sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4p66 | MTX | Dihydrofolate reductase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4p66 | MTX | Dihydrofolate reductase | / | 1.000 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.669 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.658 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.616 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.616 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.614 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.602 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.601 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.601 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.599 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.596 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.594 | |
| 3eek | 53S | Uncharacterized protein | / | 0.592 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.590 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.589 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.587 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.587 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.586 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.585 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.585 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.584 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.584 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.583 | |
| 3eej | 53R | Uncharacterized protein | / | 0.582 | |
| 3eel | 53T | Uncharacterized protein | / | 0.582 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.582 | |
| 3cse | N22 | Uncharacterized protein | / | 0.581 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.581 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.580 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.580 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.577 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.573 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.571 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.564 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.560 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.559 | |
| 3qly | 55V | Uncharacterized protein | / | 0.559 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.557 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.556 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.555 | |
| 3eem | 53V | Uncharacterized protein | / | 0.553 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.550 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.548 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.541 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.538 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.537 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.536 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.530 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.527 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.527 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.526 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.524 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.513 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.511 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.510 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.507 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.503 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.500 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.500 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4l8u | 9AZ | Serum albumin | / | 0.499 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.498 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.498 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.490 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.488 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.484 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.482 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.481 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.476 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.475 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.474 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4zas | TYD | CalS13 | / | 0.474 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.473 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.472 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.472 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.471 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.470 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.470 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.469 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.467 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.466 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.466 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.465 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.465 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.464 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.463 | |
| 2c3u | 2TP | Pyruvate synthase | / | 0.463 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.463 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.463 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.462 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.461 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.460 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.459 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2p15 | EZT | Estrogen receptor | / | 0.458 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.458 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3sr5 | Q12 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3swr | SFG | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.457 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.456 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.456 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.456 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.456 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.456 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.456 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.455 | |
| 1yre | COA | Uncharacterized protein | / | 0.455 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.455 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.455 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.455 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.455 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.455 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2mm3 | CHO | Gastrotropin | / | 0.454 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.454 | |
| 3saz | 043 | Malate synthase G | / | 0.454 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.454 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.453 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.453 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.453 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.453 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.453 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.453 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.453 | |
| 1dtn | APG | Mandelate racemase | / | 0.452 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.452 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.452 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.452 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.452 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.452 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 2fai | 459 | Estrogen receptor | / | 0.451 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3lu8 | IQX | Serum albumin | / | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 4j7x | SAS | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.451 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.451 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.450 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.450 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.450 | |
| 3dho | B2M | Streptogramin A acetyltransferase | 2.3.1 | 0.450 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.450 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.449 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.449 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.449 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4a99 | MIY | TetX family tetracycline inactivation enzyme | / | 0.449 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.449 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.448 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.448 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.447 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.447 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.447 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.447 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.447 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4egn | TWO | Cytochrome P450 | / | 0.447 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 5a3c | NAD | SIR2 family protein | / | 0.447 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.447 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.446 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.446 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.445 | |
| 1z1f | STL | Resveratrol synthase | / | 0.445 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.445 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.445 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.445 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.445 | |
| 4oal | 245 | Cytokinin dehydrogenase 4 | / | 0.445 | |
| 4rw4 | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.444 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.444 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 1p7t | ACO | Malate synthase G | / | 0.444 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.444 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.444 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1osv | CHC | Bile acid receptor | / | 0.443 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.443 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.443 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.443 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.443 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.443 | |
| 4b1f | KRH | Glutamate racemase | / | 0.443 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.443 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.442 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.442 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.442 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.442 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2chl | DKI | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.442 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.442 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3tdl | 11D | Serum albumin | / | 0.442 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.442 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.442 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.442 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.442 | |
| 1pp9 | SMA | Cytochrome b | / | 0.441 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.441 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.441 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.441 | |
| 2ybo | SAH | Methyltransferase | / | 0.441 | |
| 3p9t | TCL | Repressor | / | 0.441 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 3zra | ORB | Progesterone receptor | / | 0.441 | |
| 4aa0 | AA0 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.441 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.440 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.440 | |
| 3dmj | GWE | Pol protein | / | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.440 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.440 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.440 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4l9q | 9TP | Serum albumin | / | 0.440 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.440 |