sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ruj | VDX | Vitamin D3 receptor A |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ruj | VDX | Vitamin D3 receptor A | / | 1.000 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.771 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.749 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.728 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.711 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.709 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.701 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.698 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.698 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.698 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.694 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.691 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.690 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.689 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.686 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.685 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.683 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.683 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.682 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.682 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.682 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.681 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.681 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.678 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.678 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.675 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.674 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.674 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.673 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.671 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.669 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.668 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.668 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.662 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.661 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.660 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.659 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.659 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.657 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.656 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.656 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.655 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.655 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.653 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.653 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.653 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.653 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.653 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.653 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.652 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.652 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.652 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.650 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.650 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.648 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.647 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.645 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.644 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.644 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.641 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.639 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.637 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.627 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.618 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.616 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.614 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.614 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.612 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.605 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.591 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.502 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.487 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.487 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.485 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.483 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.483 | |
| 3bej | MUF | Bile acid receptor | / | 0.480 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.479 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.478 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.478 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.478 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.477 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.477 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.477 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.477 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.476 | |
| 1osv | CHC | Bile acid receptor | / | 0.475 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.475 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.474 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.471 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.471 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 3up0 | D7S | aceDAF-12 | / | 0.469 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.469 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.468 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.468 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.467 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.467 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.466 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.466 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.465 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.465 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.465 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.464 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 3zux | TCH | Transporter | / | 0.464 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.463 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.463 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.463 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.463 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.462 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.460 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.459 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.459 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.459 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.459 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.459 | |
| 4lb2 | DM5 | Serum albumin | / | 0.459 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.458 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.457 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.457 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.456 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.456 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.456 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.456 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.456 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.456 | |
| 1eio | GCH | Gastrotropin | / | 0.455 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.455 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.455 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 1jut | LYD | Thymidylate synthase | / | 0.454 | |
| 3nf7 | CIW | Gag-Pol polyprotein | / | 0.454 | |
| 4l8u | 9AZ | Serum albumin | / | 0.454 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.453 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.453 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.453 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.453 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 5cdt | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.452 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3f4b | TCL | Enoyl-acyl carrier protein reductase | / | 0.452 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.451 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.451 | |
| 1hw5 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.451 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.451 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4iah | 1DX | Alr2278 protein | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.451 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.450 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.450 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.450 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.450 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.450 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.450 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.449 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.449 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.449 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.449 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.449 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.449 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.449 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.448 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.448 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3lu8 | IQX | Serum albumin | / | 0.448 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3wgw | T2B | Proliferating cell nuclear antigen | / | 0.448 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.448 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.447 | |
| 1sn5 | T3 | Transthyretin | / | 0.447 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.447 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 3bhh | 5CP | Calcium/calmodulin-dependent protein kinase type II subunit beta | 2.7.11.17 | 0.447 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.447 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.447 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.447 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 1e1m | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.446 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.446 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.446 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3nfa | CBJ | Gag-Pol polyprotein | / | 0.446 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4okw | 198 | Androgen receptor | / | 0.446 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.445 | |
| 1sn0 | T44 | Transthyretin | / | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.445 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.445 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.445 | |
| 3qly | 55V | Uncharacterized protein | / | 0.445 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.445 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.445 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.445 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.444 | |
| 1gqt | ACP | Ribokinase | / | 0.444 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.444 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.444 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.444 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.444 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 4nfh | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.443 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.443 | |
| 1o1v | TCH | Gastrotropin | / | 0.443 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.443 | |
| 2zul | SAM | Probable ribosomal RNA small subunit methyltransferase | / | 0.443 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.443 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.443 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.442 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.442 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.442 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 3eej | 53R | Uncharacterized protein | / | 0.442 | |
| 3gl2 | D3M | DdmC | / | 0.442 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.442 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.442 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.442 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.442 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.442 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.442 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.441 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.441 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.441 | |
| 3dho | B2M | Streptogramin A acetyltransferase | 2.3.1 | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.441 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4iae | 1DX | Alr2278 protein | / | 0.441 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.441 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 4l4x | NDP | AmphI | / | 0.441 | |
| 4l9q | 9TP | Serum albumin | / | 0.441 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.441 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.441 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.440 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.440 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.440 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.440 |