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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5difGNPGTP-binding nuclear protein Ran

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
5difGNPGTP-binding nuclear protein Ran/1.000
5jljGNPGTP-binding nuclear protein Ran/0.769
3rslGNPGTPase HRas/0.637
5dhaGNPGTP-binding nuclear protein Ran/0.637
3oiwGNPGTPase HRas/0.636
2bkuGTPGTP-binding nuclear protein Ran/0.632
3rs7GNPGTPase HRas/0.624
3ea5GDPGTP-binding nuclear protein Ran/0.622
4g0nGNPGTPase HRas/0.622
4dsnGCPGTPase KRas/0.618
1t91GTPRas-related protein Rab-7a/0.617
3a6pGTPGTP-binding nuclear protein Ran/0.614
4dlsGNPGTPase HRas/0.613
3pitGNPRas-related protein M-Ras/0.609
1ibrGNPGTP-binding nuclear protein Ran/0.607
3kkoGNPRas-related protein M-Ras/0.607
3w3zGTPGTP-binding nuclear protein Ran/0.607
4hdoGNPRas-related protein Rap-1b/0.602
3rs5GNPGTPase HRas/0.600
2rgbGNPGTPase HRas/0.599
1e96GTPRas-related C3 botulinum toxin substrate 1/0.598
3bbpGTPRas-related protein Rab-6A/0.598
3lbnGNPGTPase HRas/0.598
4lhwGNPRas-related protein Rab-8A/0.597
3ddcGNPGTPase HRas/0.596
3rs0GNPGTPase HRas/0.596
4dltGNPGTPase HRas/0.595
3rs4GNPGTPase HRas/0.594
3l8yGNPGTPase HRas/0.593
4dlzGNPGTPase HRas/0.593
3rabGNPRas-related protein Rab-3A/0.591
3v4fGNPGTPase HRas/0.588
3lbhGNPGTPase HRas/0.587
4rkfGNPRas-related protein Rab-3/0.586
4dlvGNPGTPase HRas/0.584
4dlxGNPGTPase HRas/0.584
1k5dGNPGTP-binding nuclear protein Ran/0.582
3wyfGTPGTP-binding nuclear protein/0.582
3kudGDPGTPase HRas/0.581
5b2zGNPGTPase HRas/0.581
2c5lGTPGTPase HRas/0.578
3x1zGNPRas-related protein Rap-1b/0.578
1zbdGTPRas-related protein Rab-3A/0.576
4nyjGNPGTPase HRas/0.576
3e5hGNPRas-related protein Rab-28/0.575
3oivGNPGTPase HRas/0.575
3i3sGNPGTPase HRas/0.574
1xtsGTPGTP-binding protein Rheb/0.573
1vg8GNPRas-related protein Rab-7a/0.572
4mitGTPRho-related protein racC/0.571
2rgeGNPGTPase HRas/0.570
4o2rGDPGTP-binding protein Rheb/0.570
2ffqGSPRas-related protein Rab-6B/0.568
2fe4GDPRas-related protein Rab-6B/0.567
1g17GNPRas-related protein SEC4/0.565
4dlwGNPGTPase HRas/0.565
2rgcGNPGTPase HRas/0.562
1zd9GDPADP-ribosylation factor-like protein 8A/0.561
4o2lGTPGTP-binding protein Rheb/0.558
1x1rGDPRas-related protein M-Ras/0.557
1xtrGNPGTP-binding protein Rheb/0.555
4l9wGNPGTPase HRas/0.553
3lbiGNPGTPase HRas/0.551
3oiuGNPGTPase HRas/0.551
4nyiGNPGTPase HRas/0.547
4ol0GTPGTP-binding nuclear protein Ran/0.544
3k8yGNPGTPase HRas/0.541
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.541
1d5cGDPGTPase (Rab6)/0.540
3kucGDPRas-related protein Rap-1A/0.540
3nbzGTPGTP-binding nuclear protein Ran/0.540
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.540
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.536
2zetGTPRas-related protein Rab-27B/0.534
3a58GNPGTP-binding protein RHO1/0.534
3oesGNPGTPase RhebL1/0.532
1oixGDPRas-related protein Rab-11A/0.527
1cxzGSPTransforming protein RhoA/0.524
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.524
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.524
1g16GDPRas-related protein SEC4/0.520
4uj3GNPRas-related protein Rab-11A/0.520
1z2aGDPRas-related protein Rab-23/0.517
4o25GTPGTP-binding protein Rheb/0.515
2fg5GNPRas-related protein Rab-31/0.512
4ql3GDPGTPase KRas/0.512
4tq9GDPGTPase KRas/0.512
4l8gGDPGTPase KRas/0.511
2msdGNPMHC class I alpha chain/0.510
4ldjGDPGTPase KRas/0.509
1a2bGSPTransforming protein RhoA/0.507
4uj5GNPRas-related protein Rab-11A/0.505
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.504
