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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3r73X87Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3r73X87Cyclin-dependent kinase 22.7.11.221.000
3qqfX07Cyclin-dependent kinase 22.7.11.220.712
3rpo24ZCyclin-dependent kinase 22.7.11.220.670
3r71X86Cyclin-dependent kinase 22.7.11.220.669
3qqkX02Cyclin-dependent kinase 22.7.11.220.668
1h0w207Cyclin-dependent kinase 22.7.11.220.651
3qzgX67Cyclin-dependent kinase 22.7.11.220.628
3rk708ZCyclin-dependent kinase 22.7.11.220.622
3r7yZ04Cyclin-dependent kinase 22.7.11.220.621
3rm719ZCyclin-dependent kinase 22.7.11.220.614
3rk909ZCyclin-dependent kinase 22.7.11.220.613
3qtuX44Cyclin-dependent kinase 22.7.11.220.606
3r1yX76Cyclin-dependent kinase 22.7.11.220.606
3s0o50ZCyclin-dependent kinase 22.7.11.220.605
3qxoX65Cyclin-dependent kinase 22.7.11.220.601
2btrU73Cyclin-dependent kinase 22.7.11.220.600
3qzhX69Cyclin-dependent kinase 22.7.11.220.599
3r7eX88Cyclin-dependent kinase 22.7.11.220.599
3r1sX73Cyclin-dependent kinase 22.7.11.220.594
3r6xX84Cyclin-dependent kinase 22.7.11.220.594
3rk507ZCyclin-dependent kinase 22.7.11.220.587
4ek610KCyclin-dependent kinase 22.7.11.220.584
3qwjX6ACyclin-dependent kinase 22.7.11.220.582
3iggEFQCyclin-dependent kinase 22.7.11.220.577
3roy22ZCyclin-dependent kinase 22.7.11.220.577
1ke6LS2Cyclin-dependent kinase 22.7.11.220.575
2c6iDT1Cyclin-dependent kinase 22.7.11.220.575
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.574
1ykr628Cyclin-dependent kinase 22.7.11.220.573
3sqq99ZCyclin-dependent kinase 22.7.11.220.573
1vyzN5BCyclin-dependent kinase 22.7.11.220.572
4fkq42KCyclin-dependent kinase 22.7.11.220.572
3ql8X01Cyclin-dependent kinase 22.7.11.220.571
4fkg4CKCyclin-dependent kinase 22.7.11.220.569
3qx2X63Cyclin-dependent kinase 22.7.11.220.566
2c6o4SPCyclin-dependent kinase 22.7.11.220.565
3qrtX14Cyclin-dependent kinase 22.7.11.220.565
3qruX19Cyclin-dependent kinase 22.7.11.220.565
3rni21ZCyclin-dependent kinase 22.7.11.220.565
3s2pPMUCyclin-dependent kinase 22.7.11.220.565
4eor4SPCyclin-dependent kinase 22.7.11.220.564
2r64740Cyclin-dependent kinase 22.7.11.220.563
4fkr45KCyclin-dependent kinase 22.7.11.220.562
1pxmCK5Cyclin-dependent kinase 22.7.11.220.560
1vyw292Cyclin-dependent kinase 22.7.11.220.560
3raiX85Cyclin-dependent kinase 22.7.11.220.560
3ezrEZRCyclin-dependent kinase 22.7.11.220.559
3rm618ZCyclin-dependent kinase 22.7.11.220.559
2c6mDT5Cyclin-dependent kinase 22.7.11.220.558
3rpv26ZCyclin-dependent kinase 22.7.11.220.558
4ez30S0Cyclin-dependent kinase 22.7.11.220.557
1v1k3FPCyclin-dependent kinase 22.7.11.220.556
2uzoC62Cyclin-dependent kinase 22.7.11.220.556
3ral04ZCyclin-dependent kinase 22.7.11.220.556
3ddpRC8Cyclin-dependent kinase 22.7.11.220.555
1w8cN69Cyclin-dependent kinase 22.7.11.220.553
3r7vZ02Cyclin-dependent kinase 22.7.11.220.553
3r9hZ67Cyclin-dependent kinase 22.7.11.220.551
3qtxX43Cyclin-dependent kinase 22.7.11.220.550
3rahO1ZCyclin-dependent kinase 22.7.11.220.550
3qu0X40Cyclin-dependent kinase 22.7.11.220.548
2bhhRYUCyclin-dependent kinase 22.7.11.220.547
1e1xNW1Cyclin-dependent kinase 22.7.11.220.545
1ke7LS3Cyclin-dependent kinase 22.7.11.220.545
