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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fvv107Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fvv107Cyclin-dependent kinase 22.7.11.221.000
4fx360KCyclin-dependent kinase 22.7.11.220.586
2w17I19Cyclin-dependent kinase 22.7.11.220.568
3rak03ZCyclin-dependent kinase 22.7.11.220.566
2vv9IM9Cyclin-dependent kinase 22.7.11.220.561
3qxpX64Cyclin-dependent kinase 22.7.11.220.555
3ral04ZCyclin-dependent kinase 22.7.11.220.548
1p2a5BNCyclin-dependent kinase 22.7.11.220.547
2uzbC75Cyclin-dependent kinase 22.7.11.220.546
1pkdUCNCyclin-dependent kinase 22.7.11.220.545
2wihP48Cyclin-dependent kinase 22.7.11.220.544
1gih1PUCyclin-dependent kinase 22.7.11.220.543
2vu3LZECyclin-dependent kinase 22.7.11.220.539
2w05FRTCyclin-dependent kinase 22.7.11.220.539
3s1h56ZCyclin-dependent kinase 22.7.11.220.537
1oiyN41Cyclin-dependent kinase 22.7.11.220.535
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.533
3r9dX6BCyclin-dependent kinase 22.7.11.220.530
3rmf20ZCyclin-dependent kinase 22.7.11.220.530
3tnwF18Cyclin-dependent kinase 22.7.11.220.530
4bcmT7ZCyclin-dependent kinase 22.7.11.220.530
2uzdC85Cyclin-dependent kinase 22.7.11.220.525
1y91CT9Cyclin-dependent kinase 22.7.11.220.523
4bgh3I6Cyclin-dependent kinase 22.7.11.220.523
3rpv26ZCyclin-dependent kinase 22.7.11.220.520
3qtuX44Cyclin-dependent kinase 22.7.11.220.518
4fkr45KCyclin-dependent kinase 22.7.11.220.518
2iw84SPCyclin-dependent kinase 22.7.11.220.515
4fkv61KCyclin-dependent kinase 22.7.11.220.513
3nux3NVCyclin-dependent kinase 62.7.11.220.512
1g5sI17Cyclin-dependent kinase 22.7.11.220.511
3r9hZ67Cyclin-dependent kinase 22.7.11.220.510
1gii1PUCyclin-dependent kinase 22.7.11.220.509
3ezvEZVCyclin-dependent kinase 22.7.11.220.509
3sqq99ZCyclin-dependent kinase 22.7.11.220.509
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.509
4fkw62KCyclin-dependent kinase 22.7.11.220.508
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.507
2c6tDT5Cyclin-dependent kinase 22.7.11.220.506
1ke5LS1Cyclin-dependent kinase 22.7.11.220.505
4fkt48KCyclin-dependent kinase 22.7.11.220.505
2c6iDT1Cyclin-dependent kinase 22.7.11.220.504
1ke6LS2Cyclin-dependent kinase 22.7.11.220.503
1v1k3FPCyclin-dependent kinase 22.7.11.220.503
3my5RFZCyclin-dependent kinase 22.7.11.220.503
1finATPCyclin-dependent kinase 22.7.11.220.502
4fks46KCyclin-dependent kinase 22.7.11.220.500
1e9hINRCyclin-dependent kinase 22.7.11.220.499
2cchATPCyclin-dependent kinase 22.7.11.220.498
2j9mPY8Cyclin-dependent kinase 22.7.11.220.497
2x1nX1NCyclin-dependent kinase 22.7.11.220.497
1oguST8Cyclin-dependent kinase 22.7.11.220.496
1pyePM1Cyclin-dependent kinase 22.7.11.220.496
2eufLQQCyclin-dependent kinase 62.7.11.220.495
2fvdLIACyclin-dependent kinase 22.7.11.220.495
3qtxX43Cyclin-dependent kinase 22.7.11.220.495
1pxmCK5Cyclin-dependent kinase 22.7.11.220.493
2uznC96Cyclin-dependent kinase 22.7.11.220.493
1v0oINRCell division control protein 2 homolog2.7.11.220.492
2bheBRYCyclin-dependent kinase 22.7.11.220.492
2btsU32Cyclin-dependent kinase 22.7.11.220.492
2uzlC94Cyclin-dependent kinase 22.7.11.220.492
2vttLZDCyclin-dependent kinase 22.7.11.220.492
3r71X86Cyclin-dependent kinase 22.7.11.220.492
3rni21ZCyclin-dependent kinase 22.7.11.220.492
4qmpDKISerine/threonine-protein kinase 242.7.11.10.492
1dm2HMDCyclin-dependent kinase 22.7.11.220.491
2c6lDT4Cyclin-dependent kinase 22.7.11.220.491
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.491
2wxvWXVCyclin-dependent kinase 22.7.11.220.490
3qqkX02Cyclin-dependent kinase 22.7.11.220.490
3qzfX66Cyclin-dependent kinase 22.7.11.220.490
3s2pPMUCyclin-dependent kinase 22.7.11.220.490
3sw719KCyclin-dependent kinase 22.7.11.220.490
3uli1N3Cyclin-dependent kinase 22.7.11.220.490
2w06FRVCyclin-dependent kinase 22.7.11.220.489
3rkb12ZCyclin-dependent kinase 22.7.11.220.489
4bcnT9NCyclin-dependent kinase 22.7.11.220.489
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.489
