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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aknS5BBromodomain-containing protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aknS5BBromodomain-containing protein 2/1.000
4a9nA9NBromodomain-containing protein 2/0.621
4a9oA9OBromodomain-containing protein 2/0.616
4j0r1H2Bromodomain-containing protein 4/0.606
4uyf73BBromodomain-containing protein 2/0.601
4alhA9PBromodomain-containing protein 2/0.599
4c66H4CBromodomain-containing protein 4/0.595
4o701QKBromodomain-containing protein 4/0.588
4bjx73BBromodomain-containing protein 4/0.587
4mr41K0Bromodomain-containing protein 4/0.586
4j0s1H3Bromodomain-containing protein 4/0.582
3aqaBYHBromodomain-containing protein 2/0.581
4nqmY1ZBromodomain-containing protein 4/0.573
4bw39BMBromodomain-containing protein 4/0.571
3zyu1GHBromodomain-containing protein 4/0.570
4bw1S5BBromodomain-containing protein 4/0.565
4uyg73BBromodomain-containing protein 2/0.564
2ydwWSHBromodomain-containing protein 2/0.563
4c67L5SBromodomain-containing protein 4/0.560
4j1p1K0Bromodomain-containing protein 2/0.557
4lrg1XBBromodomain-containing protein 4/0.556
4bw2UTHBromodomain-containing protein 4/0.554
4mep24YBromodomain-containing protein 4/0.554
4a9mP9MBromodomain-containing protein 2/0.553
4lr61XABromodomain-containing protein 4/0.553
4o71CPBBromodomain-containing protein 4/0.553
2yelWSHBromodomain-containing protein 4/0.552
4a9iP9IBromodomain-containing protein 2/0.552
4flpJQ1Bromodomain testis-specific protein/0.552
4men25KBromodomain-containing protein 4/0.552
4hxs1A3Bromodomain-containing protein 4/0.549
4ogiR78Bromodomain-containing protein 4/0.548
5bt52LOBromodomain-containing protein 2/0.546
4alg1GHBromodomain-containing protein 2/0.544
4meq25OBromodomain-containing protein 4/0.544
4j3i1K0Bromodomain-containing protein 4/0.543
4hby13FBromodomain-containing protein 4/0.541
4a9lP9LBromodomain-containing protein 4/0.539
4qzsJQ1Bromodomain-containing protein 4/0.537
4f3i0S6Bromodomain-containing protein 4/0.536
4hxr1A4Bromodomain-containing protein 4/0.526
4o74R78Bromodomain-containing protein 4/0.522
2yekEAMBromodomain-containing protein 2/0.520
4a9e3PFBromodomain-containing protein 2/0.519
4mr61K0Bromodomain-containing protein 2/0.518
2yemWSHBromodomain-containing protein 4/0.516
4bw49B6Bromodomain-containing protein 4/0.512
4cfl8DQBromodomain-containing protein 4/0.510
4nr52LLCREB-binding protein/0.509
4py6R78Bromodomain protein, putative/0.509
4hxo1A6Bromodomain-containing protein 4/0.508
4lyw21QBromodomain-containing protein 4/0.502
4o78SAVBromodomain-containing protein 4/0.502
4hxn1A7Bromodomain-containing protein 4/0.500
4gpj0Q1Bromodomain-containing protein 4/0.496
4nr42LKCREB-binding protein/0.494
4a9hTVPBromodomain-containing protein 2/0.493
4hbw14ZBromodomain-containing protein 4/0.492
4mr51K0Bromodomain-containing protein 2/0.492
3vt7VDXVitamin D3 receptor/0.488
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.486
4gub0Y4Casein kinase II subunit alpha2.7.11.10.485
4e960NSBromodomain-containing protein 4/0.482
4nyv15ECREB-binding protein/0.482
3be9P04Casein kinase II subunit alpha2.7.11.10.481
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.477
3vt9YI4Vitamin D3 receptor/0.476
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.475
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.474
3svgODRBromodomain-containing protein 4/0.473
3cyxROCGag-Pol polyprotein3.4.23.160.472
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.471
4dgnLU2Casein kinase II subunit alpha2.7.11.10.471
1om1IQACasein kinase II subunit alpha2.7.11.10.469
4meo25VBromodomain-containing protein 4/0.468
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.467
4cfkLY2Bromodomain-containing protein 4/0.467
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.466
4c58824Cyclin-G-associated kinase2.7.11.10.465
2vn0TDZCytochrome P450 2C8/0.464
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
3pm9FADPutative oxidoreductase/0.463
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.463
2ovhAS0Progesterone receptor/0.462
4dgo0JWCasein kinase II subunit alpha2.7.11.10.462
4nr82LLBromodomain-containing protein 4/0.462
