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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1e1l FAD NADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 1.252
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 1.062
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 1.040
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 1.033
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 1.022
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.991
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.972
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.915
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.851
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.834
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.816
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.805
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.801
4fwj FADLysine-specific histone demethylase 1B 1 0.801
4fwf FADLysine-specific histone demethylase 1B 1 0.799
4u8o FDAUDP-galactopyranose mutase / 0.795
4gde FDAUDP-galactopyranose mutase / 0.790
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.789
3he3 FADUDP-galactopyranose mutase / 0.787
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.785
2yg6 FADPutrescine oxidase / 0.783
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.781
4u8m FDAUDP-galactopyranose mutase / 0.775
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.774
3f8d FADNADH oxidase/thioredoxin reductase / 0.773
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.770
4fwe FADLysine-specific histone demethylase 1B 1 0.770
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.768
3cnt FADPolyamine oxidase FMS1 / 0.768
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.767
4u8j FDAUDP-galactopyranose mutase / 0.764
2rgj FADFlavin-containing monooxygenase / 0.759
3hdy FADUDP-galactopyranose mutase / 0.757
3utf FDAUDP-galactopyranose mutase / 0.757
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.754
2yg3 FADPutrescine oxidase / 0.754
3cty FADProbable thioredoxin reductase / 0.753
3utg FDAUDP-galactopyranose mutase / 0.753
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.752
4u8k FDAUDP-galactopyranose mutase / 0.752
2gvc FADThiol-specific monooxygenase 1.14.13 0.750
3kkj FADRenalase / 0.747
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.747
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.745
2jb2 FADL-amino acid oxidase / 0.744
3lov FADProtoporphyrinogen oxidase / 0.744
1cf3 FADGlucose oxidase 1.1.3.4 0.743
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.742
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.741
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.741
4b63 FADL-ornithine N(5)-monooxygenase / 0.741
4cnk FADL-amino acid oxidase / 0.740
4gur FADLysine-specific histone demethylase 1B 1 0.740
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.740
1h83 FADPolyamine oxidase 1.5.3.14 0.739
1f8s FADL-amino-acid oxidase 1.4.3.2 0.738
2q0l FADThioredoxin reductase 1.8.1.9 0.738
2e1m FADL-glutamate oxidase / 0.737
2gv8 FADThiol-specific monooxygenase 1.14.13 0.737
4guu FA9Lysine-specific histone demethylase 1B 1 0.737
2jb1 FADL-amino acid oxidase / 0.736
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.736
2y48 FADLysine-specific histone demethylase 1A 1 0.735
2yg7 FADPutrescine oxidase / 0.735
4em4 FADCoenzyme A disulfide reductase / 0.735
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.735
2dw4 FADLysine-specific histone demethylase 1A 1 0.733
4u8n FDAUDP-galactopyranose mutase / 0.733
3gwd FADCyclohexanone monooxygenase / 0.731
3sz0 FADSulfide-quinone reductase / 0.731
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.731
2iw5 FADLysine-specific histone demethylase 1A 1 0.730
3t37 FADPyridoxine 4-oxidase / 0.730
3ukl FADUDP-galactopyranose mutase / 0.730
4dsg FADUncharacterized protein / 0.730
4wx1 FDAUDP-galactopyranose mutase / 0.730
1f8r FADL-amino-acid oxidase 1.4.3.2 0.729
2yg5 FADPutrescine oxidase / 0.729
1nhq FADNADH peroxidase 1.11.1.1 0.727
3cn8 FADPolyamine oxidase FMS1 / 0.727
3ish FADThioredoxin reductase 1.8.1.9 0.727
4ech FADPolyamine oxidase FMS1 / 0.727
5j60 FADThioredoxin reductase / 0.727
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.726
2xvi FADPutative flavin-containing monooxygenase / 0.726
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.726
3mj4 FADUDP-galactopyranose mutase / 0.726
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.725
4emw FADCoenzyme A disulfide reductase / 0.724
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.723