4hvh19RTyrosine-protein kinase JAK32.7.10.20.489
2iw94SPCyclin-dependent kinase 22.7.11.220.488
3ezrEZRCyclin-dependent kinase 22.7.11.220.488
1h1s4SPCyclin-dependent kinase 22.7.11.220.487
3qtzX42Cyclin-dependent kinase 22.7.11.220.487
3rk507ZCyclin-dependent kinase 22.7.11.220.487
4acm7YGCyclin-dependent kinase 22.7.11.220.487
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.487
2r3lSCWCyclin-dependent kinase 22.7.11.220.486
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.486
3qu0X40Cyclin-dependent kinase 22.7.11.220.486
1ke7LS3Cyclin-dependent kinase 22.7.11.220.485
2c5nCK8Cyclin-dependent kinase 22.7.11.220.485
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.485
3t8oATPRhodopsin kinase/0.485
1oitHDTCyclin-dependent kinase 22.7.11.220.484
1w0xOLOCyclin-dependent kinase 22.7.11.220.484
3rpy27ZCyclin-dependent kinase 22.7.11.220.484
3rk708ZCyclin-dependent kinase 22.7.11.220.483
4fko20KCyclin-dependent kinase 22.7.11.220.483
1aq1STUCyclin-dependent kinase 22.7.11.220.482
1urwI1PCyclin-dependent kinase 22.7.11.220.482
2xmyCDKCyclin-dependent kinase 22.7.11.220.482
3i60E86Mitogen-activated protein kinase 12.7.11.240.482
4erwSTUCyclin-dependent kinase 22.7.11.220.482
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.481
4ek816KCyclin-dependent kinase 22.7.11.220.481
4fkpLS5Cyclin-dependent kinase 22.7.11.220.481
2c6o4SPCyclin-dependent kinase 22.7.11.220.480
2r3iSCFCyclin-dependent kinase 22.7.11.220.480
4bchT7ZCyclin-dependent kinase 92.7.11.220.480
3lfqA28Cyclin-dependent kinase 22.7.11.220.479
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.479
3r73X87Cyclin-dependent kinase 22.7.11.220.479
1pxpCK8Cyclin-dependent kinase 22.7.11.220.478
3ddpRC8Cyclin-dependent kinase 22.7.11.220.478
4eomATPCyclin-dependent kinase 22.7.11.220.478
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.478
1yvj4STTyrosine-protein kinase JAK32.7.10.20.477
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.477
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.477
2b53D23Cyclin-dependent kinase 22.7.11.220.476
2r3jSCJCyclin-dependent kinase 22.7.11.220.476
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.476
4dgnLU2Casein kinase II subunit alpha2.7.11.10.476
4gmy0X5Tyrosine-protein kinase JAK2/0.476
4j97ACPFibroblast growth factor receptor 2/0.476
4o0wADNAurora kinase A2.7.11.10.476
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.475
1pxlCK4Cyclin-dependent kinase 22.7.11.220.475
1ykr628Cyclin-dependent kinase 22.7.11.220.475
2hog710Serine/threonine-protein kinase Chk12.7.11.10.475
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.475
3lfnA27Cyclin-dependent kinase 22.7.11.220.475
3pe2E1BCasein kinase II subunit alpha2.7.11.10.475
3zep1NXTyrosine-protein kinase JAK32.7.10.20.475
4ez50RSCyclin-dependent kinase 62.7.11.220.475
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.474
2c4g514Cyclin-dependent kinase 22.7.11.220.473
2i40BLZCyclin-dependent kinase 22.7.11.220.473
3nup3NUCyclin-dependent kinase 62.7.11.220.473
3ti1B49Cyclin-dependent kinase 22.7.11.220.473
1h1r6CPCyclin-dependent kinase 22.7.11.220.472
3r9oZ71Cyclin-dependent kinase 22.7.11.220.472
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.472
1gij2PUCyclin-dependent kinase 22.7.11.220.471
1oi9N20Cyclin-dependent kinase 22.7.11.220.471
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.471
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.471
4bbfO19Tyrosine-protein kinase JAK2/0.471
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.470
2r3p3SCCyclin-dependent kinase 22.7.11.220.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
1ke9LS5Cyclin-dependent kinase 22.7.11.220.469
2bkzSBCCyclin-dependent kinase 22.7.11.220.469
2btrU73Cyclin-dependent kinase 22.7.11.220.469
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.469
3sw418KCyclin-dependent kinase 22.7.11.220.469
4ek610KCyclin-dependent kinase 22.7.11.220.469
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.468
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.467
