sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qkd | HI0 | Bcl-2-like protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3qkd | HI0 | Bcl-2-like protein 1 | / | 1.000 | |
| 2yxj | N3C | Bcl-2-like protein 1 | / | 0.690 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.540 | |
| 1ysi | N3B | Bcl-2-like protein 1 | / | 0.539 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.525 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.504 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.504 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.504 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 3cse | N22 | Uncharacterized protein | / | 0.499 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.493 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.491 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.488 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3qly | 55V | Uncharacterized protein | / | 0.487 | |
| 2o2m | LI0 | Bcl-2-like protein 1 | / | 0.486 | |
| 3eek | 53S | Uncharacterized protein | / | 0.486 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.486 | |
| 3ghh | 2NF | CD38 molecule | / | 0.485 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.484 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.484 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.483 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.482 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.482 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.482 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.481 | |
| 3up0 | D7S | aceDAF-12 | / | 0.481 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.480 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.480 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.480 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.479 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.477 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.477 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.477 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.477 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.476 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.476 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.475 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.475 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.474 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.474 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.474 | |
| 1fkw | PUR | Adenosine deaminase | 3.5.4.4 | 0.473 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.473 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.473 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.472 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 3inq | X0J | Bcl-2-like protein 1 | / | 0.472 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.472 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.472 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.471 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.471 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.470 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.470 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.470 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.470 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.470 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.469 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3eel | 53T | Uncharacterized protein | / | 0.469 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.469 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.469 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.469 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.468 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.468 | |
| 2qhx | FE1 | Pteridine reductase 1 | 1.5.1.33 | 0.468 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.468 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.468 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2yiu | SMA | Cytochrome b | / | 0.467 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.467 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.467 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.467 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.466 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.466 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.466 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.466 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.466 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.466 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.465 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.465 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.465 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3v1u | HXC | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.465 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.465 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.465 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.465 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.465 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.464 | |
| 2jdv | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.464 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.464 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.464 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.464 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.463 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.463 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.463 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.463 | |
| 3eej | 53R | Uncharacterized protein | / | 0.463 | |
| 2aax | PDN | Mineralocorticoid receptor | / | 0.462 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.462 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.462 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.462 | |
| 3wzn | BTN | Streptavidin | / | 0.462 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.462 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.462 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.462 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.461 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.461 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.461 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.461 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.461 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.460 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.460 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.460 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.460 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.460 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.460 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 3a8i | C2F | Aminomethyltransferase | 2.1.2.10 | 0.459 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.459 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.458 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.458 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.458 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.458 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.458 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.458 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2ada | HPR | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.457 | |
| 4v26 | TF3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.457 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.456 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.456 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.456 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.456 | |
| 4l8u | 9AZ | Serum albumin | / | 0.456 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 5jad | FB2 | Platelet-activating factor acetylhydrolase | 3.1.1.47 | 0.456 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.455 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.455 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.455 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.455 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.455 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.455 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.455 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.455 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.454 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.454 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.454 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.454 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.454 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.454 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3zra | ORB | Progesterone receptor | / | 0.454 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.454 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.454 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.454 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.454 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.453 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.453 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2cul | FAD | GidA-related protein | / | 0.453 | |
| 2xvw | 9NR | Serum albumin | / | 0.453 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4iae | 1DX | Alr2278 protein | / | 0.453 | |
| 4iqq | D16 | Thymidylate synthase | / | 0.453 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.453 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.453 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.453 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.452 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.452 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.452 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.452 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.452 | |
| 3lla | ACP | Myosin heavy chain kinase A | 2.7.11.7 | 0.452 | |
| 3mb6 | 01I | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.452 | |
| 4bhw | 01K | Histone acetyltransferase p300 | / | 0.452 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 4nbb | 9CA | Terminal oxygenase component of carbazole | / | 0.452 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.451 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3aba | FLI | Cytochrome P450 | / | 0.451 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.451 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.451 | |
| 3rme | RME | Acidic mammalian chitinase | 3.2.1.14 | 0.451 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.451 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.451 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.451 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1syn | F89 | Thymidylate synthase | / | 0.450 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.450 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.450 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.450 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.450 | |
| 4ofu | DHT | Androgen receptor | / | 0.450 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.450 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.450 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.450 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.449 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.449 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4pv5 | CBW | Lactoylglutathione lyase | 4.4.1.5 | 0.449 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.448 | |
| 3dmh | SAM | Probable ribosomal RNA small subunit methyltransferase | / | 0.448 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.448 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.448 | |
| 3pd5 | TSB | Threonine--tRNA ligase | 6.1.1.3 | 0.448 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3seq | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.448 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4rw6 | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.448 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.448 | |
| 5jr3 | 4MU | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.448 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.447 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.447 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.447 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.447 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.447 | |
| 4b6l | 9ZP | Serine/threonine-protein kinase PLK3 | 2.7.11.21 | 0.447 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.447 | |
| 4iah | 1DX | Alr2278 protein | / | 0.447 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.446 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.446 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.446 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 3h18 | PMS | Esterase/lipase | / | 0.446 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.446 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3vw8 | DF6 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.446 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.446 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.446 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.445 | |
| 2b5j | 3AC | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 2bu7 | TF3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.445 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.445 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.445 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.445 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.445 | |
| 3up3 | XCA | aceDAF-12 | / | 0.445 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.445 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.445 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.445 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 4pd6 | URI | Nucleoside permease | / | 0.445 | |
| 5jr3 | SAH | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.445 | |
| 1e3k | R18 | Progesterone receptor | / | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.444 | |
| 2be2 | R22 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.444 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2qjy | SMA | Cytochrome b | / | 0.444 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.444 | |
| 2xvv | 9DN | Serum albumin | / | 0.444 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4c3s | NAD | Aldehyde Dehydrogenase | / | 0.444 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.444 | |
| 4l4x | NDP | AmphI | / | 0.444 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.444 | |
| 1err | RAL | Estrogen receptor | / | 0.443 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.443 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.443 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.443 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1rzy | 5AS | Histidine triad nucleotide-binding protein 1 | 3 | 0.443 | |
| 2c9e | PID | Peridinin-chlorophyll a protein, high-salt form | / | 0.443 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.443 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.443 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.443 | |
| 3c6u | M22 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3lm4 | HPX | Catechol 2,3-dioxygenase | / | 0.443 | |
| 3pn1 | IVH | DNA ligase | / | 0.443 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.443 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4rr9 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.443 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.442 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.442 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.442 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.442 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2ynh | EUR | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.442 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3eem | 53V | Uncharacterized protein | / | 0.442 | |
| 3gan | SVR | Protein RDM1 | / | 0.442 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.442 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.442 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.442 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1ppj | ANY | Cytochrome b | / | 0.441 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.441 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.441 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.441 | |
| 2bxq | IMN | Serum albumin | / | 0.441 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.441 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2zcq | B65 | Dehydrosqualene synthase | / | 0.441 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.441 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.441 | |
| 3wiz | LC6 | Bcl-2-like protein 1 | / | 0.441 | |
| 3zqt | TES | Androgen receptor | / | 0.441 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.441 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.440 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.440 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.440 | |
| 1l0l | FMX | Cytochrome b | / | 0.440 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1s1v | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1typ | NAP | Trypanothione reductase | 1.8.1.12 | 0.440 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.440 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2kce | D16 | Thymidylate synthase | / | 0.440 | |
| 2w8y | NDR | Progesterone receptor | / | 0.440 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.440 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3ov4 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.440 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.440 | |
| 5l7d | CLR | Smoothened homolog | / | 0.440 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.440 |