5dfcEAMBromodomain-containing protein 2/0.462
1m78NDPDihydrofolate reductase1.5.1.30.461
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.461
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.459
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.459
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1phgMYTCamphor 5-monooxygenase1.14.15.10.458
3c6uM22Gag-Pol polyprotein2.7.7.490.458
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.458
1bsvNDPGDP-L-fucose synthase/0.457
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.457
4nyw2O3CREB-binding protein/0.457
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.456
3at4CCKCasein kinase II subunit alpha2.7.11.10.456
3nxe2NCProtease/0.456
4ips1G4Mycocyclosin synthase1.14.21.90.456
3sn6P0GBeta-2 adrenergic receptor/0.456
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.455
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.455
2zjwREFCasein kinase II subunit alpha2.7.11.10.455
3r83Z14Cyclin-dependent kinase 22.7.11.220.455
4ocvANPAminoglycoside phosphotransferase/0.455
2w9hTOPDihydrofolate reductase1.5.1.30.454
3qlsNDPDihydrofolate reductase1.5.1.30.454
3s1dZIRCytokinin dehydrogenase 11.5.99.120.454
3vt8YI3Vitamin D3 receptor/0.454
4ia3BIVVitamin D3 receptor A/0.454
1ai9NDPDihydrofolate reductase1.5.1.30.453
1drbMTXDihydrofolate reductase1.5.1.30.453
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.453
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
1knuYPAPeroxisome proliferator-activated receptor gamma/0.452
1q4t4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.452
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.452
2iyaZIOOleandomycin glycosyltransferase/0.452
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.452
3at3ATKCasein kinase II subunit alpha2.7.11.10.452
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.452
4awq592Heat shock protein HSP 90-alpha/0.452
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.452
1drhNAPDihydrofolate reductase1.5.1.30.451
2c3qGTXGlutathione S-transferase theta-12.5.1.180.451
2cchATPCyclin-dependent kinase 22.7.11.220.451
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
3r324CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.451
1kkq471Peroxisome proliferator-activated receptor alpha/0.450
1y0s331Peroxisome proliferator-activated receptor delta/0.450
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.450
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.450
3kpkFADSulfide-quinone reductase/0.450
3q9xEMOCasein kinase II subunit alpha2.7.11.10.450
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.450
1xddAAYIntegrin alpha-L/0.449
2tpsTPSThiamine-phosphate synthase/0.449
3fwjCAMCamphor 5-monooxygenase1.14.15.10.449
3pe2E1BCasein kinase II subunit alpha2.7.11.10.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4wa9AXITyrosine-protein kinase ABL12.7.10.20.449
1tl7FOKAdenylate cyclase type 2/0.448
1tl7FOKAdenylate cyclase type 5/0.448
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.448
3gggNADPrephenate dehydrogenase/0.448
3ttp017Gag-Pol polyprotein3.4.23.160.448
4c59FEFCyclin-G-associated kinase2.7.11.10.448
4ix6ADPUncharacterized protein/0.448
1dr2TAPDihydrofolate reductase1.5.1.30.447
1draMTXDihydrofolate reductase1.5.1.30.447
1rx1NAPDihydrofolate reductase1.5.1.30.447
1vrwNAIEnoyl-ACP reductase/0.447
1zg32HIIsoflavone 4'-O-methyltransferase/0.447
2bpw1INGag-Pol polyprotein3.4.23.160.447
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.447
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.447
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.447
2xw7NDPDihydrofolate reductase/0.447
3ddw055Glycogen phosphorylase, liver form2.4.1.10.447
3gobHXXDdmC/0.447
3gw9VNILanosterol 14-alpha-demethylase/0.447
3nwxKVSGag-Pol polyprotein3.4.23.160.447
3qlrNDPDihydrofolate reductase1.5.1.30.447
3so9017Pol protein/0.447
4grb0XGCasein kinase II subunit alpha2.7.11.10.447
4mwhATPCasein kinase II subunit alpha2.7.11.10.447
4ryvZEAProtein LlR18A/0.447
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.447
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.447
1hxbROCGag-Pol polyprotein3.4.23.160.446
1juvNDPDihydrofolate reductase1.5.1.30.446