3qx4X4BCyclin-dependent kinase 22.7.11.220.545
3rak03ZCyclin-dependent kinase 22.7.11.220.544
2a0cCK9Cyclin-dependent kinase 22.7.11.220.543
2w06FRVCyclin-dependent kinase 22.7.11.220.543
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.542
3r1qX75Cyclin-dependent kinase 22.7.11.220.542
3rmf20ZCyclin-dependent kinase 22.7.11.220.541
1oguST8Cyclin-dependent kinase 22.7.11.220.538
1oitHDTCyclin-dependent kinase 22.7.11.220.538
3lfnA27Cyclin-dependent kinase 22.7.11.220.538
4kd11QKCyclin-dependent kinase 22.7.11.220.538
1b38ATPCyclin-dependent kinase 22.7.11.220.537
3r28XA0Cyclin-dependent kinase 22.7.11.220.536
4fki09KCyclin-dependent kinase 22.7.11.220.536
4lyn1YGCyclin-dependent kinase 22.7.11.220.536
1h1s4SPCyclin-dependent kinase 22.7.11.220.534
3r8uZ31Cyclin-dependent kinase 22.7.11.220.534
1ke5LS1Cyclin-dependent kinase 22.7.11.220.533
4bgh3I6Cyclin-dependent kinase 22.7.11.220.533
1w0xOLOCyclin-dependent kinase 22.7.11.220.532
3ddqRRCCyclin-dependent kinase 22.7.11.220.532
1g5sI17Cyclin-dependent kinase 22.7.11.220.530
1p2a5BNCyclin-dependent kinase 22.7.11.220.530
2r3iSCFCyclin-dependent kinase 22.7.11.220.530
3s1h56ZCyclin-dependent kinase 22.7.11.220.530
1pxlCK4Cyclin-dependent kinase 22.7.11.220.528
2btsU32Cyclin-dependent kinase 22.7.11.220.528
1gih1PUCyclin-dependent kinase 22.7.11.220.527
3r7uX96Cyclin-dependent kinase 22.7.11.220.527
3r9nZ68Cyclin-dependent kinase 22.7.11.220.527
3sw418KCyclin-dependent kinase 22.7.11.220.527
3qtzX42Cyclin-dependent kinase 22.7.11.220.526
4fkj11KCyclin-dependent kinase 22.7.11.220.526
4fkt48KCyclin-dependent kinase 22.7.11.220.526
3r7iX9ICyclin-dependent kinase 22.7.11.220.524
1ckpPVBCyclin-dependent kinase 22.7.11.220.523
2r3r6SCCyclin-dependent kinase 22.7.11.220.523
2r3p3SCCyclin-dependent kinase 22.7.11.220.522
3pj8404Cyclin-dependent kinase 22.7.11.220.522
1ke9LS5Cyclin-dependent kinase 22.7.11.220.521
4ek816KCyclin-dependent kinase 22.7.11.220.521
2vthLZ2Cyclin-dependent kinase 22.7.11.220.519
3rjc06ZCyclin-dependent kinase 22.7.11.220.519
5aniES4Cyclin-dependent kinase 22.7.11.220.519
1oi9N20Cyclin-dependent kinase 22.7.11.220.518
3ig7EFPCyclin-dependent kinase 22.7.11.220.518
2exmZIPCyclin-dependent kinase 22.7.11.220.517
2r3o2SCCyclin-dependent kinase 22.7.11.220.517
4acm7YGCyclin-dependent kinase 22.7.11.220.517
1e1vCMGCyclin-dependent kinase 22.7.11.220.516
2iw94SPCyclin-dependent kinase 22.7.11.220.516
3lfqA28Cyclin-dependent kinase 22.7.11.220.516
1gii1PUCyclin-dependent kinase 22.7.11.220.515
2c6lDT4Cyclin-dependent kinase 22.7.11.220.515
3r8pZ46Cyclin-dependent kinase 22.7.11.220.515
2fvdLIACyclin-dependent kinase 22.7.11.220.514
3qqlX03Cyclin-dependent kinase 22.7.11.220.514
4eol1ROCyclin-dependent kinase 22.7.11.220.514
4fkpLS5Cyclin-dependent kinase 22.7.11.220.514
2r3lSCWCyclin-dependent kinase 22.7.11.220.513
3ezvEZVCyclin-dependent kinase 22.7.11.220.513
3qwkX62Cyclin-dependent kinase 22.7.11.220.513
1oiqHDUCyclin-dependent kinase 22.7.11.220.511
2vtsLZCCyclin-dependent kinase 22.7.11.220.511
3r9dX6BCyclin-dependent kinase 22.7.11.220.511
4fks46KCyclin-dependent kinase 22.7.11.220.511
1urwI1PCyclin-dependent kinase 22.7.11.220.510
3qziX72Cyclin-dependent kinase 22.7.11.220.510
2c6kDT2Cyclin-dependent kinase 22.7.11.220.509
