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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ez30S0Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ez30S0Cyclin-dependent kinase 22.7.11.221.000
3qtxX43Cyclin-dependent kinase 22.7.11.220.666
3qtqX35Cyclin-dependent kinase 22.7.11.220.636
3rpv26ZCyclin-dependent kinase 22.7.11.220.623
3rk909ZCyclin-dependent kinase 22.7.11.220.619
2btrU73Cyclin-dependent kinase 22.7.11.220.617
1ke6LS2Cyclin-dependent kinase 22.7.11.220.616
3rm719ZCyclin-dependent kinase 22.7.11.220.616
3sqq99ZCyclin-dependent kinase 22.7.11.220.612
4fki09KCyclin-dependent kinase 22.7.11.220.611
4fkpLS5Cyclin-dependent kinase 22.7.11.220.607
1gih1PUCyclin-dependent kinase 22.7.11.220.598
2b52D42Cyclin-dependent kinase 22.7.11.220.598
3r1qX75Cyclin-dependent kinase 22.7.11.220.597
4fkq42KCyclin-dependent kinase 22.7.11.220.597
2r64740Cyclin-dependent kinase 22.7.11.220.596
4ek610KCyclin-dependent kinase 22.7.11.220.595
1ke5LS1Cyclin-dependent kinase 22.7.11.220.594
1p2a5BNCyclin-dependent kinase 22.7.11.220.594
3qqkX02Cyclin-dependent kinase 22.7.11.220.592
3qzgX67Cyclin-dependent kinase 22.7.11.220.591
3r6xX84Cyclin-dependent kinase 22.7.11.220.591
4fkt48KCyclin-dependent kinase 22.7.11.220.591
2w06FRVCyclin-dependent kinase 22.7.11.220.590
3r73X87Cyclin-dependent kinase 22.7.11.220.590
1h0w207Cyclin-dependent kinase 22.7.11.220.587
3s0o50ZCyclin-dependent kinase 22.7.11.220.587
4lyn1YGCyclin-dependent kinase 22.7.11.220.586
1h1r6CPCyclin-dependent kinase 22.7.11.220.585
2xnbY8LCyclin-dependent kinase 22.7.11.220.585
4fko20KCyclin-dependent kinase 22.7.11.220.584
1ke8LS4Cyclin-dependent kinase 22.7.11.220.583
1v1k3FPCyclin-dependent kinase 22.7.11.220.583
3qtuX44Cyclin-dependent kinase 22.7.11.220.583
3ral04ZCyclin-dependent kinase 22.7.11.220.582
3rni21ZCyclin-dependent kinase 22.7.11.220.582
3unk0BYCyclin-dependent kinase 22.7.11.220.582
4fkw62KCyclin-dependent kinase 22.7.11.220.582
3r9hZ67Cyclin-dependent kinase 22.7.11.220.581
4fkg4CKCyclin-dependent kinase 22.7.11.220.580
1ke7LS3Cyclin-dependent kinase 22.7.11.220.579
1pxmCK5Cyclin-dependent kinase 22.7.11.220.577
3sw418KCyclin-dependent kinase 22.7.11.220.577
3roy22ZCyclin-dependent kinase 22.7.11.220.576
1h1s4SPCyclin-dependent kinase 22.7.11.220.575
4acm7YGCyclin-dependent kinase 22.7.11.220.575
4ek816KCyclin-dependent kinase 22.7.11.220.575
3s2pPMUCyclin-dependent kinase 22.7.11.220.574
1oguST8Cyclin-dependent kinase 22.7.11.220.573
3r1sX73Cyclin-dependent kinase 22.7.11.220.573
3r9dX6BCyclin-dependent kinase 22.7.11.220.572
2w05FRTCyclin-dependent kinase 22.7.11.220.571
2xmyCDKCyclin-dependent kinase 22.7.11.220.571
3qwjX6ACyclin-dependent kinase 22.7.11.220.571
3qxoX65Cyclin-dependent kinase 22.7.11.220.571
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.570
4bgh3I6Cyclin-dependent kinase 22.7.11.220.570
3qu0X40Cyclin-dependent kinase 22.7.11.220.569
4fkr45KCyclin-dependent kinase 22.7.11.220.568
1di8DTQCyclin-dependent kinase 22.7.11.220.567
1ke9LS5Cyclin-dependent kinase 22.7.11.220.566
3qtzX42Cyclin-dependent kinase 22.7.11.220.566
3r8vZ62Cyclin-dependent kinase 22.7.11.220.566
3rk708ZCyclin-dependent kinase 22.7.11.220.566
3rjc06ZCyclin-dependent kinase 22.7.11.220.565
3rk507ZCyclin-dependent kinase 22.7.11.220.565
3rmf20ZCyclin-dependent kinase 22.7.11.220.565
2iw84SPCyclin-dependent kinase 22.7.11.220.564
2uzoC62Cyclin-dependent kinase 22.7.11.220.564
