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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1knr FAD L-aspartate oxidase 1.4.3.16

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1knr FADL-aspartate oxidase 1.4.3.16 1.442
1knp FADL-aspartate oxidase 1.4.3.16 1.264
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.939
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.910
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.899
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.879
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.874
1qo8 FADFumarate reductase flavoprotein subunit / 0.865
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.853
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.842
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.841
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.818
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.808
4at0 FADPossible succinate dehydrogenase / 0.801
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.799
4c3y FAD3-ketosteroid dehydrogenase / 0.778
3cuk FADD-amino-acid oxidase 1.4.3.3 0.767
3v76 FDAUncharacterized protein / 0.767
4cnk FADL-amino acid oxidase / 0.761
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.757
4wct FADFructosyl amine:oxygen oxidoreductase / 0.754
1ng3 FADGlycine oxidase 1.4.3.19 0.748
4c3x FAD3-ketosteroid dehydrogenase / 0.747
3atq FDAConserved Archaeal protein / 0.746
3atr FDAConserved Archaeal protein / 0.744
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.744
4cnj FADL-amino acid oxidase / 0.741
3gsi FADDimethylglycine oxidase 1.5.3.10 0.740
2yg6 FADPutrescine oxidase / 0.739
4gcm FADThioredoxin reductase 1.8.1.9 0.739
3pl8 FADPyranose 2-oxidase / 0.738
3axb FADPutative oxidoreductase / 0.734
4opl FDAConserved Archaeal protein / 0.734
4mok FADPyranose 2-oxidase / 0.732
1trb FADThioredoxin reductase 1.8.1.9 0.731
4yjd FADD-amino-acid oxidase 1.4.3.3 0.731
1c0l FADD-amino-acid oxidase 1.4.3.3 0.729
4jn9 FADDepH / 0.728
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.728
3ae4 FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.726
3cgb FADCoenzyme A disulfide reductase / 0.725
4opt FDAConserved Archaeal protein / 0.724
2yg4 FADPutrescine oxidase / 0.723
3f8d FADNADH oxidase/thioredoxin reductase / 0.722
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.719
3fbs FADOxidoreductase / 0.718
2b9x FADPutative aminooxidase / 0.717
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.715
1tdf FADThioredoxin reductase 1.8.1.9 0.714
4opu FDAConserved Archaeal protein / 0.714
1gpe FADGlucose oxidase 1.1.3.4 0.713
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.713
2du8 FADD-amino-acid oxidase 1.4.3.3 0.713
3dme FADPutative conserved exported protein / 0.713
4fwe FADLysine-specific histone demethylase 1B 1 0.713
1ng4 FADGlycine oxidase 1.4.3.19 0.712
2whd FADThioredoxin reductase / 0.712
1h81 FADPolyamine oxidase 1.5.3.14 0.711
4hsu FADLysine-specific histone demethylase 1B 1 0.711
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.710
2bac FADPutative aminooxidase / 0.709
3t37 FADPyridoxine 4-oxidase / 0.708
1c0k FADD-amino-acid oxidase 1.4.3.3 0.707
2e1m FADL-glutamate oxidase / 0.707
4fwf FADLysine-specific histone demethylase 1B 1 0.707
5hxw FADL-amino acid deaminase / 0.706
5i39 FADL-amino acid deaminase / 0.705
4up3 FADThioredoxin reductase / 0.704
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.703
1h83 FADPolyamine oxidase 1.5.3.14 0.702
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.701
4ysh FADGlycine oxidase / 0.701
2ba9 FADPutative aminooxidase / 0.700
4ccq FADThioredoxin reductase / 0.700
4fwj FADLysine-specific histone demethylase 1B 1 0.700
2iw5 FADLysine-specific histone demethylase 1A 1 0.699
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.699
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.698
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.697
2dw4 FADLysine-specific histone demethylase 1A 1 0.695
3lsi FADPyranose 2-oxidase / 0.695
1yy5 FADPolyamine oxidase FMS1 / 0.694
4cbq FADThioredoxin reductase / 0.693
4qi5 FADCellobiose dehydrogenase / 0.693
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.692
3qvp FADGlucose oxidase 1.1.3.4 0.691
4gdp FADPolyamine oxidase FMS1 / 0.691
1ryi FADGlycine oxidase 1.4.3.19 0.690
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.690
3qvr FADGlucose oxidase 1.1.3.4 0.689
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.687
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.687
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.687
4f07 FADStyrene monooxygenase component 2 / 0.687
4guu FA9Lysine-specific histone demethylase 1B 1 0.687
1cf3 FADGlucose oxidase 1.1.3.4 0.686
1tde FADThioredoxin reductase 1.8.1.9 0.686
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.686
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.686
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.685
2yg3 FADPutrescine oxidase / 0.685
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.685
4nte FADDepH / 0.685
3cnd FADPolyamine oxidase FMS1 / 0.684
4gut FADLysine-specific histone demethylase 1B 1 0.684
1d7y FADFerredoxin reductase / 0.683
2uxx FAJLysine-specific histone demethylase 1A 1 0.683
2yg7 FADPutrescine oxidase / 0.683
3k4c FADPyranose 2-oxidase / 0.683
