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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4d04 FAD Phenylacetone monooxygenase 1.14.13.92

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4d04 FADPhenylacetone monooxygenase 1.14.13.92 1.469
4d03 FADPhenylacetone monooxygenase 1.14.13.92 1.459
2yls FADPhenylacetone monooxygenase 1.14.13.92 1.383
2ylx FADPhenylacetone monooxygenase 1.14.13.92 1.383
2ylr FADPhenylacetone monooxygenase 1.14.13.92 1.377
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 1.343
2ylt FADPhenylacetone monooxygenase 1.14.13.92 1.341
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 1.318
2ylw FADPhenylacetone monooxygenase 1.14.13.92 1.222
3gwd FADCyclohexanone monooxygenase / 1.058
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.031
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.002
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.978
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.968
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.881
2vq7 FADPutative flavin-containing monooxygenase / 0.812
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.809
2xlp FADPutative flavin-containing monooxygenase / 0.806
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.805
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.804
2vqb FADPutative flavin-containing monooxygenase / 0.795
3qvp FADGlucose oxidase 1.1.3.4 0.790
4tlz FADKtzI / 0.790
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.787
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.784
3qvr FADGlucose oxidase 1.1.3.4 0.784
3gwf FADCyclohexanone monooxygenase / 0.780
4b64 FADL-ornithine N(5)-monooxygenase / 0.774
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.769
1y56 ATPUncharacterized protein / 0.768
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.763
2rgh FADAlpha-Glycerophosphate Oxidase / 0.761
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.759
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.759
2gvc FADThiol-specific monooxygenase 1.14.13 0.755
4ap3 FADSteroid monooxygenase / 0.752
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.749
2xvf FADPutative flavin-containing monooxygenase / 0.748
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.747
4eqw FADCoenzyme A disulfide reductase / 0.746
4b63 FADL-ornithine N(5)-monooxygenase / 0.745
4tm3 FADKtzI / 0.745
4em4 FADCoenzyme A disulfide reductase / 0.738
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.738
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.737
4ap1 FADSteroid monooxygenase / 0.735
2jb2 FADL-amino acid oxidase / 0.734
1k0l FADp-hydroxybenzoate hydroxylase / 0.733
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.732
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.732
4z24 FADPutative GMC-type oxidoreductase R135 1 0.732
4z26 FADPutative GMC-type oxidoreductase R135 1 0.732
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.731
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.730
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.726
3utf FDAUDP-galactopyranose mutase / 0.726
1zx9 FADMercuric reductase 1.16.1.1 0.725
4b69 FADL-ornithine N(5)-monooxygenase / 0.725
2xlr FADPutative flavin-containing monooxygenase / 0.724
4fwf FADLysine-specific histone demethylase 1B 1 0.724
4eqx FADCoenzyme A disulfide reductase / 0.722
1zk7 FADMercuric reductase 1.16.1.1 0.721
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.720
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.719
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.718
1f8r FADL-amino-acid oxidase 1.4.3.2 0.717
3f8p NADNADH oxidase/thioredoxin reductase / 0.714
3hdy FADUDP-galactopyranose mutase / 0.714
2e1m FADL-glutamate oxidase / 0.713
3nlc FADUncharacterized protein / 0.713
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.707
3cty FADProbable thioredoxin reductase / 0.707
3ics FADCoenzyme A disulfide reductase / 0.707
4u8l FDAUDP-galactopyranose mutase / 0.707
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.705
4emw FADCoenzyme A disulfide reductase / 0.704
4u2t FADCholesterol oxidase 1.1.3.6 0.704
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.703
3kpf FADPolyamine oxidase 1.5.3.14 0.701
3t2y FADSulfide-quinone reductase / 0.701
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.700
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
3f8r NAPNADH oxidase/thioredoxin reductase / 0.697
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
5cku FADL-ornithine N(5)-monooxygenase / 0.696
3qj4 FADRenalase / 0.695
3s5w FADL-ornithine N(5)-monooxygenase / 0.694
2eq8 FADDihydrolipoyl dehydrogenase / 0.693
4fwe FADLysine-specific histone demethylase 1B 1 0.693
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.692
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.692
3fg2 FADPutative rubredoxin reductase / 0.692
3ish FADThioredoxin reductase 1.8.1.9 0.692
3ukl FADUDP-galactopyranose mutase / 0.692
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.691
2eq7 NADDihydrolipoyl dehydrogenase / 0.691
3ada NADSubunit alpha of sarocosine oxidase / 0.691
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
3bg7 FADPyranose 2-oxidase / 0.690
4jnq FDAThioredoxin reductase / 0.690