1z0dGDPRas-related protein Rab-5C/0.503
3cphGDPRas-related protein SEC4/0.503
4dxaGSPRas-related protein Rap-1b/0.503
4epxGDPGTPase KRas/0.503
1kmqGNPTransforming protein RhoA/0.502
1zc4GNPRas-related protein Ral-A/0.502
3th5GNPRas-related C3 botulinum toxin substrate 1/0.500
4hdqGNPRas-related protein Rap-1b/0.500
4lpkGDPGTPase KRas/0.497
4dsoGSPGTPase KRas/0.496
4obeGDPGTPase KRas/0.493
3eg5GNPCell division control protein 42 homolog/0.491
3tgpGNPGTPase HRas/0.488
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.487
1gveNAPAflatoxin B1 aldehyde reductase member 310.486
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.486
4q02GDPGTPase KRas/0.486
3lawGNPRas-related protein Rab-7a/0.485
3kkqGDPRas-related protein M-Ras/0.484
1ow3GDPTransforming protein RhoA/0.483
1yu9GNPRas-related protein Rab-4A/0.482
2ce2GDPGTPase HRas/0.481
2clsGTPRho-related GTP-binding protein Rho6/0.481
3tklGTPRas-related protein Rab-1A/0.481
4epwGDPGTPase KRas/0.481
4js0GNPCell division control protein 42 homolog/0.481
4l9sGDPGTPase HRas/0.481
4lv6GDPGTPase KRas/0.480
1n6lGTPRas-related protein Rab-5A/0.476
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.476
4q03GDPGTPase KRas/0.476
1m7bGTPRho-related GTP-binding protein RhoE/0.475
1zc3GNPRas-related protein Ral-A/0.474
2c29NAPDihydroflavonol 4-reductase/0.474
4n3l2FNProthrombin3.4.21.50.474
1z2cGNPRho-related GTP-binding protein RhoC/0.472
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.472
4l1xNAPAldo-keto reductase family 1 member C2/0.471
4q0a4OAVitamin D3 receptor A/0.471
1vyrFMNPentaerythritol tetranitrate reductase/0.470
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.470
5hpyGDPTransforming protein RhoA/0.470
1fmjRTLRetinol dehydratase/0.469
2zymACXPeriplasmic binding protein/0.469
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.468
4xvqGNPGTPase HRas/0.468
2vd0D27Hematopoietic prostaglandin D synthase/0.467
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.467
2g1n1IGRenin3.4.23.150.466
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.466
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.466
3p74FMNPentaerythritol tetranitrate reductase/0.466
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.466
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.466
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.466
4wa7GDPGTPase KRas/0.466
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.465
1mrqSTRAldo-keto reductase family 1 member C1/0.465
2bmeGNPRas-related protein Rab-4A/0.465
3w0iO11Vitamin D3 receptor/0.465
4lrwGDPGTPase KRas/0.465
1cjuFOKAdenylate cyclase type 2/0.464
1cjuFOKAdenylate cyclase type 5/0.464
1cqp803Integrin alpha-L/0.464
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.464
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.464
3p62FMNPentaerythritol tetranitrate reductase/0.463
3x1wGDPRas-related protein Rap-1b/0.463
4imgNGFN-acetylneuraminate lyase/0.463
2vbpVB1Isopenicillin N synthase1.21.3.10.462
4cidANPEH domain-containing protein 2/0.462
1h63FMNPentaerythritol tetranitrate reductase/0.461
2ociTYCValacyclovir hydrolase3.10.461
3w0c6DSVitamin D3 receptor/0.461
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.460
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.460
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.460
4rrcA3TProbable threonine--tRNA ligase 26.1.1.30.460
1h50FMNPentaerythritol tetranitrate reductase/0.459
1ie8KH1Vitamin D3 receptor/0.459
