sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 1.000 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.617 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.582 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.513 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.501 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.496 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.496 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.493 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.493 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.487 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.486 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.484 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.484 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.483 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.482 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.481 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.480 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.480 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.480 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.480 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.480 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.479 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.479 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.478 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.478 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.477 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.477 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.476 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.476 | |
| 4bew | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.476 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.476 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.475 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.475 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.475 | |
| 3fgo | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.475 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.475 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.474 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.474 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.474 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.473 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.473 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.473 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.472 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.472 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.472 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.471 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.471 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.471 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 3lu8 | IQX | Serum albumin | / | 0.470 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.470 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.470 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.469 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.469 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.469 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.469 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.469 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.468 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.468 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.468 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.468 | |
| 4l9q | 9TP | Serum albumin | / | 0.468 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.467 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.466 | |
| 3wd7 | COA | Acridone synthase | / | 0.466 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.466 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.465 | |
| 1ppj | SMA | Cytochrome b | / | 0.465 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.465 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.465 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.465 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.464 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.464 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.464 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.464 | |
| 4l8u | 9AZ | Serum albumin | / | 0.464 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1ysx | 4EB | Serum albumin | / | 0.463 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.463 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.463 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.463 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.462 | |
| 1sqv | UHD | Cytochrome b | / | 0.462 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.462 | |
| 3p9t | TCL | Repressor | / | 0.462 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.462 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.462 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.461 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.461 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.461 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.461 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.460 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.460 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.460 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.459 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.459 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.459 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.459 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.459 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.459 | |
| 4iah | 1DX | Alr2278 protein | / | 0.459 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.459 | |
| 1fml | RTL | Retinol dehydratase | / | 0.458 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.458 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.458 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.458 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.458 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 4inb | 1F6 | Gag protein | / | 0.458 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.457 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.457 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.457 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.457 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.457 | |
| 3bej | MUF | Bile acid receptor | / | 0.457 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.457 | |
| 4a2z | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.457 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.457 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.457 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.457 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 2p15 | EZT | Estrogen receptor | / | 0.456 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.456 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.456 | |
| 3aba | FLI | Cytochrome P450 | / | 0.456 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3eel | 53T | Uncharacterized protein | / | 0.456 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.456 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.456 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.456 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.456 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.456 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.455 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.455 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.455 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.455 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.455 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.455 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.455 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.455 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.454 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.454 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.453 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.453 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.453 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.453 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.453 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.453 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.452 | |
| 3bzu | A21 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3qly | 55V | Uncharacterized protein | / | 0.452 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.452 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.451 | |
| 2duv | 371 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.451 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.451 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.451 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.451 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.451 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1err | RAL | Estrogen receptor | / | 0.450 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.450 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.450 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.450 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1zdw | FLV | Prenyltransferase | / | 0.450 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.450 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.450 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.450 | |
| 4a28 | ADP | Kinesin-like protein KIF11 | / | 0.450 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.450 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4l9k | EHF | Serum albumin | / | 0.450 | |
| 4okt | 198 | Androgen receptor | / | 0.450 | |
| 1ep4 | S11 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.449 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.449 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.449 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.449 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.449 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.449 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3lu6 | IMX | Serum albumin | / | 0.449 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.449 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.449 | |
| 1pp9 | SMA | Cytochrome b | / | 0.448 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.448 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.448 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2y00 | Y01 | Beta-1 adrenergic receptor | / | 0.448 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.448 | |
| 3s2p | PMU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.448 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.448 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.448 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.447 | |
| 1soz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.447 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.447 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 4egn | TWO | Cytochrome P450 | / | 0.447 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.447 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4yau | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.447 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.447 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.446 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.446 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.446 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1osv | CHC | Bile acid receptor | / | 0.446 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.446 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.446 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.446 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.446 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3o8g | O8G | HTH-type transcriptional regulator EthR | / | 0.446 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.446 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.446 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.446 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.446 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.445 | |
| 1yin | CM3 | Estrogen receptor | / | 0.445 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.445 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.445 | |
| 2j0d | ERY | Cytochrome P450 3A4 | / | 0.445 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 2y3r | TRK | TamL | / | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.445 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.445 | |
| 3mpa | SB2 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.445 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.445 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.445 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.444 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.444 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.444 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.444 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 3dmj | GWE | Pol protein | / | 0.444 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.444 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 4iwc | 1GV | Estrogen receptor | / | 0.444 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.444 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 5c93 | ACP | Two-component system histidine protein kinase | / | 0.444 | |
| 1ie4 | T44 | Transthyretin | / | 0.443 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.443 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.443 | |
| 1qxs | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.443 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.443 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.443 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.443 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.443 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.443 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.443 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4fkp | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.442 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.442 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.442 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2ybo | SAH | Methyltransferase | / | 0.442 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.442 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.442 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1tg5 | 645 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.441 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.441 | |
| 2yiu | SMA | Cytochrome b | / | 0.441 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.441 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.441 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 3cse | N22 | Uncharacterized protein | / | 0.441 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3h1j | SMA | Cytochrome b | / | 0.441 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.441 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.441 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.441 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.441 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.441 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.441 | |
| 4zca | ADP | Kinesin-like protein KIF11 | / | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1hk2 | T44 | Serum albumin | / | 0.440 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.440 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.440 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.440 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.440 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.440 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.440 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3zux | TCH | Transporter | / | 0.440 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.440 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.440 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.440 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.440 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 4la0 | 198 | Serum albumin | / | 0.440 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.440 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 |