0.666
4dna FADProbable glutathione reductase / 0.666
4k2x FADPolyketide oxygenase/hydroxylase / 0.666
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.665
4opd FDAConserved Archaeal protein / 0.665
4qi4 FADCellobiose dehydrogenase / 0.665
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.664
3f8p NADNADH oxidase/thioredoxin reductase / 0.664
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.664
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.664
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.663
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.663
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.663
4gdp FADPolyamine oxidase FMS1 / 0.663
1nhq FADNADH peroxidase 1.11.1.1 0.662
4a6n FADTetX family tetracycline inactivation enzyme / 0.662
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.661
2jb1 FADL-amino acid oxidase / 0.661
2jb2 FADL-amino acid oxidase / 0.661
3cgd FADCoenzyme A disulfide reductase / 0.661
3cnd FADPolyamine oxidase FMS1 / 0.661
4e0i FADMitochondrial FAD-linked sulfhydryl oxidase ERV1 1.8.3.2 0.661
4fwj FADLysine-specific histone demethylase 1B 1 0.661
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.661
3qvr FADGlucose oxidase 1.1.3.4 0.660
4kuk RBFPutative blue-light photoreceptor / 0.660
1cf3 FADGlucose oxidase 1.1.3.4 0.659
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.659
3nix FADFlavoprotein/dehydrogenase / 0.659
1knp FADL-aspartate oxidase 1.4.3.16 0.658
1nhr FADNADH peroxidase 1.11.1.1 0.658
2jae FADL-amino acid oxidase / 0.658
4hj4 FMNLOV protein / 0.658
4opg FDAConserved Archaeal protein / 0.657
4r38 RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.657
4tm4 FDAKtzI / 0.657
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.655
2hqm FADGlutathione reductase 1.8.1.7 0.655
2qa1 FADPgaE / 0.655
2gqw FADFerredoxin reductase / 0.654
3bi5 FADPolyamine oxidase FMS1 / 0.654
4eqr FADCoenzyme A disulfide reductase / 0.654
3cn8 FADPolyamine oxidase FMS1 / 0.653
3n39 FMNProtein NrdI / 0.653
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.653
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
4yl2 FMNLactate oxidase / 0.653
2vvl FADMonoamine oxidase N 1.4.3.4 0.652
4gur FADLysine-specific histone demethylase 1B 1 0.652
4ntc FADThioredoxin reductase gliT / 0.652
1p4m FMNRiboflavin kinase 2.7.1.26 0.651
1t6y FMNRiboflavin biosynthesis protein / 0.651
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.651
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.651
3rha FDAPutrescine oxidase / 0.651
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.650
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
3kpf FADPolyamine oxidase 1.5.3.14 0.650
3zdn FADMonoamine oxidase N 1.4.3.4 0.650
4gut FADLysine-specific histone demethylase 1B 1 0.650
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.650
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.650
4opc FDAConserved Archaeal protein / 0.650