4b67 FADL-ornithine N(5)-monooxygenase / 0.689
4u2l SFDCholesterol oxidase 1.1.3.6 0.689
3ute FADUDP-galactopyranose mutase / 0.688
4u2s FDACholesterol oxidase 1.1.3.6 0.688
3f8d FADNADH oxidase/thioredoxin reductase / 0.686
3k30 ADPHistamine dehydrogenase / 0.686
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.686
2gqw FADFerredoxin reductase / 0.685
2gv8 FADThiol-specific monooxygenase 1.14.13 0.685
3r9u FADThioredoxin reductase / 0.685
4qi7 FADCellobiose dehydrogenase / 0.683
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
3b6d FAECholesterol oxidase 1.1.3.6 0.682
1nhr FADNADH peroxidase 1.11.1.1 0.681
1h81 FADPolyamine oxidase 1.5.3.14 0.680
2vvl FADMonoamine oxidase N 1.4.3.4 0.680
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
1gal FADGlucose oxidase 1.1.3.4 0.678
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.678
4aox FADSteroid monooxygenase / 0.678
4mih FADPyranose 2-oxidase 1.1.3.10 0.678
1b8s FADCholesterol oxidase 1.1.3.6 0.677
1cbo FADCholesterol oxidase 1.1.3.6 0.677
3uth FDAUDP-galactopyranose mutase / 0.677
4rek FADCholesterol oxidase 1.1.3.6 0.677
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.677
5hhf FDAUDP-galactopyranose mutase / 0.677
2yg5 FADPutrescine oxidase / 0.676
4qi5 FADCellobiose dehydrogenase / 0.675
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.674
4b66 FADL-ornithine N(5)-monooxygenase / 0.674
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.674
3icr FADCoenzyme A disulfide reductase / 0.673
4cnk FADL-amino acid oxidase / 0.673
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
3syi FADSulfide-quinone reductase / 0.671
3t37 FADPyridoxine 4-oxidase / 0.671
4jq9 FADDihydrolipoyl dehydrogenase / 0.671
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.670
2eq6 FADDihydrolipoyl dehydrogenase / 0.670
2gr0 FADFerredoxin reductase / 0.670
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.670
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.670
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.669
1yqz FADCoenzyme A disulfide reductase / 0.669
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.669
4eqs FADCoenzyme A disulfide reductase / 0.669
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.669
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.669
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
1ges FADGlutathione reductase 1.8.1.7 0.667
2r0c FADPutative FAD-monooxygenase / 0.667
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.666
3lad FADDihydrolipoyl dehydrogenase / 0.666
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
2xvh FADPutative flavin-containing monooxygenase / 0.665
3ukf FDAUDP-galactopyranose mutase / 0.665
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.664
1fec FADTrypanothione reductase 1.8.1.12 0.664
3atr FDAConserved Archaeal protein / 0.663
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.663
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.663
4gut FADLysine-specific histone demethylase 1B 1 0.663
4nev FADTrypanothione reductase / 0.663
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.662
2igo FADPyranose 2-oxidase / 0.661
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.661
4aos FADSteroid monooxygenase / 0.660
3ihg FADAklavinone 12-hydroxylase RdmE / 0.659
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.659
4gur FADLysine-specific histone demethylase 1B 1 0.659
4u8k FDAUDP-galactopyranose mutase / 0.659
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.658
3vqr FADPutative oxidoreductase / 0.658
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.657
2hmv ADPKtr system potassium uptake protein A / 0.657
3cgb FADCoenzyme A disulfide reductase / 0.657
4u8o FDAUDP-galactopyranose mutase / 0.657
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.656
4em3 FADCoenzyme A disulfide reductase / 0.656
1fea FADTrypanothione reductase 1.8.1.12 0.655
1nhs FADNADH peroxidase 1.11.1.1 0.655
1pdh FASp-hydroxybenzoate hydroxylase / 0.655
3jsk AHZThiamine thiazole synthase / 0.655
3rha FDAPutrescine oxidase / 0.655
4cnj FADL-amino acid oxidase / 0.655
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.654
2xvi FADPutative flavin-containing monooxygenase / 0.654
3bi2 FADPolyamine oxidase FMS1 / 0.654
3cgc FADCoenzyme A disulfide reductase / 0.654
3lsm SFDPyranose 2-oxidase / 0.654
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.654
4i58 FADCyclohexylamine Oxidase / 0.654
4yry FADGlutamate synthase, beta subunit / 0.654
2dw4 FADLysine-specific histone demethylase 1A 1 0.653
1d7y FADFerredoxin reductase / 0.652
1geu FADGlutathione reductase 1.8.1.7 0.652
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.652
2jae FADL-amino acid oxidase / 0.652
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.652
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.652
2iid FADL-amino-acid oxidase 1.4.3.2 0.651
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
3q9t FAYUncharacterized protein / 0.651
4mo2 FADUDP-galactopyranose mutase / 0.651
4mok FADPyranose 2-oxidase / 0.651
4tm0 NAPKtzI / 0.651
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.650
2gew FADCholesterol oxidase 1.1.3.6 0.650
3pl8 FADPyranose 2-oxidase / 0.650
4jn9 FADDepH / 0.650
4xwr FADCholesterol oxidase 1.1.3.6 0.650