2a0cCK9Cyclin-dependent kinase 22.7.11.220.562
2btsU32Cyclin-dependent kinase 22.7.11.220.562
3s1h56ZCyclin-dependent kinase 22.7.11.220.562
3qqfX07Cyclin-dependent kinase 22.7.11.220.561
3raiX85Cyclin-dependent kinase 22.7.11.220.560
2r3lSCWCyclin-dependent kinase 22.7.11.220.559
1urwI1PCyclin-dependent kinase 22.7.11.220.558
2r3iSCFCyclin-dependent kinase 22.7.11.220.557
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.557
3sw719KCyclin-dependent kinase 22.7.11.220.557
3py0SU9Cyclin-dependent kinase 22.7.11.220.555
2w1hL0FCyclin-dependent kinase 22.7.11.220.554
1w0xOLOCyclin-dependent kinase 22.7.11.220.553
3ddqRRCCyclin-dependent kinase 22.7.11.220.553
3r28XA0Cyclin-dependent kinase 22.7.11.220.553
4fkj11KCyclin-dependent kinase 22.7.11.220.553
1g5sI17Cyclin-dependent kinase 22.7.11.220.552
2uznC96Cyclin-dependent kinase 22.7.11.220.552
1vyzN5BCyclin-dependent kinase 22.7.11.220.551
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.551
3qx2X63Cyclin-dependent kinase 22.7.11.220.551
3r8lZ30Cyclin-dependent kinase 22.7.11.220.551
3unj0BXCyclin-dependent kinase 22.7.11.220.551
2iw94SPCyclin-dependent kinase 22.7.11.220.550
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.549
3r7eX88Cyclin-dependent kinase 22.7.11.220.547
1ckpPVBCyclin-dependent kinase 22.7.11.220.546
3ddpRC8Cyclin-dependent kinase 22.7.11.220.546
1e1xNW1Cyclin-dependent kinase 22.7.11.220.545
3qwkX62Cyclin-dependent kinase 22.7.11.220.545
1oi9N20Cyclin-dependent kinase 22.7.11.220.543
3iggEFQCyclin-dependent kinase 22.7.11.220.543
4eor4SPCyclin-dependent kinase 22.7.11.220.543
1pxkCK3Cyclin-dependent kinase 22.7.11.220.542
3r71X86Cyclin-dependent kinase 22.7.11.220.542
1dm2HMDCyclin-dependent kinase 22.7.11.220.541
1b39ATPCyclin-dependent kinase 22.7.11.220.539
1oiqHDUCyclin-dependent kinase 22.7.11.220.539
1w8cN69Cyclin-dependent kinase 22.7.11.220.539
2duv371Cyclin-dependent kinase 22.7.11.220.539
2b55D31Cyclin-dependent kinase 22.7.11.220.538
2c6o4SPCyclin-dependent kinase 22.7.11.220.538
3qzhX69Cyclin-dependent kinase 22.7.11.220.538
3r7vZ02Cyclin-dependent kinase 22.7.11.220.538
2vthLZ2Cyclin-dependent kinase 22.7.11.220.537
3lfnA27Cyclin-dependent kinase 22.7.11.220.537
3r8zZ63Cyclin-dependent kinase 22.7.11.220.537
1oitHDTCyclin-dependent kinase 22.7.11.220.536
2c6tDT5Cyclin-dependent kinase 22.7.11.220.536
3pj8404Cyclin-dependent kinase 22.7.11.220.536
3rpo24ZCyclin-dependent kinase 22.7.11.220.536
3rpy27ZCyclin-dependent kinase 22.7.11.220.536
1r78FMDCyclin-dependent kinase 22.7.11.220.535
1gii1PUCyclin-dependent kinase 22.7.11.220.534
3qqhX0ACyclin-dependent kinase 22.7.11.220.534
1h0vUN4Cyclin-dependent kinase 22.7.11.220.533
3qzfX66Cyclin-dependent kinase 22.7.11.220.533
3rm618ZCyclin-dependent kinase 22.7.11.220.533
1fvt106Cyclin-dependent kinase 22.7.11.220.532
2c6iDT1Cyclin-dependent kinase 22.7.11.220.532
1oiyN41Cyclin-dependent kinase 22.7.11.220.531
3qziX72Cyclin-dependent kinase 22.7.11.220.530
3r7yZ04Cyclin-dependent kinase 22.7.11.220.530
3r8uZ31Cyclin-dependent kinase 22.7.11.220.530
2r3p3SCCyclin-dependent kinase 22.7.11.220.529
3ezrEZRCyclin-dependent kinase 22.7.11.220.529
3fz1B98Cyclin-dependent kinase 22.7.11.220.529
1pxoCK7Cyclin-dependent kinase 22.7.11.220.528
3lfqA28Cyclin-dependent kinase 22.7.11.220.528
2bhhRYUCyclin-dependent kinase 22.7.11.220.527
3qruX19Cyclin-dependent kinase 22.7.11.220.527
1pxlCK4Cyclin-dependent kinase 22.7.11.220.526
2vv9IM9Cyclin-dependent kinase 22.7.11.220.525