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.446
2vcmM11Isopenicillin N synthase1.21.3.10.446
3d84NDPDihydrofolate reductase1.5.1.30.446
3el51UNGag-Pol polyprotein/0.446
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.446
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.446
3nmpPYVAbscisic acid receptor PYL2/0.446
3uyt0CKCasein kinase I isoform delta2.7.11.10.446
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.446
3zuxTCHTransporter/0.446
1npa3NHGag-Pol polyprotein3.4.23.160.445
1npwLGZGag-Pol polyprotein3.4.23.160.445
1zeoC01Peroxisome proliferator-activated receptor gamma/0.445
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.445
2cppCAMCamphor 5-monooxygenase1.14.15.10.445
2jkkBI9Focal adhesion kinase 12.7.10.20.445
2vnhFADNADPH:ferredoxin reductase/0.445
2x7hPFNProstaglandin reductase 310.445
3bheBZNGag-Pol polyprotein3.4.23.160.445
3d7kD7KBenzaldehyde lyase/0.445
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.445
3pqbVGPPutative oxidoreductase/0.445
3u9eCOALmo1369 protein/0.445
3zptM8YGag-Pol polyprotein3.4.23.160.445
4dgmAGICasein kinase II subunit alpha2.7.11.10.445
4ia1BIVVitamin D3 receptor A/0.445
4ib4ERM5-hydroxytryptamine receptor 2B/0.445
4zm6ACON-acetyl-beta-D glucosaminidase/0.445
5cvhADPCasein kinase II subunit alpha2.7.11.10.445
5drdATPAurora kinase A2.7.11.10.445
5hs1VORLanosterol 14-alpha demethylase/0.445
1c6zROCProtease/0.444
1eioGCHGastrotropin/0.444
2g5cNADPrephenate dehydrogenase/0.444
2wotZZGTGF-beta receptor type-12.7.11.300.444
3dds26BGlycogen phosphorylase, liver form2.4.1.10.444
3nwq2NCGag-Pol polyprotein3.4.23.160.444
3sa323XProtease/0.444
4b7sQLECytochrome P450 monooxygenase PikC/0.444
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.444
4hgs15GCasein kinase I isoform gamma-32.7.11.10.444
4ho4THMGlucose-1-phosphate thymidylyltransferase/0.444
4ia2BIVVitamin D3 receptor A/0.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1difA85Gag-Pol polyprotein/0.443
1u3dFADCryptochrome-1/0.443
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.443
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.443
2pvhP19Casein kinase II subunit alpha2.7.11.10.443
2qo9ANPEphrin type-A receptor 32.7.10.10.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.443
2xlsFADPutative flavin-containing monooxygenase/0.443
2znnS44Peroxisome proliferator-activated receptor alpha/0.443
3q44D50M1 family aminopeptidase3.4.110.443
3q92XNBKetohexokinase/0.443
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4a8v2ANMajor pollen allergen Bet v 1-J/0.443
4eh60ONMitogen-activated protein kinase 14/0.443
4eji0QACytochrome P450 2A131.14.14.10.443
4iae1DXAlr2278 protein/0.443
5dn3ATPAurora kinase A2.7.11.10.443
1dr3TAPDihydrofolate reductase1.5.1.30.442
2b7aIZATyrosine-protein kinase JAK2/0.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
2uxoTACHTH-type transcriptional regulator TtgR/0.442
3r354CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.442
4g7gVFVLanosterol 14-alpha-demethylase/0.442
4r21STRCytochrome P450 family 17 polypeptide 2/0.442
1y4sADPChaperone protein HtpG/0.441
2bunFADAppA protein/0.441
2emuSAHDiphthine synthase/0.441
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
2p33J07Mitogen-activated protein kinase 102.7.11.240.441
2pvnP63Casein kinase II subunit alpha2.7.11.10.441
3f1kNAPUncharacterized oxidoreductase YciK10.441
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3och2MXDihydrofolate reductase1.5.1.30.441
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5eccNAPDehydrofolate reductase type I/0.441
1h1s4SPCyclin-dependent kinase 22.7.11.220.440
1zrzBI1Protein kinase C iota type2.7.11.130.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
3il1B5DGlutamate receptor 2/0.440
3junAKDPhenazine biosynthesis protein A/B/0.440
3lfnA27Cyclin-dependent kinase 22.7.11.220.440
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4a81DXCMajor pollen allergen Bet v 1-A/0.440
4anmWULCasein kinase II subunit alpha2.7.11.10.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4ict1EDMycocyclosin synthase1.14.21.90.440
4jlk1NODeoxycytidine kinase2.7.1.740.440
4zohFADPutative oxidoreductase FAD-binding subunit/0.440
5cvfATPCasein kinase II subunit alpha2.7.11.10.440