sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4i11 | 1CH | Beta-secretase 1 | 3.4.23.46 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4i11 | 1CH | Beta-secretase 1 | 3.4.23.46 | 1.000 | |
| 4i12 | 1BC | Beta-secretase 1 | 3.4.23.46 | 0.566 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.565 | |
| 4hzt | 0ZA | Beta-secretase 1 | 3.4.23.46 | 0.555 | |
| 4i0z | 1BB | Beta-secretase 1 | 3.4.23.46 | 0.554 | |
| 2ohr | 8IP | Beta-secretase 1 | 3.4.23.46 | 0.534 | |
| 3tpr | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.534 | |
| 2ohq | 7IP | Beta-secretase 1 | 3.4.23.46 | 0.530 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.524 | |
| 2ohp | 6IP | Beta-secretase 1 | 3.4.23.46 | 0.516 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.503 | |
| 4lxm | 1YU | Beta-secretase 1 | 3.4.23.46 | 0.503 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 1osv | CHC | Bile acid receptor | / | 0.495 | |
| 4j1c | 1HO | Beta-secretase 1 | 3.4.23.46 | 0.494 | |
| 4j1f | 1HL | Beta-secretase 1 | 3.4.23.46 | 0.490 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.489 | |
| 4j0y | 1H6 | Beta-secretase 1 | 3.4.23.46 | 0.488 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.484 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.483 | |
| 1nja | DCM | Thymidylate synthase | / | 0.481 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.479 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 4jpe | 1M7 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.477 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.477 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.476 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.475 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.475 | |
| 2ohu | IP7 | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 2fb3 | 5AD | GTP 3',8-cyclase | 4.1.99.18 | 0.473 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.473 | |
| 3pn1 | IVH | DNA ligase | / | 0.473 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 3zdn | FAD | Monoamine oxidase N | 1.4.3.4 | 0.472 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.471 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.471 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.471 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.470 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.470 | |
| 4jpc | 1M6 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 4qoe | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.470 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.470 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.468 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.468 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.468 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.468 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.467 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.467 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.467 | |
| 5doz | NDP | JamJ | / | 0.467 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.466 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4dro | 0MD | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.466 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.466 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.465 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.465 | |
| 4j17 | 1HQ | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.464 | |
| 1lcb | TMP | Thymidylate synthase | / | 0.464 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.463 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.463 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.463 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.463 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.463 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.462 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.462 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.462 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.461 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.461 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.461 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3eku | CY9 | Actin-5C | / | 0.461 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.461 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 5dp2 | NAP | CurF | / | 0.461 | |
| 1ddu | DDU | Thymidylate synthase | / | 0.460 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.460 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.460 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.460 | |
| 4q4k | FMN | Uncharacterized protein | / | 0.460 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.459 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.459 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.459 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.458 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.458 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 2e07 | SAH | Diphthine synthase | / | 0.457 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.457 | |
| 4v12 | POG | MaoC like domain protein | / | 0.457 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.456 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.456 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.456 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.456 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.456 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.456 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.456 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.456 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.455 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.455 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 4hcy | 0YN | Transketolase | / | 0.455 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.454 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.454 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.454 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.454 | |
| 4bfq | 083 | Soluble acetylcholine receptor | / | 0.454 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.454 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.454 | |
| 4xsv | CTP | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.454 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.453 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.453 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.453 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.453 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.452 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.452 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.452 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.452 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.452 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.452 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.452 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.452 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.451 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.451 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.451 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4kq2 | U5P | Glycogen [starch] synthase isoform 2 | 2.4.1.11 | 0.451 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.451 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 2p2b | PRX | Acetyl-coenzyme A synthetase | / | 0.450 | |
| 2vjm | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.450 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.450 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.450 | |
| 3r96 | ACO | MccE protein | / | 0.450 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.450 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1lce | TMF | Thymidylate synthase | / | 0.449 | |
| 1qvu | PRL | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 1sez | OMN | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.449 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2va6 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.449 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3up0 | D7S | aceDAF-12 | / | 0.449 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.449 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.449 | |
| 4hxy | NDP | Plm1 | / | 0.449 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.448 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.448 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.448 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.448 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
| 4was | COO | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.448 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.448 | |
| 1lcb | DHF | Thymidylate synthase | / | 0.447 | |
| 2g8a | UMP | Thymidylate synthase | / | 0.447 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.447 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.447 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.447 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 1bp0 | UMP | Thymidylate synthase | / | 0.446 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.446 | |
| 1t57 | FMN | Conserved protein | / | 0.446 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.446 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3anm | SYD | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.446 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.446 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.446 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4i0f | 1BF | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.446 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.445 | |
| 1tsv | UMP | Thymidylate synthase | / | 0.445 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.445 | |
| 2pcm | SAH | Diphthine synthase | / | 0.445 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 2zsc | BTN | Tamavidin2 | / | 0.445 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.445 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.445 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4b70 | WM9 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.445 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.445 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.444 | |
| 2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.444 | |
| 2g89 | UMP | Thymidylate synthase | / | 0.444 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.444 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.444 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.444 | |
| 3zmg | 6Z0 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.444 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.444 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.444 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.444 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 4zvn | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.443 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.443 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.443 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.443 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 3abi | NAD | Uncharacterized protein | / | 0.443 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 3mo0 | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.443 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.443 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.443 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4j0p | 1H8 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4k4f | K4F | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.443 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.442 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.442 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.442 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.442 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.442 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.442 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3eks | CY9 | Actin-5C | / | 0.442 | |
| 4b6s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.442 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.442 | |
| 4usr | FAD | Monooxygenase | / | 0.442 | |
| 5epe | SAH | Uncharacterized protein | / | 0.442 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.442 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.441 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.441 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.441 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1thy | UMP | Thymidylate synthase | / | 0.441 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.441 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.441 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.441 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.441 | |
| 4o7u | THF | Thymidylate synthase | / | 0.441 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.440 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.440 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.440 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2e08 | SAH | Diphthine synthase | / | 0.440 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2jdc | CAO | Probable acetyltransferase | / | 0.440 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.440 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.440 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.440 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.440 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.440 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.440 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4y0k | NAP | AntE | / | 0.440 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.440 |