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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gu94GUFocal adhesion kinase 12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4gu94GUFocal adhesion kinase 12.7.10.21.000
4k8aK8AFocal adhesion kinase 12.7.10.20.568
2j0lANPFocal adhesion kinase 12.7.10.20.564
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.526
3t8oATPRhodopsin kinase/0.525
2ijmADPFocal adhesion kinase 12.7.10.20.522
2j0m4STFocal adhesion kinase 12.7.10.20.513
3zewSTUEphrin type-B receptor 42.7.10.10.510
4jia1K3Tyrosine-protein kinase JAK2/0.510
2ijmATPFocal adhesion kinase 12.7.10.20.508
2v7a627Tyrosine-protein kinase ABL12.7.10.20.508
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.505
3ormAGSSerine/threonine protein kinase/0.505
2etm7PYFocal adhesion kinase 12.7.10.20.504
4k33ACPFibroblast growth factor receptor 32.7.10.10.492
4ic7ANPMitogen-activated protein kinase 72.7.11.240.490
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.489
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.488
3c4xATPRhodopsin kinase/0.487
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.486
1i44ACPInsulin receptor2.7.10.10.485
2vgoAD5Aurora kinase B-A2.7.11.10.485
2henADPEphrin type-B receptor 22.7.10.10.484
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.484
3c4zADPRhodopsin kinase/0.484
3qc9ADPRhodopsin kinase/0.484
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.482
4hvh19RTyrosine-protein kinase JAK32.7.10.20.482
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.482
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.481
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.480
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.480
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.479
2hog710Serine/threonine-protein kinase Chk12.7.11.10.479
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.479
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.479
1mqbANPEphrin type-A receptor 22.7.10.10.478
2cchATPCyclin-dependent kinase 22.7.11.220.478
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.478
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.478
2wqeADPAurora kinase A2.7.11.10.478
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.477
4eooATPCyclin-dependent kinase 22.7.11.220.477
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.477
4hvg19QTyrosine-protein kinase JAK32.7.10.20.477
4j95ACPFibroblast growth factor receptor 2/0.477
5av2KMPDeath-associated protein kinase 12.7.11.10.477
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.475
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.473
5dt3ATPAurora kinase A2.7.11.10.473
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.472
3c4wATPRhodopsin kinase/0.472
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.470
2w1fL0FAurora kinase A2.7.11.10.470
4gmy0X5Tyrosine-protein kinase JAK2/0.470
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.469
3pxkPXKFocal adhesion kinase 12.7.10.20.469
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.469
4fob0USALK tyrosine kinase receptor2.7.10.10.469
4i4e1BQFocal adhesion kinase 12.7.10.20.469
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.469
5dnrATPAurora kinase A2.7.11.10.469
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.468
4qmlANPSerine/threonine-protein kinase 242.7.11.10.468
3c50ADPRhodopsin kinase/0.467
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.467
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.467
1aq1STUCyclin-dependent kinase 22.7.11.220.466
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.466
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.466
4xlvACPInsulin receptor2.7.10.10.466
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.465
1jklANPDeath-associated protein kinase 12.7.11.10.464
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.464
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.464
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.463
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.463
4bbe3O4Tyrosine-protein kinase JAK2/0.463
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.463
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.463
1yvj4STTyrosine-protein kinase JAK32.7.10.20.462
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.462
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
1ir3ANPInsulin receptor2.7.10.10.461
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.461
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.461
1fvv107Cyclin-dependent kinase 22.7.11.220.460
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.460
2ckeIQUDeath-associated protein kinase 2/0.460
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.460
2x9fX9FEphrin type-B receptor 42.7.10.10.460
5av3KMPDeath-associated protein kinase 12.7.11.10.460
1pkdUCNCyclin-dependent kinase 22.7.11.220.459
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.459
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.459
2xvdAS6Ephrin type-B receptor 42.7.10.10.459
4e4m0NHTyrosine-protein kinase JAK2/0.459
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.459
4hvi19STyrosine-protein kinase JAK32.7.10.20.459
5dn3ATPAurora kinase A2.7.11.10.459
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.458
2i40BLZCyclin-dependent kinase 22.7.11.220.458
2qoqANPEphrin type-A receptor 32.7.10.10.458
2w05FRTCyclin-dependent kinase 22.7.11.220.458
