sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1eko | I84 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.662 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.661 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.623 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.616 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.595 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.589 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.589 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.580 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.580 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.574 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.574 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.572 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.572 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.571 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.569 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.554 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.552 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.550 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.548 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.538 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.528 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.526 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.520 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.517 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.517 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.512 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.511 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.510 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.510 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.509 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.506 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.504 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.503 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.502 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.502 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.501 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.501 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.498 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.497 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.496 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.496 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.496 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.496 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.495 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.494 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.494 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.493 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.492 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.491 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.491 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.490 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.490 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.490 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.490 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.489 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.488 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.486 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.486 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.485 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.485 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.484 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.483 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.483 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.483 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.482 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.482 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.481 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.481 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.480 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.480 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.480 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.480 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.477 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.477 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.476 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.475 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.475 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.475 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.474 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.473 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.473 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.472 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.472 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.472 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.469 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.468 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.467 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.466 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.466 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.465 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.464 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.463 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.463 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.463 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.463 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.462 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.462 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.462 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.462 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.461 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.460 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.460 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.460 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.460 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.459 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.459 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.459 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.459 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.459 | |
| 4kxj | P34 | Nucleoprotein | / | 0.459 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.459 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.458 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.458 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.457 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.457 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.457 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.457 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.456 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.456 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.456 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.456 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.456 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.456 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.456 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.455 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.455 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.455 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.455 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1lel | BH7 | Avidin | / | 0.454 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.454 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.454 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.454 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.454 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.453 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.453 | |
| 3jt6 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 4g0k | 0VS | Glutathionyl-hydroquinone reductase YqjG | 1.8 | 0.453 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1jf0 | CZH | Obelin | / | 0.452 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.452 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.452 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.452 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.452 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.451 | |
| 4ixt | 1H1 | Halohydrin dehalogenase | / | 0.451 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.450 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 1fml | RTL | Retinol dehydratase | / | 0.449 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.449 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.449 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.449 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.448 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.448 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.448 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.448 | |
| 2v2v | V12 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.448 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.448 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.448 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.447 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.447 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.447 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.447 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.447 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.447 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.447 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.446 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.446 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.446 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.446 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.446 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 1uhj | CZB | Aequorin-2 | / | 0.445 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.445 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.445 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 3irh | DTP | HD domain protein | / | 0.445 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3vhm | NPK | Avidin | / | 0.445 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.445 | |
| 4gtt | 7TQ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.445 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.445 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.444 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.444 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 4iae | 1DX | Alr2278 protein | / | 0.444 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.443 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.443 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.443 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.443 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.443 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.443 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1qv0 | CZH | Obelin | / | 0.442 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.442 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.442 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3jt3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3px2 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.442 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.442 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.442 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1el4 | CTZ | Obelin | / | 0.441 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.441 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.441 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.441 | |
| 4nv0 | MG7 | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.441 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.441 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2gmv | UN8 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.440 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.440 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 2y01 | Y00 | Beta-1 adrenergic receptor | / | 0.440 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.440 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.440 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.440 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.440 | |
| 2ycy | P32 | Beta-1 adrenergic receptor | / | 0.440 |