3fz1B98Cyclin-dependent kinase 22.7.11.220.509
1pxoCK7Cyclin-dependent kinase 22.7.11.220.508
2a4lRRCCyclin-dependent kinase 22.7.11.220.508
1h1r6CPCyclin-dependent kinase 22.7.11.220.507
2c4g514Cyclin-dependent kinase 22.7.11.220.507
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.507
3r83Z14Cyclin-dependent kinase 22.7.11.220.507
2iw84SPCyclin-dependent kinase 22.7.11.220.506
3rpy27ZCyclin-dependent kinase 22.7.11.220.506
2xmyCDKCyclin-dependent kinase 22.7.11.220.505
1oiyN41Cyclin-dependent kinase 22.7.11.220.504
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.504
4fkv61KCyclin-dependent kinase 22.7.11.220.504
1ke8LS4Cyclin-dependent kinase 22.7.11.220.502
2b52D42Cyclin-dependent kinase 22.7.11.220.502
2wihP48Cyclin-dependent kinase 22.7.11.220.502
3r8lZ30Cyclin-dependent kinase 22.7.11.220.502
1unlRRCCyclin-dependent-like kinase 52.7.11.10.501
2b55D31Cyclin-dependent kinase 22.7.11.220.501
1di8DTQCyclin-dependent kinase 22.7.11.220.500
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.500
3my5RFZCyclin-dependent kinase 22.7.11.220.500
3unk0BYCyclin-dependent kinase 22.7.11.220.500
1pxkCK3Cyclin-dependent kinase 22.7.11.220.499
1h0vUN4Cyclin-dependent kinase 22.7.11.220.498
1pyePM1Cyclin-dependent kinase 22.7.11.220.498
1y8yCT7Cyclin-dependent kinase 22.7.11.220.498
1y91CT9Cyclin-dependent kinase 22.7.11.220.498
2b54D05Cyclin-dependent kinase 22.7.11.220.498
2w1hL0FCyclin-dependent kinase 22.7.11.220.498
2wpa889Cyclin-dependent kinase 22.7.11.220.498
3qtqX35Cyclin-dependent kinase 22.7.11.220.498
4bcpT3CCyclin-dependent kinase 22.7.11.220.498
3sw719KCyclin-dependent kinase 22.7.11.220.497
3ti1B49Cyclin-dependent kinase 22.7.11.220.496
2w17I19Cyclin-dependent kinase 22.7.11.220.495
4eok4SPCyclin-dependent kinase 22.7.11.220.495
3wblPDYCyclin-dependent kinase 22.7.11.220.494
4fkw62KCyclin-dependent kinase 22.7.11.220.494
4fx360KCyclin-dependent kinase 22.7.11.220.494
1b39ATPCyclin-dependent kinase 22.7.11.220.493
2vv9IM9Cyclin-dependent kinase 22.7.11.220.493
4cfnJYMCyclin-dependent kinase 22.7.11.220.493
2c69CT8Cyclin-dependent kinase 22.7.11.220.491
3qzfX66Cyclin-dependent kinase 22.7.11.220.491
1fvv107Cyclin-dependent kinase 22.7.11.220.490
3unj0BXCyclin-dependent kinase 22.7.11.220.490
4fklCK2Cyclin-dependent kinase 22.7.11.220.490
1r78FMDCyclin-dependent kinase 22.7.11.220.489
2uznC96Cyclin-dependent kinase 22.7.11.220.489
4eomATPCyclin-dependent kinase 22.7.11.220.489
1fvt106Cyclin-dependent kinase 22.7.11.220.488
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.488
1oiuN76Cyclin-dependent kinase 22.7.11.220.485
1dm2HMDCyclin-dependent kinase 22.7.11.220.484
2duv371Cyclin-dependent kinase 22.7.11.220.484
2r3kSCQCyclin-dependent kinase 22.7.11.220.484
4fko20KCyclin-dependent kinase 22.7.11.220.484
4nj32KDCyclin-dependent kinase 22.7.11.220.484
1gij2PUCyclin-dependent kinase 22.7.11.220.482
1gz8MBPCyclin-dependent kinase 22.7.11.220.482
2j9mPY8Cyclin-dependent kinase 22.7.11.220.482
1finATPCyclin-dependent kinase 22.7.11.220.481
3py0SU9Cyclin-dependent kinase 22.7.11.220.481
3uli1N3Cyclin-dependent kinase 22.7.11.220.481
1oirHDYCyclin-dependent kinase 22.7.11.220.480
2r3mSCXCyclin-dependent kinase 22.7.11.220.479
