sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 1.000 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.604 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.570 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.502 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.500 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.499 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.492 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.491 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.491 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.487 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.484 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.483 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.483 | |
| 1ysx | 4EB | Serum albumin | / | 0.482 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.482 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.481 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.481 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.478 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.478 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.477 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.477 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.476 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.476 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.475 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.475 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.474 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.473 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.473 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.473 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.473 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.472 | |
| 1uyr | D1L | Acetyl-CoA carboxylase | / | 0.471 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 2x23 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.470 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.469 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.469 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.468 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.468 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.468 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.467 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.467 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.467 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.467 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.466 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4zas | TYD | CalS13 | / | 0.466 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.465 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.465 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.464 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 2p15 | EZT | Estrogen receptor | / | 0.464 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.464 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.464 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.464 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.463 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.463 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.463 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.462 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.462 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.462 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.462 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.461 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.461 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.461 | |
| 4iah | 1DX | Alr2278 protein | / | 0.461 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.461 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.461 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.460 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.460 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.459 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 2xvv | 9DN | Serum albumin | / | 0.459 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 1e7a | PFL | Serum albumin | / | 0.458 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.458 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.458 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.458 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 4l9q | 9TP | Serum albumin | / | 0.458 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.457 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.457 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.457 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.457 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.457 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.457 | |
| 3wd7 | COA | Acridone synthase | / | 0.457 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.456 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 3zux | TCH | Transporter | / | 0.456 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.455 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.455 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.455 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.455 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.454 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.454 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.454 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.454 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.453 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.453 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.453 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.452 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.452 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.452 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.452 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.452 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.452 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.452 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.451 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2xvw | 9NR | Serum albumin | / | 0.451 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.451 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.451 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.451 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.451 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.451 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.451 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.451 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1fml | RTL | Retinol dehydratase | / | 0.450 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.450 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1zdw | FLV | Prenyltransferase | / | 0.449 | |
| 2iw5 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.449 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.449 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.449 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.449 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.449 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.449 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.449 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 4l8u | 9AZ | Serum albumin | / | 0.449 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.449 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.448 | |
| 1osv | CHC | Bile acid receptor | / | 0.448 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2bxm | IMN | Serum albumin | / | 0.448 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3aba | FLI | Cytochrome P450 | / | 0.448 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3p9t | TCL | Repressor | / | 0.448 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.448 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 2acw | UPG | Glycosyltransferase | / | 0.447 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.447 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.447 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.447 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.447 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.447 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.447 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3w2o | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.447 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.447 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.447 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.447 | |
| 5ca1 | NZO | Tubulin beta-2 chain | / | 0.447 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.447 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.446 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1ppj | SMA | Cytochrome b | / | 0.446 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.446 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2bx8 | AZQ | Serum albumin | / | 0.446 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 3b9l | AZZ | Serum albumin | / | 0.446 | |
| 3bej | MUF | Bile acid receptor | / | 0.446 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3r35 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.446 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.446 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.446 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.446 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4okt | 198 | Androgen receptor | / | 0.446 | |
| 5c93 | ACP | Two-component system histidine protein kinase | / | 0.446 | |
| 6gsw | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.446 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.445 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.445 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.445 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.445 | |
| 3vf9 | 477 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4bew | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.445 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.445 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.444 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2pin | 4HY | Thyroid hormone receptor beta | / | 0.444 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.444 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.444 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.444 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.444 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1pp9 | SMA | Cytochrome b | / | 0.443 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.443 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.443 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 2duv | 371 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.443 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.443 | |
| 2y00 | Y01 | Beta-1 adrenergic receptor | / | 0.443 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3eel | 53T | Uncharacterized protein | / | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.443 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.443 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.443 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.443 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.442 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.442 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.442 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 2wpx | ACO | Orf14 | / | 0.442 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.442 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.442 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.442 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.442 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.442 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.442 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.441 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 2bxq | IMN | Serum albumin | / | 0.441 | |
| 2ejz | SAH | Diphthine synthase | / | 0.441 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
| 3cse | N22 | Uncharacterized protein | / | 0.441 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.441 | |
| 3lu8 | IQX | Serum albumin | / | 0.441 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.441 | |
| 3o8g | O8G | HTH-type transcriptional regulator EthR | / | 0.441 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 3qly | 55V | Uncharacterized protein | / | 0.441 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3upy | FOM | Oxidoreductase, putative | / | 0.441 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.441 | |
| 4an3 | 5Y0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 4fkp | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.441 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.440 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.440 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.440 |