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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.11.000
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.738
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.654
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.615
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.614
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.579
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.565
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.565
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.560
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.557
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.555
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.551
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.547
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.545
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.543
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.542
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.540
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.540
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.539
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.539
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.539
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.533
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.533
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.532
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.528
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.527
3c4xATPRhodopsin kinase/0.525
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.522
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.521
2hog710Serine/threonine-protein kinase Chk12.7.11.10.521
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.521
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.521
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.520
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.519
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.518
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.518
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.518
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.517
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.515
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.513
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.512
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.511
3t8oATPRhodopsin kinase/0.511
3gubGUBDeath-associated protein kinase 12.7.11.10.510
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.509
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.509
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.507
3a7hATPSerine/threonine-protein kinase 242.7.11.10.506
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.505
2j0lANPFocal adhesion kinase 12.7.10.20.504
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.503
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.503
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.503
4l9i8PRRhodopsin kinase/0.503
5auvAGIDeath-associated protein kinase 12.7.11.10.503
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.502
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.502
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.502
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.501
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.501
3c4zADPRhodopsin kinase/0.501
5auwQUEDeath-associated protein kinase 12.7.11.10.500
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.499
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.499
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.498
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.498
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.498
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.498
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.497
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.497
2j0m4STFocal adhesion kinase 12.7.10.20.496
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.494
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.494
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.494
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.493
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.492
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.492
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.491
2ijmATPFocal adhesion kinase 12.7.10.20.490
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.490
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.490
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.489
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.489
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.488
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.487
3gu6ADPDeath-associated protein kinase 12.7.11.10.487
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.486
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.486
4gmy0X5Tyrosine-protein kinase JAK2/0.486
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.485
2ijmADPFocal adhesion kinase 12.7.10.20.484
3c4wATPRhodopsin kinase/0.484
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.484
4fob0USALK tyrosine kinase receptor2.7.10.10.483
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.482
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.482
1bygSTUTyrosine-protein kinase CSK/0.481
5av4GENDeath-associated protein kinase 12.7.11.10.481
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.480
4ysjADPCalmodulin-like domain protein kinase/0.480
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.479
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.479
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.479
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.478
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.478
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.478
4jia1K3Tyrosine-protein kinase JAK2/0.478
5av2KMPDeath-associated protein kinase 12.7.11.10.478
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.477
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.476
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.476
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.474
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.473
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.473
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.472
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.471
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.471
4qmlANPSerine/threonine-protein kinase 242.7.11.10.471
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.470
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.470
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.470
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.469
1fvv107Cyclin-dependent kinase 22.7.11.220.468
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.468
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.468
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.468
4fv9E71Mitogen-activated protein kinase 12.7.11.240.468
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.467
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.467
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.467
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.467
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.467
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.467
4fv6E57Mitogen-activated protein kinase 12.7.11.240.467
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.466
2xvdAS6Ephrin type-B receptor 42.7.10.10.466
3pxkPXKFocal adhesion kinase 12.7.10.20.466
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.465
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.465
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.465
3s2pPMUCyclin-dependent kinase 22.7.11.220.465
4dgnLU2Casein kinase II subunit alpha2.7.11.10.465
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.465
4k8aK8AFocal adhesion kinase 12.7.10.20.465
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.464
2pvnP63Casein kinase II subunit alpha2.7.11.10.464
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.464
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.464
2qo9ANPEphrin type-A receptor 32.7.10.10.463
3i60E86Mitogen-activated protein kinase 12.7.11.240.463
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.463
4j95ACPFibroblast growth factor receptor 2/0.463
1m2pHNACasein kinase II subunit alpha2.7.11.10.462
3dfcANPDeath-associated protein kinase 12.7.11.10.462
3lltANPProtein serine/threonine kinase-1/0.462
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.462
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.461
3at4CCKCasein kinase II subunit alpha2.7.11.10.461
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.461
4qmzB49Serine/threonine-protein kinase 242.7.11.10.461
3zh8C58Protein kinase C iota type2.7.11.130.460
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.460
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.460
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.460
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.459
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.459
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.458
2wxvWXVCyclin-dependent kinase 22.7.11.220.458
4qo9627Serine/threonine-protein kinase 242.7.11.10.458
2acxANPG protein-coupled receptor kinase 62.7.11.160.457
2izuP01Casein kinase I isoform gamma-32.7.11.10.457
3c50ADPRhodopsin kinase/0.457
3ggfGVDSerine/threonine-protein kinase 26/0.457
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.456
3bu5ATPInsulin receptor2.7.10.10.456
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.456
3ztxZTXAurora kinase B-A2.7.11.10.456
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
2etm7PYFocal adhesion kinase 12.7.10.20.455
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.455
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.455
1tvoFRZMitogen-activated protein kinase 12.7.11.240.454
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.454
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.454
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.454
4fv8E63Mitogen-activated protein kinase 12.7.11.240.454
1wvxBD4Death-associated protein kinase 12.7.11.10.453
2c4g514Cyclin-dependent kinase 22.7.11.220.453
2in6839Wee1-like protein kinase2.7.10.20.453
2qoqANPEphrin type-A receptor 32.7.10.10.452
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.452
2yaaATPDeath-associated protein kinase 2/0.452
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.451
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.451
3tnwF18Cyclin-dependent kinase 22.7.11.220.451
2vgoAD5Aurora kinase B-A2.7.11.10.450
2wpa889Cyclin-dependent kinase 22.7.11.220.450
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.450
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.450
4qnaX11Serine/threonine-protein kinase 242.7.11.10.450
3my5RFZCyclin-dependent kinase 22.7.11.220.449
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.449
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.449
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.449
4jajXU1Aurora kinase A2.7.11.10.449
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.448
3bqr4RBDeath-associated protein kinase 3/0.448
4fod0UVALK tyrosine kinase receptor2.7.10.10.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
2owb626Serine/threonine-protein kinase PLK12.7.11.210.447
5e8wSTUTGF-beta receptor type-12.7.11.300.447
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.446
2x9fX9FEphrin type-B receptor 42.7.10.10.446
2xikJ60Serine/threonine-protein kinase 252.7.11.10.446
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3igoANPCalmodulin-domain protein kinase 1, putative/0.446
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.446
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.446
2ojj82AMitogen-activated protein kinase 12.7.11.240.445
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.445
3qc9ADPRhodopsin kinase/0.445
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.445
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.445
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.445
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.445
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.444
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.444
2y9qANPMitogen-activated protein kinase 12.7.11.240.444
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
4g160VMCasein kinase I isoform gamma-32.7.11.10.444
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.443
2btrU73Cyclin-dependent kinase 22.7.11.220.443
2x1nX1NCyclin-dependent kinase 22.7.11.220.443
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.443
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.443
3zptM8YGag-Pol polyprotein3.4.23.160.443
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.443
5aaaVGHALK tyrosine kinase receptor2.7.10.10.443
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.442
2qo7ANPEphrin type-A receptor 32.7.10.10.442
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.442
3ormAGSSerine/threonine protein kinase/0.442
3r73X87Cyclin-dependent kinase 22.7.11.220.442
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.442
4fyn0VETyrosine-protein kinase SYK2.7.10.20.442
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.441
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.441
3q9xEMOCasein kinase II subunit alpha2.7.11.10.441
4fmqANPMitogen-activated protein kinase 12.7.11.240.441
1pjkANPCasein kinase II subunit alpha2.7.11.10.440
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.440
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.440