3lfsA07Cyclin-dependent kinase 22.7.11.220.479
2wxvWXVCyclin-dependent kinase 22.7.11.220.478
4qmlANPSerine/threonine-protein kinase 242.7.11.10.478
2wotZZGTGF-beta receptor type-12.7.11.300.477
2uzdC85Cyclin-dependent kinase 22.7.11.220.475
2vttLZDCyclin-dependent kinase 22.7.11.220.475
1pxpCK8Cyclin-dependent kinase 22.7.11.220.474
2r3gSC9Cyclin-dependent kinase 22.7.11.220.474
3dogNNNCyclin-dependent kinase 22.7.11.220.472
4eon1ROCyclin-dependent kinase 22.7.11.220.472
4eos1ROCyclin-dependent kinase 22.7.11.220.472
3ggfGVDSerine/threonine-protein kinase 26/0.471
3qqhX0ACyclin-dependent kinase 22.7.11.220.471
3s00Z60Cyclin-dependent kinase 22.7.11.220.471
1pkdUCNCyclin-dependent kinase 22.7.11.220.470
2i40BLZCyclin-dependent kinase 22.7.11.220.470
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.469
1hckATPCyclin-dependent kinase 22.7.11.220.467
3r9oZ71Cyclin-dependent kinase 22.7.11.220.467
1h1pCMGCyclin-dependent kinase 22.7.11.220.466
3qtwX3ACyclin-dependent kinase 22.7.11.220.466
3rpr25ZCyclin-dependent kinase 22.7.11.220.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
2x1nX1NCyclin-dependent kinase 22.7.11.220.464
4qmpDKISerine/threonine-protein kinase 242.7.11.10.464
1h1q2A6Cyclin-dependent kinase 22.7.11.220.463
3tiz3TICyclin-dependent kinase 22.7.11.220.461
2c5nCK8Cyclin-dependent kinase 22.7.11.220.460
3pxyJWSCyclin-dependent kinase 22.7.11.220.460
2r3fSC8Cyclin-dependent kinase 22.7.11.220.458
3r8zZ63Cyclin-dependent kinase 22.7.11.220.458
3sheI85MAP kinase-activated protein kinase 32.7.11.10.457
4bcnT9NCyclin-dependent kinase 22.7.11.220.457
4eop1ROCyclin-dependent kinase 22.7.11.220.456
2cchATPCyclin-dependent kinase 22.7.11.220.455
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3qtsX46Cyclin-dependent kinase 22.7.11.220.455
1e9hINRCyclin-dependent kinase 22.7.11.220.454
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.454
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
2uzlC94Cyclin-dependent kinase 22.7.11.220.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.453
2b53D23Cyclin-dependent kinase 22.7.11.220.452
4eoi1ROCyclin-dependent kinase 22.7.11.220.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
2r3q5SCCyclin-dependent kinase 22.7.11.220.450
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.450
2c6tDT5Cyclin-dependent kinase 22.7.11.220.449
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.449
3rzb02ZCyclin-dependent kinase 22.7.11.220.449
1gy3ATPCyclin-dependent kinase 22.7.11.220.447
3t8oATPRhodopsin kinase/0.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.447
4i3zADPCyclin-dependent kinase 22.7.11.220.447
3qtrX36Cyclin-dependent kinase 22.7.11.220.446
4fob0USALK tyrosine kinase receptor2.7.10.10.446
5dr6SKEAurora kinase A2.7.11.10.445
2xikJ60Serine/threonine-protein kinase 252.7.11.10.444
2c68CT6Cyclin-dependent kinase 22.7.11.220.443
4bcoT6QCyclin-dependent kinase 22.7.11.220.442
3a7jADPSerine/threonine-protein kinase 242.7.11.10.441
3c4xATPRhodopsin kinase/0.441
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.441
4btjATPTau-tubulin kinase 12.7.11.10.441
1v0pPVBCell division control protein 2 homolog2.7.11.220.440
2bkzSBCCyclin-dependent kinase 22.7.11.220.440