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.459
2o4rVD5Vitamin D3 receptor/0.459
2zlcVDXVitamin D3 receptor/0.459
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.459
5iu86DZAdenosine receptor A2a/0.459
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
3w0aDS5Vitamin D3 receptor/0.458
4bfzZVZPantothenate kinase2.7.1.330.457
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.457
4twnB96Ephrin type-A receptor 32.7.10.10.457
1cjkFOKAdenylate cyclase type 2/0.456
1cjkFOKAdenylate cyclase type 5/0.456
2v59LZKBiotin carboxylase6.3.4.140.456
3h3t16HCollagen type IV alpha-3-binding protein/0.456
4b67NAPL-ornithine N(5)-monooxygenase/0.456
1hfqMOTDihydrofolate reductase1.5.1.30.455
1ky2GNPGTP-binding protein YPT7/0.455
3djfBC3Purine nucleoside phosphorylase/0.455
1tu3GNPRas-related protein Rab-5A/0.454
2rggGNPGTPase HRas/0.454
2rqfJH3Hemolymph juvenile hormone binding protein/0.454
3c14FOKAdenylate cyclase type 2/0.454
3c14FOKAdenylate cyclase type 5/0.454
1culFOKAdenylate cyclase type 2/0.453
1culFOKAdenylate cyclase type 5/0.453
1txiTX5Vitamin D3 receptor/0.453
1y3aGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.453
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.453
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.453
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.453
3ddw055Glycogen phosphorylase, liver form2.4.1.10.453
3o6o94MHeat shock protein 83/0.453
3w0hW12Vitamin D3 receptor/0.453
1cjtFOKAdenylate cyclase type 2/0.452
1cjtFOKAdenylate cyclase type 5/0.452
2hl0A3SThreonine--tRNA ligase6.1.1.30.452
2v5aLZLBiotin carboxylase6.3.4.140.452
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.452
1a4rGNHCell division control protein 42 homolog/0.451
1ta6177Prothrombin3.4.21.50.451
1xxjUNCUricase1.7.3.30.451
2mscGDPMHC class I alpha chain/0.451
2q3fGNPRas-related GTP-binding protein D/0.451
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.451
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.451
1gwnGTPRho-related GTP-binding protein RhoE/0.450
1rx1NAPDihydrofolate reductase1.5.1.30.450
2zbaZBATrichothecene 3-O-acetyltransferase/0.450
3ekuCY9Actin-5C/0.450
3ha5SFGHydroxymycolate synthase MmaA42.1.10.450
3nmpPYVAbscisic acid receptor PYL2/0.450
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.450
3vt3VDXVitamin D3 receptor/0.450
4fflADPUncharacterized protein/0.450
1m2oGNPSmall COPII coat GTPase SAR13.6.50.449
1qiqACCIsopenicillin N synthase1.21.3.10.449
2o4jVD4Vitamin D3 receptor/0.449
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.449
4qzuRTLRetinol-binding protein 2/0.449
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.449
1obnASVIsopenicillin N synthase1.21.3.10.448
1xddAAYIntegrin alpha-L/0.448
2bxmIMNSerum albumin/0.448
2harOCCVitamin D3 receptor/0.448
2pksG44Prothrombin3.4.21.50.448
4gojGNPADP-ribosylation factor-like protein 3/0.448
4pnmNU1Tankyrase-22.4.2.300.448
4tx9AMZPhosphoribosyl isomerase A/0.448
1cdeDZFPhosphoribosylglycinamide formyltransferase/0.447
1dr5NAPDihydrofolate reductase1.5.1.30.447
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.447
3gy9COAGCN5-related N-acetyltransferase/0.447
3k8q22APurine nucleoside phosphorylase2.4.2.10.447
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.447
4kxjP34Nucleoprotein/0.447
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.446
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.446
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1rx8FOLDihydrofolate reductase1.5.1.30.446