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.722
2rgh FADAlpha-Glycerophosphate Oxidase / 0.722
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.721
4gcm FADThioredoxin reductase 1.8.1.9 0.721
2b9y FADPutative aminooxidase / 0.720
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.719
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.719
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.718
3ka7 FADPutative oxidoreductase / 0.718
3ukk FADUDP-galactopyranose mutase / 0.718
3uth FDAUDP-galactopyranose mutase / 0.718
4dsh FDAUncharacterized protein / 0.716
4u8i FDAUDP-galactopyranose mutase / 0.716
5hhf FDAUDP-galactopyranose mutase / 0.716
2vq7 FADPutative flavin-containing monooxygenase / 0.713
4b64 FADL-ornithine N(5)-monooxygenase / 0.713
4z26 FADPutative GMC-type oxidoreductase R135 1 0.713
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.712
4eqx FADCoenzyme A disulfide reductase / 0.712
3c96 FADFlavin-containing monooxygenase / 0.711
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.711
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.711
3cgc FADCoenzyme A disulfide reductase / 0.709
3bi5 FADPolyamine oxidase FMS1 / 0.708
1reo FADL-amino-acid oxidase 1.4.3.2 0.707
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.707
1ger FADGlutathione reductase 1.8.1.7 0.706
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.706
1yqz FADCoenzyme A disulfide reductase / 0.706
4z24 FADPutative GMC-type oxidoreductase R135 1 0.706
3t2k FADSulfide-quinone reductase / 0.705
4gdp FADPolyamine oxidase FMS1 / 0.705
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.704
2cvj FADThioredoxin reductase related protein / 0.703
3hdy FDAUDP-galactopyranose mutase / 0.703
3qj4 FADRenalase / 0.703
4cnj FADL-amino acid oxidase / 0.703
1yy5 FADPolyamine oxidase FMS1 / 0.702
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.702
4mih FADPyranose 2-oxidase 1.1.3.10 0.701
4qi7 FADCellobiose dehydrogenase / 0.701
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.701
2q7v FADThioredoxin reductase / 0.700
2vqb FADPutative flavin-containing monooxygenase / 0.700
4usr FADMonooxygenase / 0.699
4yry FADGlutamate synthase, beta subunit / 0.699
3kpk FADSulfide-quinone reductase / 0.698
4jnq FDAThioredoxin reductase / 0.698
4tm4 FDAKtzI / 0.698
1tdf FADThioredoxin reductase 1.8.1.9 0.697
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.697
3cgb FADCoenzyme A disulfide reductase / 0.697
2bac FADPutative aminooxidase / 0.696
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.696
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.696
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.696
2jae FADL-amino acid oxidase / 0.695
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.694
1y56 ATPUncharacterized protein / 0.694
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
3f8p NADNADH oxidase/thioredoxin reductase / 0.694
3ukf FDAUDP-galactopyranose mutase / 0.694
2yvf FADFerredoxin reductase / 0.693
3cge FADCoenzyme A disulfide reductase / 0.691
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.690
4up3 FADThioredoxin reductase / 0.689
1nhs FADNADH peroxidase 1.11.1.1 0.688
2cul FADGidA-related protein / 0.688
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.688
3f8r NAPNADH oxidase/thioredoxin reductase / 0.687
4xbf FADLysine-specific histone demethylase 1A 1 0.687
5cku FADL-ornithine N(5)-monooxygenase / 0.686
1tde FADThioredoxin reductase 1.8.1.9 0.684
2xls FADPutative flavin-containing monooxygenase / 0.684
1rsg FADPolyamine oxidase FMS1 / 0.683
2xve FADPutative flavin-containing monooxygenase / 0.683
3k30 ADPHistamine dehydrogenase / 0.683
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.682
4b69 FADL-ornithine N(5)-monooxygenase / 0.682
4qi4 FADCellobiose dehydrogenase / 0.682
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
1fea FADTrypanothione reductase 1.8.1.12 0.680
1nhp FADNADH peroxidase 1.11.1.1 0.680
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.680
2xvf FADPutative flavin-containing monooxygenase / 0.680
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.680
4eqw FADCoenzyme A disulfide reductase / 0.680
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.679
3t2y FADSulfide-quinone reductase / 0.679
3ukk FDAUDP-galactopyranose mutase / 0.679
4tm1 FDAKtzI / 0.679
1c0k FADD-amino-acid oxidase 1.4.3.3 0.678
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.678
2r9z FADGlutathione amide reductase / 0.678
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.678