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.467
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.467
2duv371Cyclin-dependent kinase 22.7.11.220.466
2in6839Wee1-like protein kinase2.7.10.20.466
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.466
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.466
3wblPDYCyclin-dependent kinase 22.7.11.220.466
5av2KMPDeath-associated protein kinase 12.7.11.10.466
1fvt106Cyclin-dependent kinase 22.7.11.220.465
2bhhRYUCyclin-dependent kinase 22.7.11.220.465
2ckeIQUDeath-associated protein kinase 2/0.465
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.465
3qzgX67Cyclin-dependent kinase 22.7.11.220.465
4qmySTUSerine/threonine-protein kinase 242.7.11.10.465
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.464
3a62STURibosomal protein S6 kinase beta-12.7.11.10.464
3c4xATPRhodopsin kinase/0.464
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.464
1y8yCT7Cyclin-dependent kinase 22.7.11.220.463
2j0m4STFocal adhesion kinase 12.7.10.20.463
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.463
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.463
3roy22ZCyclin-dependent kinase 22.7.11.220.463
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.462
3qxoX65Cyclin-dependent kinase 22.7.11.220.462
3r8zZ63Cyclin-dependent kinase 22.7.11.220.462
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.462
4l9i8PRRhodopsin kinase/0.462
2b52D42Cyclin-dependent kinase 22.7.11.220.461
2vtsLZCCyclin-dependent kinase 22.7.11.220.461
3r1sX73Cyclin-dependent kinase 22.7.11.220.461
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.461
4bcqTJFCyclin-dependent kinase 22.7.11.220.461
4ez30S0Cyclin-dependent kinase 22.7.11.220.461
4j95ACPFibroblast growth factor receptor 2/0.461
1vyw292Cyclin-dependent kinase 22.7.11.220.460
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.460
2xnbY8LCyclin-dependent kinase 22.7.11.220.460
3qtqX35Cyclin-dependent kinase 22.7.11.220.460
3rk909ZCyclin-dependent kinase 22.7.11.220.460
4hvg19QTyrosine-protein kinase JAK32.7.10.20.460
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.459
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.459
4aguD15Cyclin-dependent kinase-like 1/0.459
4f081RSTyrosine-protein kinase JAK2/0.459
4fkg4CKCyclin-dependent kinase 22.7.11.220.459
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.458
3dogNNNCyclin-dependent kinase 22.7.11.220.458
3zh8C58Protein kinase C iota type2.7.11.130.458
4aqc88ATyrosine-protein kinase JAK2/0.458
4fkq42KCyclin-dependent kinase 22.7.11.220.458
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.458
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.457
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.457
2r3kSCQCyclin-dependent kinase 22.7.11.220.457
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.457
1oiqHDUCyclin-dependent kinase 22.7.11.220.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.456
3ggfGVDSerine/threonine-protein kinase 26/0.456
3r7yZ04Cyclin-dependent kinase 22.7.11.220.456
4g170VNCasein kinase I isoform gamma-32.7.11.10.456
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2pvhP19Casein kinase II subunit alpha2.7.11.10.455
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.455
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.455
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.455
4hvi19STyrosine-protein kinase JAK32.7.10.20.455
4lyn1YGCyclin-dependent kinase 22.7.11.220.455
5dt0SKEAurora kinase A2.7.11.10.455
1di8DTQCyclin-dependent kinase 22.7.11.220.454
2c6mDT5Cyclin-dependent kinase 22.7.11.220.454
2r64740Cyclin-dependent kinase 22.7.11.220.454
2wpa889Cyclin-dependent kinase 22.7.11.220.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.454
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.454
4ic7ANPMitogen-activated protein kinase 72.7.11.240.454
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.453
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.453