1s3uTQDDihydrofolate reductase1.5.1.30.446
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.446
2zhw12UProthrombin3.4.21.50.446
3ix4TX1Transcriptional activator protein LasR/0.446
3qge26FGenome polyprotein2.7.7.480.446
4ixd1HVIntegrin alpha-L/0.446
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.445
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.445
3br3ETHTH-type transcriptional regulator QacR/0.445
3f03FMNPentaerythritol tetranitrate reductase/0.445
3k9lGNPGTPase HRas/0.445
3pdqKC6Lysine-specific demethylase 4A1.14.110.445
3t1tGDPProbable gliding protein mglA/0.445
3vhxGTPADP-ribosylation factor 6/0.445
4bahMELProthrombin3.4.21.50.445
4fidGDPG protein alpha subunit, putative/0.445
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.445
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.444
3akn11DFatty acid-binding protein, intestinal/0.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3ndjJHZMethyltransferase/0.444
3p67FMNPentaerythritol tetranitrate reductase/0.444
3qlsNDPDihydrofolate reductase1.5.1.30.444
4dzzADPPlasmid partitioning protein ParF/0.444
4kvgGTPRas-related protein Rap-1A/0.444
4rrbA3TProbable threonine--tRNA ligase 26.1.1.30.444
4rrdA3TProbable threonine--tRNA ligase 26.1.1.30.444
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.444
1ay0TPPTransketolase 12.2.1.10.443
1efaNPFLactose operon repressor/0.443
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.443
2bxqIMNSerum albumin/0.443
2vczVC3Hematopoietic prostaglandin D synthase/0.443
3c16GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.443
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3fun798Leukotriene A-4 hydrolase3.3.2.60.443
3p8iFMNPentaerythritol tetranitrate reductase/0.443
3up0D7SaceDAF-12/0.443
3vruYS3Vitamin D3 receptor/0.443
4nu6NADPhosphonate dehydrogenase1.20.1.10.443
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.443
1lfdGNPGTPase HRas/0.442
1n08ADPRiboflavin kinase2.7.1.260.442
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.442
1qm5PLPMaltodextrin phosphorylase2.4.1.10.442
2hbhXE4Vitamin D3 receptor A/0.442
3cx6GDPGuanine nucleotide-binding protein subunit alpha-13/0.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.442
3juqAJDPhenazine biosynthesis protein A/B/0.442
3oafOAGDihydrofolate reductase1.5.1.30.442
3t4hMD5Alpha-ketoglutarate-dependent dioxygenase AlkB1.14.11.330.442
4xvrGNPGTPase HRas/0.442
4zu44TGWxcM-like protein/0.442
1n5tOALActVA 6 protein/0.441
1oytFSNProthrombin3.4.21.50.441
1rjkVDZVitamin D3 receptor/0.441
1txtCAAHMG-CoA synthase/0.441
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2pmnK51Protein kinase 7/0.441
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
3lqfNADGalactitol dehydrogenase/0.441
4auxXTCTetracycline repressor protein class D/0.441
1cdeGARPhosphoribosylglycinamide formyltransferase/0.440
1drhNAPDihydrofolate reductase1.5.1.30.440
1f8sFADL-amino-acid oxidase1.4.3.20.440
1h62ANBPentaerythritol tetranitrate reductase/0.440
1p0pBCHCholinesterase3.1.1.80.440
1r58AO5Methionine aminopeptidase 2/0.440
2cjfRP43-dehydroquinate dehydratase4.2.1.100.440
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.440
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.440
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3tjzGNPADP-ribosylation factor 1/0.440
4impNDPPolyketide synthase extender modules 3-4/0.440
4lu3AZMCarbonic anhydrase 144.2.1.10.440
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.440
4xymCOAAcyl-CoA synthetase (NDP forming)/0.440