5br7 FADUDP-galactopyranose mutase / 0.678
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.677
2h94 FADLysine-specific histone demethylase 1A 1 0.677
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.677
4yac NAIC alpha-dehydrogenase / 0.677
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.676
1qo8 FADFumarate reductase flavoprotein subunit / 0.676
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.675
4b65 FADL-ornithine N(5)-monooxygenase / 0.675
2xlp FADPutative flavin-containing monooxygenase / 0.674
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.674
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.674
3r9u FADThioredoxin reductase / 0.674
4gus FADLysine-specific histone demethylase 1B 1 0.674
4x4j FADPutative oxygenase / 0.674
3kve FADL-amino-acid oxidase / 0.672
3qvp FADGlucose oxidase 1.1.3.4 0.672
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.671
4tm3 FADKtzI / 0.671
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.670
4ysh FADGlycine oxidase / 0.670
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.669
4i58 FADCyclohexylamine Oxidase / 0.669
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.668
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.668
1h81 FADPolyamine oxidase 1.5.3.14 0.667
3qvr FADGlucose oxidase 1.1.3.4 0.667
1gpe FADGlucose oxidase 1.1.3.4 0.666
3uka FADUDP-galactopyranose mutase / 0.666
1gal FADGlucose oxidase 1.1.3.4 0.665
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
1tdn FADL-amino-acid oxidase 1.4.3.2 0.664
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.664
3gyj FADCholesterol oxidase 1.1.3.6 0.664
3ihg FADAklavinone 12-hydroxylase RdmE / 0.664
4em3 FADCoenzyme A disulfide reductase / 0.664
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.663
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
2yqu FADDihydrolipoyl dehydrogenase / 0.662
3ada NADSubunit alpha of sarocosine oxidase / 0.662
3fg2 FADPutative rubredoxin reductase / 0.662
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.662
4x9m FADUncharacterized protein MG039 homolog / 0.662
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.660
3gyi FADCholesterol oxidase 1.1.3.6 0.660
4u2t FADCholesterol oxidase 1.1.3.6 0.660
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.659
1cl0 FADThioredoxin reductase 1.8.1.9 0.658
1d7y FADFerredoxin reductase / 0.658
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
2b9x FADPutative aminooxidase / 0.658
2bab FADPutative aminooxidase / 0.658
4u8l FDAUDP-galactopyranose mutase / 0.658
2eq7 FADDihydrolipoyl dehydrogenase / 0.657
3bi2 FADPolyamine oxidase FMS1 / 0.657
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.657
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.657
3v76 FDAUncharacterized protein / 0.657
4aox FADSteroid monooxygenase / 0.657
4rek FADCholesterol oxidase 1.1.3.6 0.657
4ynt FDAGlucose oxidase, putative / 0.657
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.656
1get FADGlutathione reductase 1.8.1.7 0.656
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.656
4c3y FAD3-ketosteroid dehydrogenase / 0.656
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
2eq9 FADDihydrolipoyl dehydrogenase / 0.655
4b1b FADThioredoxin reductase 1.8.1.9 0.655
4b66 FADL-ornithine N(5)-monooxygenase / 0.655
4b68 FADL-ornithine N(5)-monooxygenase / 0.655
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.655
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.654
1tll FMNNitric oxide synthase, brain 1.14.13.39 0.654
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.654
3zdn FADMonoamine oxidase N 1.4.3.4 0.654
1b8s FADCholesterol oxidase 1.1.3.6 0.653
1f3p FADFerredoxin reductase / 0.653
3dme FADPutative conserved exported protein / 0.653
3gwf FADCyclohexanone monooxygenase / 0.653
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.653
4eqr FADCoenzyme A disulfide reductase / 0.653
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.652
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
1tdk FADL-amino-acid oxidase 1.4.3.2 0.651
2wba FADTrypanothione reductase 1.8.1.12 0.651
2xvh FADPutative flavin-containing monooxygenase / 0.651
3lad FADDihydrolipoyl dehydrogenase / 0.651
3urh FADDihydrolipoyl dehydrogenase / 0.651
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4mo2 FADUDP-galactopyranose mutase / 0.651
1trb FADThioredoxin reductase 1.8.1.9 0.650
2hqm FADGlutathione reductase 1.8.1.7 0.650
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.650
4eqs FADCoenzyme A disulfide reductase / 0.650
4tlz FADKtzI / 0.650