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.453
4jqeANPCasein kinase II subunit alpha2.7.11.10.453
2b55D31Cyclin-dependent kinase 22.7.11.220.452
2dwbANPAurora kinase A2.7.11.10.452
2vthLZ2Cyclin-dependent kinase 22.7.11.220.452
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3qqfX07Cyclin-dependent kinase 22.7.11.220.452
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.452
4eok4SPCyclin-dependent kinase 22.7.11.220.452
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.452
1ke8LS4Cyclin-dependent kinase 22.7.11.220.451
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.451
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.451
2vtqLZACyclin-dependent kinase 22.7.11.220.451
4hge15VTyrosine-protein kinase JAK2/0.451
2a0cCK9Cyclin-dependent kinase 22.7.11.220.450
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.450
3be9P04Casein kinase II subunit alpha2.7.11.10.450
3ddqRRCCyclin-dependent kinase 22.7.11.220.450
5dr9SKEAurora kinase A2.7.11.10.450
1oirHDYCyclin-dependent kinase 22.7.11.220.449
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.449
3rjc06ZCyclin-dependent kinase 22.7.11.220.449
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.449
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.449
2cjmATPCyclin-dependent kinase 22.7.11.220.448
2izuP01Casein kinase I isoform gamma-32.7.11.10.448
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.448
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
3r7uX96Cyclin-dependent kinase 22.7.11.220.448
4btjADPTau-tubulin kinase 12.7.11.10.448
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.448
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.447
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.447
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3iggEFQCyclin-dependent kinase 22.7.11.220.447
3rm719ZCyclin-dependent kinase 22.7.11.220.447
4grb0XGCasein kinase II subunit alpha2.7.11.10.447
3c4zADPRhodopsin kinase/0.446
3le62BZCyclin-dependent kinase 22.7.11.220.446
4eol1ROCyclin-dependent kinase 22.7.11.220.446
1pxkCK3Cyclin-dependent kinase 22.7.11.220.445
2f2cAP9Cyclin-dependent kinase 62.7.11.220.445
2pvlP55Casein kinase II subunit alpha2.7.11.10.445
2r3r6SCCyclin-dependent kinase 22.7.11.220.445
2uzeC95Cyclin-dependent kinase 22.7.11.220.445
2uzoC62Cyclin-dependent kinase 22.7.11.220.445
3qzhX69Cyclin-dependent kinase 22.7.11.220.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.445
4e6d0NUTyrosine-protein kinase JAK2/0.445
4fv6E57Mitogen-activated protein kinase 12.7.11.240.445
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
3bu5ATPInsulin receptor2.7.10.10.444
3gu7ADPDeath-associated protein kinase 12.7.11.10.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4jia1K3Tyrosine-protein kinase JAK2/0.444
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.443
2wipP49Cyclin-dependent kinase 22.7.11.220.443
3fz1B98Cyclin-dependent kinase 22.7.11.220.443
3gxlQIGTGF-beta receptor type-12.7.11.300.443
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.443
2vtrLZBCyclin-dependent kinase 22.7.11.220.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.442
4bcpT3CCyclin-dependent kinase 22.7.11.220.442
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.442
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
5dnrATPAurora kinase A2.7.11.10.442
5e8wSTUTGF-beta receptor type-12.7.11.300.442
1h0w207Cyclin-dependent kinase 22.7.11.220.441
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.441
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.441
3hx4ANPCalmodulin-domain protein kinase 1/0.441
3lltANPProtein serine/threonine kinase-1/0.441
3qtrX36Cyclin-dependent kinase 22.7.11.220.441
3qtwX3ACyclin-dependent kinase 22.7.11.220.441
2pwlACPFibroblast growth factor receptor 2/0.440
3lfsA07Cyclin-dependent kinase 22.7.11.220.440
3pj8404Cyclin-dependent kinase 22.7.11.220.440
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.440
4k33ACPFibroblast growth factor receptor 32.7.10.10.440