1oirHDYCyclin-dependent kinase 22.7.11.220.523
1vyw292Cyclin-dependent kinase 22.7.11.220.523
3ql8X01Cyclin-dependent kinase 22.7.11.220.523
1gij2PUCyclin-dependent kinase 22.7.11.220.522
1oiuN76Cyclin-dependent kinase 22.7.11.220.522
4eok4SPCyclin-dependent kinase 22.7.11.220.522
1pyePM1Cyclin-dependent kinase 22.7.11.220.521
4eon1ROCyclin-dependent kinase 22.7.11.220.519
4kd11QKCyclin-dependent kinase 22.7.11.220.519
3r83Z14Cyclin-dependent kinase 22.7.11.220.518
3pxyJWSCyclin-dependent kinase 22.7.11.220.517
3uli1N3Cyclin-dependent kinase 22.7.11.220.517
2a4lRRCCyclin-dependent kinase 22.7.11.220.516
1e9hINRCyclin-dependent kinase 22.7.11.220.515
1ykr628Cyclin-dependent kinase 22.7.11.220.515
4fklCK2Cyclin-dependent kinase 22.7.11.220.512
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.511
2j9mPY8Cyclin-dependent kinase 22.7.11.220.511
2w17I19Cyclin-dependent kinase 22.7.11.220.509
4fx360KCyclin-dependent kinase 22.7.11.220.509
5aniES4Cyclin-dependent kinase 22.7.11.220.509
2r3r6SCCyclin-dependent kinase 22.7.11.220.507
3r7uX96Cyclin-dependent kinase 22.7.11.220.506
2wxvWXVCyclin-dependent kinase 22.7.11.220.505
4bcpT3CCyclin-dependent kinase 22.7.11.220.505
2r3gSC9Cyclin-dependent kinase 22.7.11.220.504
2wotZZGTGF-beta receptor type-12.7.11.300.503
1unlRRCCyclin-dependent-like kinase 52.7.11.10.502
2bheBRYCyclin-dependent kinase 22.7.11.220.501
3s00Z60Cyclin-dependent kinase 22.7.11.220.501
2wpa889Cyclin-dependent kinase 22.7.11.220.500
3ig7EFPCyclin-dependent kinase 22.7.11.220.500
3rkb12ZCyclin-dependent kinase 22.7.11.220.500
1aq1STUCyclin-dependent kinase 22.7.11.220.499
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.499
2vu3LZECyclin-dependent kinase 22.7.11.220.499
2b54D05Cyclin-dependent kinase 22.7.11.220.498
2r3kSCQCyclin-dependent kinase 22.7.11.220.497
2r3o2SCCyclin-dependent kinase 22.7.11.220.496
4eos1ROCyclin-dependent kinase 22.7.11.220.495
1h1q2A6Cyclin-dependent kinase 22.7.11.220.494
3r7iX9ICyclin-dependent kinase 22.7.11.220.494
3bhtMFRCyclin-dependent kinase 22.7.11.220.492
3rzb02ZCyclin-dependent kinase 22.7.11.220.492
4qmpDKISerine/threonine-protein kinase 242.7.11.10.492
2vtsLZCCyclin-dependent kinase 22.7.11.220.491
1pxpCK8Cyclin-dependent kinase 22.7.11.220.490
2c6mDT5Cyclin-dependent kinase 22.7.11.220.490
3qtrX36Cyclin-dependent kinase 22.7.11.220.490
2c69CT8Cyclin-dependent kinase 22.7.11.220.489
3ti1B49Cyclin-dependent kinase 22.7.11.220.488
4eoi1ROCyclin-dependent kinase 22.7.11.220.488
2exmZIPCyclin-dependent kinase 22.7.11.220.487
3dogNNNCyclin-dependent kinase 22.7.11.220.485
3rpr25ZCyclin-dependent kinase 22.7.11.220.485
2r3mSCXCyclin-dependent kinase 22.7.11.220.484
1h1pCMGCyclin-dependent kinase 22.7.11.220.483
3tnwF18Cyclin-dependent kinase 22.7.11.220.483
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.481
4fkv61KCyclin-dependent kinase 22.7.11.220.481
4eop1ROCyclin-dependent kinase 22.7.11.220.480
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.479
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.478
2c5yMTWCyclin-dependent kinase 22.7.11.220.477
3qqlX03Cyclin-dependent kinase 22.7.11.220.477
3r9oZ71Cyclin-dependent kinase 22.7.11.220.477
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.477
3r8pZ46Cyclin-dependent kinase 22.7.11.220.476
3rahO1ZCyclin-dependent kinase 22.7.11.220.476
2c4g514Cyclin-dependent kinase 22.7.11.220.475
2x1nX1NCyclin-dependent kinase 22.7.11.220.475