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.683
1z6l FADPolyamine oxidase FMS1 / 0.682
3lsh FADPyranose 2-oxidase / 0.682
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.682
3kpf FADPolyamine oxidase 1.5.3.14 0.681
3nlc FADUncharacterized protein / 0.681
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.681
4gur FADLysine-specific histone demethylase 1B 1 0.681
4uir FADOleate hydratase 4.2.1.53 0.681
4x9n FADUncharacterized protein MG039 homolog / 0.681
1fnc FDAFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.680
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
3q9t FAYUncharacterized protein / 0.680
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
3itj FADThioredoxin reductase 1 1.8.1.9 0.679
4x9m FADUncharacterized protein MG039 homolog / 0.678
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.677
3r9u FADThioredoxin reductase / 0.676
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
5buk FADFADH2-dependent halogenase / 0.676
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.675
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.675
4ech FADPolyamine oxidase FMS1 / 0.675
2gqf FADUncharacterized protein HI_0933 / 0.674
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.674
2gr0 FADFerredoxin reductase / 0.673
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.673
3kkj FADRenalase / 0.673
1cl0 FADThioredoxin reductase 1.8.1.9 0.672
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.672
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.672
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.672
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.671
1xpq FADPolyamine oxidase FMS1 / 0.670
1rz1 FADPhenol 2-hydroxylase component B / 0.668
3cn8 FADPolyamine oxidase FMS1 / 0.668
2zbw FADFerredoxin--NADP reductase / 0.667
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.666
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.666
1bx1 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.665
1fnd FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.665
2b9w FADPutative aminooxidase / 0.665
2wow FADTrypanothione reductase / 0.665
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.664
2jb2 FADL-amino acid oxidase / 0.664
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.664
4em3 FADCoenzyme A disulfide reductase / 0.664
1q1r FADPutidaredoxin reductase 1.18.1.5 0.663
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.663
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
2bab FADPutative aminooxidase / 0.662
2y48 FADLysine-specific histone demethylase 1A 1 0.662
3bm1 FMNPutative NAD(P)H nitroreductase YdjA / 0.662
3lov FADProtoporphyrinogen oxidase / 0.662
3vqr FADPutative oxidoreductase / 0.662
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.662
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
2jb1 FADL-amino acid oxidase / 0.659
3ad9 FADSubunit beta of sarcosine oxidase / 0.659
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.658
2hqm FADGlutathione reductase 1.8.1.7 0.658
2rgh FADAlpha-Glycerophosphate Oxidase / 0.658
2vvl FADMonoamine oxidase N 1.4.3.4 0.658
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.658
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.658
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.657
4ewn 0VRImidazole glycerol phosphate synthase subunit HisF 4.1.3 0.657
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.657
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.656
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.655
1q1w FADPutidaredoxin reductase 1.18.1.5 0.655
2yvj FADFerredoxin reductase / 0.655
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
3ish FADThioredoxin reductase 1.8.1.9 0.655
3qj4 FADRenalase / 0.655
4dsg FADUncharacterized protein / 0.655
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.654
1yrx FMNAppA protein / 0.654
3cgd FADCoenzyme A disulfide reductase / 0.654
3k4n FADPyranose 2-oxidase / 0.654
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.654
4rsl FADFructosyl peptide oxidase / 0.654
1fdr FADFerredoxin--NADP reductase 1.18.1.2 0.653
2yg5 FADPutrescine oxidase / 0.653
2yqu FADDihydrolipoyl dehydrogenase / 0.653
3gyj FADCholesterol oxidase 1.1.3.6 0.653
4jnq FDAThioredoxin reductase / 0.653
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.653
4z24 FADPutative GMC-type oxidoreductase R135 1 0.653
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.652
2reh FADNitroalkane oxidase 1.7.3.1 0.652
4emw FADCoenzyme A disulfide reductase / 0.652
4gus FADLysine-specific histone demethylase 1B 1 0.652
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.652
4jq9 FADDihydrolipoyl dehydrogenase / 0.652
1b8s FADCholesterol oxidase 1.1.3.6 0.651
1fea FADTrypanothione reductase 1.8.1.12 0.651
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
1rz0 FADPhenol 2-hydroxylase component B / 0.651
3ept FDAPutative FAD-monooxygenase / 0.651
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4yry FADGlutamate synthase, beta subunit / 0.651
1bx0 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.650
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
2gqw FADFerredoxin reductase / 0.650
2q7v FADThioredoxin reductase / 0.650
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.650
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.650