4b99R4LMitogen-activated protein kinase 72.7.11.240.458
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.457
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.457
4ccbOFGALK tyrosine kinase receptor2.7.10.10.457
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.457
2qo9ANPEphrin type-A receptor 32.7.10.10.456
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.456
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2izsBRQCasein kinase I isoform gamma-32.7.11.10.455
3bqr4RBDeath-associated protein kinase 3/0.455
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.455
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.454
4nka2K7Fibroblast growth factor receptor 1/0.454
4nks2M2Fibroblast growth factor receptor 1/0.454
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.454
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.453
2iw84SPCyclin-dependent kinase 22.7.11.220.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.453
5auvAGIDeath-associated protein kinase 12.7.11.10.453
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.452
2x1nX1NCyclin-dependent kinase 22.7.11.220.452
3qyw6PBMitogen-activated protein kinase 12.7.11.240.452
4jqeANPCasein kinase II subunit alpha2.7.11.10.452
1bygSTUTyrosine-protein kinase CSK/0.451
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.451
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.451
5eg3ACPFibroblast growth factor receptor 2/0.451
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.450
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.450
2p33J07Mitogen-activated protein kinase 102.7.11.240.450
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.450
3my5RFZCyclin-dependent kinase 22.7.11.220.450
3oroAGSSerine/threonine protein kinase/0.450
4dgnLU2Casein kinase II subunit alpha2.7.11.10.450
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.450
2acxANPG protein-coupled receptor kinase 62.7.11.160.449
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
2uzdC85Cyclin-dependent kinase 22.7.11.220.449
2x6dX6DAurora kinase A2.7.11.10.449
3a62STURibosomal protein S6 kinase beta-12.7.11.10.449
3a7jADPSerine/threonine-protein kinase 242.7.11.10.449
3gu6ADPDeath-associated protein kinase 12.7.11.10.449
3l8p0CEAngiopoietin-1 receptor2.7.10.10.449
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.449
4l9i8PRRhodopsin kinase/0.449
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.449
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
3js2VM1Fibroblast growth factor receptor 1/0.448
3lltANPProtein serine/threonine kinase-1/0.448
3oriAGSSerine/threonine protein kinase/0.448
3ortAGSSerine/threonine protein kinase/0.448
3ztxZTXAurora kinase B-A2.7.11.10.448
4bcmT7ZCyclin-dependent kinase 22.7.11.220.447
4cd0AWJALK tyrosine kinase receptor2.7.10.10.447
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.447
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.447
4jrnANPRhoptry kinase family protein/0.447
5auxKMPDeath-associated protein kinase 12.7.11.10.447
1ol7ADPAurora kinase A2.7.11.10.446
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.446
2vd5BI8Myotonin-protein kinase2.7.11.10.446
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.446
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.446
3lctADPALK tyrosine kinase receptor2.7.10.10.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4j97ACPFibroblast growth factor receptor 2/0.446
4jboWPHAurora kinase A2.7.11.10.446
4y93746Tyrosine-protein kinase/0.446
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3zxtACPDeath-associated protein kinase 12.7.11.10.445
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.445
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.445
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.445
5auwQUEDeath-associated protein kinase 12.7.11.10.445
2itqITQEpidermal growth factor receptor2.7.10.10.444
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.444
3a7hATPSerine/threonine-protein kinase 242.7.11.10.444
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3clyACPFibroblast growth factor receptor 2/0.444
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.444
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.444
4bcqTJFCyclin-dependent kinase 22.7.11.220.444
4btjADPTau-tubulin kinase 12.7.11.10.444
4c3pACPAurora kinase A2.7.11.10.444
2qo7ANPEphrin type-A receptor 32.7.10.10.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.443
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.443
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fx360KCyclin-dependent kinase 22.7.11.220.443
4g1wG1WMitogen-activated protein kinase 82.7.11.240.443
5auzGENDeath-associated protein kinase 12.7.11.10.443
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.442
3igoANPCalmodulin-domain protein kinase 1, putative/0.442
3wowANPCasein kinase II subunit alpha2.7.11.10.442
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.441
3bu5ATPInsulin receptor2.7.10.10.441
4c4jX21Dual specificity protein kinase TTK2.7.12.10.441
4deeADPAurora kinase A2.7.11.10.441
4f630S7Fibroblast growth factor receptor 1/0.441
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4yuqKS1Calmodulin-like domain protein kinase/0.441
1finATPCyclin-dependent kinase 22.7.11.220.440
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4btkDTQTau-tubulin kinase 12.7.11.10.440
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.440
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.440