3ggfGVDSerine/threonine-protein kinase 26/0.475
4bcmT7ZCyclin-dependent kinase 22.7.11.220.474
2xikJ60Serine/threonine-protein kinase 252.7.11.10.473
2c5nCK8Cyclin-dependent kinase 22.7.11.220.472
4cfnJYMCyclin-dependent kinase 22.7.11.220.472
2r3fSC8Cyclin-dependent kinase 22.7.11.220.470
3qrtX14Cyclin-dependent kinase 22.7.11.220.470
4dgo0JWCasein kinase II subunit alpha2.7.11.10.470
3sheI85MAP kinase-activated protein kinase 32.7.11.10.469
3lfsA07Cyclin-dependent kinase 22.7.11.220.468
4nj32KDCyclin-dependent kinase 22.7.11.220.468
1pkdUCNCyclin-dependent kinase 22.7.11.220.466
2uzeC95Cyclin-dependent kinase 22.7.11.220.466
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.466
1gz8MBPCyclin-dependent kinase 22.7.11.220.465
1y8yCT7Cyclin-dependent kinase 22.7.11.220.465
2uzlC94Cyclin-dependent kinase 22.7.11.220.465
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.464
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.462
2eufLQQCyclin-dependent kinase 62.7.11.220.461
2wihP48Cyclin-dependent kinase 22.7.11.220.461
3wblPDYCyclin-dependent kinase 22.7.11.220.461
2cchATPCyclin-dependent kinase 22.7.11.220.460
3r9nZ68Cyclin-dependent kinase 22.7.11.220.460
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.460
2uzdC85Cyclin-dependent kinase 22.7.11.220.459
4bcnT9NCyclin-dependent kinase 22.7.11.220.459
4eomATPCyclin-dependent kinase 22.7.11.220.459
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.458
3gubGUBDeath-associated protein kinase 12.7.11.10.458
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.456
1m2rMNYCasein kinase II subunit alpha2.7.11.10.455
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.453
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.452
3tiz3TICyclin-dependent kinase 22.7.11.220.452
4eol1ROCyclin-dependent kinase 22.7.11.220.452
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.452
1e1vCMGCyclin-dependent kinase 22.7.11.220.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
2b53D23Cyclin-dependent kinase 22.7.11.220.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.450
1unhIXMCyclin-dependent-like kinase 52.7.11.10.448
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.448
3qqgX06Cyclin-dependent kinase 22.7.11.220.448
4i22IREEpidermal growth factor receptor2.7.10.10.448
1v0pPVBCell division control protein 2 homolog2.7.11.220.447
1xjdSTUProtein kinase C theta type2.7.11.130.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
1qmzATPCyclin-dependent kinase 22.7.11.220.446
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.446
1py5PY1TGF-beta receptor type-12.7.11.300.445
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.445
3qx4X4BCyclin-dependent kinase 22.7.11.220.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
1vjy460TGF-beta receptor type-12.7.11.300.444
2b7aIZATyrosine-protein kinase JAK2/0.444
3mtlFEFCyclin-dependent kinase 162.7.11.220.444
3qtwX3ACyclin-dependent kinase 22.7.11.220.444
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.444
5dr6SKEAurora kinase A2.7.11.10.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
2pvnP63Casein kinase II subunit alpha2.7.11.10.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.441
1eh4IC1Casein kinase I homolog 12.7.11.10.440
1finATPCyclin-dependent kinase 22.7.11.220.440
2dwbANPAurora kinase A2.7.11.10.440
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.440
3nup3NUCyclin-dependent kinase 62.7.11.220.440
5drdATPAurora kinase A2.7.11.10.440