sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4wec | NAD | Short chain dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 4wec | NAD | Short chain dehydrogenase | / | 1.156 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.933 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.912 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.903 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.902 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.884 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.879 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.878 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.867 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.854 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.852 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.850 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.848 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.848 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.847 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.835 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.835 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.822 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.816 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.816 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.815 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.812 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.811 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.809 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.804 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.803 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.802 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.800 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.799 | |
| 4kwh | NAP | Reductase homolog | / | 0.798 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.797 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.795 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.794 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.794 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.793 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.792 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.791 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.790 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.790 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.788 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.788 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.788 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.787 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.787 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.787 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.786 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.786 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.786 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.783 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.783 | |
| 4qec | NAP | ElxO | / | 0.783 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.782 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.782 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.779 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.779 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.779 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.777 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.777 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.777 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.777 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.776 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.776 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.776 | |
| 1iy8 | NAD | Levodione reductase | / | 0.775 | |
| 3sju | NDP | Keto reductase | / | 0.774 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.773 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.772 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.771 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.770 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.769 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.768 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.766 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.765 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.764 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.763 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.763 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.763 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.760 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.758 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.758 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.757 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.757 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.756 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.755 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.755 | |
| 4qed | NAP | ElxO | / | 0.754 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.753 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.752 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.751 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.750 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.750 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.750 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.749 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.749 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.748 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.746 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.746 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.746 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.746 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.745 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.744 | |
| 4u7w | NDP | MxaA | / | 0.743 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.741 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.741 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.740 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.739 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.739 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.739 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.738 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.738 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.736 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.736 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.735 | |
| 2bzg | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.734 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.734 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.733 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.733 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.732 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.732 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.731 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.730 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.728 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.728 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.728 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.728 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.726 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.725 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.725 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.725 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.725 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.724 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.724 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.724 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.723 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.722 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.722 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.722 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.721 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.721 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.720 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.720 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.720 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.720 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.720 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.719 | |
| 4hxy | NDP | Plm1 | / | 0.719 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.718 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.718 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.718 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.718 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.718 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.717 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.716 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.716 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.715 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.714 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.713 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.712 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.712 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.710 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.710 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.709 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.709 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.707 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.707 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.707 | |
| 1sny | NAP | LD36273p | / | 0.706 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.705 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.705 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.705 | |
| 3grv | ADN | Probable ribosomal RNA small subunit methyltransferase A | / | 0.705 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.704 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.704 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.703 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.702 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.702 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.701 | |
| 4tm3 | FAD | KtzI | / | 0.701 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.700 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.700 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.699 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.698 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.697 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.697 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.697 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.697 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.697 | |
| 5d2e | NAP | MlnE | / | 0.697 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.696 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.696 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.696 | |
| 4fgz | SAH | Phosphoethanolamine N-methyltransferase | / | 0.696 | |
| 4o29 | SAH | Protein-L-isoaspartate O-methyltransferase | / | 0.696 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.695 | |
| 3bmo | NAP | Pteridine reductase | / | 0.695 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.695 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.695 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.694 | |
| 4ymg | SAM | Putative SAM-dependent O-methyltranferase | / | 0.694 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.693 | |
| 3oe4 | 610 | Catechol O-methyltransferase | 2.1.1.6 | 0.693 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.692 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.691 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.691 | |
| 3g07 | SAM | 7SK snRNA methylphosphate capping enzyme | 2.1.1 | 0.691 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.690 | |
| 4gbe | SAH | DNA adenine methylase | 2.1.1.72 | 0.690 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.689 | |
| 4iv8 | SAM | Phosphoethanolamine N-methyltransferase,putative | / | 0.689 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.688 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.688 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.687 | |
| 4y9d | NAI | C alpha-dehydrogenase | / | 0.687 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.686 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.686 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.686 | |
| 4gqb | 0XU | Protein arginine N-methyltransferase 5 | / | 0.686 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.686 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.684 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.684 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.683 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.682 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.681 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.681 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.681 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.680 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.680 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.680 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.679 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.679 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.679 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.679 | |
| 2p35 | SAH | Trans-aconitate 2-methyltransferase | / | 0.679 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.679 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.678 | |
| 4clo | NAP | Pteridine reductase | / | 0.678 | |
| 4krh | SAM | Phosphoethanolamine N-methyltransferase 2 | / | 0.678 | |
| 1wy7 | SAH | Uncharacterized protein | / | 0.677 | |
| 2jib | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.677 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.676 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.676 | |
| 3nt2 | NAI | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.676 | |
| 2ore | SAH | DNA adenine methylase | 2.1.1.72 | 0.675 | |
| 4nzh | FAD | L-ornithine N(5)-monooxygenase | / | 0.675 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.675 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.674 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.674 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.674 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.673 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.672 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.672 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.672 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.671 | |
| 4xcx | SAH | Small RNA 2'-O-methyltransferase | / | 0.671 | |
| 1uay | ADN | Oxidoreductase | / | 0.670 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.670 | |
| 1zq9 | SAM | Probable dimethyladenosine transferase | / | 0.669 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.669 | |
| 3fpf | MTA | Uncharacterized protein | / | 0.669 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.668 | |
| 2ibt | NEA | Modification methylase TaqI | 2.1.1.72 | 0.668 | |
| 1sqf | SAM | Ribosomal RNA small subunit methyltransferase B | 2.1.1.176 | 0.667 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.667 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.667 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.667 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.666 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.665 | |
| 4fr0 | SAM | Arsenic methyltransferase | / | 0.665 | |
| 1grg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.664 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.664 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.664 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.664 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.664 | |
| 1grh | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.663 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.663 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.663 | |
| 2zth | SAM | Catechol O-methyltransferase | 2.1.1.6 | 0.663 | |
| 3uj7 | SAM | Phosphoethanolamine N-methyltransferase | / | 0.663 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.662 | |
| 2np7 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.662 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.661 | |
| 1ty8 | ADP | Probable ADP-ribose 1''-phosphate phosphatase YML087W | 3.1.3.84 | 0.661 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.661 | |
| 2hv9 | SFG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.661 | |
| 3a27 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.661 | |
| 3c3y | SAH | O-methyltransferase | / | 0.661 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.661 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.661 | |
| 1v59 | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.659 | |
| 4b69 | FAD | L-ornithine N(5)-monooxygenase | / | 0.659 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.659 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.659 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.659 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.659 | |
| 3mje | NDP | AmphB | / | 0.658 | |
| 3wv8 | ATP | Hmd co-occurring protein HcgE | / | 0.658 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.657 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.657 | |
| 2np6 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.657 | |
| 3u81 | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.657 | |
| 4pyn | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.657 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.656 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.656 | |
| 2bh2 | SAH | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | / | 0.656 | |
| 2yxl | SFG | 450aa long hypothetical fmu protein | / | 0.656 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.656 | |
| 4k9d | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.656 | |
| 2jg7 | NAD | Antiquitin | / | 0.655 | |
| 2rgj | FAD | Flavin-containing monooxygenase | / | 0.655 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.655 | |
| 3hvk | 719 | Catechol O-methyltransferase | 2.1.1.6 | 0.654 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.653 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.653 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.653 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.652 | |
| 2ih5 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.652 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.652 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.652 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.652 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.652 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.651 | |
| 1khh | SAH | Guanidinoacetate N-methyltransferase | 2.1.1.2 | 0.651 | |
| 3m2t | NAD | Probable dehydrogenase | / | 0.651 | |
| 4xvy | SAH | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.651 | |
| 3k30 | ADP | Histamine dehydrogenase | / | 0.650 | |
| 3nt6 | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.650 | |
| 3o7w | SAM | Leucine carboxyl methyltransferase 1 | 2.1.1.233 | 0.650 | |
| 3oc4 | FAD | Oxidoreductase, pyridine nucleotide-disulfide family | / | 0.650 |